Alcohol (Hanover, York County, Pa.)最新文献

{"title":"Disrupted decision making in adult male rats after prolonged withdrawal from ethanol vapor exposure.","authors":"Yifeng Cheng, Nikhila Kalapatapu, Patricia H Janak","doi":"10.1111/acer.70143","DOIUrl":"https://doi.org/10.1111/acer.70143","url":null,"abstract":"<p><strong>Background: </strong>Chronic alcohol use disrupts decision making and cognitive flexibility, but its long-term effects after adult exposure remain poorly understood. While prior studies have shown moderate disruptions in behavioral flexibility weeks after ethanol (EtOH) withdrawal, we tested whether such deficits persist after prolonged abstinence (>6 months) in male rats.</p><p><strong>Methods: </strong>Male rats underwent 4 weeks of EtOH vapor or air exposure starting at postnatal day 75. After approximately 7 months of withdrawal, rats (postnatal day ~300) completed a series of reversal learning tasks featuring distinct reward probabilities with deterministic (100/0%) and uncertain (90/10% and 80/20%) schedules. We assessed win-stay and lose-shift behaviors, as well as response latencies. Reinforcement learning (RL) models were fit hierarchically to identify group differences in value updating during reward-guided decision making.</p><p><strong>Results: </strong>When rats had novel reversal experience under deterministic conditions, ethanol (EtOH)-exposed rats showed increased lose-shift behavior in trials preceding the reversal point. When a moderate outcome uncertainty (90/10) was introduced, EtOH rats displayed reduced win-stay behavior in trials after reversal when learning new contingencies. With continued training under greater outcome uncertainty (80/20), these changes were not manifested. Furthermore, RL models revealed that rats employed distinct learning processes depending on the reward schedule. Across all RL models, EtOH-exposed rats exhibited a consistently high decay of unchosen action values, either through faster forgetting or enhanced updating after negative outcomes.</p><p><strong>Conclusions: </strong>These findings demonstrate that a remote history of adult alcohol exposure can lead to persistent, uncertainty-sensitive disruptions in reward-based decision making, even after exceptionally long withdrawal.</p>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144876922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An exploratory analysis of the relationship between ultraprocessed food consumption, alcohol intake, body composition, and cardiometabolic markers in individuals with alcohol use disorder.","authors":"Jennifer J Barb, Lillian C King, Shanna Yang, Sara Turner, Carlotta Vizioli, Ryan E Tyler, Kong Y Chen, Mehdi Farokhnia, Gwenyth R Wallen, Lorenzo Leggio","doi":"10.1111/acer.70140","DOIUrl":"https://doi.org/10.1111/acer.70140","url":null,"abstract":"<p><strong>Background: </strong>Ultraprocessed foods (UPFs) are often high in salt, fat, and sugar and low in fiber and nutrients. Research has suggested that UPFs are associated with all-cause mortality and have recently been proposed to align with properties of addictive substances. While research suggests that people with alcohol use disorder (AUD) have poor dietary habits in general, little is known about whether these people consume more UPFs than those without AUD. In an exploratory analysis, we examined how UPFs, diet quality, and added sugars consumption would be associated with other health outcomes in newly abstinent and currently drinking people with AUD and compared those to healthy individuals.</p><p><strong>Methods: </strong>Participants were individuals with AUD who were newly abstinent or currently drinking, and healthy controls. Two weeks of food intake records in an outpatient setting were assessed for UPF, diet quality, and added sugars, and were compared between the three groups. Correlations were assessed across diet and alcohol measures, body composition, resting energy expenditure, and atherosclerotic cardiovascular disease (ASCVD) risk scores within each group.</p><p><strong>Results: </strong>All groups consumed similar poor quality diets with >55% usual foods from UPFs and >8% of energy intake from added sugars. Within groups, only the newly abstinent individuals showed associations between ASCVD risk and alcohol use history along with diet quality and body composition.</p><p><strong>Conclusions: </strong>Despite the lack of statistically significant differences in diet quality measures between groups, nutrition support for healthier food choices in people with AUD, especially during alcohol recovery, should be carefully investigated.</p>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144838687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of agitation and aggression in inpatients with alcohol use disorder: A systematic review of informant-based scales","authors":"Willem S. Eikelboom,&nbsp;Denice S. A. M. Verberkt,&nbsp;Yvonne C. M. Rensen,&nbsp;Gwenny T. L. Janssen,&nbsp;Roy P. C. Kessels","doi":"10.1111/acer.70138","DOIUrl":"10.1111/acer.70138","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Agitation and aggression are commonly observed in inpatients with alcohol use disorder (AUD). Adequate assessment is essential to provide appropriate care for these behaviors. To date, a systematic evaluation of existing measurement scales for use in AUD is lacking. The aim of this systematic review was to provide an overview of existing informant-based scales to assess agitation and/or aggression and to evaluate their psychometric properties and applicability in people with AUD.