Aging brain最新文献_第2页

Pulsatility analysis of the circle of Willis 威利斯圈脉动分析

Aging brain Pub Date : 2024-01-01 DOI: 10.1016/j.nbas.2024.100111

Henning U. Voss , Qolamreza R. Razlighi

{"title":"Pulsatility analysis of the circle of Willis","authors":"Henning U. Voss , Qolamreza R. Razlighi","doi":"10.1016/j.nbas.2024.100111","DOIUrl":"https://doi.org/10.1016/j.nbas.2024.100111","url":null,"abstract":"<div><h3>Purpose</h3><p>To evaluate the phenomenological significance of cerebral blood pulsatility imaging in aging research.</p></div><div><h3>Methods</h3><p>N = 38 subjects from 20 to 72 years of age (24 females) were imaged with ultrafast MRI with a sampling rate of 100 ms and simultaneous acquisition of pulse oximetry data. Of these, 28 subjects had acceptable MRI and pulse data, with 16 subjects between 20 and 28 years of age, and 12 subjects between 61 and 72 years of age. Pulse amplitude in the circle of Willis was assessed with the recently developed method of analytic phase projection to extract blood volume waveforms.</p></div><div><h3>Results</h3><p>Arteries in the circle of Willis showed pulsatility in the MRI for both the young and old age groups. Pulse amplitude in the circle of Willis significantly increased with age (p = 0.01) but was independent of gender, heart rate, and head motion during MRI.</p></div><div><h3>Discussion and conclusion</h3><p>Increased pulse wave amplitude in the circle of Willis in the elderly suggests a phenomenological significance of cerebral blood pulsatility imaging in aging research. The physiologic origin of increased pulse amplitude (increased pulse pressure vs. change in arterial morphology vs. re-shaping of pulse waveforms caused by the heart, and possible interaction with cerebrospinal fluid pulsatility) requires further investigation.</p></div>","PeriodicalId":72131,"journal":{"name":"Aging brain","volume":"5 ","pages":"Article 100111"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589958924000069/pdfft?md5=2d9cc69256644deecc2a248e601b1ef4&pid=1-s2.0-S2589958924000069-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140066838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aging brain Pub Date : 2024-01-01 DOI: 10.1016/j.nbas.2024.100107

J. Russell Ravenel , Amy E. Perkins , Angela Tomczik , Ana Defendini , Helen K. Strnad , Elena Varlinskaya , Terrence Deak , Robert L. Spencer

{"title":"Age-related decline in social interaction is associated with decreased c-Fos induction in select brain regions independent of oxytocin receptor expression profiles","authors":"J. Russell Ravenel , Amy E. Perkins , Angela Tomczik , Ana Defendini , Helen K. Strnad , Elena Varlinskaya , Terrence Deak , Robert L. Spencer","doi":"10.1016/j.nbas.2024.100107","DOIUrl":"https://doi.org/10.1016/j.nbas.2024.100107","url":null,"abstract":"<div><p>Social behavior decreases with aging, and we have previously found a substantial decline in social investigative behavior of old female rats. In this study we examined the neural activation pattern (<em>c-Fos</em> mRNA) of young (3 month) and old (18 month) female rats after brief 10 min exposure to a novel female rat in order to identify forebrain regions that show selective age-related alterations in their neural response to social investigation. We also measured relative oxytocin receptor expression (<em>Oxtr</em> mRNA) as a possible factor in age-related declines in <em>c-Fos</em> induction after social interaction. Young rats exposed to a social partner had a greater <em>c-Fos</em> mRNA response than those exposed to novel context alone in the lateral septum and septohypothalamic area, with blunted increases evident in old rats. In addition, <em>c-Fos</em> mRNA levels in the lateral septum were positively correlated with social investigative behavior. Interestingly, age-related differences in <em>c-Fos</em> gene induction were unrelated to the local amount of <em>Oxtr</em> expression within specific brain regions, although we found an age-related decline in <em>Oxtr</em> expression in the ventromedial hypothalamus. This functional neuroanatomical characterization may point to certain brain regions that are especially sensitive to age-related declines associated with social interaction behavior.</p></div>","PeriodicalId":72131,"journal":{"name":"Aging brain","volume":"5 ","pages":"Article 100107"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589958924000021/pdfft?md5=81a4a7da92868c991b73dd80046dea42&pid=1-s2.0-S2589958924000021-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139548592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sleep-dependent memory consolidation in young and aged brains 年轻人和老年人大脑中依赖睡眠的记忆巩固

