Ahmed A. Y. Ragab, Margaret F. Doyle, Jiachen Chen, Kathryn L. Lunetta, Joanne M. Murabito
{"title":"酒精消费和免疫细胞概况：来自弗雷明汉心脏研究的见解。","authors":"Ahmed A. Y. Ragab, Margaret F. Doyle, Jiachen Chen, Kathryn L. Lunetta, Joanne M. Murabito","doi":"10.1111/acer.70122","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Background</h3>\n \n <p>Alcohol consumption affects immune function, with excessive intake linked to immune suppression and inflammation. However, its impact on immune cell phenotypes remains unclear. This study investigates the association between alcohol consumption and immune cell profiles in a well-characterized Framingham Heart Study (FHS) cohort while examining sex-specific differences in alcohol-immune cell associations.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>We analyzed data from 996 participants of the FHS Offspring cohort who underwent immune cell phenotyping and completed an alcohol questionnaire during Exam 7 (1998–2001). Alcohol intake was categorized as abstainer, moderate, at-risk, or heavy drinking. Linear mixed-effects models examined associations between alcohol intake and 15 immune cell phenotypes, adjusting for age, sex, and Cytomegalovirus (CMV) (Model 1) and additional covariates (Model 2). False discovery rate (FDR) correction was applied for multiple testing.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>The CD4+ Tn/Tm ratio showed a significant nonlinear relationship with alcohol categories in Model 1 (<i>p</i> = 0.002, FDR = 0.03), with higher ratios in moderate (<i>β</i> = 0.26) and at-risk drinkers (<i>β</i> = 0.26) compared with abstainers; effects were smaller in Model 2 (<i>β</i> = 0.23 and <i>β</i> = 0.23, respectively). Sex-stratified analyses revealed that among males, alcohol consumption was associated with several immune cell phenotypes in Model 1, and with CD8+ Tn/Tm ratio in Model 2 (<i>p</i> = 0.0001, FDR = 0.002), where moderate drinking was associated with higher CD8+ Tn/Tm ratio compared with abstainers (<i>β</i> = 0.29). Among male drinkers, consumption level was also associated with CD8+ Tn/Tm ratio in both models: at-risk and heavy consumption showed significantly lower CD8+ Tn/Tm ratio compared with moderate drinkers (<i>β</i> = −0.43 and <i>β</i> = −0.46, respectively, in Model 2).</p>\n </section>\n \n <section>\n \n <h3> Conclusions</h3>\n \n <p>Alcohol consumption exhibits a nonlinear relationship with certain immune cells, with moderate intake potentially benefiting immunity, while higher consumption may compromise immune homeostasis. Given the study's cross-sectional design, causality cannot be inferred; nonetheless, our sex-specific, dose-dependent findings merit confirmation in longitudinal cohorts.</p>\n </section>\n </div>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":"49 9","pages":"1953-1961"},"PeriodicalIF":2.7000,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Alcohol consumption and immune cell profiles: Insights from the Framingham Heart Study\",\"authors\":\"Ahmed A. Y. Ragab, Margaret F. Doyle, Jiachen Chen, Kathryn L. Lunetta, Joanne M. Murabito\",\"doi\":\"10.1111/acer.70122\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Background</h3>\\n \\n <p>Alcohol consumption affects immune function, with excessive intake linked to immune suppression and inflammation. However, its impact on immune cell phenotypes remains unclear. This study investigates the association between alcohol consumption and immune cell profiles in a well-characterized Framingham Heart Study (FHS) cohort while examining sex-specific differences in alcohol-immune cell associations.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Methods</h3>\\n \\n <p>We analyzed data from 996 participants of the FHS Offspring cohort who underwent immune cell phenotyping and completed an alcohol questionnaire during Exam 7 (1998–2001). Alcohol intake was categorized as abstainer, moderate, at-risk, or heavy drinking. Linear mixed-effects models examined associations between alcohol intake and 15 immune cell phenotypes, adjusting for age, sex, and Cytomegalovirus (CMV) (Model 1) and additional covariates (Model 2). False discovery rate (FDR) correction was applied for multiple testing.