Alcohol (Hanover, York County, Pa.)最新文献

{"title":"Alcohol consumption and high-molecular-weight adiponectin levels are interactively associated with all-cause mortality among community-dwelling persons","authors":"Ryuichi Kawamoto,&nbsp;Asuka Kikuchi,&nbsp;Daisuke Ninomiya,&nbsp;Teru Kumagi,&nbsp;Masanori Abe","doi":"10.1111/acer.70037","DOIUrl":"10.1111/acer.70037","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Decreased levels of high-molecular-weight (HMW) adiponectin are associated with metabolic syndrome and insulin resistance. This relationship may be further confounded by alcohol consumption, which plays a role in the development of liver dysfunction. In Japan, few studies have investigated the relationship between HMW adiponectin levels and alcohol consumption with mortality.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The study included 845 male participants (mean age, 61 ± 13 years; range, 20–89 years) and 1065 female participants (mean age, 63 ± 11 years; range, 22–88 years). Of the participants, 809 (42.4%) were classified as nondrinkers, 561 (29.4%) as occasional drinkers, 346 (18.1%) as daily light drinkers, and 194 (10.2%) as daily heavy drinkers. A Cox proportional hazards model was used to calculate hazard ratios (HR) for all-cause mortality, adjusting for various confounders, including HMW adiponectin levels.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Individuals who abstained from alcohol consumption (hazard ratio [HR], 1.23; 95% confidence interval [CI], 1.00–1.52) or engaged in daily heavy drinking (HR, 1.39; 95% CI, 1.04–1.86) exhibited significantly higher overall mortality than occasional drinkers. Additionally, those with the 3rd standard deviation (SD) level of HMW adiponectin (HR, 1.39; 95% CI, 1.07–1.80) and 4th SD level (HR, 1.65; 95% CI, 1.23–2.23) had a similarly increased risk of all-cause mortality compared to those with the lowest levels. After adjusting for confounders, the HR for individuals with the 3rd + 4th SD levels of HMW adiponectin was significantly elevated in nondrinkers (HR, 1.89; 95% CI, 1.09–3.29), occasional drinkers (HR, 1.84; 95% CI, 1.05–3.21), and daily heavy drinkers (HR, 1.90; 95% CI, 1.05–3.44), but not in daily light drinkers. The interaction between alcohol consumption and HMW adiponectin levels was significantly associated with all-cause mortality.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>These findings suggest that alcohol consumption and elevated HMW adiponectin levels are interactively associated with all-cause mortality in community-dwelling individuals.</p>\u0000 </section>\u0000 </div>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":"49 5","pages":"1097-1105"},"PeriodicalIF":3.0,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/acer.70037","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143744582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal analysis for between- and within-person influences of descriptive alcohol drinking norms and attitudes on drinking outcomes","authors":"Angelo M. DiBello,&nbsp;Mary Beth Miller,&nbsp;Melissa R. Hatch,&nbsp;Nadine R. Mastroleo,&nbsp;Kate B. Carey","doi":"10.1111/acer.70008","DOIUrl":"10.1111/acer.70008","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The study aimed to expand on existing research related to the theory of planned behavior (TPB) by exploring both between-person and within-person effects of descriptive norms and attitudes toward moderate and heavy drinking on drinking outcomes, including drinks per week, blackouts, and alcohol-related consequences. While previous studies focus on between-person effects, this study uniquely investigates both between-person effects as well as within-person changes over time, using longitudinal data collected at six points over 12 months.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Participants included 484 mandated college students (<i>M</i>_age = 18.66, SD_age = 0.758; 55.6% male). Participants completed measures of descriptive drinking norms, attitude toward moderate and heavy drinking, drinking intentions, and drinking outcomes, including drinks per week, blackout, and alcohol-related consequences. Multilevel models were run to examine the unique between-and within-person effects of descriptive drinking norms and attitude toward moderate and heavy drinking on drinking outcomes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Overall, the results from the multilevel models showed that at the between-person level, descriptive norms were associated with drinks per week, and a more favorable attitude toward heavy drinking was associated with higher weekly alcohol consumption and related consequences. At the within-person level, within-person fluctuations in descriptive norms and attitude toward heavy drinking were associated with higher weekly drinking, blackout, and alcohol-related consequences, while favorable attitude toward moderate drinking were associated with lower odds of blackouts and fewer alcohol-related consequences.