Alcohol (Hanover, York County, Pa.)最新文献

{"title":"Neuropeptide Y1 receptor expressing circuit from the central amygdala to lateral hypothalamus modulates binge-like ethanol consumption in a sex-dependent manner.","authors":"Sophie C Bendrath, Ashlyn Stone, Anne M Dankert, Todd E Thiele","doi":"10.1111/acer.70151","DOIUrl":"https://doi.org/10.1111/acer.70151","url":null,"abstract":"<p><strong>Background: </strong>Alcohol use disorder is characterized by maladaptive patterns of alcohol consumption, with emerging evidence suggesting that neuropeptide Y (NPY) signaling through Y1 and Y2 receptors (Y1R and Y2R) within the central amygdala (CeA) plays a critical role in modulating ethanol intake. The current experiments investigate the neural mechanisms underlying binge-like ethanol drinking, focusing on the involvement of Y1R+ CeA-to-lateral hypothalamus (LH) projections, dynamic interactions between Y1R and Y2R within the CeA, and the impact of chronic ethanol exposure on Y1R protein expression.</p><p><strong>Methods: </strong>NPY1R-ires-cre mice received LH cannulation, were infused with cre-dependent inhibitory (Gi) Designer Receptor Exclusively Activated by Designer Drug (DREADD) or control virus into the CeA, and went through drinking in the dark (DID). Other animals were treated intra-CeA with an NPY overexpression vector (FIB-NPY) or control, and went through DID, intermittent access to ethanol (IAE), and open-field testing. Viral placements and receptor targets were assessed via qPCR. Finally, mice went through six cycles of DID, and Y1R immunohistochemical (IHC) labeling on neurons was assessed for animals sacrificed after the final DID session or after a 24-h period of abstinence.</p><p><strong>Results: </strong>Chemogenetic inhibition of Y1R+ CeA-LH projections selectively reduced binge-like ethanol drinking in male mice without affecting female mice. Viral NPY overexpression revealed behavioral effects and predictive relationships between receptor mRNA expression and intake patterns. Although no significant differences were found in Y1R/NeuN colocalization across sex and treatment groups, correlational analyses revealed that Y1R expression varied with individual ethanol consumption.</p><p><strong>Conclusions: </strong>Collectively, these results support a model wherein Y1R signaling within the CeA regulates ethanol consumption through circuit-specific mechanisms and broader neuroadaptive changes influenced by sex and individual drinking patterns. This research advances our understanding of the neurobiological mechanisms underlying binge-like ethanol intake and highlights the complex, sex-dependent roles of NPY-Y1R and Y2R signaling in the CeA.</p>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144980623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Results of a pilot randomized controlled trial of Tuning in to Kids for children with FASD in nonbiological parent care.","authors":"Christie L M Petrenko, Carson Kautz-Turnbull, Madeline N Rockhold, Elizabeth D Handley, Sophie S Havighurst, Sheree L Toth","doi":"10.1111/acer.70153","DOIUrl":"https://doi.org/10.1111/acer.70153","url":null,"abstract":"<p><strong>Background: </strong>Emotion regulation difficulties and placements with nonbiological parents are common in children with fetal alcohol spectrum disorders (FASD). We tested whether the Tuning in to Kids (TIK) intervention would improve emotion regulation in children with FASD living with nonbiological parents by targeting caregiver emotion socialization.</p><p><strong>Method: </strong>A two-arm pilot randomized controlled trial of the 8-week, group-based TIK program was conducted from 8/2017 to 9/2021 (ClinicalTrials.gov #NCT03524664). Multimethod data collection occurred at baseline, post-intervention, and three-month follow-up. Eighty-nine children (ages 4-12) with FASD and their caregivers were enrolled, with 87 randomly assigned to study conditions (54 TIK, 33 waitlist control). At the onset of COVID-19, intervention delivery and data collection were transitioned to remote methods. Data were analyzed using multivariate regression.</p><p><strong>Results: </strong>A total of 37 (68.5%) caregivers completed at least five TIK group sessions. Ratings of satisfaction and perceived impact of the program were high. Findings of exploratory analyses indicated that families with younger caregivers responded more favorably to TIK, as evidenced by improvements in both caregiver (p = 0.005) and child (p = 0.04) emotion regulation, and caregiver empathy (p = 0.008) and emotion coaching (p < 0.001) immediately post-intervention. No significant effects were found at three-month follow up (ps > 0.05).