Alcohol (Hanover, York County, Pa.)最新文献

{"title":"Alcohol-associated liver disease is associated with less adverse outcomes compared to nonalcohol-associated liver disease in patients with COVID-19","authors":"Jessica A. Musto,&nbsp;Thomas M. Piasecki,&nbsp;Jeannina Smith,&nbsp;Wendy S. Slutske,&nbsp;Michael C. Fiore,&nbsp;Michael R. Lucey","doi":"10.1111/acer.70124","DOIUrl":"10.1111/acer.70124","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>A multicenter cohort of patients hospitalized with COVID-19 was examined to consider the impact of comorbid liver disease in general, and alcohol-associated liver disease (ALD) in particular, on short-term outcomes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Data from patients with COVID-19 hospitalized at 21 participating healthcare systems between February 2020 and January 2022 were examined. The analyses used generalized linear mixed model logistic regression including random intercepts to account for clustering within healthcare systems.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Among 145,944 patients hospitalized with COVID-19, 7951 (5.4%) had comorbid liver disease; 1153 (14.5%) had ALD, and 6798 (85.5%) had nonalcohol-associated liver disease (NAALD). The presence of liver disease was associated with increased mortality (adjusted odds ratio [aOR] 3.39, <i>p</i> &lt; 0.001), assisted ventilation (aOR 2.95, <i>p</i> &lt; 0.001), and ICU admission (aOR 2.27, <i>p</i> &lt; 0.001). There was a clear gradient of mortality among the severity of liver disease such that fibrosis &lt; cirrhosis &lt; decompensated cirrhosis. When compared to patients with NAALD, ALD was associated with reduced mortality (aOR 0.36, <i>p</i> &lt; 0.001), assisted ventilation (aOR 0.38, <i>p</i> &lt; 0.001), and ICU admission (aOR 0.56, <i>p</i> &lt; 0.001). On multivariable analysis, liver disease, male gender, increasing age, higher BMI, and former smoking status, but not ALD, were associated with increased mortality with COVID-19.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>In this large cohort of hospitalized COVID-19 patients, the presence of liver disease increased the odds of all tested adverse outcomes with a mortality gradient that correlated with the severity of liver disease. When compared to liver disease not related to alcohol, ALD was associated with reduced odds of mortality, assisted ventilation, and ICU admission.</p>\u0000 </section>\u0000 </div>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":"49 9","pages":"1983-1992"},"PeriodicalIF":2.7,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/acer.70124","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144755247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alcohol consumption and immune cell profiles: Insights from the Framingham Heart Study","authors":"Ahmed A. Y. Ragab,&nbsp;Margaret F. Doyle,&nbsp;Jiachen Chen,&nbsp;Kathryn L. Lunetta,&nbsp;Joanne M. Murabito","doi":"10.1111/acer.70122","DOIUrl":"10.1111/acer.70122","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Alcohol consumption affects immune function, with excessive intake linked to immune suppression and inflammation. However, its impact on immune cell phenotypes remains unclear. This study investigates the association between alcohol consumption and immune cell profiles in a well-characterized Framingham Heart Study (FHS) cohort while examining sex-specific differences in alcohol-immune cell associations.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We analyzed data from 996 participants of the FHS Offspring cohort who underwent immune cell phenotyping and completed an alcohol questionnaire during Exam 7 (1998–2001). Alcohol intake was categorized as abstainer, moderate, at-risk, or heavy drinking. Linear mixed-effects models examined associations between alcohol intake and 15 immune cell phenotypes, adjusting for age, sex, and Cytomegalovirus (CMV) (Model 1) and additional covariates (Model 2). False discovery rate (FDR) correction was applied for multiple testing.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The CD4+ Tn/Tm ratio showed a significant nonlinear relationship with alcohol categories in Model 1 (<i>p</i> = 0.002, FDR = 0.03), with higher ratios in moderate (<i>β</i> = 0.26) and at-risk drinkers (<i>β</i> = 0.26) compared with abstainers; effects were smaller in Model 2 (<i>β</i> = 0.23 and <i>β</i> = 0.23, respectively). Sex-stratified analyses revealed that among males, alcohol consumption was associated with several immune cell phenotypes in Model 1, and with CD8+ Tn/Tm ratio in Model 2 (<i>p</i> = 0.0001, FDR = 0.002), where moderate drinking was associated with higher CD8+ Tn/Tm ratio compared with abstainers (<i>β</i> = 0.29). Among male drinkers, consumption level was also associated with CD8+ Tn/Tm ratio in both models: at-risk and heavy consumption showed significantly lower CD8+ Tn/Tm ratio compared with moderate drinkers (<i>β</i> = −0.43 and <i>β</i> = −0.46, respectively, in Model 2).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Alcohol consumption exhibits a nonlinear relationship with certain immune cells, with moderate intake potentially benefiting immunity, while higher consumption may compromise immune homeostasis. Given the study's cross-sectional design, causality cannot be inferred; nonetheless, our sex-specific, dose-dependent findings merit confirmation in longitudinal cohorts.