Alcohol (Hanover, York County, Pa.)最新文献

{"title":"Impact of early alcohol consumption on adolescent development: Commentary on a longitudinal study conducted by Ferariu et al. (2024)","authors":"Panpan Zhang","doi":"10.1111/acer.15497","DOIUrl":"10.1111/acer.15497","url":null,"abstract":"","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":"49 1","pages":"99-101"},"PeriodicalIF":3.0,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142683907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pain prospectively predicts alcohol use disorder among people living with HIV: A commentary on Palfai et al. (2024)","authors":"Emily L. Zale","doi":"10.1111/acer.15499","DOIUrl":"10.1111/acer.15499","url":null,"abstract":"<p>Alcohol use and pain are common among People Living with HIV/AIDS (PLWH) and present a significant public health concern in this high-risk group. The Reciprocal Model of Pain and Substance Use posits that bidirectional interactions between pain and alcohol use maintain and exacerbate one another (Ditre et al., <span>2019</span>). As research and clinical interest in pain–alcohol associations continue to grow, the field will be advanced by (a) prospective studies that are capable of identifying changes in pain and alcohol use over time, (b) research that focuses on high-risk populations who evince pain and alcohol-related health disparities, and (c) examination of pain–alcohol associations across a spectrum of pain and alcohol-related characteristics. Palfai et al. (<span>2024</span>) made a significant contribution to the literature in all of these domains through their examination of both pain intensity and interference as prospective predictors of heavy drinking and Alcohol Use Disorder (AUD) among a racially and ethnically diverse sample of PLWH. Leveraging data from an existing cohort study, they found that PLWH with moderate/severe pain (vs. no/mild pain) at baseline were more than twice as likely to meet DSM-5 criteria for AUD at 12-month follow-up. Moreover, those with moderate/severe pain-related interference (vs. no/mild interference) in daily functioning were more than 3 times more likely to meet criteria for AUD. In both instances, greater pain and interference were further associated with greater AUD severity. The study conducted by Palfai et al. (<span>2024</span>) provides a rich context for considering the current state-of-the-art and future directions in pain–alcohol research.</p><p>PLWH are an ideal population in which to study pain–alcohol associations because HIV is highly comorbid with both pain and alcohol use, and PLWH face disparities across numerous health outcomes. Indeed, prevalence rates of unhealthy alcohol use (i.e., a range that encompasses risky or potentially harmful drinking through AUD) are up to six times greater among PLWH than among the general population (e.g., Duko et al., <span>2019</span>; SAMHSA, <span>2024</span>). This is of particular concern given that PLWH experience disproportionate alcohol-related disease burdens because of the adverse effects on HIV-related outcomes (Molina et al., <span>2018</span>). Like unhealthy alcohol use, chronic pain is more prevalent among PLWH, with rates about twice as high as the general population (Madden et al., <span>2020</span>; Yong et al., <span>2022</span>). This is reflected in baseline rates of pain and alcohol use in Palfai et al.'s (<span>2024</span>) sample, with nearly half of participants reporting moderate to severe pain intensity and interference and 53% reporting unhealthy alcohol use (i.e., either heavy drinking or AUD) at baseline.</p><p>Drawing from a larger literature on diverse pain conditions (e.g., musculoskeletal pain, arthritis), the Recipr","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":"49 1","pages":"102-105"},"PeriodicalIF":3.0,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11740164/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142683908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An online assessment of pricing for ready-to-drink alcohol products: Implications for risk and policy solutions","authors":"Matthew E. Rossheim,&nbsp;Kayla K. Tillett,&nbsp;Viktor Vasilev,&nbsp;Cassidy R. LoParco,&nbsp;Theresa Agwuncha,&nbsp;Vishaldeep K. Sekhon,&nbsp;Edna P. Mendoza,&nbsp;Olivia Townsend,&nbsp;Maria T. Julian,&nbsp;Ryan D. Treffers,&nbsp;Melvin D. Livingston,&nbsp;Michael B. Siegel,&nbsp;David H. Jernigan","doi":"10.1111/acer.15491","DOIUrl":"10.1111/acer.15491","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Alcohol pricing policies can reduce population-level alcohol consumption. To inform these policies, it is essential to understand the price per standard alcoholic drink of the least expensive brands. This study focused on prices of ready-to-drink products because of their accessibility, popularity among young people, and market expansion in recent years.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>In 2023, we systematically identified 39 retail stores selling alcohol online in Fort Worth, Texas. For each product, we recorded information regarding brand name, alcohol-by-volume (abv), liquid volume, and price (<i>n</i> = 10,818). Ready-to-drink products encompassed beer, malt liquor, cider, premixed cocktails, and flavored alcoholic beverages (FAB) including hard beverages (seltzer, soda, tea, lemonade), excluding wine and distilled spirits. We limited analyses to brands sold by at least three stores and deduplicated products within stores. Our analytic sample size was 3924.