Alcohol (Hanover, York County, Pa.)最新文献

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Profiles of impulsivity and alcohol use: Unveiling personality, cognitive traits, and DSM diagnoses 冲动和酒精使用的概况:揭示个性、认知特征和DSM诊断。
IF 2.7
Alcohol (Hanover, York County, Pa.) Pub Date : 2025-08-07 DOI: 10.1111/acer.70116
Chloe Lau, Danielle Downie, R. Michael Bagby, Bruce G. Pollock, Anthony C. Ruocco, Lena C. Quilty
{"title":"Profiles of impulsivity and alcohol use: Unveiling personality, cognitive traits, and DSM diagnoses","authors":"Chloe Lau,&nbsp;Danielle Downie,&nbsp;R. Michael Bagby,&nbsp;Bruce G. Pollock,&nbsp;Anthony C. Ruocco,&nbsp;Lena C. Quilty","doi":"10.1111/acer.70116","DOIUrl":"10.1111/acer.70116","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Impulsivity is closely associated with alcohol use, but limited research has explored distinct latent profiles encompassing impulsivity traits and alcohol use disorder symptoms.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This study used latent profile analysis (LPA) to investigate these patterns among 201 adult outpatients (50% female, 50% male) from a tertiary care setting. Participants completed self-reported measures such as the Alcohol Use Disorders Identification Test (AUDIT), Impaired Control Scale, and UPPS-P Impulsivity Scale, as well as performance-based tasks like the Probability Reward Task (PRT) and Stop Signal Reaction Time Task.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>LPA identified three profiles using AUDIT, impaired control, and UPPS-P: (1) Low-Risk Profile—characterized by low levels of alcohol use disorder (AUD) symptoms and impulsivity; (2) Emotionally Reactive Profile—characterized by elevated impulsivity with low AUD symptoms; and (3) High-Risk Profile—characterized by elevated levels of both AUD symptoms and impulsivity. ANCOVA results revealed that Emotionally Reactive individuals scored higher on neuroticism, negative affectivity, and psychoticism and lower on conscientiousness compared to the Low-Risk group. Both Emotionally Reactive and High-Risk groups showed lower agreeableness, antagonism, and disinhibition relative to the Low-Risk group. On cognitive tasks, the Low-Risk group outperformed the High-Risk group in PRT accuracy and discriminability, while Emotionally Reactive and Low-Risk groups showed similar advantages over High Risk.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>These findings reveal distinct personality and cognitive profiles linked to reward and control processes, informing tailored interventions for impulsivity and alcohol-related harms.</p>\u0000 </section>\u0000 </div>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":"49 9","pages":"2049-2063"},"PeriodicalIF":2.7,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/acer.70116","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144801073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A model of ethanol self-administration in head-fixed mice 头颅固定小鼠乙醇自我给药模型。
IF 2.7
Alcohol (Hanover, York County, Pa.) Pub Date : 2025-08-07 DOI: 10.1111/acer.70132
Amy L. Ward, Kion T. Winston, Sophie Buchmaier, Cynara J. Cooper, Rachel E. Clarke, Michael R. Martino, Kelsey M. Vollmer, Jacqueline E. Paniccia, Marcus S. Bell, Elizabeth M. Doncheck, Roger I. Grant, Joshua Boquiren, Jade Baek, Logan M. Manusky, Annaka M. Westphal, Lisa M. Green, Bayleigh E. Pagoota, James M. Otis, Jennifer A. Rinker
{"title":"A model of ethanol self-administration in head-fixed mice","authors":"Amy L. Ward,&nbsp;Kion T. Winston,&nbsp;Sophie Buchmaier,&nbsp;Cynara J. Cooper,&nbsp;Rachel E. Clarke,&nbsp;Michael R. Martino,&nbsp;Kelsey M. Vollmer,&nbsp;Jacqueline E. Paniccia,&nbsp;Marcus S. Bell,&nbsp;Elizabeth M. Doncheck,&nbsp;Roger I. Grant,&nbsp;Joshua Boquiren,&nbsp;Jade Baek,&nbsp;Logan M. Manusky,&nbsp;Annaka M. Westphal,&nbsp;Lisa M. Green,&nbsp;Bayleigh E. Pagoota,&nbsp;James M. Otis,&nbsp;Jennifer A. Rinker","doi":"10.1111/acer.70132","DOIUrl":"10.1111/acer.70132","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Significant advances in neurotechnology, such as the application of two-photon (2P) imaging of biosensors in vivo, have enabled unparalleled longitudinal and high-resolution access to neural circuits that coordinate behavior in rodents. Integration of these techniques would be groundbreaking for the study of alcohol use disorder (AUD). AUD is rooted in significant neural adaptations that could be functionally monitored and manipulated at the single-cell level across the development of dependence in rodents. However, 2P imaging and related methodologies often require or are facilitated by head fixation, and a lack of head-fixed models has hindered their integration for the study of alcohol dependence.