Alcohol (Hanover, York County, Pa.)最新文献

{"title":"Alcohol Attentional Bias Predicts Same-Day Desire to Get Drunk and Alcohol Consumption in Non-Treatment Seeking Young Adults Identified With Hazardous Alcohol Use in the Emergency Department","authors":"Brian Suffoletto,&nbsp;Tammy Chung","doi":"10.1111/acer.70327","DOIUrl":"10.1111/acer.70327","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Attentional bias (AB) toward alcohol cues is theorized to reflect automatic motivational processes that contribute to heavy drinking, but ecologically valid, real-time assessments of how these biases manifest in daily life remain limited. This study used ecological momentary assessment (EMA) and weekly mobile Stroop tasks to test whether daily AB predicts same-day desire to get drunk and alcohol use among non-treatment-seeking young adults with hazardous drinking.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This secondary analysis used data from young adults (<i>N</i> = 579; aged 18–25) with hazardous drinking recruited from Emergency Departments enrolled in a clinical trial testing different text-message interventions. Procedures included weekly alcohol-neutral Stroop task and same-day EMA of desire to get drunk and subsequent drinking for 14 weeks. AB scores were decomposed into within-person (day-to-day fluctuations) and between-person (stable individual differences) components. Mixed-effects logistic models tested whether same-day AB predicted (1) any desire to get drunk and (2) alcohol use, adjusting for covariates. Exploratory analyses tested whether within-person associations differed on days with prior drinking and whether impulsivity traits predicted between-person AB.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>AB showed substantial within-person fluctuation. On days when individuals showed faster-than-usual responses to alcohol cues, they had significantly greater desire to get drunk and heavier drinking. These associations were absent on days when drinking had already begun. Impulsivity traits explained &lt; 1% of between-person AB variance.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Alcohol AB in this young adult sample functioned as a dynamic, state-like cognitive process. Faster response to alcohol cues was associated with same-day desire to get drunk and heavier drinking, suggesting AB may serve as a proximal indicator of motivation.</p>\u0000 </section>\u0000 </div>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":"50 7","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148426636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contextual Moderators of the Relationship Between Alcohol-Induced Blackouts and Alcohol-Related Consequences Among Young Adults","authors":"Veronica L. Richards,&nbsp;Shannon D. Glenn,&nbsp;Kimberly A. Mallett,&nbsp;Michael R. Sladek,&nbsp;Robert J. Turrisi,&nbsp;Julie M. Croff,&nbsp;Sarah Ackerman,&nbsp;Michael A. Russell","doi":"10.1111/acer.70310","DOIUrl":"10.1111/acer.70310","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Alcohol-induced blackouts (AIBs) are a common and serious consequence of drinking in young adults. AIBs are associated with experiencing increased alcohol-related consequences. To inform efforts to reduce alcohol-related harms on especially risky drinking days that result in AIBs, we sought to identify contextual factors that contribute to excess AIB-associated harms. This study aims to (1) examine relationships between AIBs and four consequence domains; and (2) explore how these relationships differ by social context and location.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Young adults (<i>N =</i> 175, 52.6% female, 86.9% White, <i>M</i>_age = 20.8) with recent heavy drinking and AIBs wore alcohol sensors and completed surveys about their consequences (including AIBs) and the social context and locations in which drinking occurred over six weekends. Four consequence domains included positive (reflective of desired alcohol expectancies), common (relatively acute, low potential for personal harm), uncommon (relatively serious, i.e., sexual, legal, great potential for personal harm), and alcohol-related problems (related to impaired control and physical dependence). Multilevel structural equation models were conducted to test for main effects of AIBs and moderating effects of contextual factors.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>AIBs were significantly associated with experiencing 15% more positive consequences, 205% more common consequences, 367% more uncommon consequences, and 166% more alcohol-related problems. AIBs were more strongly associated with common consequences and alcohol-related problems when drinking occurred exclusively with family, friend(s), and/or a romantic partner (vs. with a large group). AIBs were also more strongly associated with common consequences when drinking took place exclusively at a residential location (vs. non-residential). No other significant moderating effects were observed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Days with an AIB were associated with experiencing significantly more positive and negative alcohol-related consequences compared to days without an AIB. Our findings support the notion that the context in which drinking occurs is an important consideration for reducing alcohol-related harms.