Alcohol (Hanover, York County, Pa.)最新文献

{"title":"Subjective responses to simultaneous alcohol and cannabis use relative to alcohol-only use and cannabis-only use: An ecological momentary assessment investigation","authors":"Sophie G. Coelho,&nbsp;Christian S. Hendershot,&nbsp;Jeffrey D. Wardell","doi":"10.1111/acer.70017","DOIUrl":"10.1111/acer.70017","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Few studies have examined subjective responses to simultaneous alcohol and cannabis use in naturalistic settings. The current study used ecological momentary assessment (EMA) to compare subjective responses between simultaneous use and both alcohol-only use and cannabis-only use sessions, while also examining the moderating role of quantities of alcohol and cannabis consumed at both the session and person levels.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Young adults (<i>N</i> = 149, 59.73% women) reporting recent simultaneous use completed three 21-day EMA bursts, spaced 6 months apart. Participants completed a survey each time they initiated a new session of alcohol or cannabis use, along with two hourly follow-up surveys. Surveys assessed alcohol use (quantities), cannabis use (quantities, forms of cannabis), and current acute subjective responses.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>At the session level, simultaneous use (vs. alcohol-only use) was associated with greater peak sedation and intoxication, with the latter association strengthened during sessions involving relatively lighter drinking. Simultaneous use sessions also involved greater peak liking ratings relative to alcohol-only use sessions, though only among participants who reported relatively lower average alcohol consumption. In addition, relative to cannabis-only use sessions, simultaneous use sessions were associated with greater peak energized and liking ratings, with the former association strengthened during sessions involving relatively heavier cannabis concentrate use. Simultaneous use sessions also involved lower peak sedated and anxious ratings relative to cannabis-only use sessions, though only among participants who reported relatively lighter average cannabis consumption.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Overall, simultaneous use was experienced as more impairing (i.e., greater intoxication and sedation) than alcohol-only use and as more reinforcing (i.e., greater stimulation and liking) than cannabis-only use. Some differences in subjective responses between simultaneous use and single-substance use sessions depended on session-level or person-level consumption amounts, which may inform tailored interventions for simultaneous use.</p>\u0000 </section>\u0000 </div>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":"49 4","pages":"923-940"},"PeriodicalIF":3.0,"publicationDate":"2025-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/acer.70017","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143588337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Species differences in comorbid alcohol use disorder and major depressive disorder: A narrative review","authors":"Garrett A. Winkler,&nbsp;Nicholas J. Grahame","doi":"10.1111/acer.70015","DOIUrl":"10.1111/acer.70015","url":null,"abstract":"<p>Alcohol use disorder (AUD) and major depressive disorder (MDD) are often comorbid, and it is estimated that between 15 % to 33% of people dependent on alcohol have an MDD diagnosis. Mood-related symptoms are also common in humans during acute withdrawal, but by most accounts, symptoms abate after 2–4 weeks of alcohol abstinence. Preclinical studies, important for understanding the etiology and finding treatments for this comorbidity, also find depression-like and anxiety-like phenotypes in early abstinence along with protracted negative affect detectable past 2 weeks postcessation. In this narrative review, we focus on the translational divergence of AUD and MDD comorbidity with a focus on the time line mismatch between species in concurrent AUD + MDD and MDD following AUD. We also highlight the preclinical success and clinical failure of classic antidepressants for AUD and the relative absence of withdrawal and negative affect in high-drinking selected lines of mice and rats. We suggest sources of these discrepancies, including discussion of relief/reward-driven drinking subpopulations and future directions for the field.</p>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":"49 4","pages":"712-724"},"PeriodicalIF":3.0,"publicationDate":"2025-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/acer.70015","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143588408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Concomitant caffeine increases voluntary alcohol consumption in male, but not female, adolescent C57BL/6J mice","authors":"Amarpreet Kaur,&nbsp;Anna G. Johnston,&nbsp;Jaytee Wesolowski,&nbsp;Jennifer N. Berry","doi":"10.1111/acer.70023","DOIUrl":"10.1111/acer.70023","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The notion that stimulating qualities of energy drinks reduce overall depressant effects of alcohol has resulted in an increase in the popularity of combining energy drinks with alcohol among young adults and teenagers. Alcohol misuse often emerges during or shortly after vulnerable adolescent years. Even though energy drinks are frequently advertised to and enjoyed by adolescents, there are limited investigations on the neurobehavioral effects of combining caffeine with alcohol during adolescence. This study sought to examine the impact of exposing C57BL/6J adolescent mice to concurrent alcohol and caffeine.