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We developed a head-fixed model in which animals learned to self-administer ethanol across ~14 days. Active lever responding resulted in a tone cue and ethanol reward, whereas responding on the inactive lever resulted in neither cue nor ethanol reward. Following acquisition, animals extinguished lever pressing across a minimum of 10 days. Finally, animals were tested separately for both cue- and ethanol-induced reinstatement of lever pressing.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Here we show, for the first time, that in our head-fixed ethanol self-administration model, male and female mice reliably pressed an active, but not inactive, lever for an oral ethanol reward. Ethanol rewards positively correlated with blood ethanol concentrations at pharmacologically relevant levels. Furthermore, mice extinguished ethanol self-administration when the ethanol reward and cue were omitted, suggesting active lever pressing was ethanol-directed. Following extinction, presentation of the ethanol-associated cue or priming with ethanol itself invigorated reinstatement of ethanol seeking, modeling relapse in a manner that replicates decades of work in freely moving rodent studies.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Overall, our head-fixed ethanol self-administration model will allow for incorporation of novel technologies that require or are greatly facilitated by head fixation, improving our ability to study and understand the neural adaptations and computations that underlie alcohol dependence.</p>\u0000 </section>\u0000 </div>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":"49 9","pages":"2103-2112"},"PeriodicalIF":2.7,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/acer.70132","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144801059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Alcohol consumption in P301S mice accelerates gait impairments, modifies aggregation of pathological tau and alters microglia within the hippocampus P301S小鼠的饮酒加速了步态障碍,改变了病理性tau蛋白的聚集,并改变了海马体内的小胶质细胞。
IF 2.7
Alcohol (Hanover, York County, Pa.) Pub Date : 2025-08-04 DOI: 10.1111/acer.70123
Nicole M. Maphis, Dominic A. Furlano, Seth A. David, David N. Linsenbardt
{"title":"Alcohol consumption in P301S mice accelerates gait impairments, modifies aggregation of pathological tau and alters microglia within the hippocampus","authors":"Nicole M. Maphis,&nbsp;Dominic A. Furlano,&nbsp;Seth A. David,&nbsp;David N. Linsenbardt","doi":"10.1111/acer.70123","DOIUrl":"10.1111/acer.70123","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Excessive alcohol use has emerged as the strongest modifiable risk factor for the development of Alzheimer's disease (AD), but the underlying neural mechanisms are only beginning to be understood. Recent preclinical work suggests that alcohol consumption may have an impact on many pathologies and phenomena crucial to the development and pathogenesis of AD. However, little attention has been focused on pure tauopathy models to closely examine tau pathogenesis and neuroinflammation within a voluntary alcohol exposure paradigm.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We exposed a mouse model of pathological tau (pTau), P301S, to a voluntary alcohol paradigm known as drinking-in-the-dark (DID) for 21 days of voluntary daily alcohol consumption.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In P301S mice, moderate alcohol consumption contributed to gait disruptions, acceleration of pTau spread, and enhancement of damage-associated microglia.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This work identifies key interactions between alcohol and AD-related phenotypes which set the stage for future investigation into the neurobiological mechanisms behind these interactions.</p>\u0000 </section>\u0000 </div>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":"49 9","pages":"1936-1952"},"PeriodicalIF":2.7,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144777033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rat models of fetal alcohol spectrum disorders for studying the critical role of cerebellar damage: A scoping review 用于研究小脑损伤关键作用的胎儿酒精谱系障碍大鼠模型:范围综述。