IF 1.7

Aging brain Pub Date : 2024-01-01 DOI: 10.1016/j.nbas.2024.100124

Deependra Kumar, Masashi Yanagisawa, Hiromasa Funato

引用次数: 0

Differences between sub-second and supra-second durations for the assessment of timing deficits in amnestic mild cognitive impairment 亚秒级和超秒级持续时间在评估失忆性轻度认知障碍患者计时缺陷方面的差异

IF 1.7

Aging brain Pub Date : 2024-01-01 DOI: 10.1016/j.nbas.2024.100120

Giovanna Mioni , Thomas Wolbers , Martin Riemer

{"title":"Differences between sub-second and supra-second durations for the assessment of timing deficits in amnestic mild cognitive impairment","authors":"Giovanna Mioni , Thomas Wolbers , Martin Riemer","doi":"10.1016/j.nbas.2024.100120","DOIUrl":"https://doi.org/10.1016/j.nbas.2024.100120","url":null,"abstract":"<div><p>Previous studies have often reported timing deficits in older adults with different degrees of cognitive decline, however, the exact nature of impairments in time perception is still to be elucidated. In particular, it is unclear if the deficits are more pronounced for short or long intervals, consistent with notions that different cognitive processes and neuroanatomical areas are involved in the processing of durations of different ranges. The present study aims to further investigate timing abilities in amnestic mild cognitive impairment (aMCI) patients and age-matched controls. Participants were asked to decide whether an acoustic event occurred within the first or the second half of a reference duration. The results revealed a bias towards larger PSE values and reduced precision in aMCI patients compared to healthy controls. Further analyses showed that the bias towards larger PSE values correlated with memory performance, especially when sub-second durations were tested. Overall, the results demonstrate that memory deficits in aMCI patients coincide with changes in time perception in the sub-second interval range.</p></div>","PeriodicalId":72131,"journal":{"name":"Aging brain","volume":"6 ","pages":"Article 100120"},"PeriodicalIF":1.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589958924000161/pdfft?md5=afbf6637b9cc370465137a9693d2c29f&pid=1-s2.0-S2589958924000161-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141480519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aging brain Pub Date : 2024-01-01 DOI: 10.1016/j.nbas.2024.100106

Lauren Revie, Claudia Metzler-Baddeley

{"title":"Age-related fornix decline predicts conservative response strategy-based slowing in perceptual decision-making","authors":"Lauren Revie, Claudia Metzler-Baddeley","doi":"10.1016/j.nbas.2024.100106","DOIUrl":"https://doi.org/10.1016/j.nbas.2024.100106","url":null,"abstract":"<div><p>Aging leads to response slowing but the underpinning cognitive and neural mechanisms remain elusive. We modelled older and younger adults’ response times (RT) from a flanker task with a diffusion drift model (DDM) and employed diffusion-weighted magnetic resonance imaging and spectroscopy to study neurobiological predictors of DDM components (drift-rate, boundary separation, non-decision time). Microstructural indices were derived from white matter pathways involved in visuo-perceptual and attention processing [optic radiation, inferior and superior longitudinal fasciculi (ILF, SLF), fornix]. Estimates of metabolite concentrations [N-acetyl aspartate (NAA), glutamate (Glx), and γ-aminobutyric acid (GABA), creatine (Cr), choline (Cho), myoinositol (mI)] were measured from occipital (OCC), anterior cingulate (ACC) and posterior parietal cortices (PPC). Age-related increases in RT, boundary separation, and non-decision time were observed with response conservatism acounting for RT slowing. Aging was associated with reductions in white matter microstructure (lower fractional anisotropy and restricted signal fraction, larger diffusivities) and in metabolites (NAA in ACC and PPC, Glx in ACC). Regression analyses identified brain regions involved in top-down (fornix, SLF, ACC, PPC) and bottom-up (ILF, optic radiation OCC) processing as predictors for DDM parameters and RT. Fornix FA was the strongest predictor for increases in boundary separation (beta = −0.8) and mediated the effects of age on RT. These findings demonstrate that response slowing in visual discrimination is driven by the adoption of a more conservative response strategy. Age-related fornix decline may result in noisier communication of contextual information from the hippocampus to anterior decision-making regions and thus contribute to the conservative response strategy shift.</p></div>","PeriodicalId":72131,"journal":{"name":"Aging brain","volume":"5 ","pages":"Article 100106"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S258995892400001X/pdfft?md5=3e196de7b04dfb9332521fa56c30b1da&pid=1-s2.0-S258995892400001X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139548591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sleep discrepancy and brain glucose metabolism in community-dwelling older adults 社区老年人的睡眠差异与脑葡萄糖代谢