</p>\u0000 </section>\u0000 </div>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":"49 9","pages":"1953-1961"},"PeriodicalIF":2.7,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144735808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Embracing the complexity of alcohol's immunomodulatory effects: Commentary on Monnig, Lamb, Clark, and Monti—“Acute changes in immune biomarkers under low and moderate dose alcohol in light and heavy drinkers: A randomized, placebo-controlled trial”","authors":"Erica N. Grodin,&nbsp;Kaitlin McManus","doi":"10.1111/acer.70120","DOIUrl":"10.1111/acer.70120","url":null,"abstract":"","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":"49 9","pages":"1893-1896"},"PeriodicalIF":2.7,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144719226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Articles of Public Interest","authors":"","doi":"10.1111/acer.70119","DOIUrl":"https://doi.org/10.1111/acer.70119","url":null,"abstract":"","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":"49 7","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144687944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contingency management and the expanding role of hepatology in alcohol use disorder","authors":"Mohammed Abdulrasak","doi":"10.1111/acer.70118","DOIUrl":"10.1111/acer.70118","url":null,"abstract":"","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":"49 9","pages":"1889-1890"},"PeriodicalIF":2.7,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144664117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A longitudinal person-centered analysis of anxiety sensitivity risk for young adult alcohol misuse: Examining the role of injunctive norms","authors":"Charlotte Corran,&nbsp;Alexandre J. S. Morin,&nbsp;Christian S. Hendershot,&nbsp;Roisin M. O'Connor","doi":"10.1111/acer.70113","DOIUrl":"10.1111/acer.70113","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Alcohol use and problems increase during adolescence and peak in early adulthood. Tension reduction theory points to anxiety sensitivity as a risk factor for alcohol misuse, and the theory of planned behavior suggests that injunctive norms (i.e., perceived approval of risky drinking) may be central to this risk trajectory.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This study utilized a longitudinal person-centered approach to identify unique patterns of injunctive norms (by three referent groups: typical students, friends, and parents) among 223 college students (<i>M</i>_age = 18.82, 62.2% women).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Latent profile analyses revealed three distinct injunctive norm profiles, which proved to be identical across the three measurement points. These profiles were characterized by mixed levels of perceived approval (high typical students, neutral friends, low parents; <i>Mixed Tolerance</i> profile), low levels of perceived approval (low typical students, friends, parents; <i>Low Tolerance</i> profile), and high levels of perceived approval (high typical students and friends, neutral parents; <i>High Tolerance</i> profile). Student membership in these profiles was moderate to highly stable over time. A higher level of anxiety sensitivity was associated with membership in profiles characterized by high perceived approval of risky drinking. The <i>Mixed Tolerance</i> profile was associated with the <i>least</i> amount of alcohol misuse and problems (protective), the <i>Low Tolerance</i> profile was associated with <i>some</i> risk, and the <i>High Tolerance</i> profile was associated with the <i>most</i> risk.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Our findings demonstrate the nature and stability of injunctive norm profiles and offer new insight into the role of injunctive norm topologies in Alcohol-Related Social Risk (AS-risk) for young adult alcohol misuse and related problems.</p>\u0000 </section>\u0000 </div>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":"49 9","pages":"2025-2037"},"PeriodicalIF":2.7,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/acer.70113","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144644204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does paternal alcohol consumption affect the severity of traits of fetal alcohol spectrum disorders?","authors":"Philip A. May,&nbsp;Julie M. Hasken,&nbsp;Jason Blankenship,&nbsp;Anna-Susan Marais,&nbsp;J. Phillip Gossage,&nbsp;Wendy O. Kalberg,&nbsp;Marlene De Vries,&nbsp;Luther K. Robinson,&nbsp;David Buckley,&nbsp;Melanie Manning,&nbsp;Charles D. H. Parry,&nbsp;H. Eugene Hoyme,&nbsp;Barbara Tabachnick,&nbsp;Soraya Seedat","doi":"10.1111/acer.70105","DOIUrl":"10.1111/acer.70105","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Animal models suggest that paternal alcohol consumption may influence offspring traits, yet few human studies exist.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Data from population-based studies of fetal alcohol spectrum disorders (FASD) among first-grade students provided case–control data to explore traits of fathers of children with: FASD, alcohol exposure, and unexposed controls.