</p>\u0000 </section>\u0000 </div>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":"50 7","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148426711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alcohol or Stress Exposure During Late Adolescence Impairs Risk Assessment Later in Life, Disrupting the Ethological Structure of Behavior in Mice","authors":"Beatriz Deo Sorigotto,&nbsp;Isabel Marian Hartmann de Quadros,&nbsp;Karina Possa Abrahao","doi":"10.1111/acer.70328","DOIUrl":"10.1111/acer.70328","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Decision-making relies on risk assessment as a critical process that enables organisms to evaluate threats before exploring potentially dangerous areas. While adolescence is a period of heightened vulnerability to external factors such as substance use and stress, it remains unclear how these factors disrupt risk assessment, particularly at the level of behavior structure: sequential actions, organization and transition probabilities between defensive and exploratory behaviors. We investigated whether repeated ethanol intoxication or pharmacological stress during late adolescence alters behavioral structure in early adulthood.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Male and female C57BL/6 mice received four intermittent injections of saline, ethanol (4.0 g/kg), or the α2-adrenergic antagonist yohimbine (2.0 mg/kg) during late adolescence (7–8^th weeks). In early adulthood (9^th week), animals were tested in the Light–Dark Box and Elevated Plus Maze. In addition to measuring classical anxiety-like and exploratory behavior, we focused on risk assessment behaviors (stretches/head-outs) categorized as NoGo (evaluation without entering the aversive area) or Go (evaluation followed by entry). We used 1^st order transition probability Markov chain analyses to map the transitions between these states, defining the behavioral structure.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Both ethanol and yohimbine produced persistent reductions in NoGo risk assessment behaviors in adulthood, in both sexes, with minimal effects on classical anxiety-like and exploratory measures. Transition probability and correlation analyses revealed a reorganization of behavioral structure, characterized by reduced transitions toward risk assessment events and a bias toward risk-taking actions.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>These findings indicate that repeated late adolescent alcohol intoxication or stress exposure induces long-lasting alterations in risk assessment and decision-making strategies.</p>\u0000 </section>\u0000 </div>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":"50 7","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/acer.70328","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148426654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends in Alcohol–Related Deaths in the United States Over 55 Years: 1968–2023","authors":"Mohid Zulfiqar,&nbsp;Muhammad Salik Uddin,&nbsp;Faizan Abbas,&nbsp;Asim Sajjad,&nbsp;Ammad Uddin,&nbsp;Syed Ahmed Ali Shah,&nbsp;Gregg C. Fonarow,&nbsp;Saad Ahmed Waqas,&nbsp;Hermann Yokolo,&nbsp;Shaheer Qureshi","doi":"10.1111/acer.70321","DOIUrl":"10.1111/acer.70321","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Alcohol consumption is a leading cause of preventable mortality worldwide. We examined long-term trends in alcohol-related deaths in the United States over 55 years (1968–2023) and analyzed demographic disparities.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Using CDC WONDER data, we identified alcohol-related deaths among adults aged ≥ 25 years. Age-adjusted mortality rates (AAMRs) per 100,000 population were calculated, and joinpoint regression analyzed temporal trends by sex, race, age, and geographic region.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>From 1968 to 2023, 1,321,804 alcohol-related deaths occurred. AAMRs increased from 13.1 to 19.3 (AAPC: 0.7, <i>p</i> &lt; 0.001), with a sharp acceleration during 2018–2021 (APC: 14.1) followed by a decline during 2021–2023 (APC: −6.9). Males consistently had higher mortality than females, though the gender gap narrowed. A striking racial inversion occurred: mortality among Black individuals declined from 27.7 to 13.5 (AAPC: −1.4), while mortality among White individuals increased from 11.3 to 21.1 (AAPC: 1.1) with older adults (65+) showing the steepest long-term increase (AAPC: 1.4). Regionally, the Midwest experienced the greatest rise in mortality (AAPC: 1.4), while the Northeast remained stable.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Alcohol-related mortality has increased substantially over 55 years, with profound demographic shifts including a complete racial disparity inversion and narrowing gender gap. Recent declines (2021–2023) offer cautious optimism, but sustained, targeted interventions are needed for high-risk populations.</p>\u0000 </section>\u0000 </div>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":"50 7","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148426761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Fall Rate From Transdermal Alcohol Concentration on Alcohol-Related Consequences in College Students","authors":"Yiping Li,&nbsp;Veronica L. Richards,&nbsp;Shannon D. Glenn,&nbsp;Robert J. Turrisi,&nbsp;Kimberly A. Mallett,&nbsp;Michael A. Russell","doi":"10.1111/acer.70369","DOIUrl":"10.1111/acer.70369","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Background&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Alcohol elimination rate is associated with acute alcohol consequences, yet it remains difficult to measure reliably in real-world settings. Wearable transdermal alcohol concentration (TAC) sensors provide a feasible option through passive, continuous monitoring of biological alcohol exposure. This facilitates precise testing of whether alcohol elimination rate predicts alcohol-related consequences in naturalistic environments. Additionally, a faster alcohol elimination rate may buffer or reduce the risk of alcohol-related consequences following high and/or rapid consumption.