Alcohol (Hanover, York County, Pa.)最新文献

{"title":"Peripheral alcohol metabolism dictates ethanol consumption and drinking microstructure in mice","authors":"Bryan Mackowiak,&nbsp;David L. Haggerty,&nbsp;Taylor Lehner,&nbsp;Yu-Hong Lin,&nbsp;Yaojie Fu,&nbsp;Hongkun Lu,&nbsp;Robert J. Pawlosky,&nbsp;Tianyi Ren,&nbsp;Wonhyo Seo,&nbsp;Dechun Feng,&nbsp;Li Zhang,&nbsp;David M. Lovinger,&nbsp;Bin Gao","doi":"10.1111/acer.70036","DOIUrl":"10.1111/acer.70036","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Ethanol metabolism is intimately linked with the physiological and behavioral aspects of ethanol consumption. Ethanol is mainly oxidized by alcohol dehydrogenase (ADH) to acetaldehyde and further to acetate via aldehyde dehydrogenases (ALDHs). Understanding how ethanol and its metabolites work together to initiate and drive continued ethanol consumption is crucial for identifying interventions for alcohol use disorder (AUD). Therefore, the goal of our study was to determine how ADH1, which is mainly peripherally expressed and metabolizes &gt;90% of ingested ethanol, modulates ethanol metabolite distribution and downstream behaviors.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Ethanol consumption in drinking-in-the-dark (DID) and two-bottle choice (2BC) drinking paradigms, ethanol metabolite concentrations, and lickometry were assessed after ADH1 inhibition and/or in <i>Adh1</i>-knockout (<i>Adh1</i> KO) mice.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>We found that <i>Adh1</i> KO mice of both sexes exhibited decreased ethanol consumption and preference compared with wild-type (WT) mice in DID and 2BC. ADH1 inhibitor fomepizole (4-MP) also significantly decreased normal and sweetened ethanol consumption in DID studies. Measurement of ethanol and its metabolites revealed that ethanol was increased at 1 h but not 15 min, peripheral acetaldehyde was slightly decreased at both timepoints, and ethanol-induced increases in acetate were abolished after ethanol administration in <i>Adh1</i> KO mice compared with controls. Similarly, ethanol accumulation as a function of consumption was 2-fold higher in <i>Adh1</i> KO or 4-MP-treated mice compared with controls. We then used lickometry to determine how this perturbation in ethanol metabolism affects drinking microstructure. <i>Adh1</i> KO mice consume most of their ethanol in the first 30 min, like WT mice, but display altered temporal shifts in drinking behaviors and do not form normal bout structures, resulting in lower ethanol consumption.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Our study demonstrates that ADH1-mediated ethanol metabolism is a key determinant of ethanol consumption, highlighting a fundamental knowledge gap regarding how ethanol and its metabolites drive ethanol consumption.</p>\u0000 </section>\u0000 </div>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":"49 5","pages":"970-984"},"PeriodicalIF":3.0,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143671775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differential impact of recent heavy drinking on first and recurrent acute pancreatitis","authors":"Christie Y. Jeon,&nbsp;Yu Ye,&nbsp;Georgios I. Papachristou,&nbsp;James L. Buxbaum,&nbsp;Joseph R. Pisegna,&nbsp;Cheryl J. Cherpitel,&nbsp;Esther A. Adeniran,&nbsp;Minoti Apte,&nbsp;Eleanor Chang,&nbsp;Anil K. Dasyam,&nbsp;Gayathri D. Jalluri,&nbsp;Charlotte A. Lansky,&nbsp;Aurelia Lugea,&nbsp;Zarine K. Shah,&nbsp;Richard T. Waldron,&nbsp;Stephen J. Pandol,&nbsp;Dhiraj Yadav","doi":"10.1111/acer.70030","DOIUrl":"10.1111/acer.70030","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>While alcohol is known to sensitize the pancreas to acute injury, the role of short-term episodic drinking in regular drinkers is unknown.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We conducted a case-crossover study to (1) determine the hazardous period of drinking prior to a first episode of acute pancreatitis (FAP) or recurrent acute pancreatitis (RAP) and (2) evaluate the dose–response association between short-term drinking and FAP/RAP. Patients hospitalized for FAP/RAP with an AUDIT-C score of ≥3 were enrolled. Recent and lifetime drinking history were collected through interviews. Drinking prior to the index pancreatitis attack was compared to that of an asymptomatic control period. Conditional logistic regression quantified the association of heavy drinking and FAP/RAP.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Of 141 patients who completed a short-term drinking questionnaire, 77 had RAP, and 64 experienced FAP. We found that both FAP and RAP patients drank at moderate-to-heavy levels regularly, with modest day-to-day variation (intraclass correlation of drinks/day 67%–82%). Alcohol consumption increased 2 days preceding the onset of the index pancreatitis attack as compared to the week prior. Stratifying by prior AP history, heavy drinking in the hazard period was associated with RAP (OR = 3.79, 95% confidence interval [CI] 1.57–9.12). Each drink was associated with 1.22-fold (95%CI 1.10–1.35) increased odds of RAP. Short-term heavy drinking was not associated with a FAP (OR = 1.06, 95%CI 0.43–2.57).