Aging brain最新文献

{"title":"Soft tissue changes in Dementia: A comprehensive systematic review","authors":"Francesco Pipitone , Caterina Bernetti , Gianfranco Di Gennaro , Federico Greco , Luca Pugliese , Bruno Beomonte Zobel , Carlo A. Mallio","doi":"10.1016/j.nbas.2026.100159","DOIUrl":"10.1016/j.nbas.2026.100159","url":null,"abstract":"","PeriodicalId":72131,"journal":{"name":"Aging brain","volume":"9 ","pages":"Article 100159"},"PeriodicalIF":2.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148001288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inter- and intra- individual variability in audiovisual multisensory processes in healthy ageing","authors":"Naomi K. Middelmann,&nbsp;Lauriane Ecabert,&nbsp;Eduardo Villar Ortega,&nbsp;Alessandra Griffa,&nbsp;Andrea Brioschi-Guevara,&nbsp;Gilles Allali,&nbsp;James E. Bartlett,&nbsp;Micah M. Murray","doi":"10.1016/j.nbas.2026.100168","DOIUrl":"10.1016/j.nbas.2026.100168","url":null,"abstract":"<div><div>With an increasingly large segment of the population facing age-related cognitive impairment, understanding subtle changes before cognitive decline is crucial. Typically, sensory processing in ageing has been studied in isolation, and studies of multisensory processes have yielded mixed results. Furthermore, studies of reaction times (RTs) have often focused on aggregate measures, while a growing body of work shows the relevance of characterising intra-individual variability as a precursor to cognitive decline and fall risk. Lastly, changes in auditory processing of pitch have also been linked to cognitive decline. There is thus an imperative to identify cost-effective and accessible screening tools for assessing sensory and cognitive (dys)functions, particularly with ageing populations that may be reluctant to visit clinics or undergo brain imaging or extensive cognitive testing. Here, <strong>55 cognitively healthy, older participants (aged 60–84 years) completed a simple detection task with auditory, visual, and simultaneous audiovisual multisensory stimuli. RTs to multisensory stimuli were significantly faster and less variable than those to either visual or auditory stimuli, and those to auditory stimuli were slowest and most variable. This speeding exceeded predictions based on probability summation, suggestive of integration prior to initiating motor responses. Further analyses revealed RT differences between auditory stimuli according to their pitch. On the one hand, the results underscore how multisensory contexts can improve stimulus processing during healthy ageing. On the other hand, the results highlight sensitivity to age-related changes in auditory sensory processing. Collectively, the results support detection tasks as a promising assessment of age-related changes in sensory processing.</strong></div></div>","PeriodicalId":72131,"journal":{"name":"Aging brain","volume":"10 ","pages":"Article 100168"},"PeriodicalIF":2.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148995217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beta-band oscillations accompanying fast, targeted ankle plantarflexions in older adults: the effects of resistance training","authors":"S. Walker,&nbsp;S. Sipilä,&nbsp;H. Pesonen,&nbsp;I.M. Tarkka,&nbsp;J.P. Ahtiainen,&nbsp;T. Parviainen,&nbsp;J. Kujala","doi":"10.1016/j.nbas.2026.100160","DOIUrl":"10.1016/j.nbas.2026.100160","url":null,"abstract":"<div><div>This study evaluated short- and long-term resistance training on cortical movement-related beta-band oscillations, purportedly an indicator of somatosensory processing, in older adults. A cross-sectional comparison between long-term resistance-trained (<em>n</em> = 10) versus untrained individuals (<em>n</em> = 8) and a longitudinal 12-month intervention of short-term resistance training (<em>n</em> = 20) were employed in &gt;70-year-old adults. Cortical activity was recorded by 306-channel whole-head magnetoencephalography (MEG) inside a magnetically shielded room. Participants underwent maximal unilateral plantarflexion force tests using a custom-built MEG-compatible dynamometer, from which 15% and 50% force levels were displayed on a screen. Thereafter, participants performed isometric contractions as fast and as