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Attitudes toward drinking, particularly heavy drinking, at both between-person and within-person levels, are strong predictors of alcohol use and its consequences. Furthermore, attitude toward moderate drinking are protective. Interventions promoting a moderate drinking attitude and reducing heavy drinking attitude and descriptive drinking norms will likely be effective in reducing alcohol-related harm.</p>\u0000 </section>\u0000 </div>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":"49 4","pages":"883-892"},"PeriodicalIF":3.0,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/acer.70008","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143722760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abnormal neurobehavior profiles observed in the newborn period following low-to-moderate prenatal alcohol exposure","authors":"Jessie R. Maxwell,&nbsp;Melissa H. Roberts,&nbsp;Jean Lowe,&nbsp;Xingya Ma,&nbsp;Jillian F. Kotulski,&nbsp;Amy L. Salisbury,&nbsp;Ludmila Bakhireva","doi":"10.1111/acer.70013","DOIUrl":"10.1111/acer.70013","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Prenatal alcohol exposure (PAE) has lifelong consequences on affected individuals, with a range of physical, neurodevelopmental, learning, and behavioral adverse outcomes. There is no method to identify children at risk of these outcomes shortly after birth, resulting in delayed diagnosis and access to therapeutic modalities. The Neonatal Intensive Care Unit (NICU) Network Neurobehavioral Scale, First Edition (NNNS-I), has demonstrated utility in the risk stratification of substance-exposed infants but has not been previously used to assess infants with PAE. The purpose of this study was to assess the utility of NNNS-I in the identification of infants with low-to-moderate PAE.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The Ethanol, Neurodevelopment, Infant, and Child Health (ENRICH-2) prospective cohort included maternal assessments in the second and third trimesters of pregnancy and infant assessments at birth. PAE was evaluated by prospective, repeated Timeline Follow Back interviews and a comprehensive panel of ethanol biomarkers. During the birth hospitalization, certified examiners completed the NNNS-I assessment, which included infant neurobehavioral organization summarized into 12 summary scores. Summary scores and profiles, generated by latent profile analysis (LPA), were compared between PAE and no-PAE groups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>This analysis included 130 caregiver-infant dyads (71 with PAE and 59 with no-PAE). The absolute alcohol ounces per day in the PAE group were 0.08 ± 0.11, on average, or ~1.1 standard drinks per week. In multivariable analysis, PAE was associated with lower <i>attention</i> (<i>β</i> = −0.79) and higher <i>lethargy</i> (<i>β</i> = −0.86) scores (<i>p</i>'s &lt; 0.05) on NNNS-I after controlling for maternal mental health, marijuana use during pregnancy, and family income. LPA identified three profiles of neurobehavior, with a high-risk profile demonstrating poor infant self-regulation and decreased <i>attention</i>.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Low-to-moderate PAE was associated with neurobehavioral findings identifiable on the NNNS-I assessment, highlighting its potential utility for screening and risk stratification of infants with PAE shortly after birth.