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>In summary, we found that patients with a prior history of AP face a higher risk of RAP due to excess drinking. Drinking intensity did not increase prior to a FAP, which may have been triggered by other cofactors warranting further examination.</p>\u0000 </section>\u0000 </div>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":"49 5","pages":"1053-1063"},"PeriodicalIF":3.0,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143665541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of risk factors associated with suicidality in children and adolescents with fetal alcohol spectrum disorder in Western Australia","authors":"Grace Kuen Yee Tan,&nbsp;Sophia G. Connor,&nbsp;Sunee Quinn,&nbsp;James Fitzpatrick,&nbsp;Isabelle Adams,&nbsp;Carmela F. Pestell","doi":"10.1111/acer.70039","DOIUrl":"10.1111/acer.70039","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Individuals with fetal alcohol spectrum disorder (FASD) are at an elevated suicide risk compared with those in the general population. This public health issue warrants further research attention to help inform the development of prevention and intervention efforts. Our study is the first to characterize suicidality (i.e., suicidal ideation/suicide attempt) and explore associated risk factors in young individuals with FASD within the Australian context.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Retrospective file reviews from a diagnostic clinic in Western Australia obtained data on demographic variables and risk factors, including psychosocial stressors (i.e., child protection and justice system involvement, history of abuse/neglect) and comorbid diagnoses (i.e., attention-deficit-hyperactivity disorder (ADHD), attachment disorder, conduct disorder, anxiety disorder, depression, substance use disorder, and sleep disorder). Data on suicidality were collected via formal suicide risk assessments and source documentation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>One hundred and ninety-five participants diagnosed with FASD were included in the study (<i>M</i>_age = 11.75 years, range = 5–21 years). Of these, 40 (21%) reported suicidality, with the youngest being 5 years old. There was a significant positive correlation between suicidality and age. A greater proportion of individuals with FASD who had been involved with the justice system (<i>n</i> = 30, 35%) reported suicidality. Participants with attachment disorder (<i>n</i> = 19, 34%), conduct disorder (<i>n</i> = 10, 40%), substance use disorder (<i>n</i> = 14, 50%), and depression (<i>n</i> = 12, 60%) had significantly higher rates of suicidality than individuals without these comorbidities. The risk of suicidality increased in participants with comorbid depression (OR = 4.20) after controlling for age as a covariate.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>These findings add to the growing body of evidence that highlights the vulnerability of individuals with FASD to suicidality compared with the general population, underscoring the need for targeted, culturally safe suicide intervention/prevention efforts.</p>\u0000 </section>\u0000 </div>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":"49 5","pages":"1149-1160"},"PeriodicalIF":3.0,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/acer.70039","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143665540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Considerations for understanding the neurobiology of pathological alcohol choice preference: Commentary on Perini, Karlsson, McIntyre, Heilig—“Neural correlates of choosing alcohol over palatable food reward in humans”","authors":"Erica N. Grodin","doi":"10.1111/acer.70026","DOIUrl":"10.1111/acer.70026","url":null,"abstract":"","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":"49 5","pages":"957-959"},"PeriodicalIF":3.0,"publicationDate":"2025-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143652351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neutrophil extracellular traps (NETs) and NETosis in alcohol-associated diseases: A systematic review","authors":"Mohammed A. S. Khan,&nbsp;Byoung-Joon Song,&nbsp;Xin Wang,&nbsp;Shams Iqbal,&nbsp;Gyongyi Szabo,&nbsp;Sulie L. Chang","doi":"10.1111/acer.70019","DOIUrl":"10.1111/acer.70019","url":null,"abstract":"<p>Heavy alcohol consumption is implicated in the alteration of the antimicrobial function of neutrophils, such as phagocytosis, chemotaxis, the formation of neutrophil extracellular traps (NETs), and the occurrence of NETosis. NETosis is an endogenous process of elimination of invading microbes, autoantibodies, and inflammatory elements such as danger-associated molecular patterns (DAMPs) and pathogen-associated patterns (PAMPs). However, both exaggeration and suppression of NETosis modulate normal physiological and metabolic processes by influencing events at the molecular and cellular levels. Recent research shows that binge alcohol consumption induces NETosis, leading to tissue damage and inflammation. Binge alcohol consumption, chronic