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Method&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Two observational studies (Alcohol Habits Study [&lt;i&gt;n&lt;/i&gt; = 222] and Project ACE [&lt;i&gt;n&lt;/i&gt; = 79]), each using a different alcohol sensor, were used in this study. Participants of both studies were young adults from universities who frequently engaged in heavy episodic drinking. Alcohol-related consequences were collected through daily self-reports the morning after drinking days and included metrics across multiple domains such as physical symptoms, interpersonal conflict, safety risk, sexual risk, and miscellaneous. Alcohol elimination rate and other dynamics were extracted from TAC-positive trajectories for each day. Associations were tested using multilevel modeling.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Both studies showed that days with faster elimination rates were associated with more alcohol-related consequences, although statistical significance was observed only in Project ACE. In the Alcohol Habits Study, a significant day-level interaction indicated that the association between peak TAC and alcohol-related consequences was reduced on days with faster alcohol elimination rates. Similar findings emerged in Project ACE but did not reach significance. Both studies demonstrated the same pattern of conditional association: as the daily fall rate increased, the simple association between peak TAC and alcohol-related consequences diminished to the point of non-significance.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusion&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Our results provide novel evidence that alcohol elimination may have (a) an independent association with alcohol-related consequences in natural settings and (b) a buffering impact on the association between peak TAC and alcohol-related consequences. The results span two studies using two separate wearable sensors, supporting the validity of findings. Future research testing these associations in larger and more diverse samples is warranted.&lt;/p&gt;\u0000 &lt;/s","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":"50 7","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/acer.70369","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148413845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of GLP-1 Receptor Agonist Prescriptions and Alcohol Consumption in the National Institutes of Health's All of Us Cohort","authors":"Benjamin Tyndall,&nbsp;Angela Gasdaska,&nbsp;M. Daniel Brannock,&nbsp;Ed Preble,&nbsp;Melissa McPheeters,&nbsp;Laura Marcial,&nbsp;Ariba Huda,&nbsp;Josephine Egan,&nbsp;Tamara R. Litwin,&nbsp;Jennifer Adjemian,&nbsp;Chandan Sastry,&nbsp;Mehdi Farokhnia,&nbsp;Lorenzo Leggio","doi":"10.1111/acer.70357","DOIUrl":"10.1111/acer.70357","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Growing evidence suggests glucagon-like peptide-1 receptor agonists (GLP-1RAs) may represent a novel potential pharmacotherapeutic tool for alcohol use disorder (AUD). The objective of this study is to examine the association between GLP-1RA prescriptions and alcohol use.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This cohort study used a cross-sectional measure of alcohol consumption and longitudinal electronic health record (EHR) data collected between 1981 and October 2023 from NIH's <i>All of Us</i> Research Program, a large program to recruit and collect surveys, EHR, genomic, and wearable data from a wide array of Americans. Among 15,447 participants with at least two recorded GLP-1RA prescriptions on separate days, we created three groups based on the timing of Alcohol Use Disorders Identification Test-Consumption (AUDIT-C) responses relative to first GLP-1RA prescription. This resulted in 3650 with current GLP-1RA prescriptions, 5642 with future GLP-1RAs (primary comparison group), and 544 with previous GLP-1RAs. AUDIT-C scores were compared across these groups and to propensity-score matched comparison groups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Those with current GLP-1RA prescriptions had statistically significant but modestly lower AUDIT-C scores compared with those with future prescriptions (incidence rate ratio [IRR] = 0.95; 95% CI: 0.91–0.99; <i>p</i> = 0.01). Participants with a previous GLP-1RA prescription had lower AUDIT-C scores compared with those with future prescriptions, but this difference was not statistically significant. Results were similar using a matched comparison group with the current GLP-1RA group (IRR = 0.89; 95% CI: 0.85–0.93; <i>p</i> ≤ 0.001) and no significant difference for the previous prescription group. Analysis of individual AUDIT-C questions shows a significant association with GLP-1RA prescriptions and frequency of drinking but not drinks per occasion or binge drinking.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This study's findings indicate that GLP-1RAs may reduce alcohol consumption by decreasing use frequency. Experimental studies and randomized controlled trials are needed to test the mechanisms and potential efficacy of GLP-1RAs in people with AUD.