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>In the current study, adolescent (<i>n</i> = 98, 50 males and 48 females) C57BL/6J mice were given access to two bottles using an intermittent access (IA) two-bottle choice drinking paradigm for a total of 4 weeks. The experimental bottle contained either caffeine (0.015% w/v), alcohol (10% v/v), or a combination of alcohol + caffeine at the aforementioned concentrations. Adolescent male and female mice were given free access to the substance(s) for 24 h, after which the experimental bottle was taken away for another 24 h.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Male adolescent mice consumed significantly more alcohol when combined with caffeine compared to male adolescent mice that had access to alcohol alone. Further, this trend was shown only in male adolescent mice and not in female adolescent mice, as females did not show any differences in alcohol consumption regardless of whether there was caffeine in the mixture. Ten days following the final removal of alcohol and/or caffeine bottles, mice were given a secondary bottle containing alcohol (10%) for 24 h. Male mice previously exposed to alcohol + caffeine consumed a significantly higher quantity of alcohol during the 24-h challenge period.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>These data suggest that adolescent males may be more vulnerable to consuming higher amounts of alcohol when combined with caffeinated beverages.</p>\u0000 </section>\u0000 </div>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":"49 4","pages":"911-922"},"PeriodicalIF":3.0,"publicationDate":"2025-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143588404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of at-risk alcohol use on nighttime blood pressure, urinary catecholamines, and sleep quality in midlife adults","authors":"Keng-Yu Chang,&nbsp;Tabitha Haun,&nbsp;Zhaoli Liu,&nbsp;Alfredo Gil,&nbsp;Ziba Taherzadeh,&nbsp;Paul J. Fadel,&nbsp;Shane A. Phillips,&nbsp;Mariann R. Piano,&nbsp;Chueh-Lung Hwang","doi":"10.1111/acer.70021","DOIUrl":"10.1111/acer.70021","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The association between alcohol and hypertension has been predominantly based on office blood pressure (BP) measurements. However, little is known about the effect of alcohol use on nighttime BP and the underlying mechanisms. The purpose of this study was to investigate the effects of at-risk alcohol use on nighttime BP, urinary catecholamines, and sleep quality in midlife adults.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A total of 32 midlife men and 30 postmenopausal women, free of major clinical diseases and nonsmokers (age: 58 ± 4; mean ± SD), were included. Among all participants, 22 were currently taking antihypertensive medications. At-risk drinkers were defined as those who had a dried blood spot phosphatidylethanol level ≥20 ng/mL. All participants completed 24-h ambulatory BP monitoring and urine collection to determine nighttime (or asleep) BP and nighttime urinary catecholamine levels. Sleep quality was determined by using the Pittsburgh Sleep Quality Index.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In midlife adults free of antihypertensive medications, at-risk drinkers had a higher nighttime systolic (118 ± 14 vs. 107 ± 14 mmHg, <i>p</i> = 0.02) and diastolic BP (70 ± 9 vs. 62 ± 9 mmHg, <i>p</i> = 0.003) than low-risk drinkers with no between-group differences in sleep quality component scores (<i>p</i> ≥ 0.14). In midlife adults taking antihypertensive medications, no difference in nighttime BP was found between at-risk drinkers and low-risk drinkers (<i>p</i> ≥ 0.68), with a higher score for the “use of sleeping medication” component in high-risk drinkers (<i>p</i> = 0.02). Regardless of antihypertensive medication use, no difference between at-risk drinkers and low-risk drinkers was found in nighttime urinary catecholamine levels (<i>p</i> ≥ 0.19).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Our findings suggest that in midlife adults free of antihypertensive medication use, at-risk alcohol use is associated with an increase in nighttime BP, and the increase in nighttime BP may be mediated by mechanisms other than increased catecholamines and poor sleep quality.</p>\u0000 </section>\u0000 </div>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":"49 4","pages":"843-853"},"PeriodicalIF":3.0,"publicationDate":"2025-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143588406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the impact of graded alcohol use on atherogenic lipid profiles among Latinos with underlying chronic liver disease","authors":"Shyam Patel,&nbsp;Laura Bull,&nbsp;Kian Salimi,&nbsp;Amy M. Shui,&nbsp;Kevin Siao,&nbsp;Bokun Yang,&nbsp;Jacquelyn J. Maher,&nbsp;Mandana Khalili","doi":"10.1111/acer.70010","DOIUrl":"10.1111/acer.70010","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Alcohol use and hepatitis C virus (HCV) often coexist and are associated with cardiovascular disease. One of the underlying drivers is dyslipidemia. We assessed lipid and lipoprotein levels and the relationship between alcohol use and atherogenic lipid profiles, specifically small dense low-density lipoprotein cholesterol (sdLDL-C), in Latinos with and without HCV.