accurately as possible to the target force line and relaxed as fast as possible. Thirty trials to each force level (15% and 50%) were performed sequentially. Average force, force and timing coefficient of variation, and rate of force development were analysed from both force levels. Only 15% trials were viable for MEG analysis, examining peak beta (10–30 Hz) suppression and rebound frequency, amplitude and timing, due to large magnitude artifacts from 50% trials. Long-term training was accompanied by lower relaxation time coefficient of variation (<em>P</em> = 0.021–0.027). After short-term training, beta rebound amplitude increased (∼107Δ%, <em>P</em> = 0.003) and time to peak rebound reduced (∼1.49 to ∼1.27 s, <em>P</em> = 0.039) with similar but non-significant differences between long-term trained and untrained individuals (∼1.27 vs. ∼1.57 s, <em>P</em> = 0.083). Both short- and long-term effects suggest more efficient sensorimotor processing and lower force variability accompanying resistance training in older age.</div></div>","PeriodicalId":72131,"journal":{"name":"Aging brain","volume":"10 ","pages":"Article 100160"},"PeriodicalIF":2.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13380231/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148498305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The DentoNeural Axis: A Piezo channel-mediated mechanosensory pathway linking tooth loss to cognitive decline","authors":"Kyung-A Oh","doi":"10.1016/j.nbas.2026.100169","DOIUrl":"10.1016/j.nbas.2026.100169","url":null,"abstract":"<div><h3>Background</h3><div>Two independent meta-analyses—one of 18 cohort studies (<em>n</em> = 356,297) and one dose-response analysis of 14 longitudinal studies (<em>n</em> = 34,074)—demonstrate dose-dependent associations between tooth loss and dementia. The latter reported hazard ratio (HR) 1.48 (95% CI 1.18–1.87) for cognitive impairment and HR 1.28 (95% CI 1.09–1.49) for dementia; the former reported relative risk (RR) 1.20 and 1.15 for the same outcomes. The 2024 Lancet Commission expanded modifiable dementia risk factors to 14 yet omitted oral health. The mechanism remains unknown.</div></div><div><h3>The hypothesis</h3><div>We propose the “DentoNeural Axis”—a Piezo2-mediated mechanosensory pathway connecting periodontal ligament to hippocampal function. Tooth loss removes pulp and periodontal innervation, while periosteal and mucosal afferents persist, potentially disrupting dual neuromodulatory pathways: (1) Piezo2+ trigeminal neurons → paraventricular nucleus (PVN) → dopaminergic signaling, and (2) Tac1 (substance P)-expressing neurons → locus coeruleus → noradrenergic signaling. Both pathways converge on hippocampus to regulate brain-derived neurotrophic factor (BDNF) and synaptic plasticity.</div></div><div><h3>Evidence integration</h3><div>This synthesis integrates Piezo channel discovery (2010), Piezo2 immunolocalization in the human periodontal ligament (2024), and trigeminal–locus coeruleus–hippocampal pathways supported by animal models and human MRI evidence linking tooth loss to hippocampal atrophy in mild periodontitis. This hypothesis relies primarily on animal data; human mechanistic validation remains a gap.</div></div><div><h3>Implications</h3><div>If validated, tooth preservation could join hearing aids as sensory-based dementia prevention. This model may explain the “Implant Paradox”—why dental implants, lacking Piezo2-expressing periodontal ligament, may provide incomplete neuroprotection despite restoring mastication.</div></div>","PeriodicalId":72131,"journal":{"name":"Aging brain","volume":"10 ","pages":"Article 100169"},"PeriodicalIF":2.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149153906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improved cardiorespiratory fitness is associated with functional changes in hippocampus during episodic memory pattern completion","authors":"Emma Simonsson,&nbsp;Micael Andersson,&nbsp;Mattias Hedlund,&nbsp;Erik Rosendahl,&nbsp;Lars Nyberg,&nbsp;Carl-Johan Boraxbekk","doi":"10.1016/j.nbas.2026.100172","DOIUrl":"10.1016/j.nbas.2026.100172","url":null,"abstract":"<div><h3>Background</h3><div>Aerobic exercise that improves cardiorespiratory fitness (CRF) may induce hippocampal changes that help counteract age-related memory decline. The Umeå HIT Study, a randomized controlled trial, examined three months of controlled high-intensity interval training (HIT) and moderate-intensity training (MIT) in older adults. Here, we tested whether increases in CRF (VO₂peak), regardless of training modality, predicted changes in episodic-memory pattern completion and hippocampal structure and function (CA4/DG, CA2/3, CA1).