IF 1.7

Aging brain Pub Date : 2024-01-01 DOI: 10.1016/j.nbas.2024.100130

Nadia Soh , Michael Weinborn , James D. Doecke , Rodrigo Canovas , Vincent Doré , Ying Xia , Jurgen Fripp , Kevin Taddei , Romola S. Bucks , Hamid R. Sohrabi , Ralph N. Martins , Melissa Ree , Stephanie R. Rainey-Smith

{"title":"Sleep discrepancy and brain glucose metabolism in community-dwelling older adults","authors":"Nadia Soh , Michael Weinborn , James D. Doecke , Rodrigo Canovas , Vincent Doré , Ying Xia , Jurgen Fripp , Kevin Taddei , Romola S. Bucks , Hamid R. Sohrabi , Ralph N. Martins , Melissa Ree , Stephanie R. Rainey-Smith","doi":"10.1016/j.nbas.2024.100130","DOIUrl":"10.1016/j.nbas.2024.100130","url":null,"abstract":"<div><div>Sleep discrepancy (negative discrepancy reflects worse self-reported sleep than objective measures, such as actigraphy, and positive discrepancy the opposite) has been linked to adverse health outcomes. This study is first to investigate the relationship between sleep discrepancy and brain glucose metabolism (assessed globally and regionally via positron emission tomography), and to evaluate the contribution of insomnia severity and depressive symptoms to any associations. Using data from cognitively unimpaired community-dwelling older adults (<em>N</em> = 68), cluster analysis was used to characterise sleep discrepancy (for total sleep time (TST), wake after sleep onset (WASO), and sleep efficiency (SE)), and logistic regression was used to explore sleep discrepancy’s associations with brain glucose metabolism, while controlling for insomnia severity and depressive symptoms. Lower glucose metabolism across multiple brain regions was associated with negative discrepancy for WASO and SE, and positive discrepancy for WASO only (large effect sizes; β ≥ 0.5). Higher glucose metabolism in the superior parietal and posterior cingulate regions was associated with negative discrepancy for TST (large effect sizes; β ≥ 0.5). These associations remained when controlling for insomnia severity and depressive symptoms, suggesting a unique role of sleep discrepancy as a potential early behavioural marker of brain health.</div></div>","PeriodicalId":72131,"journal":{"name":"Aging brain","volume":"6 ","pages":"Article 100130"},"PeriodicalIF":1.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142702199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Why women may be more prone to Alzheimer’s disease 为什么女性更容易罹患阿尔茨海默病

IF 1.7

Aging brain Pub Date : 2024-01-01 DOI: 10.1016/j.nbas.2024.100121

Sadashiva K. Pai

引用次数: 0

Visual contrast sensitivity is associated with community structure integrity in cognitively unimpaired older adults: the Brain Networks and Mobility (B-NET) Study 视觉对比敏感度与认知能力未受损的老年人群落结构完整性相关：脑网络与移动性（B-NET）研究

IF 1.7

Aging brain Pub Date : 2024-01-01 DOI: 10.1016/j.nbas.2024.100122

Alexis D. Tanase , Haiying Chen , Michael E. Miller , Christina E. Hugenschmidt , Jeff D. Williamson , Stephen B. Kritchevsky , Paul J. Laurienti , Atalie C. Thompson