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The least expensive brands included the following: Four Loko, MXD Drinks Co., Steel Reserve (High Gravity Lager and Alloy Series), Hurricane High Gravity, Natural Ice, Natty Daddy, Clubtails, Sauza Agave Cocktails, Truly Extra, and Icehouse. The average abv among all products was 5.9%. Among the 20 least expensive brands, the average abv was 9.0%, and 70% were available in single-serve containers.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The least expensive brands of ready-to-drink alcohol products were often high abv, single-serve containers of FAB, malt liquor, or beer. Retail price assessments can strengthen the case for policy solutions, such as targeted taxes and re-classification of products, to reduce the risks posed by low-priced alcohol. The current study identifies some brands these retail assessments should include.</p>\u0000 </section>\u0000 </div>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":"49 1","pages":"226-233"},"PeriodicalIF":3.0,"publicationDate":"2024-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11740171/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142649794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neural correlates associated with a family history of alcohol use disorder: A narrative review of recent findings","authors":"Anita Cservenka,&nbsp;Sheeva Azma","doi":"10.1111/acer.15488","DOIUrl":"10.1111/acer.15488","url":null,"abstract":"<p>A family history of alcohol use disorder (AUD) is associated with a significantly increased risk of developing AUD in one's lifetime. The previously reviewed literature suggests there are structural and functional neurobiological markers associated with familial AUD, but to our knowledge, no recent review has synthesized the latest findings across neuroimaging studies in this at-risk population. For this narrative review, we conducted keyword searches in electronic databases to find cross-sectional and longitudinal studies (2015-present) that used magnetic resonance imaging (MRI), diffusion tensor imaging, task-based functional MRI (fMRI), and/or resting state functional connectivity MRI. These studies were used to identify gray matter, white matter, and brain activity markers of risk and resilience in family history positive (FHP) individuals with a family history of AUD. FHP individuals have greater early adolescent thinning of executive functioning (frontal lobe) regions; however, some studies have reported null effects or greater gray matter volume and thickness relative to family history negative (FHN) peers without familial AUD. FHP individuals also have white matter microstructure alterations, such as reduced integrity of fronto-striatal pathways. Recent fMRI studies have found greater inhibitory control activity in FHP individuals, while reward-related findings are mixed. A growing interest in identifying intrinsic connectivity differences between FHP and FHN individuals has emerged in recent years. Familial AUD is related to both structural and functional brain alterations. Research should continue to focus on (1) longitudinal analyses with larger samples, (2) assessment of personal substance use and prenatal exposure to alcohol, (3) the effects of comorbid familial psychopathology, (4) examination of sex-specific markers of risk and resilience, (5) neural predictors of alcohol use initiation, and (6) brain–behavior relationships. These efforts would aid the design of neurobiologically informed prevention and intervention efforts focused on this at-risk population.</p>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":"49 1","pages":"62-80"},"PeriodicalIF":3.0,"publicationDate":"2024-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142649797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Proximal antecedents and acute outcomes of simultaneous alcohol and cannabis use: Systematic review of daily- and event-level studies","authors":"Kyra N. Farrelly,&nbsp;Tahmina Amini,&nbsp;Sophie G. Coelho,&nbsp;Nicolle Fox,&nbsp;Nicole Dimitrova,&nbsp;Christian S. Hendershot,&nbsp;Jeffrey D. Wardell","doi":"10.1111/acer.15484","DOIUrl":"10.1111/acer.15484","url":null,"abstract":"<p>Many studies have revealed that individuals who engage in simultaneous use of alcohol and cannabis report elevated substance-related consequences relative to those who use only alcohol or cannabis; however, evidence from emerging studies examining within-person differences across simultaneous use and single substance use occasions is less consistent. This systematic review aimed to synthesize findings from existing day- and event-level studies of within-person differences in the proximal antecedents and acute outcomes associated with simultaneous use versus single substance use episodes. Our search strategy revealed 30 eligible articles. Two categories of antecedents (i.e., internal [e.g., motives] and external [e.g., social context]) and three categories of outcomes (i.e., consumption behavior, general positive and negative consequences, and specific consequences) were identified. The current literature consistently suggests that greater day- or event-level social and enhancement motives, as well as being in a social context, predict greater likelihood of engaging in simultaneous use compared with alcohol- or cannabis-only use. However, there was heterogeneity in findings regarding the role of other person-level antecedents. Further, while most evidence pointed to heavier alcohol consumption on simultaneous use occasions versus alcohol-only occasions, findings for elevations in acute negative and positive substance-related consequences on simultaneous use versus single substance use occasions were mixed. Additionally, four studies found that increased consequences on simultaneous use occasions depended on the level of alcohol consumed. This review identifies several antecedents for simultaneous use events but suggests that simultaneous use occasions are not always associated with more acute harms than single substance use occasions. Given the extent to which the current literature is mixed, this review emphasizes the importance of methodological improvements and future research examining the mechanisms linking simultaneous use with substance-related consequences to help reconcile findings across within-person and between-person studies.