</p><p><strong>Conclusions: </strong>The TIK program did not lead to significant improvement compared to waitlist controls overall in this sample. Findings suggest caregiver age is an important consideration in emotion coaching interventions in these settings.</p>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144980573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A commentary on the prevalence, outcomes, and state-of-science on solitary drinking.","authors":"Jack T Waddell, Samuel F Acuff","doi":"10.1111/acer.70150","DOIUrl":"https://doi.org/10.1111/acer.70150","url":null,"abstract":"","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144980561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Altered neuronal network connectivity in children with fetal alcohol spectrum disorder and its association with inhibitory function.","authors":"Maryam H Alsameen, Felicha T Candelaria-Cook, Cassandra M Cerros, Dina E Hill, Julia M Stephen","doi":"10.1111/acer.70144","DOIUrl":"10.1111/acer.70144","url":null,"abstract":"<p><strong>Background: </strong>Fetal alcohol spectrum disorder (FASD) is associated with widespread neurocognitive deficits, including impairments in executive function, attention, and inhibitory control. However, understanding of the neural mechanisms underlying these deficits in young children 6-8 years of age remains limited. This study investigated functional connectivity (FC) alterations in key brain networks related to inhibitory control and executive function in children with FASD compared to typically developing controls (TDC).</p><p><strong>Methods: </strong>Seed-based connectivity (SBC) analysis was conducted in 27 children with FASD and 30 TDC, focusing on the medial prefrontal cortex (MPFC) within the Default Mode Network (DMN) and Frontal Parietal Network (FPN). FC differences were assessed across resting-state conditions (eyes closed vs. eyes open) and correlated with Conners Continuous Performance Test (CPT).</p><p><strong>Results: </strong>Children with FASD exhibited significantly reduced FC between MPFC and limbic regions, including the amygdala, hippocampus, and brainstem, suggesting impairments in emotion regulation and cognitive control. The FPN showed altered connectivity with the middle temporal gyrus and inferior lateral occipital cortex, regions crucial for higher order cognitive processing. Significant interactions between groups and resting-state condition were observed, with altered connectivity patterns in the MPFC and FPN suggesting sensory-motor and cognitive control disruptions. FC patterns in these networks were significantly correlated with CPT performance, including increased errors of omission and reaction time variability, indicating deficits in sustained attention and response inhibition.</p><p><strong>Conclusion: </strong>Our findings reveal early disruptions in FC within the DMN and FPN in young children with FASD, highlighting altered interactions between key brain regions implicated in inhibitory control and executive function. These neural alterations were associated with behavioral deficits in attention and cognitive control, suggesting that FC abnormalities may underlie core cognitive impairments in FASD. Findings underscore the importance of early identification and intervention strategies targeting neural network dysfunctions to improve cognitive outcomes in children with FASD.</p>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12407249/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144980643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of alcohol withdrawal therapy on gut microbiota in alcohol use disorder and its link to inflammation and craving","authors":"Phileas J. Proskynitopoulos,&nbsp;Sabrina Woltemate,&nbsp;Mathias Rhein,&nbsp;Isabell Böke,&nbsp;Jannis Molks,&nbsp;Sebastian Schröder,&nbsp;Hans-Udo Schneider,&nbsp;Stefan Bleich,&nbsp;Helge Frieling,&nbsp;Robert Geffers,&nbsp;Alexander Glahn,&nbsp;Marius Vital","doi":"10.1111/acer.70128","DOIUrl":"10.1111/acer.70128","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Alcohol use disorder (AUD) is linked to changes in the function and composition of the human gut microbiome (GM). The GM affects inflammation by producing anti-inflammatory molecules such as short-chain fatty acids (SCFA), in particular butyrate, which are linked to appetite regulation, a mechanism involved in alcohol craving. This study investigates changes in GM composition and functional capacity to produce SCFA during alcohol withdrawal and their link to inflammation and craving.