alcohol intake, and alcohol use disorder (AUD) can affect immunity and often lead to alcohol-associated liver disease (ALD) and/or other organ damage. Alcohol can lead to detrimental consequences in multiple organs, including the brain, liver, pancreas, and gut. Gut-derived microbial substances, such as endotoxins in the circulation, induce systemic inflammation. Sterile danger signals from damaged cells, cytokines, and prostaglandins act as proinflammatory stimuli and are involved in multiple signaling pathways. The alcohol-induced proinflammatory cytokines chemoattract neutrophils, which interact and coordinate with other immune cells to exaggerate or suppress inflammation within the inflammatory milieu, depending on the alcohol effects. Several proteins, including different receptors, play important roles in the activation and formation of NETs as well as the initiation and execution of NETosis. This review article specifically gathers the current information on NETosis, its biological components, and signaling pathways relating to the formation of NETs and the occurrence of NETosis associated with ALD and AUD in multiorgans, specifically in the brain, liver, and gut. We also briefly describe various therapeutic strategies against AUD-associated NETosis in experimental models and human disease states.</p>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":"49 4","pages":"697-711"},"PeriodicalIF":3.0,"publicationDate":"2025-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143652352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Check your data before you wreck your model: The impact of careless responding on substance use data quality","authors":"Abby L. Braitman,&nbsp;Anna M. Petrey,&nbsp;Jennifer L. Shipley,&nbsp;Rachel Ayala Guzman,&nbsp;Emily Renzoni,&nbsp;Alison Looby,&nbsp;Adrian J. Bravo,&nbsp;Stimulant Norms and Prevalence 2 (SNAP2) Study Team","doi":"10.1111/acer.70024","DOIUrl":"10.1111/acer.70024","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The accuracy of survey responses is a concern in research data quality, especially in college student samples. However, examination of the impact of removing participants from analyses who respond inaccurately or carelessly is warranted given the potential for loss of information or sample diversity. This study aimed to understand if careless responding varies across a number of demographic indices, substance use behaviors, and the timing of survey completion.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Method</h3>\u0000 \u0000 <p>College students (<i>N</i> = 5809; 70.7% female; 75.7% White, non-Hispanic) enrolled in psychology classes from six universities completed an online survey assessing a variety of demographic and substance use-related information, which included four attention check questions dispersed throughout the hour-long survey. Differences in careless responding were assessed across multiple demographic groups, and we examined the impact of careless responding on data quality via a confirmatory factor analysis of a validated substance use measure, the Drinking Motives Questionnaire-Revised Short Form.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Careless responding varied significantly by participant race, sex, gender, sexual orientation, and socioeconomic status. Substance use was generally unassociated with careless responding, though careless responding was associated with experiencing more alcohol-related problems. Careless responding was more prevalent when the survey was completed near the end of the semester. Finally, the factor structure of the drinking motives measure was affected by the inclusion of those who failed two or more attention check questions.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Including attention checks in surveys is an effective method to detect and address careless responding. However, omitting participants from analyses who evidence any careless responding may bias the sample demographics. We discuss recommendations for the use of attention check questions in undergraduate substance use cross-sectional surveys, including retaining participants who fail only one attention check, as this has a minimal impact on data quality while preserving sample diversity.</p>\u0000 </section>\u0000 </div>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":"49 4","pages":"941-951"},"PeriodicalIF":3.0,"publicationDate":"2025-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/acer.70024","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143652348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient perspectives on medications for alcohol use disorder: A systematic scoping review","authors":"Devin C. Tomlinson,&nbsp;Autumn Rae Florimbio,&nbsp;Carol A. Lee,&nbsp;Mark A. Ilgen,&nbsp;Lewei A. Lin,&nbsp;Lara N. Coughlin","doi":"10.1111/acer.70022","DOIUrl":"10.1111/acer.70022","url":null,"abstract":"<p>Front-line treatments for alcohol use disorder (AUD) include psychotherapy and medication, and both treatments are underused. However, utilization rates of medications for alcohol use disorder (MAUD) are particularly low. The