</p>\u0000 </section>\u0000 </div>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":"50 7","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/acer.70357","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148413611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does Housing Eviction Modify the Effects of Alcohol Outlet Density on Hospitalizations for Assault and Alcohol Use Disorder in Pennsylvania?","authors":"Michelle Dougherty,&nbsp;Robert W. S. Coulter,&nbsp;Sarah L. Pedersen,&nbsp;Maya I. Ragavan,&nbsp;Sara E. Baumann,&nbsp;Christina Mair","doi":"10.1111/acer.70372","DOIUrl":"10.1111/acer.70372","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Examining how the relationship between alcohol outlet density and alcohol-related harms may vary by neighborhood-level factors is important for informing the evaluation and implementation of environmental alcohol interventions and identifying other community conditions that can be modified to reduce alcohol-related harms and inequities. This study aims to extend prior research by testing whether housing eviction—a cause of housing insecurity and neighborhood destabilization—modifies the impact of alcohol outlet density on hospitalizations for assault and alcohol use disorder (AUD) in Pennsylvania ZIP codes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We used Bayesian hierarchical space–time misalignment models to examine the associations between inpatient assault and AUD hospitalizations and housing eviction filing rates, alcohol outlet density, and the proportion of outlets selling alcohol for off-premise consumption at the ZIP code level in Pennsylvania 2018–2022 (<i>n</i> = 7257 space–time units), reporting relative rates (RR) and 95% credible intervals (CIs). We tested whether eviction filing rates modified the associations between outlet density/the proportion of off-premise outlets and hospitalizations for AUD and assault.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In main effects models, a one percent increase in the eviction filing rate was associated with a 1.2% increase in AUD hospitalizations (95% CI: 1.01, 1.015) and a 1.9% increase in assault hospitalizations (95% CI: 1.002, 1.038). The addition of one outlet per square mile was associated with a 0.3% increase in AUD hospitalizations (95% CI: 1.002, 1.004) and a 0.6% increase in assault hospitalizations (95% CI: 1.003, 1.008). In interaction models, eviction filing rates strengthened the positive associations between outlet density and hospitalizations for both assault and AUD.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Reducing housing evictions may mitigate the impact of alcohol outlet density on AUD and assault. Future research, policy, and practice should explore opportunities for jointly addressing the alcohol environment and neighborhood housing conditions.</p>\u0000 </section>\u0000 </div>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":"50 7","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/acer.70372","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148413767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low-Level Alcohol Consumption in Children 11–12 Years Old Is Linked to Neural Substrates Involved in Reward Processing and Inhibitory Control: Results From a Brain-Wide Association Study","authors":"Isabella F. Jackson,&nbsp;Francisco A. C. Meyer,&nbsp;Ryan M. Sullivan,&nbsp;Ashley L. Watts","doi":"10.1111/acer.70370","DOIUrl":"10.1111/acer.70370","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>We comprehensively examined the cross-sectional and prospective structural (i.e., cortical volume and subcortical volume) and functional (i.e., activation during the Monetary Incentive Delay task and the emotional N-back task) neural correlates of alcohol sipping in early adolescence across two waves of data from the Adolescent Brain Cognitive Development (ABCD) Study (baseline: ages 9–10, <i>n</i> = 7555; 2-year follow-up: ages 11–12, <i>n</i> = 5892).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Generalized linear mixed models examined individual brain regions of interests' ability to predict alcohol sipping.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>At the 2-year follow-up, sipping was associated with activation during the MID large reward versus neutral contrast in 12 regions (e.g., nucleus accumbens), and activation during the MID large loss versus neutral contrast in 13 regions (e.g., insula).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>These findings aligned with existing literature on alcohol consumption, with neural regions involved in reward and inhibitory control being associated with alcohol sipping. Given that the findings from year 2 mirror several well-established neural correlates of alcohol use and alcohol use disorder in adults, alcohol sipping may be an important phenotype for predicting future alcohol involvement.