</div></div><div><h3>Method</h3><div>Forty-two older adults (66–79 years, 45% males) not engaged in regular physical exercise participated in 3 months of twice-weekly supramaximal HIT (20 min including 10 × 6-s intervals) or aerobic MIT (40 min including 3 × 8-m intervals). Before and after the exercise interventions, the participants underwent magnetic resonance imaging (MRI) of the hippocampus, including an episodic memory pattern completion task with concomitant functional MRI.</div></div><div><h3>Results</h3><div>Exercise-induced change in VO₂peak (M = 1.5 mL/kg/min, 95% CI[0.8; 2.3]) after three months aerobic exercise of HIT or MIT did not predict change in pattern completion (F_(1,33) = 0.02, B = −0.061 <em>p</em> = .883, r² = 0.001). However, change in VO₂peak predicted BOLD signal change in the left hippocampal subfield CA4/DG (F_(1,33) = 4.56, B = 0.06 <em>p</em> = .04, r² = 0.12), which in turn, predicted change in pattern completion (F_(1,34) = 5.19, B = 0.026, <em>p</em> = .029, r² = 0.13).</div></div><div><h3>Conclusion</h3><div>Three months of high- or moderate-intensity training which improves CRF may lead to hippocampal functional changes that, in turn, are linked to enhanced episodic memory pattern completion.</div></div>","PeriodicalId":72131,"journal":{"name":"Aging brain","volume":"10 ","pages":"Article 100172"},"PeriodicalIF":2.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149199281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasma neurofilament light is associated with hippocampal volume and memory performance but not functional connectivity in older adults with and without mild cognitive decline","authors":"Youjin Jung ,&nbsp;Scott E. Counts ,&nbsp;Benjamin M. Hampstead ,&nbsp;Scott J. Peltier ,&nbsp;Henry L. Paulson ,&nbsp;Bruno Giordani ,&nbsp;Arijit K. Bhaumik ,&nbsp;John S. Beck ,&nbsp;Jessica S. Damoiseaux","doi":"10.1016/j.nbas.2026.100157","DOIUrl":"10.1016/j.nbas.2026.100157","url":null,"abstract":"<div><div>Plasma neurofilament light chains (pNfL) have shown promise as a biomarker for tracking and predicting neurodegeneration, such as cortical atrophy and hypometabolism, in Alzheimer’s Disease (AD). However, it is still not clear whether neurofilament light chains (NfL) also reflect alterations in the functional connectivity (FC) of the default mode network (DMN), a functional network showing alterations in earlier stages of AD. In this cross-sectional study including 62 cognitively unimpaired (CU) and 47 cognitively impaired (CI) older adults likely due to AD, we measured FC in the posterior midline DMN, and its FC with frontal DMN, temporoparietal DMN, and hippocampus. We also examined whether the previously observed relationships between pNfL and hippocampal volume, as well as memory function, are replicated in our dataset. pNfL showed no association with DMN FC in either the CI or the CU group. However, higher pNfL was associated with lower right hippocampal volume and memory score in the CI group. Our results support the utility of pNfL as a biomarker tracking hippocampal atrophy and memory function but not for predicting DMN FC in older adults with cognitive decline of Alzheimer’s type.</div></div>","PeriodicalId":72131,"journal":{"name":"Aging brain","volume":"9 ","pages":"Article 100157"},"PeriodicalIF":2.