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Existing reviews on the assessment of agitation and/or aggression in psychiatric populations and neurocognitive disorders were searched to identify existing instruments to assess agitation and aggression. Next, for each scale, systematic literature searches were conducted in Embase, MEDLINE, and PsychINFO to evaluate the use in AUD and to identify psychometric studies using a validated methodological search filter. We applied the COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN) to evaluate the psychometric properties.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>We included 20 unique scales for which we identified 86 studies reporting on psychometric properties and 65 studies that used any of these scales in AUD. To assess agitation and aggression retrospectively, the Rating Scale for Aggressive Behavior in the Elderly (RAGE) and Cohen-Mansfield Agitation Inventory (CMAI) have the best psychometric qualities. The Pittsburgh Agitation Scale (PAS) showed the best psychometric properties of all scales that assess agitation and aggression during a prospective observation period. To assess agitation and aggression following an incident, the Overt Aggression Scale (OAS) has the best psychometric properties. Sixty-five studies used any of the included scales to assess agitation and/or aggression in individuals with AUD, with the MOAS and OAS as the most commonly used scales within the AUD population.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This review is the first to provide an overview of existing scales to assess agitation and aggression together with their psychometric properties and use in AUD. Findings guide clinicians and researchers to select the most appropriate instruments to improve the diagnosis and treatment of agitation and aggression in AUD.</p>\u0000 </section>\u0000 </div>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":"49 9","pages":"1877-1888"},"PeriodicalIF":2.7,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/acer.70138","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144838688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of blood phosphatidylethanol as an alcohol consumption biomarker in patients with alcohol use disorder and liver disease at a liver transplant center","authors":"J. Watt,&nbsp;K. C. Morley,&nbsp;P. S. Haber,&nbsp;D. Seth,&nbsp;A. Volovets","doi":"10.1111/acer.70133","DOIUrl":"10.1111/acer.70133","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Phosphatidylethanol (PEth), ethyl glucuronide (EtG), and ethyl sulphate (EtS) are highly sensitive and specific biomarkers of alcohol intake. This study investigated their application and relationship to traditional self-report measures in a mixed cohort of liver disease patients to guide decision making in liver transplant populations.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We recruited 183 participants (mean age 49.2 years, 62% male), with <i>N</i> = 99 liver disease (88% alcohol-associated liver disease [ALD]), <i>N</i> = 35 alcohol use disorder (AUD), and <i>N</i> = 49 healthy volunteers. Patient-reported alcohol intake and AUDIT score served as references and were compared to traditional biomarkers, PEth and serum EtG/EtS. Receiver operating characteristic (ROC) analysis and a range of biomarker cutoffs were examined to determine optimal test characteristics. A subset of blood samples modified to a standardized hematocrit analyzed the relationship between hematocrit and PEth.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Compared to traditional biomarkers, both PEth and EtG were sensitive and specific for alcohol intake. At the limit of detection (LOD), PEth was 95% sensitive at detecting any drinking. PEth cutoff of 300 μg/L was 86% sensitive and 92% specific for “heavy drinking,” and 600 μg/L was 88% sensitive and specific for “very heavy drinking.” PEth displayed superior test characteristics (sensitivity, specificity, PPV, NPV, and AUC) to all measured traditional biomarkers over two-day and one-month time frames. A subset of participants suspected of drinking but reporting abstinence had positive PEth tests (35%), suggestive of unreported drinking. PEth was positively correlated with hematocrit (<i>r</i>² = 0.83, <i>p</i> &lt; 0.01) and correction to a standardized median resulted in increases in PEth concentration in most cases.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>PEth is clinically useful as an alcohol biomarker in patients with liver disease and is superior to traditional biomarkers, providing good test characteristics for “heavy” and “very heavy” drinking using stepwise cutoffs. PEth detected a subset of patients underreporting their alcohol use, with implications for the management of patients in liver transplant clinics.