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Most males in this population drank, but more fathers of children with FASD drank during pregnancy (<span></span><math></math> = 73.2%) than fathers of controls (<span></span><math></math> = 63.4%). Among drinkers, fathers of children with FASD: (a) consumed more drinks per occasion than controls (<span></span><math></math> = 11.5 vs. 9.7 for maternally exposed controls and 8.1 for maternally unexposed controls), (b) drank more frequently and binged, and (c) were reported to have had a drinking problem (<span></span><math></math> = 27.8% vs. <span></span><math></math> = 18.8%). Partial correlations, controlling for maternal average drinks per drinking day (DDD) by trimester and maternal tobacco use, indicated a significant, negative association between paternal heavy/binge drinking (≥5) and child outcomes resulting in a significant reduction in child height, head circumference, and verbal IQ. Categorical analysis of combined levels of maternal and paternal drinking indicated a significant mean reduction in child height, head circumference, and verbal IQ centile, and a significant increase in total dysmorphology score, did not occur without maternal drinking. Combined paternal and maternal drinking pattern analysis also indicated that paternal drinking was not independently associated with child total dysmorphology scores or neurocognitive outcomes. Models of maternal and paternal drinking were significant, but main and significant effects on total dysmorphology and neurocognitive outcomes were via maternal alcohol consumption. Likewise, paternal alcohol consumption was not independently associated with an FASD diagnosis when controlling for prenatal maternal alcohol and tobacco use.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Paternal alcohol consumption was associated with an independent, negative influence on child height, head circumference, and verbal IQ. Maternal drinking, when combined with heavy male drinking, was associated with more severe FASD outcomes.</p>\u0000 </section>\u0000 </div>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":"49 8","pages":"1716-1729"},"PeriodicalIF":2.7,"publicationDate":"2025-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144621488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Concomitant treatment of alcohol associated liver disease and alcohol use disorder in the nontransplant setting: A scoping review","authors":"Sawsan Fathma,&nbsp;Sherry A. McKee,&nbsp;Alyssa A. Grimshaw,&nbsp;Sarpong Boateng,&nbsp;David A. Fiellin,&nbsp;Lamia Haque,&nbsp;Wajahat Z. Mehal,&nbsp;Bubu A. Banini","doi":"10.1111/acer.70112","DOIUrl":"10.1111/acer.70112","url":null,"abstract":"<p>Alcohol-associated liver disease (ALD) is a leading cause of liver-related deaths in the United States and worldwide, occurring in persons with alcohol use disorder (AUD). Effective treatment of AUD is essential to curtail the progression of ALD and/or reverse the disease course, yet there is a paucity of information on care models for the concomitant treatment of AUD in persons with ALD, particularly when liver transplant is not imminent or warranted. Here, we reviewed existing literature on care models for the concomitant treatment of ALD and AUD among individuals not undergoing liver transplant evaluation or consideration. A comprehensive search of electronic databases including Cochrane Library, CINAHL, Ovid MEDLINE, Ovid Embase, Scopus, Google Scholar, PubMed, and Web of Science Core Collection from inception to July 2024 was conducted to identify original studies reporting care for both ALD and AUD in persons not undergoing liver transplant evaluation or consideration. From the 1146 publications identified, 43 studies were selected for further review, of which three articles were selected for data charting and inclusion in the review. Concomitant treatment of ALD and AUD were implemented both within inpatient and outpatient settings, with multidisciplinary care teams typically involving hepatology and addiction medicine and/or addiction psychiatry. One study showed that attention and care for AUD led to improvement in liver disease and a decrease in emergency department visits and frequency of hospitalization. The studies reviewed suggest that concomitant care for ALD and AUD in the nontransplant setting may improve outcomes for some patients. The limited number of studies highlights the need for more prospective and longitudinal studies evaluating concomitant treatment, especially in persons for whom liver transplant may not be an option or a consideration.