IF 2.7
Alcohol (Hanover, York County, Pa.) Pub Date : 2025-08-04 DOI: 10.1111/acer.70127
Fátima Nogales, Karick Jotty, Diego Pascual-Vaca, María del Carmen Gallego-López, Olimpia Carreras, María Luisa Ojeda
{"title":"Rat models of fetal alcohol spectrum disorders for studying the critical role of cerebellar damage: A scoping review","authors":"Fátima Nogales,&nbsp;Karick Jotty,&nbsp;Diego Pascual-Vaca,&nbsp;María del Carmen Gallego-López,&nbsp;Olimpia Carreras,&nbsp;María Luisa Ojeda","doi":"10.1111/acer.70127","DOIUrl":"10.1111/acer.70127","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Fetal alcohol spectrum disorder (FASD) refers to the neurodevelopmental condition of lifelong cognitive, emotional, and behavioral challenges that can occur in individuals exposed to alcohol before birth. FASD is a preventable, chronic condition with no direct diagnosis and no treatment, and is considered the leading cause of developmental cognitive impairment in Western countries. The best-known effects of prenatal alcohol exposure (PAE) are those that affect the brain. Among these structures, the cerebellum, a key coordinative tissue, is particularly sensitive to PAE, leading to motor and cognitive disorders. Since 1994, the use of different rat models of FASD has greatly influenced the understanding of the effects of perinatal alcohol exposure on cerebellum development.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We conducted a scoping review of research from the past 30 years to answer an important question for the scientific community: “Which rat model of Fetal Alcohol Spectrum Disorders (FASD) offers the most relevant insights for selecting an appropriate experimental design, specifically for investigating alcohol-induced effects on the cerebellum?”</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Considering the unique developmental characteristics of the cerebellum, five developmental time windows have been identified in rats for studying its state after ethanol exposure. In each window, the route and dose of ethanol administration result in different blood alcohol concentration (BAC) levels, each with distinct advantages and disadvantages. This information is presented in three tables, which also indicate the type of study conducted: morphological, biochemical, electrophysiological, or behavioral.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The third-trimester equivalent period is the most susceptible to alcohol-induced cerebellar damage and is thus the most widely studied by researchers. More research is needed on the effects of alcohol during lactation.</p>\u0000 </section>\u0000 </div>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":"49 9","pages":"1855-1876"},"PeriodicalIF":2.7,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/acer.70127","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144777035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
High-throughput quantitation of acetaldehyde and ethanol in mice using gas chromatography/mass spectrometry positive chemical ionization 用气相色谱/质谱法测定小鼠体内乙醛和乙醇的高通量定量。
IF 2.7
Alcohol (Hanover, York County, Pa.) Pub Date : 2025-08-04 DOI: 10.1111/acer.70126
Yu-Hong Lin, Cheng Chen, Shoupeng Wei, Guillot Adrien, Bryan Mackowiak, Hongna Pan, Yaojie Fu, Luca Maccioni, Tianyi Ren, Li Zhang, Joseph Hibbeln, Robert Pawlosky, Bin Gao
{"title":"High-throughput quantitation of acetaldehyde and ethanol in mice using gas chromatography/mass spectrometry positive chemical ionization","authors":"Yu-Hong Lin,&nbsp;Cheng Chen,&nbsp;Shoupeng Wei,&nbsp;Guillot Adrien,&nbsp;Bryan Mackowiak,&nbsp;Hongna Pan,&nbsp;Yaojie Fu,&nbsp;Luca Maccioni,&nbsp;Tianyi Ren,&nbsp;Li Zhang,&nbsp;Joseph Hibbeln,&nbsp;Robert Pawlosky,&nbsp;Bin Gao","doi":"10.1111/acer.70126","DOIUrl":"10.1111/acer.70126","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Acetaldehyde, an immediate ethanol metabolite, mediates many ethanol-induced behavioral effects and is both psychoactive and toxic to animals and humans. Monitoring the kinetics of acetaldehyde using rodent models of alcohol misuse is essential for understanding and managing ethanol-associated diseases. However, quantitation of acetaldehyde in biological specimens after alcohol consumption has been challenging due to its high volatility, relatively low concentrations, and strong reactivity toward biochemical molecules. It was necessary to develop and establish an accurate and high-throughput method to quantitate acetaldehyde and ethanol.