</p>\u0000 </section>\u0000 </div>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":"49 9","pages":"2013-2024"},"PeriodicalIF":2.7,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/acer.70133","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144838690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Measuring alcohol consumption with biomarkers in intervention studies: A scoping review","authors":"Jeremy C. Kane,&nbsp;Priya Chirayil,&nbsp;Rhea Pawar,&nbsp;Sachi Inoue,&nbsp;Tamara Hofer,&nbsp;Michael McDonell,&nbsp;Carl Latkin,&nbsp;Geetanjali Chander,&nbsp;Silvia S. Martins,&nbsp;M. Claire Greene,&nbsp;Michael Vinikoor,&nbsp;Anjali Sharma,&nbsp;Judith A. Hahn","doi":"10.1111/acer.70114","DOIUrl":"10.1111/acer.70114","url":null,"abstract":"<p>In intervention studies, alcohol consumption is often measured by self-report alone, which can be impacted by social desirability, recall, and other biases. Biomarkers and biosensors have gained popularity as objective measurements of alcohol consumption that can improve the accuracy of results. This scoping review provides a narrative overview and describes the use of biomarkers in alcohol intervention studies to inform future research. We conducted a review of alcohol intervention literature including published studies and Clinicaltrials.gov registrations (2000–2021). Randomized controlled trials, quasi-experimental, and nonexperimental studies were included if they piloted or evaluated an intervention aimed at reducing unhealthy alcohol consumption and if an alcohol biomarker was used. Data charting included type of biomarker(s), the country and context of the study location, and a description of how the biomarker was used in analysis. We identified 168 alcohol intervention studies that included at least one biomarker. Blood alcohol content was the most used (<i>N</i> = 76). There was an upward trend in biomarker use over time; 24% of studies were published between 2000 and 2010, and 76% between 2011 and 2021. The use of direct biomarkers, phosphatidylethanol and ethyl glucuronide, and biosensors has increased in frequency over time relative to indirect biomarkers, such as aspartate aminotransferase, carbohydrate-deficient transferrin, and alanine aminotransferase. Most studies were conducted in high-income countries; only 15% were conducted in a low- or middle-income country. More than half of completed studies did not report on comparisons between self-report and biomarker results even when both were collected. Among studies that did report a comparison, 26% reported discordance between self-report and biomarker results. The use of direct biomarkers and biosensors is accelerating. There is a need for more consistency in reporting biomarker/self-report concordance results, more comparisons between multiple biomarkers, and for greater geographic representation within the alcohol biomarker literature.</p>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":"49 9","pages":"1843-1854"},"PeriodicalIF":2.7,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144838689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Behavioral interventions for individuals with fetal alcohol spectrum disorder: A review of systematic reviews","authors":"Eric Flake,&nbsp;Elizabeth H. Lee,&nbsp;Kyle Patrick Apilado,&nbsp;Rachel Sayko Adams,&nbsp;Alyssa MacMahon,&nbsp;Tracey Perez Koehlmoos","doi":"10.1111/acer.70129","DOIUrl":"10.1111/acer.70129","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Individuals diagnosed under the spectrum of fetal alcohol spectrum disorders (FASD) experience numerous cognitive and behavioral impairments, including learning disabilities, executive functioning dysfunction, and difficulties in emotional regulation. Studies of direct child-centered nonpharmacological behavioral interventions to improve outcomes have steadily developed over the past few decades. Systematic reviews of this literature have documented the wide collection of studies, and an overall review of these reviews permits a single, comprehensive analysis encompassing behavioral intervention research.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Electronic databases were searched for systematic reviews from 2005 to 2024. Included reviews reported the effectiveness of child-centered behavioral, nonpharmacological interventions in noneducational settings for individuals with FASD from birth until the age of 18. Abstract screening, full-text screening, and data extraction were conducted using Covidence. AMSTAR-2 was utilized to assess the methodological quality of systematic reviews.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of seven systematic reviews were included for comprehensive analysis. Two reviews were of high quality, two were of low quality, and three were of critically low quality, as per AMSTAR-2 grading criteria. Categories of behavioral interventions within systematic reviews included executive functioning interventions, self-management interventions, social skill interventions, family-based interventions, cognitive behavioral interventions, and applied behavior analysis-based treatment. While numerous positive outcomes were identified across several behavioral interventions, the systematic reviews identified multiple limitations, such as high risk of bias and small sample sizes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Numerous positive outcomes were identified from among systematic reviews regarding FASD interventions; however, the current evidence base is limited by methodological weaknesses and potential risks of bias. Further research and implementation are necessary to strengthen the delivery of interventions and continue improving outcomes for individuals with FASD.