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>From June 1, 2002, to January 1, 2016, 150 Latino adults underwent demographic, clinical, metabolic, lipid/lipoprotein, and genetic evaluations. Linear regression (adjusted for age, sex, and recent alcohol use) assessed factors associated with sdLDL-C.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Participant characteristics were as follows: median age 44 years, 64% male, 39% HCV+, and alcohol use in the last 12 months was 19% heavy and 47% moderate. Ancestries were as follows: 52% European, 40% Native American (NA), and 4.3% African. 29% had non-CC <i>PNPLA3</i>, 89% non-CC <i>TM6SF2</i>, and 73% non-CC <i>IL-28b</i> genotypes. High-density lipoprotein (HDL) cholesterol, HDL-3, apolipoprotein A-1, and lipoprotein-associated phospholipase A2 levels differed by alcohol use groups (<i>p</i> &lt; 0.05). On multivariable analysis, female sex (est. –6.08, <i>p</i> &lt; 0.001), HCV+ status (est. –8.49, <i>p</i> &lt; 0.001), and heavy alcohol use (vs. none) (est. –4.32, <i>p</i> = 0.03) were associated with lower, while NA ancestry (est. 0.92; <i>p</i> = 0.01) and adipose tissue insulin resistance (est. 3.30, <i>p</i> &lt; 0.001) were associated with higher sdLDL-C levels. The positive association between NA ancestry and sdLDL-C was dampened by the presence of a non-CC <i>IL28b</i> genotype (interaction est. −1.95, <i>p</i> = 0.01).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>In this Latino cohort, ancestry and metabolic dysfunction, independent of alcohol use and HCV, were associated with atherogenic risk. In addition to HCV treatment in this population, cardiometabolic health should be optimized.</p>\u0000 </section>\u0000 </div>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":"49 4","pages":"792-803"},"PeriodicalIF":3.0,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143532245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ethanol causes rapid decreases in the hepatic retinoid levels shaping the early steps of alcohol-associated liver disease","authors":"Xiao-Han Tang,&nbsp;Glen Pesola,&nbsp;Qiuying Chen,&nbsp;Dawson Miller,&nbsp;Laura E. Nagy,&nbsp;Megan R. McMullen,&nbsp;Robert E. Schwartz,&nbsp;Sergey Tsoy,&nbsp;Christine Lim,&nbsp;Shireen Chikara,&nbsp;Steven S. Gross,&nbsp;Steven E. Trasino,&nbsp;Lorraine J. Gudas,&nbsp;Marta Melis","doi":"10.1111/acer.70011","DOIUrl":"10.1111/acer.70011","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Chronic alcohol drinking causes hepatic vitamin A (retinoids and derivatives) decreases, which correlate with the progression and severity of alcohol-associated liver disease (ALD). However, the effects of short-term ethanol (EtOH) intake on liver retinoids and ALD are still undefined.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Using high-performance liquid chromatography and high-performance liquid chromatography coupled with tandem mass spectrometry (HPLC, HPLC–MS/MS), and molecular biology techniques in mice and cultured human hepatocytes, we investigated the temporal EtOH effects on retinoids and ALD.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In female and male mice, acute EtOH intake caused hepatic retinol (ROL) and retinyl palmitate (RP) decreases within hours, whereas it did not significantly change the retinoic acid (RA) levels, and those of the RA catabolism metabolite, 4-oxo-RA. After EtOH withdrawal, the liver recovered the ROL and RP levels within 48 h, whereas RA and 4-oxo-RA levels remained almost undetectable by this time point. Compared with control diet-fed mice, hepatic ROL and RP levels remained decreased in the 10-day and 3-week-long EtOH treatments, while retinyl oleate and linoleate increased. Interestingly, some of the RA signaling receptors, <i>Rarβ</i>, along with <i>Cyp26a1</i>, revealed dramatic transcript increases during the 10-day-long experiments that attenuated over time (up to 8 weeks), reflecting impaired RA signaling. Our work also showed that primary human hepatocytes serve as a model to better define the role of EtOH in retinoid biology.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This work reveals that acute and short-term exposures to EtOH disrupt retinoid homeostasis, identifying key events in the early pathogenesis of ALD.</p>\u0000 </section>\u0000 </div>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":"49 4","pages":"754-770"},"PeriodicalIF":3.0,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143525300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Content analysis of substance use disorder recovery discourse on Twitter: From personal recovery narratives to marketing of addiction treatment","authors":"Alex M. Russell,&nbsp;Danny Valdez,&nbsp;Mingxuan Wang,&nbsp;Jon-Patrick Allem,&nbsp;Brandon G. Bergman,&nbsp;John F. Kelly,&nbsp;Dana M. Litt,&nbsp;Philip M. Massey","doi":"10.1111/acer.15531","DOIUrl":"10.1111/acer.15531","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Substance use disorder (SUD) is a prodigious public health issue characterized by a substantial treatment gap. Despite challenges, millions have resolved a prior significant alcohol or drug problem, increasingly using online supports as a part of their recovery efforts (e.g., virtual mutual-help group meetings, traditional social networking sites [SNS]). However, the content surrounding SUD recovery-related discussion on SNS such as Twitter remains largely unexamined. To fill this gap, we explored public tweets using SUD recovery-related hashtags.