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Gas chromatography/mass spectrometry in positive chemical ionization mode coupled with a 111-vial headspace autosampler was employed to quantitate acetaldehyde and ethanol using <sup>2</sup>H<sub>4</sub>-acetaldehyde and <sup>2</sup>H<sub>5</sub>-ethanol as internal standards. A multidimensional approach was used to develop the method, including sample collection and processing, instrumental data analysis, optimization, and validation. Blood and tissues collected from genetically modified mouse models and their wild-type counterparts were studied.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The method was validated and applied to quantitate acetaldehyde and ethanol in blood and tissues from multiple mouse studies on ethanol metabolism. Acetaldehyde and ethanol were well-resolved from chromatographic interferences with linear ranges of 6.25–800 μM for acetaldehyde and 1.25–160 mM for ethanol. Both regression coefficients for calibration curves were &gt;0.999. The within- and between-run precisions for ethanol in plasma, whole blood, and serum were all &lt;5.0%, and for acetaldehyde in plasma and serum were &lt;9.0%, while in whole blood it was 19.2%. Sample throughput was on the order of 60 samples per 15 h daily, with a maximum of 111 per batch.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Despite some limitations, this validated method proved to be specific, accurate, and reproducible for high-throughput quantitation of acetaldehyde and ethanol in rodent plasma, whole blood, serum, and visceral organs.</p>\u0000 </section>\u0000 </div>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":"49 9","pages":"1897-1911"},"PeriodicalIF":2.7,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/acer.70126","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144777034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Relationship between biological sex and the endocrine stress response following a binge-like dose of alcohol 生理性别与狂饮后内分泌应激反应的关系
IF 2.7
Alcohol (Hanover, York County, Pa.) Pub Date : 2025-08-01 DOI: 10.1111/acer.70094
Robert M. Anthenelli, Mary J. Miles, Richard Hauger, Marc A. Schuckit, Benjamin S. McKenna
{"title":"Relationship between biological sex and the endocrine stress response following a binge-like dose of alcohol","authors":"Robert M. Anthenelli,&nbsp;Mary J. Miles,&nbsp;Richard Hauger,&nbsp;Marc A. Schuckit,&nbsp;Benjamin S. McKenna","doi":"10.1111/acer.70094","DOIUrl":"10.1111/acer.70094","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Rates of heavy drinking in the United States are rising faster in young women than in men. When “binged” rapidly, larger amounts of alcohol may activate the sexually dimorphic, limbic-hypothalamic–pituitary–adrenal (LHPA) stress axis. We examined plasma adrenocorticotropic hormone (ACTH) and cortisol responses to high-dose alcohol in the lab to determine whether social drinkers exhibited sex-specific stress responses when intoxicated. Given that one-third of young women use hormonal contraceptives (HC), which also might affect stress hormone release, we explored in a post-hoc fashion whether HC use related to LHPA responsivity among women.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Fifty-one participants (<i>M</i> age = 22.5 ± 1.3 years, 53% women) consumed alcohol (<i>M</i> = 54.7 ± 11.5 gm, sex-adjusted) in a 20% by volume solution over 10 min at 0900 h. Breath alcohol concentration (BrAC), blood pressure, and heart rate readings were obtained serially. Blood samples were obtained at baseline and every 30 min for up to 4 h postconsumption. Repeated measures ANCOVA and area-under-the-curve models tested sex effects in hormones.