</p>\u0000 </section>\u0000 </div>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":"49 9","pages":"2064-2075"},"PeriodicalIF":2.7,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/acer.70129","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144823311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Social influence increases the value and consumption of alcohol in the laboratory","authors":"Jack Yates,&nbsp;Benjamin Miller,&nbsp;Alazne Arraztio Cordoba,&nbsp;Jasmine Grace Warren,&nbsp;Michael Batterley,&nbsp;Jessica Catherine Gay,&nbsp;Abigail K. Rose,&nbsp;Carl A. Roberts,&nbsp;Andrew Jones","doi":"10.1111/acer.70115","DOIUrl":"10.1111/acer.70115","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Previous research has demonstrated the perceived value of alcohol is transient in hypothetical social and environmental contexts. This study sought to further expand on this by examining whether the social influence of a confederate and the physical environment could be manipulated to influence the value of alcohol and ad libitum alcohol consumption, and thus provide support for the role of value as a mechanism underlying alcohol use.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Method</h3>\u0000 \u0000 <p>A total of 140 (90 female, Mean age = 25.81, SD = 14.20, Mean AUDIT = 11.51, SD = 5.38) participants completed a between-subjects 2 (environment: bar labortaory vs. standard unadorned) × 2 (social influence: positive appraisal vs. negative appraisal) design in which they completed a brief assessment of alcohol demand, a concurrent choice task, and a visual analogue scale measuring alcohol value, following a limited drinking session with a confederate in one of two laboratory settings, and then completed an ad libitum bogus taste test.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Social influence had a significant effect on intensity index of demand (<i>F</i> (1,133) = 4.74, <i>p</i> = 0.031, ηp² = 0.03) and on ad libitum consumption (<i>F</i> (1,135) = 7.60, <i>p</i> = 0.007, <i>ηp</i>^<i>2</i> = 0.05) with positive appraisal having greater intensity scores (Mean = 4.34, SD = 2.80) compared with the negative appraisal (Mean = 3.39, SD = 2.23) and more alcohol consumed (Mean = 221.07 mL, SD = 121.76 vs. Mean = 164.71 mL, SD = 111.80). The intensity index also mediated the relationship between social influence and ad libitum consumption (B = 10.40, 95% Bootstrapped CIs = 0.34 to 23.59). There were no significant main effects of environment and no interactions between social influence and environment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>These findings suggest alcohol value is sensitive to social influence. Increased value as a result of positive alcohol appraisals by others had a significant effect on ad libitum consumption and that the intensity index of demand mediated the relationship.</p>\u0000 </section>\u0000 </div>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":"49 9","pages":"2038-2048"},"PeriodicalIF":2.7,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/acer.70115","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144823313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluations of potential sex differences in alcohol use and problems in 454 offspring from the San Diego Prospective Study","authors":"Marc A. Schuckit,&nbsp;Tom L. Smith,&nbsp;George Danko,&nbsp;Hannah N. Fisher,&nbsp;Lee Anne Mendoza","doi":"10.1111/acer.70136","DOIUrl":"10.1111/acer.70136","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Some studies have reported that the course of alcohol problems, including alcohol use disorder (AUD), differs across males and females. In contrast, 30 years ago, we reported that the course of these conditions was quite similar across the sexes in participants in a large collaborative study. This paper reevaluates potential sex differences in alcohol problems using offspring from the recent San Diego Prospective Study (SDPS).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Standardized clinical interviews and validated questionnaires were used to evaluate 230 male and 224 female SDPS drinking offspring (median age 26), including 140 males and 96 females with AUD. ANOVA, correlations, regression analyses, and structural equation models were used to evaluate three hypotheses regarding potential sex differences in the course of alcohol use and problems.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Despite changes over recent decades in alcohol use and problems in US populations, especially in females, and differences in demographic characteristics between our current study and our published work in the mid-1990s, the course of alcohol use and of AUDs had many similarities across the sexes. For offspring with AUD, males and females were similar regarding the number of the 11 AUD criteria endorsed, and the proportions reporting experience with nine of the 11 criteria, as well as with their drinking frequencies. After adjustment for probable blood alcohol concentrations per drink, males and females had similar alcohol quantities and levels of response (LRs) to alcohol. In both correlational analyses and structural equation models, the two sexes demonstrated similar relationships of LR to drinking quantities, frequencies, personality characteristics, and alcohol problems.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The data revealed many similarities across the sexes for a wide range of characteristics regarding the course of alcohol-related problems. However, the study population was too young for evaluations of potential differences in patterns of alcohol-related health problems.