{"title":"Visual contrast sensitivity is associated with community structure integrity in cognitively unimpaired older adults: the Brain Networks and Mobility (B-NET) Study","authors":"Alexis D. Tanase , Haiying Chen , Michael E. Miller , Christina E. Hugenschmidt , Jeff D. Williamson , Stephen B. Kritchevsky , Paul J. Laurienti , Atalie C. Thompson","doi":"10.1016/j.nbas.2024.100122","DOIUrl":"10.1016/j.nbas.2024.100122","url":null,"abstract":"<div><p>Older adults with impairment in contrast sensitivity (CS), the ability to visually perceive differences in light and dark, are more likely to demonstrate limitations in mobility function, but the mechanisms underlying this relationship are poorly understood. We sought to determine if functional brain networks important to visual processing and mobility may help elucidate possible neural correlates of this relationship. This cross-sectional analysis utilized functional MRI both at rest and during a motor imagery (MI) task in 192 community-dwelling, cognitively-unimpaired older adults <span><math><mo>≥</mo></math></span> 70 years of age from the Brain Networks and Mobility study (B-NET). Brain networks were partitioned into network communities, groups of regions that are more interconnected with each other than the rest of the brain, the spatial consistency of the communities for multiple brain subnetworks was assessed. Lower baseline binocular CS was significantly associated with degraded sensorimotor network (SMN) community structure at rest. During the MI task, lower binocular CS was significantly associated with degraded community structure in both the visual (VN) and default mode network (DMN). These findings may suggest shared neural pathways for visual and mobility dysfunction that could be targeted in future studies.</p></div>","PeriodicalId":72131,"journal":{"name":"Aging brain","volume":"6 ","pages":"Article 100122"},"PeriodicalIF":1.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589958924000185/pdfft?md5=25af366b1c6e9bcd719b3cd70dc80f4f&pid=1-s2.0-S2589958924000185-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141951133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Protein quality control gone awry in Alzheimer’s 阿尔茨海默氏症的蛋白质质量控制出了问题

Aging brain Pub Date : 2024-01-01 DOI: 10.1016/j.nbas.2024.100113

Sadashiva K. Pai

引用次数: 0

Intrinsic functional connectivity strength of SuperAgers in the default mode and salience networks: Insights from ADNI SuperAgers 在默认模式和显著性网络中的内在功能连接强度：来自 ADNI 的启示

Aging brain Pub Date : 2024-01-01 DOI: 10.1016/j.nbas.2024.100114

Haley E. Keenan , Alexis Czippel , Sepideh Heydari , Jodie R. Gawryluk , Erin L. Mazerolle , for the Alzheimer's Disease Neuroimaging Initiative

{"title":"Intrinsic functional connectivity strength of SuperAgers in the default mode and salience networks: Insights from ADNI","authors":"Haley E. Keenan , Alexis Czippel , Sepideh Heydari , Jodie R. Gawryluk , Erin L. Mazerolle , for the Alzheimer's Disease Neuroimaging Initiative","doi":"10.1016/j.nbas.2024.100114","DOIUrl":"https://doi.org/10.1016/j.nbas.2024.100114","url":null,"abstract":"<div><p>There exists a group of older individuals who appear to be resistant to age-related memory decline. These “SuperAgers” have been shown to demonstrate preservation of cortical thickness and functional connectivity strength across the cortex which positively correlates with memory performance. Over the last decade, roughly 30 articles have been published regarding SuperAgers; however, to our knowledge, no replications of these studies have been published. The current study sought to conceptually replicate Zhang and colleagues’ (2020) findings that SuperAgers demonstrate stronger intrinsic functional connectivity within the default mode (DMN) and salience networks (SN), and that connectivity strength within these networks correlates with memory performance. We identified 20 SuperAgers and 20 matched Normal Agers in the control cohort of the Alzheimer’s Disease Neuroimaging Initiative (ADNI) database. We compared the functional connectivity strength of the DMN and SN between these groups, and used the Rey Auditory Verbal Learning Test (RAVLT) to evaluate correlations between functional connectivity and memory performance. Our results did not replicate Zhang and colleagues’ (2020) results, as we found negligible differences between SuperAgers and Normal Agers in the DMN and SN, and no significant correlations between functional connectivity and memory performance after accounting for multiple comparisons. More replications are needed to confirm existing work. In addition, more research with larger SuperAger samples and more consistent definitions of SuperAging is needed, so that we can better understand this remarkable group of older adults.</p></div>","PeriodicalId":72131,"journal":{"name":"Aging brain","volume":"5 ","pages":"Article 100114"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589958924000100/pdfft?md5=9dcf31d863b6e46a018ab3c41bc0d9fd&pid=1-s2.0-S2589958924000100-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140181075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0