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Despite the sexes having nearly overlapping BrACs (peak = 0.12 gm/dL at 60-min postconsumption) throughout the lab session, men exhibited a significantly elevated plasma ACTH (sex-by-time effect, <i>p</i> = 0.023) and cortisol (<i>p</i> = 0.030) response to high-dose alcohol compared with women. Among the 27 women, a post hoc exploratory analysis found that use of combination (ethinyl estradiol + progestin) oral contraceptive pills (<i>N</i> = 7) was associated with higher baseline and postconsumption levels of cortisol compared with naturally cycling women (<i>N</i> = 11) and women (<i>N</i> = 9) using long-acting reversible contraceptives. However, removing those participants from the analysis did not change the sex-specific results.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>A person's biological sex relates to the endocrine response to a binge-like drinking episode. Sex differences in LHPA axis reactivity to higher doses of alcohol might influence women's and men's proclivity to develop neuroendocrine tolerance when imbibing the drug more chronically.</p>\u0000 </section>\u0000 </div>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":"49 8","pages":"1678-1691"},"PeriodicalIF":2.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144762464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Early signs of cardiovascular abnormalities in patients with alcohol misuse 酒精滥用患者心血管异常的早期迹象
IF 2.7
Alcohol (Hanover, York County, Pa.) Pub Date : 2025-08-01 DOI: 10.1111/acer.70099
Lisa A. Farinelli, Garrick Sherman, Daria Piacentino, Melanie L. Schwandt, Valerie Espinal Abreu, Diane Cooper, Lorenzo Leggio
{"title":"Early signs of cardiovascular abnormalities in patients with alcohol misuse","authors":"Lisa A. Farinelli,&nbsp;Garrick Sherman,&nbsp;Daria Piacentino,&nbsp;Melanie L. Schwandt,&nbsp;Valerie Espinal Abreu,&nbsp;Diane Cooper,&nbsp;Lorenzo Leggio","doi":"10.1111/acer.70099","DOIUrl":"10.1111/acer.70099","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Developing integrative screening strategies to improve early identification of alcohol use disorder (AUD) is critical. This study examines cardiovascular parameters and alcohol-related phenotypes associated with two groups of alcohol drinkers: high-risk and low-risk.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Data from 520 high-risk and 586 low-risk non-smoking alcohol drinkers were analyzed. Generalized linear models analyzed the relationship between AUD-related outcomes (Alcohol Dependence Scale, number of DSM Alcohol Dependence criteria, Clinical Institute Withdrawal Assessment for Alcohol, Revised, and Penn Alcohol Craving Scale) and cardiovascular measures (mean arterial pressure, heart rate, QTcF, QRSD, and PR intervals, and QRS, P-wave, and T-wave axes). Multiple logistic regression examined associations of sociodemographic and cardiovascular variables with the odds of being a high-risk drinker. Statistically significant cardiovascular variables were retained as explanatory variables in Tweedie regression models for alcohol-related phenotypes. Interaction effects of risk group by cardiovascular measure were included in each model testing the association between cardiovascular parameters and alcohol-related phenotypes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Higher mean arterial pressure (MAP) and heart rate (HR) were associated with increased odds of high-risk drinking, while greater P-wave axis was associated with increased odds of low-risk drinking. Compared with low-risk drinkers, alcohol outcomes for those who engaged in high-risk drinking were not only significantly greater but also significantly less dependent on MAP and HR variations. The P-wave axis was significantly associated with low-risk drinking; however, it showed no significant association with any other alcohol outcomes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Findings from this study suggest that MAP, HR, and an abnormal P-wave axis can be useful signals for detecting increasing and potentially harmful alcohol drinking among patients who do not yet meet the threshold for high-risk drinking. Early, objective, and targeted identification can improve the current undertreatment of this population at risk by decreasing the interval between onset of AUD and initial clinical care and treatment.</p>\u0000 </section>\u0000 </div>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":"49 8","pages":"1704-1715"},"PeriodicalIF":2.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12321216/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144762461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prevalence and gender-specific correlates of hazardous and binge drinking among Swedish and Finnish older adults 瑞典和芬兰老年人危险饮酒和酗酒的患病率及性别相关性