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>The CD4+ Tn/Tm ratio showed a significant nonlinear relationship with alcohol categories in Model 1 (<i>p</i> = 0.002, FDR = 0.03), with higher ratios in moderate (<i>β</i> = 0.26) and at-risk drinkers (<i>β</i> = 0.26) compared with abstainers; effects were smaller in Model 2 (<i>β</i> = 0.23 and <i>β</i> = 0.23, respectively). Sex-stratified analyses revealed that among males, alcohol consumption was associated with several immune cell phenotypes in Model 1, and with CD8+ Tn/Tm ratio in Model 2 (<i>p</i> = 0.0001, FDR = 0.002), where moderate drinking was associated with higher CD8+ Tn/Tm ratio compared with abstainers (<i>β</i> = 0.29). Among male drinkers, consumption level was also associated with CD8+ Tn/Tm ratio in both models: at-risk and heavy consumption showed significantly lower CD8+ Tn/Tm ratio compared with moderate drinkers (<i>β</i> = −0.43 and <i>β</i> = −0.46, respectively, in Model 2).</p>\\n </section>\\n \\n <section>\\n \\n <h3> Conclusions</h3>\\n \\n <p>Alcohol consumption exhibits a nonlinear relationship with certain immune cells, with moderate intake potentially benefiting immunity, while higher consumption may compromise immune homeostasis. Given the study's cross-sectional design, causality cannot be inferred; nonetheless, our sex-specific, dose-dependent findings merit confirmation in longitudinal cohorts.</p>\\n </section>\\n </div>\",\"PeriodicalId\":72145,\"journal\":{\"name\":\"Alcohol (Hanover, York County, Pa.)\",\"volume\":\"49 9\",\"pages\":\"1953-1961\"},\"PeriodicalIF\":2.7000,\"publicationDate\":\"2025-07-29\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Alcohol (Hanover, York County, Pa.)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1111/acer.70122\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"SUBSTANCE ABUSE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Alcohol (Hanover, York County, Pa.)","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/acer.70122","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"SUBSTANCE ABUSE","Score":null,"Total":0}
Alcohol consumption and immune cell profiles: Insights from the Framingham Heart Study
Background
Alcohol consumption affects immune function, with excessive intake linked to immune suppression and inflammation. However, its impact on immune cell phenotypes remains unclear. This study investigates the association between alcohol consumption and immune cell profiles in a well-characterized Framingham Heart Study (FHS) cohort while examining sex-specific differences in alcohol-immune cell associations.
Methods
We analyzed data from 996 participants of the FHS Offspring cohort who underwent immune cell phenotyping and completed an alcohol questionnaire during Exam 7 (1998–2001). Alcohol intake was categorized as abstainer, moderate, at-risk, or heavy drinking. Linear mixed-effects models examined associations between alcohol intake and 15 immune cell phenotypes, adjusting for age, sex, and Cytomegalovirus (CMV) (Model 1) and additional covariates (Model 2). False discovery rate (FDR) correction was applied for multiple testing.
Results
The CD4+ Tn/Tm ratio showed a significant nonlinear relationship with alcohol categories in Model 1 (p = 0.002, FDR = 0.03), with higher ratios in moderate (β = 0.26) and at-risk drinkers (β = 0.26) compared with abstainers; effects were smaller in Model 2 (β = 0.23 and β = 0.23, respectively). Sex-stratified analyses revealed that among males, alcohol consumption was associated with several immune cell phenotypes in Model 1, and with CD8+ Tn/Tm ratio in Model 2 (p = 0.0001, FDR = 0.002), where moderate drinking was associated with higher CD8+ Tn/Tm ratio compared with abstainers (β = 0.29). Among male drinkers, consumption level was also associated with CD8+ Tn/Tm ratio in both models: at-risk and heavy consumption showed significantly lower CD8+ Tn/Tm ratio compared with moderate drinkers (β = −0.43 and β = −0.46, respectively, in Model 2).
Conclusions
Alcohol consumption exhibits a nonlinear relationship with certain immune cells, with moderate intake potentially benefiting immunity, while higher consumption may compromise immune homeostasis. Given the study's cross-sectional design, causality cannot be inferred; nonetheless, our sex-specific, dose-dependent findings merit confirmation in longitudinal cohorts.
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