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147421125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distinct theta and alpha electrophysiological dynamics during audiovisual semantic processing in healthy aging and mild cognitive impairment","authors":"Jessica Ip,&nbsp;William C. Heindel,&nbsp;Brian R. Ott,&nbsp;Elena K. Festa","doi":"10.1016/j.nbas.2026.100163","DOIUrl":"10.1016/j.nbas.2026.100163","url":null,"abstract":"<div><div>Semantic memory decline is increasingly recognized as an early feature of Alzheimer's disease (AD) and amnestic mild cognitive impairment (MCI), yet the neural dynamics supporting automatic and controlled semantic retrieval in healthy aging remain poorly defined. This study examined task-evoked oscillatory activity during audiovisual object recognition in young adults (YA; <em>N</em> = 27), healthy older adults (OA; <em>N</em> = 33), and individuals with amnestic MCI (<em>N</em> = 21). Participants judged object orientation while viewing living and nonliving images paired with congruent or incongruent characteristic sounds, allowing semantic relationships to be manipulated under implicit retrieval demands. Accuracy was high across groups, although participants with MCI showed reduced performance under the more perceptually challenging inverted conditions. Reaction times were slower in OA than YA and further slowed in MCI, with group differences varying by object animacy and semantic congruency. Event-related spectral perturbation analyses revealed distinct group-related patterns. Healthy older adults showed reduced early and increased late theta activity in frontocentral and parieto-occipital regions, consistent with delayed recruitment of control-related and perceptual-attentional processes. In contrast, MCI participants showed elevated and less condition-sensitive posterior alpha power, together with task- and condition-specific differences in frontocentral theta. The principal pattern of delayed theta recruitment in healthy aging and elevated posterior alpha in MCI was also observed in a supplementary task requiring explicit audiovisual semantic judgments. These findings provide preliminary evidence that healthy aging and amnestic MCI are associated with partly distinct patterns of task-evoked oscillatory activity during audiovisual semantic processing.</div></div>","PeriodicalId":72131,"journal":{"name":"Aging brain","volume":"10 ","pages":"Article 100163"},"PeriodicalIF":2.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148644668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cerebellar nuclei remain vulnerable to cuprizone-induced demyelination in adult and aged mice: A longitudinal multimodal MRI-histology study","authors":"Derya R. Shimshek,&nbsp;Stefan Zurbruegg,&nbsp;Anna Neuhaus,&nbsp;Arno Doelemeyer,&nbsp;Nicolau Beckmann","doi":"10.1016/j.nbas.2026.100171","DOIUrl":"10.1016/j.nbas.2026.100171","url":null,"abstract":"<div><div>Age is a major determinant of demyelination and remyelination capacity. Here, we investigated age-dependent brain responses to acute cuprizone exposure in female C57BL/6 mice using longitudinal multimodal Magnetic resonance imaging (MRI) and histological analyses. Our aim was to determine whether any brain region in very old animals remains susceptible to cuprizone-induced pathology. Adult (6-month-old) and aged (18-month-old) mice received 0.2% cuprizone in the diet for 5 weeks, followed by 4 weeks of recovery on normal chow, with in vivo MRI performed at baseline, during intoxication, and throughout recovery. Magnetization transfer ratio (MTR) and T₂-weighted signal were used as MRI surrogates of myelin integrity and neuroinflammation, respectively, whereas T₁-weighted signal was assessed as a potential marker sensitive to oxidative stress. In adult mice, cuprizone induced robust and region-specific pathology, including reduced MTR and increased T₂-weighted signal in the corpus callosum, accompanied by microgliosis, astrocytosis, and increased APP-positive dystrophic neurites. These abnormalities showed only partial recovery following cuprizone withdrawal. In contrast, cuprizone elicited little or no detectable change in these forebrain white-matter regions and in other brain areas in aged mice. However, the cerebellar nuclei remained susceptible at both ages, exhibiting persistent MTR decreases and T₂-weighted signal increases, corroborated by histological evidence of demyelination and gliosis. T₁-weighted signal increased broadly in adult, but not in aged, mice during intoxication, consistent with cuprizone-associated oxidative stress. Together, these findings demonstrate pronounced age- and region-dependent effects of cuprizone and identify the cerebellar nuclei as a sensitive target of demyelination across the lifespan. Moreover, the non-invasive nature of MRI enables efficient assessment of regional differences over time.