IF 2.7
Alcohol (Hanover, York County, Pa.) Pub Date : 2025-08-01 DOI: 10.1111/acer.70098
Wossenseged Birhane Jemberie, Johan Niklasson, Knut Lönnroth, Erika Boman
{"title":"Prevalence and gender-specific correlates of hazardous and binge drinking among Swedish and Finnish older adults","authors":"Wossenseged Birhane Jemberie,&nbsp;Johan Niklasson,&nbsp;Knut Lönnroth,&nbsp;Erika Boman","doi":"10.1111/acer.70098","DOIUrl":"10.1111/acer.70098","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Alcohol consumption is a leading modifiable risk factor for a range of diseases and social harms globally. Older adults are vulnerable to alcohol-related harms due to physiological changes, multimorbidity, and medication use; however, many older adults continue to drink at high-risk levels. This study examined the prevalence and gender-specific correlates of hazardous and heavy episodic drinking (HED) among Swedish and Finnish community-dwelling older adults.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Cross-sectional data from the 2021/2022 Gerontological Regional Database (GERDA) survey included 11,747 participants aged 65, 70, 75, 80, 85 and 90 years. Missing data were multiple imputed by chained equations. Hazardous drinking was defined as an AUDIT-C score of four or more, and HED was defined as consuming six or more drinks on a single occasion at least monthly. Sociodemographic, psychosocial, functional status, and health-related factors were analyzed using multinomial and logistic regression models, stratified by gender and accounting for regional differences.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Overall, 30.2% (95% CI, 29.0–31.4) of men and 9.8% (95% CI, 9.1–10.6) of women were classified as hazardous drinkers. HED prevalence was 13.0% (95% CI, 12.1–13.9) in men and 2.9% (95% CI, 2.5–3.3) in women. Hazardous drinking and HED in women were associated with higher socioeconomic status and psychosocial stressors, such as depression and bereavement, while functional and health-related factors were significant predictors of problematic alcohol use in men. Across both genders, religious participation was a protective factor, while self-reported cardiovascular disease was associated with increased risk of hazardous drinking.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Hazardous and are prevalent among older adults in Sweden and Finland with some regional differences, and notable gender differences in associated risk factors. There is a need for interventions that focus on strengthening resilience to psychosocial stressors and provide older adults with clear, consistent health communication about alcohol's harmful effects on cardiovascular and overall health.</p>\u0000 </section>\u0000 </div>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":"49 8","pages":"1744-1758"},"PeriodicalIF":2.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/acer.70098","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144762463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Knowledge as prevention: A cost-effective intervention to reduce prenatal alcohol exposure 知识作为预防:降低产前酒精暴露的成本效益干预措施。
IF 2.7
Alcohol (Hanover, York County, Pa.) Pub Date : 2025-08-01 DOI: 10.1111/acer.70089
Orlagh Keating, Ruth H. Brown, Stewart McDougall, Renate Kuenssberg, Suzanne O'Rourke
{"title":"Knowledge as prevention: A cost-effective intervention to reduce prenatal alcohol exposure","authors":"Orlagh Keating,&nbsp;Ruth H. Brown,&nbsp;Stewart McDougall,&nbsp;Renate Kuenssberg,&nbsp;Suzanne O'Rourke","doi":"10.1111/acer.70089","DOIUrl":"10.1111/acer.70089","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Prenatal alcohol exposure (PAE) remains high despite international guidelines recommending alcohol abstinence during pregnancy. This poses a significant public health concern, as PAE is known to have harmful effects on fetal development and is the cause of fetal alcohol spectrum disorder (FASD). Enhancing knowledge and shifting attitudes toward PAE may help reduce its occurrence, but evidence remains limited. This study examined the impact of an educational intervention on knowledge and attitudes toward PAE among pregnant and recently pregnant women.