goal of the present scoping review is to characterize patient perspectives about MAUD to identify barriers to MAUD and potential areas of future work to increase access, initiation, and retention on MAUD. Searches of titles and abstracts were conducted on PubMed, EMBASE, PsycINFO, and CINAHL until March 2024 with patient perspective-, MAUD-, and alcohol-related keywords. Articles were assessed for eligibility and included in the present review if they examined adult patients' perspectives of MAUD. Fourteen studies were included in the review. The majority of patient populations assessed were individuals with AUD, and most studies evaluated MAUD in general (<i>n</i> = 7) or specific medications (i.e., naltrexone, <i>n</i> = 5; disulfiram, <i>n</i> = 2; acamprosate, <i>n</i> = 1). Important themes related to patient-perceived barriers to MAUD were identified, including a lack of awareness and misunderstanding about the effectiveness and effects of MAUD, apprehensiveness or experience with side effects, and perceived stigma of MAUD. Future work incorporating patient perspectives of MAUD into interventions and strategies may help improve MAUD uptake, including person-centered discussions factoring in unique patient perspectives about MAUD to increase patient MAUD knowledge and reduce MAUD stigma.</p>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":"49 4","pages":"725-735"},"PeriodicalIF":3.0,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/acer.70022","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143606100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identifying family environment profiles in families of children with prenatal alcohol exposure","authors":"Riley J. Felicicchia,&nbsp;Matthew T. Hyland,&nbsp;Scott C. Roesch,&nbsp;Sarah N. Mattson","doi":"10.1111/acer.70016","DOIUrl":"10.1111/acer.70016","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Individuals with prenatal alcohol exposure (PAE) may face unique family environments that potentially influence adaptive functioning and behavioral challenges. This study aimed to identify profiles of families of children with PAE based on family characteristics, including cohesion, conflict, and organization, and to examine the relationship between family environment profiles and child outcomes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Data were collected from caregivers of 283 youth (5–17 years) with histories of PAE. Caregivers completed several questionnaires, including the Child Behavior Checklist (CBCL), Vineland Adaptive Behavior Scales (VABS), and Family Environment Scale (FES). Latent profile analysis (LPA) was used to identify profiles in the family environment using three subscales from the FES (Cohesion, Conflict, and Organization). Model fit was determined by comparing 1-, 2-, 3-, 4-, and 5-profile solutions. One-way ANCOVA follow-up tests were conducted to explore differences in adaptive and behavioral functioning across family environment profiles.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The 4-profile solution was considered the best fit for the data. Interpretation of conditional response probabilities indicated that Profile 1 was defined by low cohesion; Profile 2 was defined by low organization; Profile 3 was defined as high cohesion and organization; and Profile 4 was defined as high conflict. After controlling for race, sex, age, and ethnicity, there were significant profile differences on the Internalizing, Externalizing, and Total Problem Behavior scales of the CBCL. There were no significant differences in adaptive functioning across profiles.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The results of this study highlight the importance of the family environment in understanding the strengths and challenges experienced by children with PAE. Four unique profiles of family environments emerged in families of children with PAE. The high-conflict profile was associated with increased behavioral problems in children. These findings can be used to support families of children with PAE and to identify treatment targets for interventions for children with PAE and their caregivers.</p>\u0000 </section>\u0000 </div>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":"49 4","pages":"771-782"},"PeriodicalIF":3.0,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/acer.70016","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143606065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Traumatic stress-enhanced ethanol drinking: Sex, but not stress responsivity, alters sensitivity to the effects of a CRF-R1 antagonist and a GPR39 agonist in mice","authors":"Melinda L. Helms,&nbsp;Deborah A. Finn,&nbsp;Michelle A. Nipper,&nbsp;Andrey E. Ryabinin,&nbsp;Rita P. Cervera-Juanes","doi":"10.1111/acer.70005","DOIUrl":"10.1111/acer.70005","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Predator stress (PS) is used to model trauma leading to post-traumatic stress disorder, and it increases ethanol drinking in a proportion of male and female rodents. The goals of the present studies were to identify male and female mice with prior binge drinking experience that exhibited sensitivity and resilience to PS-enhanced drinking and then to test two target molecules (corticotropin releasing factor receptor 1 [CRF-R1] antagonist NBI-27914 [NBI] and G-protein coupled receptor 39 [GPR39] agonist TC-G 1008 [TC-G]) for their ability to selectively reduce PS-enhanced drinking.