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>From January 1, 2022, to December 31, 2022, 455,968 public tweets were collected using SUD recovery-related hashtags. Natural language processing was used to identify and remove irrelevant groupings of tweets from the dataset, resulting in a final corpus of 186,460 tweets. A random subsample of 1800 tweets was extracted for content analysis, involving codebook development, manual annotation by trained coders, and inter-rater reliability assessment (average Cohen's <i>κ</i> = 0.77).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Nearly half (41.7%) of SUD recovery-related posts were from individuals in or seeking recovery, while 21.3% originated from addiction treatment industry accounts. Common themes included addiction treatment marketing (27.4%; some of which promoted scientifically unsupported products or services), emotional support (15.6%), celebrating a recovery milestone (15.4%), alcohol/drug-related sociopolitical commentary (14.7%), expressions of gratitude (11.5%), and mutual-help group participation (8.7%).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>SUD recovery-related content on Twitter reflected individuals seeking social support during efforts to initiate or maintain recovery. However, these accounts may be met with marketing material from entities that misrepresent their services or promote products based on unsubstantiated claims. Stricter (or enforcement of existing) regulations may be warranted to protect vulnerable SNS platform users from entities seeking to exploit them for financial gain.</p>\u0000 </section>\u0000 </div>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":"49 3","pages":"629-640"},"PeriodicalIF":3.0,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143477162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Developing and testing health warnings about alcohol and risk for breast cancer: Results from a national experiment with young adult women in the United States","authors":"Zachary B. Massey,&nbsp;Allison B. Anbari,&nbsp;Na Wang,&nbsp;Abigail Adediran,&nbsp;LaRissa L. Lawrie,&nbsp;Priscilla Martinez,&nbsp;Denis McCarthy","doi":"10.1111/acer.70003","DOIUrl":"10.1111/acer.70003","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>This study sought to identify effective health warnings about alcohol consumption and breast cancer risk among young adult female participants.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We tested a pool of health warnings in a national pilot study. We used the most effective designs from the pilot in the main experiment where young (ages 21–29) U.S. adult female participants (<i>N</i> = 1038) reporting past 30-day alcohol consumption were randomly assigned into 1 of 4 conditions where they viewed a health warning about (1) mortality, (2) mastectomy, (3) hair loss, or (4) control (non-health warning message). Participants were then randomly assigned to view 1 of 2 message types within each condition: text-only or pictorial. Warnings were shown apart from products. Outcomes were message reactions (attention to and cognitive elaboration of warnings, fear, hope, and perceived message effectiveness), attitudes and beliefs (perceived severity and susceptibility to alcohol harms, and perceived response and self-efficacy to prevent alcohol harms), and behavioral intentions to stop or to reduce alcohol consumption in the next month.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Multivariate analysis of covariance (MANCOVA) models testing between warning conditions showed estimated marginal means (EMM) for every health warning condition were significantly higher than the control for attention (control = 5.80 vs. mortality = 6.63, mastectomy = 6.81, hair loss = 6.83, all <i>p</i>s &lt; 0.05), fear (control = 2.45 vs. mortality = 4.11, mastectomy = 4.16, hair loss = 4.02, <i>p</i>s &lt; 0.05), perceived message effectiveness (control = 3.44 vs. mortality = 5.75, mastectomy = 5.82, hair loss = 6.09, <i>p</i>s &lt; 0.05), and perceived severity of alcohol harms (control = 5.51 vs. mortality = 6.25, mastectomy = 6.09, hair loss = 6.35, <i>p</i>s &lt; 0.05). There were no significant differences between the health warnings about cancer effects for perceived message effectiveness. EMMs for intentions to reduce alcohol consumption in the next month were significantly higher in the mortality (6.44) and hair loss (6.35) conditions versus control (5.61, <i>p</i>s &lt; 0.05).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Exposure to health warnings about alcohol consumption and breast cancer risk (vs. control) resulted in greater attention, fear, perceived message effectiveness, perceived severity of alcohol harms, and intentions to reduce alcohol consumption.