</p>\u0000 </section>\u0000 </div>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":"49 4","pages":"818-828"},"PeriodicalIF":3.0,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143722757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Social network alcohol use is associated with individual-level alcohol use among Black sexually minoritized men and gender-expansive people: Findings from the Neighborhoods and Networks (N2) cohort study","authors":"Cho-Hee Shrader,&nbsp;Dustin T. Duncan,&nbsp;Anthony Santoro,&nbsp;Elvin Geng,&nbsp;Henry R. Kranzler,&nbsp;Deborah Hasin,&nbsp;Donna Shelley,&nbsp;Bryan Kutner,&nbsp;Scott E. Sherman,&nbsp;Yen-Tyng Chen,&nbsp;Mainza Durrell,&nbsp;Rebecca Eavou,&nbsp;Hanson Hillary,&nbsp;William Goedel,&nbsp;John A. Schneider,&nbsp;Justin R. Knox","doi":"10.1111/acer.70009","DOIUrl":"10.1111/acer.70009","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Black sexually minoritized men and gender-expansive people (SGM), including transgender women, have higher levels of alcohol use and experience greater negative consequences from alcohol consumption than the general population. We investigated the role of multilevel factors contributing to alcohol use among these groups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We analyzed data collected from HIV-negative participants in the Neighborhoods and Network (N2) cohort study in Chicago, IL (<i>N</i> = 138). Participants completed a social network inventory (November 2018–April 2019) and reported alcohol use (frequency, quantity, and frequency of binge drinking) during a quantitative assessment. We used stepwise negative binomial regression to identify associations with social network and individual-level alcohol use while controlling for sociodemographic variables.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Most participants drank alcohol in the past month (68%), with a mean of 2.5 drinks (SD = 1.9) per drinking day. Participants nominated 377 confidants (<i>M</i>_nominated = 2.7), of whom 93% were Black and 78% were friends/family. Among the confidants, 30% drank alcohol at least several times per week. Identifying as Latine (RR = 2.21; 95% CI: 1.44–3.10), having a higher Generalized Anxiety Disorder-7 score (RR = 1.03; 95%CI: 1.00–1.05), living with a problem drinker during one's childhood (RR = 1.80; 95% CI: 1.39–2.34), and having a greater proportion of regular drinkers in one's social network (RR = 1.49; 95% CI: 1.02–2.17) were positively associated with alcohol use.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Black SGM exposed to social network alcohol use during childhood and adulthood reported increased alcohol use. Interventions targeting Black SGM should address social norms around alcohol, intersectional discrimination, and mental health.</p>\u0000 </section>\u0000 </div>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":"49 4","pages":"783-791"},"PeriodicalIF":3.0,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143722762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"History of mental comorbidities and their relationships with drinking milestones, hazardous drug use, suicide attempts, and the ADH1B and ALDH2 genotypes in 4116 Japanese men with alcohol dependence: An exploratory study","authors":"Akira Yokoyama,&nbsp;Tetsuji Yokoyama,&nbsp;Yosuke Yumoto,&nbsp;Tsuyoshi Takimura,&nbsp;Tomomi Toyama,&nbsp;Junichi Yoneda,&nbsp;Kotaro Nishimura,&nbsp;Ruriko Minobe,&nbsp;Takanobu Matsuzaki,&nbsp;Mitsuru Kimura,&nbsp;Sachio Matsushita","doi":"10.1111/acer.70014","DOIUrl":"10.1111/acer.70014","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Alcohol dependence (AD) is often comorbid with other mental disorders. We assessed how comorbidities are associated with the clinical features of AD.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Information on the history of mental comorbidities, hazardous drug use, suicide attempts, and drinking milestones was collected on a semi-structured medical history form from 4116 Japanese male AD inpatients (2007–2018); the subjects' <i>ADH1B</i> and <i>ALDH2</i> genotypes (rs1229984/rs671) were also determined.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Of the total, 889 (21.60%) patients reported a history of mental comorbidities, including mood disorders (15.48%) and insomnia (2.89%); 202 (4.91%) reported a history of hazardous drug use, and 614 (14.92%) reported suicide attempts. Comorbidities were most commonly diagnosed around the time of onset of advanced alcohol use disorder (aAUD). Patients with comorbidities who began drinking regularly showed more rapid progression to aAUD and to the start of treatment for AD. Multivariate odds ratios (MORs [95%CI]) for the fast-metabolizing <i>ADH1B*1/*2</i> and <i>ADH1B*2/*2</i>, protective against AD, were higher in patients with comorbidities [1.43 (1.16–1.76) and 1.35 (1.11–1.66)], drug use [1.64 (1.09–2.46) and 1.60 (1.07–2.38)], and suicide attempts [1.45 (1.13–1.85) and 1.49 (1.17–1.88)] compared with the <i>ADH1B*1/*1</i>. MORs for the inactive protective <i>ALDH2*1/*2</i> were increased only in patients with insomnia [2.65 (1.75–4.02)] compared with the <i>ALDH2*1/*1</i>. MORs for smoking [0.74 (0.58–0.94)] and for age ≤15 years at first drink [0.66 (0.54–0.81)] were lower in patients with comorbidities. MORs for suicide attempts were 2.87 (2.36–3.48) in patients with comorbidities and 3.38 (2.47–4.62) in patients with drug use.