</p>\u0000 </section>\u0000 </div>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":"49 9","pages":"1924-1935"},"PeriodicalIF":2.7,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144823312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrating breathing-based stress reduction to address stress and alcohol misuse: A novel digital intervention delivered via telehealth and smartphone application","authors":"Dongju Seo,&nbsp;Justin J. Choi,&nbsp;Lisa M. Goldberg,&nbsp;Rajita Sinha","doi":"10.1111/acer.70131","DOIUrl":"10.1111/acer.70131","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Stress is a critical factor in the development and progression of alcohol use disorder (AUD) and is associated with negative treatment outcomes. Despite its significance, few behavioral interventions specifically address the stress-related pathology underlying AUD, including stress-induced drinking. To address this gap, this study developed and piloted a novel digital intervention, <i>Emotion Regulation</i> via <i>Breathing for Alcohol Misuse (EBA),</i> targeting stress and alcohol misuse.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Method</h3>\u0000 \u0000 <p>EBA integrates breathing-based stress regulation techniques with cognitive-behavioral strategies to address stress and hazardous drinking, delivered through telehealth and smartphone applications. The effectiveness of EBA was assessed pre- and post-intervention for stress and alcohol-related behaviors across two separate samples of individuals with Alcohol Use Disorder (AUD), each receiving a different EBA intervention dose. Study 1 included 27 individuals with AUD who completed a brief 4-week EBA intervention, followed by a 30-day monitoring period. Study 2 involved 64 individuals with AUD who completed an 8-week EBA intervention, with a 90-day follow-up. During the intervention periods, participants engaged in brief daily self-guided breathing exercises via a smartphone app.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Results demonstrated significant postintervention reductions in alcohol misuse severity, consumption, and cravings, as well as decreases in stress, anxiety, and depressed mood compared to baseline (<i>ps</i> &lt; 0.001), alongside improved self-control (<i>ps</i> &lt; 0.001). These improvements were maintained throughout the follow-up periods (<i>ps</i> &lt; 0.001) in both studies. Furthermore, reductions in stress and anxiety, along with improved self-control during the intervention, were associated with decreased alcohol misuse severity (<i>ps</i> &lt; 0.05).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The findings demonstrate the promising initial effectiveness of EBA in reducing stress- and alcohol-related behaviors. Sustained improvements observed during follow-up highlight the intervention's potential as a viable treatment option. These positive findings support the need for efficacy testing in future randomized controlled trials to establish EBA as an effective treatment approach for managing AUD, particularly in addressing stress-related alcohol misuse.</p>\u0000 </section>\u0000 </div>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":"49 9","pages":"2076-2091"},"PeriodicalIF":2.7,"publicationDate":"2025-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144805397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Declines in alcohol consumption in Russia, 2008–2020, are accompanied by decreases in alcohol harm","authors":"Vadim Radaev,&nbsp;Yana Roshchina","doi":"10.1111/acer.70130","DOIUrl":"10.1111/acer.70130","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Previous studies have shown a decline in alcohol consumption in Russia, particularly among younger cohorts. Given the variability in existing empirical evidence on the relationship between alcohol consumption and related harm across countries, it is crucial to investigate whether alcohol-related harm decreases in concert with declines in alcohol consumption in Russia.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Data were collected from the Russian Longitudinal Monitoring Survey (RLMS-HSE), a nationally representative survey conducted by HSE University during 2008–2009, 2012–2014, and 2020. The sample included 17,989 individuals aged 15–80 (41,370 cases). Logistic regression models were estimated, employing alcohol-related problems with health, family, work, or studies as dependent variables. The volume of alcohol consumption and time periods (survey years) were major predictors. Additionally, the effects of education, income, and risky social drinking practices were assessed. Control variables included age, occupation, ethnicity, marital status, number of children in the household, and type of residence.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>All self-reported indicators of alcohol-related harm—including problems with health, work/studies, and family—exhibited a strong association with the volume of alcohol consumption. A significant decline in both parameters was observed between 2008 and 2014, followed by a deceleration or stabilization. This association remained consistent over time and displayed a parabolic trend. These findings were consistent across both genders, with more pronounced declines in males than in females.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>All indicators of self-reported alcohol-related harm decreased in concert with declines in the volumes of alcohol consumption in Russia during the 2010s.</p>\u0000 </section>\u0000 </div>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":"49 9","pages":"2003-2012"},"PeriodicalIF":2.7,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144801072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}