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Sixty-three patients (mean age 48, SD = 12) with AUD were enrolled. We collected stool (<i>n</i> = 63) and blood (<i>n</i> = 48) during the first 48 h (timepoint A) of withdrawal therapy and between Days 10–14 (timepoint B). Microbiota were analyzed using shotgun metagenomics along with bacterial load determinations. TNF-α, IL-6, IL-8, and IL-10 were measured in plasma.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Bacterial diversity (species richness, Shannon Index) did not change significantly throughout withdrawal, while overall bacterial load increased. Abundances of several taxa changed, and the overall community composition during withdrawal was approaching those of healthy controls; the potential to synthesize butyrate, a key SCFA, increased. However, it remained at lower levels compared with controls. Both diversity parameters correlated with cell concentrations and the butyrate pathway at baseline. The latter was negatively associated with IL-6 at baseline. IL-8 and IL-10 levels decreased significantly during withdrawal, as did craving, which was linked to abundance alterations of six species and IL-8.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Alcohol withdrawal affected GM composition and increased concentration of the butyrate pathway along with overall bacterial load. Changes in bacterial composition and the butyrate production capacity demonstrate a shift toward healthier microbiota during withdrawal therapy. Changes in some species and IL-8 were linked to alcohol craving, replicating findings of previous studies. Our study adds new findings helping to understand the microbiome–gut–brain axis.</p>\u0000 </section>\u0000 </div>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":"49 9","pages":"1912-1923"},"PeriodicalIF":2.7,"publicationDate":"2025-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/acer.70128","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144980631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Discontinuation of treatment for alcohol use disorder during pregnancy and postpartum in the United States","authors":"Caitlin E. Martin,&nbsp;Jennifer K. Bello,&nbsp;Bridget M. Galati,&nbsp;Joanna L. Buss,&nbsp;Mishka Terplan,&nbsp;Hendrée E. Jones,&nbsp;Kathleen T. Mitchell,&nbsp;Silvia S. Martins,&nbsp;Richard A. Grucza,&nbsp;Elizabeth A. Suarez,&nbsp;Kevin Y. Xu","doi":"10.1111/acer.70117","DOIUrl":"10.1111/acer.70117","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The degree of alcohol use disorder (AUD) treatment utilization during the perinatal period is unknown. We report the prevalence of preconception receipt of medications for AUD (MAUD) and psychosocial interventions (PSY), discontinuation during pregnancy, and postpartum resumption in a multi-state sample, comparing pregnant and nonpregnant people with AUD.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Using MarketScan combined commercial and Medicaid claims (2016–2019), we identified individuals with AUD who had continuous insurance coverage throughout pregnancy, classifying those with a live birth as pregnant, and compared their MAUD and PSY patterns to nonpregnant peers matched by age, insurance type, and calendar time. All individuals had ≥1 claim for: (a) AUD diagnosis and (b) MAUD or PSY in the year preceding the study. Outcomes—filled MAUD prescriptions (naltrexone, acamprosate, and disulfiram) and receipt of PSY—were identified via claims. We computed rates of MAUD and PSY receipt, stratifying by five observation windows for pregnant individuals (12-week preconception; first, second, and third trimesters; 12 weeks postpartum) and nonpregnant peers (by corresponding windows). We assessed time to treatment discontinuation using multivariable Cox regression, adjusting for sociodemographics and comorbidities.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Our sample consisted of 2080 pregnant persons with AUD and 7564 matched nonpregnant AUD peers. During pregnancy, MAUD receipt declined from 12.1% (preconception) to 0.3% (third trimester) among pregnant people and from 13.5% to 8.1% in nonpregnant peers during the equivalent time period (<i>p</i> &lt; 0.001). Postpartum resumption of MAUD was uncommon in the pregnant cohort (pregnant = 1.9%; nonpregnant = 7.8%, <i>p</i> &lt; 0.001). PSY declined for both the pregnant and nonpregnant cohorts yet remained modestly higher in the nonpregnant cohort (postpartum 10.3% vs. 13.8%, <i>p</i> &lt; 0.001). In adjusted analyses, pregnant people were more likely to discontinue MAUD than nonpregnant peers (HR = 2.11 [1.71–2.60]) yet not more likely to discontinue PSY (HR = 1.01 [0.87–1.17]).