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Mental comorbidities and a history of suicide attempts were frequent in Japanese patients with AD. Risk factors for AD (<i>ADH1B*1/*1</i>, smoking, early initiation of drinking) were negatively associated with the risk of comorbidities, suggesting interactions between comorbidities and AD risk factors. Insomnia was positively associated with the inactive <i>ALDH2*1/*2</i>. AD patients with mental comorbidities require multifaceted interventions, including suicide prevention.</p>\u0000 </section>\u0000 </div>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":"49 4","pages":"804-817"},"PeriodicalIF":3.0,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143722759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trauma-related guilt, shame, and trauma type among patients with co-occurring PTSD and SUD","authors":"Nathalie N. M. Faber,&nbsp;Sera A. Lortye,&nbsp;Loes A. Marquenie,&nbsp;Anna E. Goudriaan,&nbsp;Arnoud Arntz,&nbsp;Marleen M. de Waal","doi":"10.1111/acer.70028","DOIUrl":"10.1111/acer.70028","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Background&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Substance use disorder (SUD) frequently co-occurs with posttraumatic stress disorder (PTSD). Feelings of shame and guilt are associated with either disorder but have not been studied in patients with both disorders. Index trauma characteristics are associated with PTSD severity and trauma-related shame. This study examines the effects of trauma-related guilt and shame, and index trauma on SUD and PTSD severity in a clinical sample of individuals with co-occurring SUD and PTSD.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Participants were SUD-treatment-seeking patients with co-occurring PTSD (&lt;i&gt;N&lt;/i&gt; = 209) who completed the Clinician-Administered PTSD scale for Diagnostic and Statistical Manual of Mental Disorders (DSM-5; CAPS-5), Alcohol Use Disorder Identification Test (AUDIT), Drug Use Disorders Identification Test (DUDIT), Trauma-Related Guilt Inventory (TRGI) and Trauma-Related Shame Inventory (TRSI). Regression analyses examined the predictive values of PTSD severity, trauma-related guilt, and shame on alcohol and drug use problems, and the predictive values of trauma-related guilt and shame on PTSD severity. One-way ANOVA and follow-up &lt;i&gt;t&lt;/i&gt;-tests examined the effects of index trauma on PTSD severity and trauma-related shame.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;PTSD severity was significantly associated with drug use disorder (DUD) severity and showed a curvilinear relationship to alcohol use disorder (AUD) severity. Trauma-related guilt was not significantly associated with SUD severity, while trauma-related shame was significantly associated with DUD severity (but not AUD severity). Both trauma-related guilt and shame were significantly associated with PTSD severity; however, only trauma-related shame showed an independent association. Interpersonal (especially sexual) index traumas were associated with increased trauma-related guilt and shame, while childhood index traumas were associated with increased PTSD severity.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusions&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Trauma-related guilt and shame might be important focus points in PTSD treatment, but for SUD problems, this study only showed an association between trauma-related shame and drug use problems. Trauma-related shame seems to be a more important treatment focus point than trauma-related guilt in the treatment of PTSD. It becomes particularly relevant for interpersonal index traumas (especially sexual trauma). Childhood traumas require attention in SUD-PTSD co-occurrence, given the higher severity of PTSD.