</div></div>","PeriodicalId":72131,"journal":{"name":"Aging brain","volume":"10 ","pages":"Article 100171"},"PeriodicalIF":2.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149199294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lipofuscin autofluorescence confounds intracellular amyloid β detection in the aged mouse brain.","authors":"Godfried Dougnon, Hideaki Matsui","doi":"10.1016/j.nbas.2025.100148","DOIUrl":"10.1016/j.nbas.2025.100148","url":null,"abstract":"<p><p>Intracellular amyloid β (Aβ) accumulation is a contentious feature of Alzheimer's disease (AD), increasingly reported in young adults and aged animal models of AD. However, autofluorescent lipofuscin granules which consist of a mixture of highly oxidized lipids, misfolded proteins, and metals, accumulates with aging in neurons and microglia and renders difficult the interpretation of immunofluorescence-based studies. Here, we show that lipofuscin accumulation in aged wild-type (WT) mouse brains exhibits significant spectral overlap with commonly used antibodies for Aβ detection, leading to potential misinterpretation of intracellular Aβ signals. Through a combination of dye staining, immunohistochemistry (IHC), and confocal microscopy, we show that fluorescence signals resembling intracellular Aβ and commonly reported in aged animal models of AD, may reflect the presence of lipofuscin granules. Importantly, these signals persisted in control sections where primary Aβ antibodies were omitted, but disappeared following TrueBlack autofluorescence quencher. We also performed Aβ immunofluorescence staining using 5xFAD mice as model for AD, revealing that intracellular Aβ in these models can be diminished by TrueBlack treatment, thus confounding the interpretation of true intracellular Aβ signals. Our findings underscore the need for caution in interpreting intracellular Aβ signals in young adults and aged models of Aβ pathology inside neurons or microglia.</p>","PeriodicalId":72131,"journal":{"name":"Aging brain","volume":"8 ","pages":"100148"},"PeriodicalIF":2.7,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12356383/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144876958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contributions of lifestyle, education, and cardiovascular risk factors to the brain age gap","authors":"Kostas Stoitsas ,&nbsp;Pieter Bakx ,&nbsp;Trudy Voortman ,&nbsp;Jing Yu ,&nbsp;Gennady Roshchupkin ,&nbsp;Daniel Bos","doi":"10.1016/j.nbas.2025.100149","DOIUrl":"10.1016/j.nbas.2025.100149","url":null,"abstract":"<div><div>The brain age gap is the difference between chronological age and the age predicted from Magnetic Resonance Imaging (MRI) brain scans. We investigated the influence of life habits and cardio-metabolic factors on this gap. A convolutional neural network (CNN) was trained on structural MRI scans from dementia-free participants in the Rotterdam Study.</div><div>Scans were collected every 3–4 years from 2005 to 2016. 10,989 images from 5,167 participants (mean age: 64 years [range: 45–98], 54 % female) were used to train and evaluate the model. We run analysis of variance and linear mixed models to assess associations between brain age gap and smoking, sleep, alcohol consumption, education, and cardio-metabolic factors.</div><div>The brain age gap in participants who developed dementia was elevated relative to cognitively healthy individuals and showed a progressive increase throughout the study period.</div><div>We found that together, the examined factors explained no more than 21% of the variance in brain age gap. Smoking, alcohol consumption, and elevated glucose levels are significantly associated with an increased brain age gap, consistent with earlier studies linking these factors to brain atrophy and cognitive decline.</div></div>","PeriodicalId":72131,"journal":{"name":"Aging brain","volume":"8 ","pages":"Article 100149"},"PeriodicalIF":2.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144810059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}