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Among pregnant people with preconception AUD receiving treatment, MAUD utilization is low and discontinuation is widespread, persisting postpartum.</p>\u0000 </section>\u0000 </div>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":"49 9","pages":"1972-1982"},"PeriodicalIF":2.7,"publicationDate":"2025-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144980607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between changes in AUDIT-C scores and acute mental healthcare utilization over the next year in a primary care population","authors":"Megan L. Lee,&nbsp;Helen E. Jack,&nbsp;Theresa E. Matson,&nbsp;Malia Oliver,&nbsp;Jennifer F. Bobb,&nbsp;Douglas Berger,&nbsp;Katharine A. Bradley,&nbsp;Kevin A. Hallgren","doi":"10.1111/acer.70125","DOIUrl":"10.1111/acer.70125","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Unhealthy alcohol use (UAU) is common in primary care populations and can significantly impact mental health. Screening for UAU within primary care is increasingly used for point-in-time identification of UAU, but it is less clear whether changes in alcohol screening scores effectively capture changes in alcohol-related risk.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This retrospective cohort study used data from adult primary care patients in a Northwest US health system who had completed two AUDIT-C screens 11–24 months apart (T1, T2). Scores were grouped into five categories from no use to very high-risk UAU. Generalized estimating equation models tested whether changes in AUDIT-C categories from T1 to T2 were associated with changes in risk for nonaddiction mental health acute care utilization (emergency department or hospital admission) over 1 year after T1 and T2.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Of 165,101 patients (61% female; mean age 55), mental health acute care utilization risks were 0.9% after T1 and 0.8% after T2. Compared to those with stable drinking (T1 utilization 0.8%, T2 0.8%), mental health acute care utilization risk decreased for patients with a one-level decrease (T1 1.1%, T2 0.9%, <i>p</i> &lt; 0.01) or greater than or equal to two-level decrease (T1 2.5%, T2 1.4%, <i>p</i> &lt; 0.001). Increases in AUDIT-C categories were not associated with increased risk of mental health acute care utilization.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Changes in AUDIT-C score categories over time, particularly decreases, may reflect real changes in an important risk of UAU. Changes in alcohol screening scores may offer clinicians, health systems, and researchers meaningful information about changes in health risk.</p>\u0000 </section>\u0000 </div>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":"49 9","pages":"1993-2002"},"PeriodicalIF":2.7,"publicationDate":"2025-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144980562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Theory of mind deficits in Korsakoff's syndrome and alcohol use disorder: Similar deficits but different underlying cognitive processes","authors":"Alice Laniepce,&nbsp;Pierre Maurage,&nbsp;Ludivine Ritz,&nbsp;Céline Boudehent,&nbsp;Nicolas Cabé,&nbsp;Shailendra Segobin,&nbsp;Hélène Beaunieux,&nbsp;Anne-Lise Pitel","doi":"10.1111/acer.70135","DOIUrl":"10.1111/acer.70135","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Preliminary studies reported Theory of Mind (ToM) deficits in patients with Korsakoff's syndrome (KS). However, they presented several limits as they did not (1) control for key biasing factors (e.g., understanding of the task, amnesia); (2) compare KS with severe alcohol use disorder (sAUD) regarding ToM deficits; (3) explore the links between ToM abilities and other cognitive abilities. We thus directly compared cognitive ToM in patients with KS and sAUD, while considering task understanding and other cognitive deficits.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Sixteen patients with KS, 70 patients with sAUD, and 69 healthy controls (HC) underwent a neuropsychological examination including a global cognitive screening, working memory and executive tests, as well as a cognitive ToM task designed to reduce cognitive load through the use of nonverbal materials (comic-stories). The ToM task measured the ability to attribute first- and second-order mental states to others and the level of understanding of the story with a control task.