Nigrostriatal dopaminergic neurotransmission and resilience to peripheral systemic risk factors for gait slowing upon transition to uneven surfaces in older adult

IF 1.7 Q3 CLINICAL NEUROLOGY

Aging brain Pub Date : 2025-01-01 DOI:10.1016/j.nbas.2025.100143

Lana M. Chahine , Andrea Rosso , Ian Troidl , Mary Ganguli , Anne Newman , Steven Cummings , Stephanie Studenski , Brian Lopresti , Sarah Royse , Theodore Huppert , Mark Redfern , Patrick J. Sparto , Nico I. Bohnen , Caterina Rosano

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Abstract

Identifying mechanisms that compensate for slow gait speed in older adults is crucial. Dopaminergic neurotransmission curbs deleterious associations of cerebrovascular disease with gait, but whether it compensates for peripheral systemic risk factors (PSRF) for gait slowing has not been studied. In this cross-sectional study of community-dwelling older adults, we examined the relationship between nigrostriatal dopaminergic terminal integrity and gait speed in individuals with and without ≥ 1 PSRF for gait slowing: obesity, joint pain, or reduced muscle strength. The primary outcome was gait speed cost (%GSC) on transition from even to uneven surface. Participants underwent dopaminergic imaging with dihydrotetrabenazine [¹¹C]DTBZ positron emission tomography. Among 197 individuals, (mean (SD) age 74.92 (4.53) years; 61.93 % female; 90.86 % White), 130 (65.99 %) had ≥ 1 PSRF. Relationship between posterior putamen [¹¹C]DTBZ binding and %GSC was modified by PSRF; in those with ≥ 1 PSRF (but not in those with no PSRF), posterior putamen [¹¹C]DTBZ binding was associated with %GSC (β = 0.198, p = 0.03) independent of potential confounders. This cross-sectional study indicates that higher striatal dopaminergic neurotransmission may compensate for the effects of PSRF on gait slowing.

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黑质纹状体多巴胺能神经传递和对周围系统危险因素的恢复能力在老年人过渡到不平整的表面时步态减慢

确定补偿老年人慢速步态的机制至关重要。多巴胺能神经传递抑制了脑血管疾病与步态的有害关联，但它是否补偿了周围系统危险因素（PSRF）对步态减慢的影响尚未得到研究。在这项社区老年人的横断面研究中，我们研究了黑质纹状体多巴胺能末端完整性与步态速度之间的关系，这些个体有或没有≥1个PSRF导致步态减慢：肥胖、关节疼痛或肌肉力量下降。主要结局是步态速度成本（%GSC）从平坦的表面过渡到不平坦的表面。参与者使用二氢四苯那嗪[11C]DTBZ正电子发射断层扫描进行多巴胺能成像。197例个体中，平均（SD）年龄74.92（4.53）岁；女性占61.93%；90.86%（白人），130例（65.99%）PSRF≥1。PSRF改变后壳核[11C]DTBZ结合与%GSC的关系；在PSRF≥1的患者中（而非无PSRF的患者），后壳核[11C]DTBZ结合与%GSC相关（β = 0.198, p = 0.03），独立于潜在的混杂因素。这项横断面研究表明，较高的纹状体多巴胺能神经传递可能补偿PSRF对步态减慢的影响。

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来源期刊

Aging brain Neuroscience (General), Geriatrics and Gerontology

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