&lt;/p&gt;\u0000 ","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":"49 5","pages":"1064-1075"},"PeriodicalIF":3.0,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/acer.70028","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143712309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of adolescent drinking on traumatic brain injury-induced cognitive deficits and alcohol preference in adult C57BL/6J mice","authors":"Yunhui H. Xu,&nbsp;Hannah G. Sexton,&nbsp;Angela N. Henderson-Redmond,&nbsp;Christian Harris,&nbsp;Jason D. Huber,&nbsp;Mary-Louise Risher","doi":"10.1111/acer.70027","DOIUrl":"10.1111/acer.70027","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Industrial workers and active military personnel within combat roles face heightened risk for blast pressure wave traumatic brain injury (bTBI). Previous studies have shown that experiencing TBI is associated with increased alcohol (EtOH) consumption and illicit substance use. Notably, alcohol use typically begins during late adolescence or early adulthood, a period that precedes many TBI incidents; moreover, early-onset drinking is further associated with heightened risk of developing an alcohol use disorder (AUD) even in the absence of TBI. Adolescent binge drinking can induce lasting cognitive and astrocyte changes, impacting brain recovery and repair. However, the impact of adolescent drinking history on behavioral recovery after bTBI and its role in the subsequent escalation of alcohol consumption remain unexplored. Here, we used a mouse model to investigate how adolescent (PND28-42) and young adult (PND60-90) EtOH consumption affects behavioral outcomes following bTBI. We aim to determine whether the history of adolescent binge drinking contributes to bTBI-induced escalation in EtOH intake, preference, or worsened fear memory and anxiety.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Adolescent mice were subjected to drinking in the dark (DID) EtOH paradigm for 4 weeks, then randomly assigned to sham, mild-bTBI, or severe-bTBI. Behavioral testing was conducted, followed by a second DID.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Both EtOH and bTBI independently induced hyperlocomotor activity in a sex-dependent manner. These findings reflect an increase in risk-taking rather than generalized anxiety. Importantly, a history of adolescent EtOH consumption synergistically worsened bTBI-induced impaired fear extinction in both sexes. Changes in EtOH preference post-bTBI are context-dependent, with male mice showing a significant decrease in preference following mild-bTBI and prior EtOH exposure, while females exhibited a trend toward increased preference post-bTBI, with significant increases in preference observed only when comparing pre- to post-bTBI drinking behavior.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Both males and females exhibited vulnerability to the combined effects of adolescent EtOH consumption and bTBI on fear extinction, while female mice showed a unique vulnerability to the escalation in EtOH preference.</p>\u0000 </section>\u0000 </div>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":"49 5","pages":"1013-1027"},"PeriodicalIF":3.0,"publicationDate":"2025-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blood phosphatidylethanol measurements indicate GLP-1 receptor stimulation causes delayed decreases in alcohol consumption","authors":"Mathias E. Jensen,&nbsp;Mette K. Klausen,&nbsp;Marianne L. Bergmann,&nbsp;Gitte M. Knudsen,&nbsp;Tina Vilsbøll,&nbsp;Christophe Stove,&nbsp;Anders Fink-Jensen","doi":"10.1111/acer.70041","DOIUrl":"10.1111/acer.70041","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The investigation of glucagon-like peptide 1 (GLP-1) receptor agonists (GLP-1RA) as a potential treatment for individuals with alcohol use disorder (AUD) and obesity is currently underway. In this secondary analysis of a randomized placebo-controlled trial, we included AUD patients with comorbid obesity and assessed the effect of the GLP-1RA exenatide versus placebo on alcohol consumption as measured by the alcohol biomarker phosphatidylethanol (PEth).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Thirty AUD patients (9 females, 21 males), with an average age of 53 years and a body mass index (BMI) of at least 30 kg/m², were included in this secondary analysis. Blood samples for PEth were collected at baseline and at weeks 4, 12, 20, and 26. The effect of time and treatment on PEth levels was analyzed using a baseline-adjusted linear mixed model.