</p>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":"49 8","pages":"1631-1639"},"PeriodicalIF":2.7,"publicationDate":"2025-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144621487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep disturbances relate to problematic alcohol use via effortful control and negative emotionality","authors":"Matison W. McCool,&nbsp;Chloe E. Martinez,&nbsp;Maria M. Wong,&nbsp;Matthew R. Pearson,&nbsp;Protective Strategies Study Team","doi":"10.1111/acer.70080","DOIUrl":"10.1111/acer.70080","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Sleep disturbances, such as insomnia, are highly prevalent among college students. Alcohol use (and other substance use) peaks during emerging adulthood (18–25 years old). Short sleep duration and sleep disturbances have been shown to be a risk marker for the development of problematic alcohol use. Putative mechanisms that account for this relationship include facets of executive functioning and emotion regulation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>In a large cross-sectional sample of college students (<i>n</i> = 5074), we examined the relationship between insomnia symptoms and problematic alcohol use (negative consequences and alcohol use disorder symptoms) via negative emotionality (stress, depression, anxiety, social anxiety) and effortful control (activation, attentional, and inhibitory) using structural equation modeling with bootstrapping (CFI = 0.979, TLI = 0.971, RMSEA = 0.038 [90% CI: 0.035, 0.041], SRMR = 0.045).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Insomnia symptoms were associated with higher negative emotionality (<i>β</i> = 0.539, <i>p</i> &lt; 0.001) and lower effortful control (<i>β</i> = −0.283, <i>p</i> &lt; 0.001); negative emotionality (<i>β</i> = 0.207, <i>p</i> &lt; 0.001) and effortful control (<i>β</i> = −0.267, <i>p</i> &lt; 0.001) were each related to problematic alcohol use. The relationship between insomnia and problematic alcohol use (<i>β</i> = 0.173, <i>p</i> &lt; 0.001) dropped to nonsignificance when controlling for negative emotionality and effortful control (<i>β</i> = −0.014, <i>p</i> = 0.698).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Although the cross-sectional nature of the data prohibits causal inference, these indirect effects support the plausibility that facets of executive functioning and emotion regulation account for the relationship between insomnia symptoms and problematic alcohol use. Understanding the relationships among these factors can help guide the development and tailoring of effective interventions that target sleep–alcohol use dynamics.</p>\u0000 </section>\u0000 </div>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":"49 7","pages":"1554-1563"},"PeriodicalIF":3.0,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144610444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of the GLP-1 receptor agonist exenatide on pro-inflammatory and metabolic biomarkers in individuals with alcohol use disorder: Post hoc results from a randomized, double-blinded, placebo-controlled clinical trial","authors":"Malthe E. B. Hviid,&nbsp;Lea A. N. Christoffersen,&nbsp;Mette K. Klausen,&nbsp;Thorsten Brodersen,&nbsp;Ole B. Pedersen,&nbsp;Sisse R. Ostrowski,&nbsp;Margit H. Larsen,&nbsp;Mette Kongstad,&nbsp;Mathias E. Jensen,&nbsp;Tina Vilsbøll,&nbsp;Anders Fink-Jensen","doi":"10.1111/acer.70110","DOIUrl":"10.1111/acer.70110","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Alcohol use disorder (AUD) has been associated with inflammation, metabolic syndrome, and increased risk of all-cause mortality. This study aimed to compare the pro-inflammatory and metabolic biomarker profiles in individuals with AUD with individuals without AUD, and to evaluate the effect of exenatide on these biomarkers in individuals with AUD.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Serum concentrations of 25 biomarkers (interferon-γ [IFN-γ], tumor necrosis factor-α [TNF-α], interleukin (IL)-1β, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12p70, IL-13, monocyte chemoattractant protein-1 [MCP-1], C-peptide, gastric inhibitory polypeptide [GIP], glucagon-like peptide [GLP-1], glucagon, insulin, leptin, pancreatic polypeptide [PP], adiponectin, high sensitivity C-reactive protein [hsCRP], fibroblast growth factor 21 [FGF-21], total cholesterol [CHOL], high-density lipoprotein [HDL], low-density lipoprotein [LDL], and triglycerides [TG]) from individuals with AUD were measured at baseline and after 26 weeks of treatment with the GLP-1 receptor agonist (GLP-1RA) exenatide once-weekly or placebo, using multiplexed immunoassays, enzyme-linked immunosorbent assay (ELISA), and line immunoassays. Serum samples from 23 individuals with no record of AUD or treatment with a GLP-1RA were measured once for comparison with individuals with AUD.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>IL-6 (1.56 vs. 0.62 pg/mL), hsCRP (3.30 vs. 1.34 mg/L), and FGF-21 (1794.97 vs. 306.11 pg/mL) were significantly higher, whereas GIP (63.06 vs. 111.07 pg/mL) was significantly lower in individuals with AUD (<i>n</i> = 124) than in those without AUD (<i>n</i> = 23). No significant changes in biomarker levels were observed after treatment with exenatide (<i>n</i> = 40) compared with treatment with placebo (<i>n</i> = 37).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Our findings support the well-established link between AUD and inflammation. However, treatment with the GLP-1 receptor agonist exenatide did not impact pro-inflammatory and metabolic biomarkers.</p>\u0000 </section>\u0000 </div>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":"49 8","pages":"1659-1666"},"PeriodicalIF":2.7,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/acer.70110","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144593018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}