</p>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":"49 1","pages":"43-61"},"PeriodicalIF":3.0,"publicationDate":"2024-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11740185/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142649808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alcohol-attributable deaths in Thai people from 2015 to 2021 using the comparative risk assessment approach","authors":"Jiraluck Nontarak,&nbsp;Jürgen Rehm,&nbsp;Pol Rovira,&nbsp;Sawitri Assanangkornchai","doi":"10.1111/acer.15489","DOIUrl":"10.1111/acer.15489","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The alcohol-attributable mortality rate is an important health indicator for surveillance of health-related impacts of alcohol consumption. This study aimed to estimate the annual number and rate of alcohol-attributable deaths among the Thai population aged 15 years and over during 2015–2021.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Mortality data were drawn from the National Death Registry based on ICD-10. We used the standard methodology of comparative risk assessments for alcohol within the general framework of the Global Burden of Disease Studies and used alcohol-attributable fractions, derived from exposure, and relative risk compared to lifetime abstainers as the counterfactual. Age-standardization was used to adjust mortality rates which were calculated by cause, age group, and sex.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The estimated annual number of alcohol-attributable deaths was 20,039 (men: 17,726 [6.50% of total annual deaths of the Thai population] and women: 2312 [1.11%]). The age-standardized alcohol-attributable mortality rates continuously increased from 33.8 to 37.5 deaths per 100,000 population from 2015 to 2019 and slightly decreased to 34.5 and 35.3 in 2020 and 2021, respectively. The three leading causes of death attributed to alcohol consumption were road injuries, cirrhosis and other liver diseases, and other unintentional injuries.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Alcohol remains an important preventable cause of death among Thais. The alcohol-attributable mortality rate increased from 2015 to 2019 but declined in 2020 and 2021, possibly due to the coronavirus pandemic and lockdown measures. Culturally appropriate, cost-effective interventions should be used to control alcohol accessibility, particularly among young people who frequently sustain injuries from external causes and have high mortality rates.</p>\u0000 </section>\u0000 </div>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":"49 1","pages":"142-152"},"PeriodicalIF":3.0,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142633599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Why and how: Engaging high school students in meaningful research opportunities","authors":"Lindsay R. Meredith,&nbsp;Amber M. Jarnecke,&nbsp;Rachel L. Tomko,&nbsp;Louise Mewton,&nbsp;Anna E. Kirkland,&nbsp;Brittney D. Browning,&nbsp;Lindsay M. Squeglia","doi":"10.1111/acer.15482","DOIUrl":"10.1111/acer.15482","url":null,"abstract":"","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":"48 12","pages":"2412-2417"},"PeriodicalIF":3.0,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142633585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal alcohol consumption during pregnancy and child development: Role of ADH1B and ALDH2 gene polymorphisms—The Yamanashi Adjunct Study of the Japan Environment and Children's Study","authors":"Kunio Miyake,&nbsp;Sanae Otawa,&nbsp;Megumi Kushima,&nbsp;Hideki Yui,&nbsp;Ryoji Shinohara,&nbsp;Sayaka Horiuchi,&nbsp;Yuka Akiyama,&nbsp;Tadao Ooka,&nbsp;Reiji Kojima,&nbsp;Hiroshi Yokomichi,&nbsp;Zentaro Yamagata,&nbsp;The Yamanashi Adjunct Study of the Japan Environment and Children's Study Group","doi":"10.1111/acer.15487","DOIUrl":"10.1111/acer.15487","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The role of polymorphisms in genes regulating alcohol metabolism, particularly those modulating the impact of prenatal alcohol exposure on the neurodevelopment of offspring, remains inconclusive. Herein, we aimed to determine the involvement of <i>ADH1B</i> and <i>ALDH2</i> gene polymorphisms in maternal alcohol consumption during pregnancy and the risk of developmental delay in offspring in a Japanese population.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Method<b>s</b></h3>\u0000 \u0000 <p>We analyzed 1727 mother–child pairs from the Yamanashi Adjunct Study of the Japan Environment and Children's Study. Maternal alcohol consumption during pregnancy was determined through a mid-pregnancy questionnaire and categorized into three groups: never-drinkers, those who quit drinking in early pregnancy, and current drinkers. Developmental delays in children were assessed in five domains using the Japanese version of the Ages and Stages Questionnaire, Third Edition (J-ASQ-3) at 3 years of age. We conducted a logistic regression analysis to explore the relationship between maternal drinking status during pregnancy and developmental delays in offspring with respect to maternal <i>ADH1B</i> (rs1229984) or <i>ALDH2</i> (rs671) gene polymorphisms.