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A total of 1536 UK-based women aged 19–50 years (<i>M</i> = 33.3 years) participated in an anonymous online questionnaire with an embedded intervention consisting of an existing information leaflet, “Alcohol and Pregnancy,” developed by the Royal College of Obstetricians and Gynaecologists. Participants completed pre- and postintervention evaluations of their knowledge and attitudes toward PAE.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The intervention led to significantly increased negative attitudes toward PAE (<i>z</i> = −9.67, <i>p</i> &lt; 0.001, <i>r</i> = 0.29) and improved knowledge of its associated risks (<i>z</i> = −21.16, <i>p</i> &lt; 0.001, <i>r</i> = 0.65). Regression analysis indicated that participants with alcohol-exposed pregnancies, and with more positive initial attitudes and lower baseline knowledge of PAE-associated risks, experienced the greatest changes postintervention (<i>F</i> [11, 1021] = 25.42, <i>p</i> &lt; 0.001, adj. <i>R</i><sup>2</sup> = 0.208).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>These findings highlight the effectiveness of low-cost, self-administered educational interventions in enhancing knowledge of risks and discouraging alcohol use during pregnancy. Implementation of such interventions in community, clinical, and online settings is recommended to reduce prenatal alcohol consumption.</p>\u0000 </section>\u0000 </div>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":"49 8","pages":"1792-1802"},"PeriodicalIF":2.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/acer.70089","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144762462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Alcohol-induced dysregulation of amygdala circuits and fear extinction: Integrating computational predictions with empirical evidence 酒精引起的杏仁核回路失调和恐惧消退:将计算预测与经验证据相结合。
IF 2.7
Alcohol (Hanover, York County, Pa.) Pub Date : 2025-07-30 DOI: 10.1111/acer.70121
Yi-Hsin Chiang, Lien-Chung Wei
{"title":"Alcohol-induced dysregulation of amygdala circuits and fear extinction: Integrating computational predictions with empirical evidence","authors":"Yi-Hsin Chiang,&nbsp;Lien-Chung Wei","doi":"10.1111/acer.70121","DOIUrl":"10.1111/acer.70121","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Computational models suggest that both acute and chronic alcohol exposure impair fear extinction learning by destabilising amygdala circuitry, yet empirical validation has been limited.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To synthesise recent circuit manipulation studies with advanced neural network modelling and highlight their joint implications for alcohol induced dysregulation of amygdala circuits, fear extinction, and related comorbidities.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We review chemogenetic and optogenetic investigations targeting basolateral and central amygdala sub circuits, neuromodulatory systems, and stress hormone pathways, and integrate these findings with attractor network and alternative computational approaches.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Key Findings</h3>\u0000 \u0000 <p>Contemporary data corroborate model predictions that chronic intermittent ethanol heightens basolateral amygdala excitability, alters non Hebbian synaptic plasticity, and disrupts medial prefrontal cortex–amygdala communication. These changes elevate fear responses and anxiety like behaviours, mirroring post traumatic stress disorder (PTSD) and alcohol use disorder (AUD) phenotypes. Computational frameworks further explain how stress hormones and developmental timing modulate these effects, offering testable hypotheses for rodent to human translation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>By unifying computational and empirical advances, this commentary refines mechanistic understanding of alcohol related fear extinction deficits and underscores the clinical relevance of targeting amygdala circuits in PTSD AUD comorbidity.</p>\u0000 </section>\u0000 </div>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":"49 9","pages":"1891-1892"},"PeriodicalIF":2.7,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144755248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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