</p>\u0000 </section>\u0000 </div>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":"49 3","pages":"665-677"},"PeriodicalIF":3.0,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143477168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alcohol consumption and childhood trauma impact serum immunoglobulin levels in patients with alcohol use disorder","authors":"Kelly M. Abshire,&nbsp;Melanie L. Schwandt,&nbsp;Nancy Diazgranados,&nbsp;Mehdi Farokhnia,&nbsp;Lorenzo Leggio","doi":"10.1111/acer.15537","DOIUrl":"10.1111/acer.15537","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Alcohol Use Disorder (AUD) and childhood trauma both have detrimental effects on immune regulation. Immunoglobulins, key biomarkers of the adaptive immune system, may be selectively targeted by heavy alcohol consumption as well as childhood trauma. In this study, we investigated the relationship between alcohol drinking behavior, history of childhood trauma, and circulating levels of immunoglobulin A (IgA), immunoglobulin G (IgG), and immunoglobulin M (IgM) in individuals with AUD.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Using linear regression, multiple variables, drinks per drinking day and childhood trauma questionnaire (CTQ) score, were evaluated in relation to immunoglobulin levels. All participants (<i>N</i> = 445) were treatment-seeking and admitted to the National Institutes of Health Clinical Center, where they underwent a battery of laboratory and psychological assessments.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Analyses showed a significant positive association between alcohol consumption and IgA. Furthermore, there was a significant negative association between childhood trauma and IgG. Other significant results include a negative association between substance use disorder diagnosis (other than alcohol) and IgA, while anxiety disorder diagnosis was associated with lower IgG.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Heavy alcohol drinking is associated with elevated IgA levels, which may be a potential risk factor for alcohol-associated liver disease. On the other hand, childhood trauma's association with decreased IgG levels may be indicative of broader immune dysfunction. Taken together, changes in immunoglobulins may be valuable markers linking alcohol consumption and childhood trauma to immune health and disease progression.</p>\u0000 </section>\u0000 </div>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":"49 3","pages":"599-608"},"PeriodicalIF":3.0,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11928251/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143477157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Greater alcohol intake predicts accelerated brain aging in humans, which mediates the relationship between alcohol intake and behavioral inflexibility","authors":"Jillian T. Battista,&nbsp;Elena Vidrascu,&nbsp;Madeline M. Robertson,&nbsp;Donita L. Robinson,&nbsp;Charlotte A. Boettiger","doi":"10.1111/acer.15534","DOIUrl":"10.1111/acer.15534","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Hazardous use of alcohol is associated with cognitive-behavioral impairments and accelerated aging. To date, however, accelerated brain aging has not been tested as a mediating factor between alcohol use and associated task-based behavioral deficits, such as behavioral inflexibility. Here, we evaluated hazardous alcohol use as a predictor of machine learning-derived brain aging and tested if this measure accounted for the relationship between hazardous alcohol use and a task-based measure of behavioral flexibility.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>In this secondary analysis, we applied <i>brainageR</i>, a machine learning algorithm, to anatomical T1-weighted magnetic resonance imaging (MRI) images to estimate brain age for a sample of healthy adults (ages 22–40) who self-reported alcohol use with the alcohol use disorder identification test (AUDIT) and performed the hidden association between images task (HABIT), a behavioral flexibility task. Behavioral inflexibility was quantified as the proportion of perseverative errors performed on the HABIT as a measure of habitual action selection. We then analyzed AUDIT score as a predictor of brain aging, and brain aging as a predictor of behavioral inflexibility. Lastly, we conducted a mediation analysis to evaluate brain aging as a mediator between alcohol use and behavioral inflexibility.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Controlling for chronological age and sex, a higher AUDIT score predicted significantly more accelerated brain aging, which was further associated with more perseverative errors on the HABIT. Moreover, brain aging significantly mediated the association between AUDIT scores and behavioral inflexibility.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Our findings demonstrate that alcohol use is a significant predictor of accelerated brain aging, even in young adulthood. In addition, our findings suggest that such brain changes may mechanistically link more hazardous alcohol use to impaired behavioral flexibility. Future studies should also explore factors, such as other lifestyle behaviors, that may mitigate alcohol- and age-related processes.</p>\u0000 </section>\u0000 </div>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":"49 3","pages":"564-572"},"PeriodicalIF":3.0,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143477178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}