</p>\u0000 </section>\u0000 </div>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":"50 7","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/acer.70370","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148413762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Manifestation of Drinking Profiles in Daily Life: Associations With Momentary Negative Affect, Impulsivity, and Drinking","authors":"Derek D. Morgan,&nbsp;Caroline C. Boyd-Rogers,&nbsp;Paige L. DeGennaro,&nbsp;Phillip K. Wood,&nbsp;Denis M. McCarthy,&nbsp;Timothy J. Trull","doi":"10.1111/acer.70367","DOIUrl":"10.1111/acer.70367","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Negative affect and impulsivity can influence one another and have momentary influences on emerging adult drinking behaviors. Heterogeneity in drinking patterns/profiles, such as frequent heavy or light drinking, may also reflect differences in these momentary effects potentially due to distinct putative drinking mechanisms.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Emerging adults (<i>N</i> = 366; 64.4% women) with at least one binge drinking episode in the past 30 days completed a baseline survey and 14-day ecological momentary assessments (EMA) with multiple daily surveys (<i>n</i> ≥ 7; <i>M</i> = 5.33). Latent profile analysis (LPA) was used to identify alcohol use patterns from baseline surveys. Next, multilevel models examined negative affectivity and impulsivity on momentary drinking and the number of drinks consumed using the full sample and the LPA drinking profiles.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>LPA identified three drinking profiles: (1) low binge drinkers; (2) moderate binge drinkers; and (3) heavy binge drinkers. Multilevel models revealed that for the full sample and among low and moderate binge drinkers, negative affect significantly predicted lower chances of drinking in the moment, while the impulsivity facets of urgency and sensation-seeking predicted greater chances of momentary drinking. Urgency and sensation-seeking also served as significant mediators that suppressed the negative association from negative affect on momentary drinking. For the heavy binge drinkers, only negative affect significantly predicted lower chances of drinking in the moment. Similar effects were observed for momentary drink number models.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Identifying latent alcohol use profiles and targeting approaches to reduce momentary impulsivity via approaches such as just-in-time adaptive intervention may provide prevention opportunities for low and moderate binge drinkers at risk for developing more severe alcohol use problems and disorders. For those who may be in the early stages of developing alcohol use disorders (i.e., the heavy binge drinking sample), alternative intervention approaches utilizing motivational interviewing and cognitive behavioral therapy for alcohol use may be more appropriate.</p>\u0000 </section>\u0000 </div>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":"50 7","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148378317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychosocial Risk Factors and Outcomes Among Men and Women With Alcohol-Associated Liver Disease Undergoing Transplant Evaluation","authors":"Shaina Hasan,&nbsp;Olivia Becker,&nbsp;Meera Jain,&nbsp;Anuragh Gudur,&nbsp;Wendy Novicoff,&nbsp;David Martin,&nbsp;Matthew Stotts,&nbsp;Lauren Carlini","doi":"10.1111/acer.70360","DOIUrl":"10.1111/acer.70360","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Women with alcohol-associated liver disease (ALD) have been shown to be listed for transplant less frequently and have more psychiatric comorbidities as compared to men. This study aimed to analyze differences in psychosocial risk factors between men and women with ALD using the Stanford Integrated Psychosocial Assessment for Transplant (SIPAT), a pre-transplantation tool that assesses a candidate's psychosocial risk factors. The secondary aim was to determine if SIPAT scores are associated with transplant-related outcomes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A single-center, retrospective cohort study was conducted. All outpatients with ALD who were evaluated for liver transplant between 2015 and 2021 and who had at least one completed SIPAT evaluation were included. Fisher's exact and Mann–Whitney <i>U</i> tests were used to compare baseline characteristics and SIPAT scores. Multivariable logistic regression was used to analyze transplant outcomes. Survival differences were assessed using survival analysis, with comparisons evaluated using the log-rank test.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Total SIPAT scores were similar between men and women, but women were found to have significantly higher psychopathology domain scores, related to higher rates of depression and anxiety. Higher psychopathology domain scores and presence of anxiety were associated with lower odds of death among women only. There were no differences in waitlisting, transplantation, or death between men and women with ALD.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This study highlights gender differences in psychosocial risk factors among patients with ALD undergoing transplant evaluation. The mechanism by which anxiety is associated with lower odds of death among women is unclear, and it remains to be seen whether this finding would be reproduced in a larger, prospective study or would generalize to women with other etiologies of cirrhosis. Overall, these findings underscore the importance of incorporating gender-sensitive, nuanced psychosocial assessment in the liver transplant evaluation process.</p>\u0000 </section>\u0000 </div>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":"50 7","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/acer.70360","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148378330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}