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A significant interaction between time and treatment was observed at Week 26, with PEth levels reduced by −0.9 <i>μ</i>mol/L in the exenatide group compared to placebo (95% CI [−1.6 to −0.1], <i>p</i> = 0.03). However, the difference in PEth blood levels between the exenatide and placebo groups was not significant at earlier time points.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This secondary analysis indicates that exenatide has a delayed yet significant impact on alcohol consumption in individuals with AUD and obesity, as assessed by PEth levels. These findings warrant further investigation, which is currently underway (NCT05895643).</p>\u0000 </section>\u0000 </div>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":"49 5","pages":"1161-1165"},"PeriodicalIF":3.0,"publicationDate":"2025-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/acer.70041","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Articles of Public Interest","authors":"","doi":"10.1111/acer.70025","DOIUrl":"10.1111/acer.70025","url":null,"abstract":"","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":"49 3","pages":"502"},"PeriodicalIF":3.0,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143671780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronic alcohol exposure during young adulthood attenuates microglial reactivity and downstream immune response pathways in a mouse model of tauopathy later in life","authors":"Tiara Wolf,&nbsp;Lauren Moss,&nbsp;Charles Hudson,&nbsp;Alexis M. Winters,&nbsp;Salma S. Abdelmaboud,&nbsp;Marta Avlas,&nbsp;Jessica Wohlfahrt,&nbsp;Jennifer Guergues,&nbsp;Paula C. Bickford,&nbsp;Stanley M. Stevens Jr.","doi":"10.1111/acer.70034","DOIUrl":"10.1111/acer.70034","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Alzheimer's disease (AD) is a progressive neurodegenerative disorder marked by the buildup of amyloid-β and tau protein tangles. Alcohol use has been identified as a risk factor for AD; however, the molecular mechanisms underlying this potential causal link remain elusive. An emerging area of research focuses on the role of microglia, the brain's innate immune cells, in AD pathogenesis, with evidence suggesting that alcohol exposure may prime microglia to exhibit an exaggerated immune response when they are subsequently exposed to proinflammatory stimuli.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We used a single 10-day chronic-plus-binge alcohol exposure model in male and female C57BL/6J mice aged 8–10 weeks One month later, tauopathy was induced via adenoviral vector (AAV)-mediated overexpression of h-p301L Tau. After 2.5 months, the mice underwent behavioral and cognitive testing. Two weeks later, microglia were collected using fluorescence-activated cell sorting (FACS) and processed for unbiased, mass spectrometry-based proteomic analysis to determine the molecular pathways related to microglial reactivity.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Microglia from mice exposed to alcohol in young adulthood exhibited a blunted immune response when challenged with AAV-mediated delivery and accumulation of human tau later in life. This was characterized by decreased expression of MHC II- and interferon-associated proteins and bioinformatic prediction of inhibited inflammation-related pathways in the absence of gross histological, behavioral, or cognitive deficits. These results demonstrate unique, temporally specific microglial reactivity to tau that is modulated by early adulthood alcohol exposure, implicating a microglial response that could negatively affect the mechanisms necessary for tau clearance and potentially exacerbate tau pathogenesis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This study provides novel insights into the long-term effects of alcohol exposure in early adulthood on microglial function and the complexity of context-dependent microglial involvement in tauopathy. Consideration of early-adulthood environmental factors is critical for understanding and potentially mitigating the risk of neurodegenerative diseases, such as AD.</p>\u0000 </section>\u0000 </div>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":"49 5","pages":"985-1000"},"PeriodicalIF":3.0,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143671769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}