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>We found no group effect on performance for the control condition. For both the first- and second-order items of the ToM condition, HC performed significantly better than patients with sAUD and KS, who did not differ from each other. Results remained unchanged when controlling for the performance on the control task. However, when controlling for global cognitive status, patients with KS did not differ from HC anymore, contrary to patients with sAUD who remained altered. When controlling for executive/working memory performance, the main group effect was no longer observed. Flexibility was the only predictor of ToM performance in patients with sAUD.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Cognitive ToM is similarly affected in patients with KS and sAUD, but global cognitive deterioration may underlie ToM deficits in patients with KS, whereas they may be more specifically related to flexibility impairments in patients with sAUD.</p>\u0000 </section>\u0000 </div>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":"49 9","pages":"1962-1971"},"PeriodicalIF":2.7,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/acer.70135","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144980598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasma apolipoproteins and memory function in alcohol use disorder: Findings in male C57BL/6J mice and men suggest a role for APOAI.","authors":"Berta Escudero, Max Kreifeldt, Kiera Fleck, Catherine Lopez, Candice Contet, Laura Orio","doi":"10.1111/acer.70149","DOIUrl":"https://doi.org/10.1111/acer.70149","url":null,"abstract":"<p><strong>Background: </strong>Memory impairment is frequent among alcohol use disorder (AUD) patients, and we lack specific biomarkers to detect it. Certain apolipoproteins were linked to cognition, and carrying the APOE4 gene is a vulnerability factor to memory impairment in AUD patients. We explored memory deficits in alcohol-dependent male mice and humans versus controls, and their relationship to Apolipoprotein AI (APOAI), apolipoprotein B (APOB), and apolipoprotein E (APOE) plasma levels.</p><p><strong>Methods: </strong>Male C57BL/6J mice underwent voluntary alcohol drinking (two-bottle choice, 2BC) and chronic intermittent ethanol vapor exposure (CIE) as a model of alcohol dependence; memory was assessed by the Object Location Test (OLT) and Novel Object Recognition Test (NORT). Additionally, male AUD-diagnosed patients were recruited in Spain during an alcohol dishabituation program and assessed by the Wechsler Memory Scale-IV (WMS-IV). Plasma APOAI, APOB, and APOE levels were checked in mice and humans by ELISA kits and Luminex immunoassay technology. APOAI immunolabeling was quantified in mouse brain in early withdrawal and following alcohol consumption.</p><p><strong>Results: </strong>CIE-2BC mice (n = 8) escalated alcohol consumption compared to Air-2BC controls (n = 11) and showed deficits in spatial memory (OLT) and recognition memory (NORT) while AUD patients (n = 12) showed deficits in verbal and visual memory (WMS-IV) versus controls (n = 16). Higher plasma levels of APOAI were detected in CIE-2BC mice and AUD patients, with no differences in APOB and APOE in animals and humans. Significant negative correlations were found between levels of APOAI, APOB, and APOE and memory function tests/scales in the entire sample, with APOAI showing consistent results in both animals and humans. APOAI immunoreactivity was detected in the mice subfornical organ, but the signal did not differ between experimental groups.</p><p><strong>Conclusions: </strong>Both CIE-2BC mice and AUD patients exhibited elevated plasma levels of APOAI during early abstinence. APOAI correlated with poorer memory performance in both species, suggesting a potential role for this apolipoprotein in the context of alcohol-induced cognitive impairment.</p>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144980636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Articles of Public Interest","authors":"","doi":"10.1111/acer.70141","DOIUrl":"https://doi.org/10.1111/acer.70141","url":null,"abstract":"","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":"49 8","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144869772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}