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Adult male and female C57BL/6J mice received seven binge ethanol sessions, a period of abstinence, and acclimation to lickometer chambers to examine the effects of NBI or TC-G on stress-associated drinking. Following establishment of stable baseline (BL) drinking and four intermittent PS exposures, mice were classified into “Sensitive” and “Resilient” subgroups, based on the change in ethanol drinking from BL after PS2-4. Then, mice received injections of vehicle or drug (NBI or TC-G) in a within-subjects design. Control studies examined the effects of NBI or TC-G on binge drinking, locomotor activity, and saccharin intake.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>NBI and TC-G significantly suppressed binge drinking in male and female mice in the control studies. However, sensitivity to the ability of the compounds to decrease PS-enhanced drinking did not differ between animals in the “PS-sensitive” versus “PS-resilient” subgroups, and female mice were insensitive to TC-G in the traumatic stress drinking model. Specifically, NBI doses of 5 and 10 mg/kg (males) and 12.5 mg/kg (females) significantly decreased PS-associated drinking in both subgroups. TC-G (7.5 mg/kg) significantly decreased PS-associated drinking in both subgroups of male mice but not in female mice.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The present findings suggest that stress sensitivity and subsequent enhanced ethanol drinking in the “Sensitive” subgroup may not increase sensitivity to CRF-R1 antagonism or GPR39 agonism.</p>\u0000 </section>\u0000 </div>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":"49 4","pages":"866-882"},"PeriodicalIF":3.0,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/acer.70005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143606827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contingency management to promote treatment engagement in comorbid alcohol use disorder and alcohol-related liver disease: Findings from a pilot randomized controlled trial","authors":"Sofia Hemrage,&nbsp;Nicola Kalk,&nbsp;Naina Shah,&nbsp;Stephen Parkin,&nbsp;Paolo Deluca,&nbsp;Colin Drummond","doi":"10.1111/acer.70018","DOIUrl":"10.1111/acer.70018","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Alcohol-related liver disease (ARLD) is a leading cause of preventable death and health inequalities. Evidence-based interventions for comorbid alcohol use disorder (AUD) and ARLD remain limited, and only a small proportion of this clinical population engages with treatment. There is a need to improve patient outcomes by bridging this gap through novel, person-centred interventions. Contingency management (CM) is a psychosocial intervention that involves gradual, increasing incentives upon the completion of treatment-related goals, such as treatment attendance. This single-centre, randomized pilot trial of voucher-based CM was conducted to promote treatment engagement in comorbid AUD and ARLD.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Thirty service users were recruited from an inpatient setting, offered integrated liver care (ILC) and allocated to ILC only or ILC + CM. Primary outcomes included feasibility criteria (recruitment, study retention post-randomization, completeness of data and protocol fidelity). Secondary outcome data on engagement, alcohol intake, and liver function were also collected. Data were gathered at baseline, post-ILC, and 12 weeks post-ILC and analyzed through descriptive statistics.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The feasibility of the research was subject to challenges inherent to conducting applied health research in a real-world clinical setting. The recruitment and retention rates were 73.20% and 36.70%, respectively. All participants received CM per protocol. An increasing trend in engagement was observed in the ILC + CM compared to ILC only (67% vs. 33%). A trending 76% reduction in alcohol intake and an overall improvement in liver outcomes were observed among participants engaging with the trial, with no significant differences between control and treatment groups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Overall, the CM intervention was feasible to deliver and appears promising in improving outcomes in individuals with comorbid AUD and ARLD. Aspects related to recruitment, study retention post-randomization, and protocol fidelity need to be further adapted before proceeding with a definitive trial.</p>\u0000 </section>\u0000 </div>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":"49 4","pages":"893-910"},"PeriodicalIF":3.0,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/acer.70018","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143598211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}