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Children born to mothers who continued alcohol consumption during pregnancy had a higher risk of delayed communication skills at 3 years of age compared with children born to mothers who did not drink alcohol (adjusted odds ratio [OR], 5.82; 95% confidence interval, 1.84–18.38). Analysis by <i>ALDH2</i> gene polymorphism revealed that alcohol consumption by mothers carrying the wild-type <i>ALDH2</i> (*1/*1) increased the risk of delayed communication skills at 3 years of age, whereas alcohol consumption by mothers carrying a heterozygotic genotype of <i>ALDH2</i> (*1/*2) enhanced the risk of developmental delay in all five domains of the J-ASQ-3. The impact of <i>ADH1B</i> gene polymorphism could not be clearly elucidated.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Our results suggest that alcohol consumption by pregnant females carrying the deficient variant <i>ALDH2</i>*2 genotype may increase the risk of developmental delay in their offspring.</p>\u0000 </section>\u0000 </div>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":"49 1","pages":"117-127"},"PeriodicalIF":3.0,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11740163/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142633610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Next-generation biomarkers for alcohol consumption and alcohol use disorder diagnosis, prognosis, and treatment: A critical review","authors":"Shaunna L. Clark,&nbsp;Emily E. Hartwell,&nbsp;Doo-Sup Choi,&nbsp;John H. Krystal,&nbsp;Robert O. Messing,&nbsp;Laura B. Ferguson","doi":"10.1111/acer.15476","DOIUrl":"10.1111/acer.15476","url":null,"abstract":"<p>This critical review summarizes the current state of omics-based biomarkers in the alcohol research field. We first provide definitions and background information on alcohol and alcohol use disorder (AUD), biomarkers, and “omic” technologies. We next summarize using (1) genetic information as risk/prognostic biomarkers for the onset of alcohol-related problems and the progression from regular drinking to problematic drinking (including AUD), (2) epigenetic information as diagnostic biomarkers for AUD and risk biomarkers for alcohol consumption, (3) transcriptomic information as diagnostic biomarkers for AUD, risk biomarkers for alcohol consumption, and (4) metabolomic information as diagnostic biomarkers for AUD, risk biomarkers for alcohol consumption, and predictive biomarkers for response to acamprosate in subjects with AUD. In the final section, the clinical implications of the findings are discussed, and recommendations are made for future research.</p>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":"49 1","pages":"5-24"},"PeriodicalIF":3.0,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142633620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of digital screening and brief intervention for alcohol misuse among college students: A state-wide cluster randomized trial from India","authors":"Abhishek Ghosh,&nbsp;Blessy B. George,&nbsp;Narayanan C. Krishnan,&nbsp;Renjith R. Pillai,&nbsp;Kathirvel Soundappan,&nbsp;Mamta Sharma,&nbsp;Anil Kumar,&nbsp;Debasish Basu","doi":"10.1111/acer.15485","DOIUrl":"10.1111/acer.15485","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Alcohol misuse is prevalent among college students globally, including in India. Digital screening and brief interventions (DSBI) promise to address this issue. This study assesses DSBI's effectiveness in a state-wide cluster randomized trial among college students in India.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We recruited 548 participants (274 in each DSBI and digital screening and brief advice-DSBA) from 40 colleges across 10 districts of Punjab, India. Colleges were selected via two-stage cluster random sampling and were allocated to groups using permuted block randomization. Participants with Alcohol Use Disorder Identification Test (AUDIT) scores between 8 and 19 were included. The digital platform directed eligible participants to their respective groups. DSBI participants received information on alcohol harms, normative and personalized feedback, a decisional balance checklist, and a menu of options. DSBA participants received screening and alcohol harm information. Follow-ups were conducted at 3- and 6-month post-intervention. Primary outcome: reduction in AUDIT scores; secondary outcomes: frequency of drinking, drinks per drinking day, and frequency of heavy episodic drinking (HED).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Baseline demographics and clinical variables did not significantly differ between groups, except for participants' age. 37.6% were women. Follow-up rates were 513/548 at 3 months and 483/548 at 6 months, with no group differences in attrition. AUDIT scores significantly decreased in both groups at 3 and 6 months (Time <i>F</i> = 1870.11, <i>p</i> &lt; 0.001, partial <i>η</i>² = 0.77), with no Group × Time effects (<i>F</i> = 0.160, <i>p</i> = 0.85). Drinking frequency, HED frequency, and drinks per drinking day decreased significantly in both groups without between-group differences.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The study highlights the potential policy implications of integrating brief digital interventions for alcohol misuse into educational health initiatives.</p>\u0000 </section>\u0000 </div>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":"49 1","pages":"205-216"},"PeriodicalIF":3.0,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142633604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}