Aging brain最新文献

Tau aggregation induces cell death in iPSC-derived neurons Tau 聚集诱导 iPSC 衍生神经元的细胞死亡

IF 1.7

Aging brain Pub Date : 2025-01-01 DOI: 10.1016/j.nbas.2025.100136

Hirokazu Tanabe , Sumihiro Maeda , Etsuko Sano , Norio Sakai , Setsu Endoh-Yamagami , Hideyuki Okano

{"title":"Tau aggregation induces cell death in iPSC-derived neurons","authors":"Hirokazu Tanabe , Sumihiro Maeda , Etsuko Sano , Norio Sakai , Setsu Endoh-Yamagami , Hideyuki Okano","doi":"10.1016/j.nbas.2025.100136","DOIUrl":"10.1016/j.nbas.2025.100136","url":null,"abstract":"<div><div>Abnormal accumulation of tau proteins in the brain is a hallmark of neurodegenerative diseases such as Alzheimer’s disease and is closely linked with neuronal cell death. Tau accumulation is a prominent therapeutic target for Alzheimer’s disease, since tau accumulation correlates well with the disease progression, and tau-targeting drugs hold potentials to halt the disease progression. Given the differential response of human and mouse neuronal cells, there is a critical need for a human cellular platform to quickly screen for tau-related neurodegenerative disease therapeutics. However, inducing rapid, tau-dependent neuronal cell death in human models remains challenging. In this study, we established a human cellular model capable of inducing tau aggregation-dependent neuronal cell death within two weeks via tau overexpression. Additionally, we demonstrated the neuroprotective efficacy of known tau-targeting compounds within this system. These findings suggest that our cellular model recapitulates the molecular pathogenesis of tau-induced neurodegeneration and could serve as a valuable platform for drug screening in tauopathies.</div></div>","PeriodicalId":72131,"journal":{"name":"Aging brain","volume":"7 ","pages":"Article 100136"},"PeriodicalIF":1.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143816765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Frontal theta oscillations and cognitive flexibility: Age-related modulations in EEG activity 额叶θ波振荡与认知灵活性：脑电图活动的年龄相关调节

IF 1.7

Aging brain Pub Date : 2025-01-01 DOI: 10.1016/j.nbas.2025.100142

Margarita Darna , Christopher Stolz , Hannah-Sophia Jauch , Hendrik Strumpf , Jens-Max Hopf , Constanze I. Seidenbecher , Björn H. Schott , Anni Richter

{"title":"Frontal theta oscillations and cognitive flexibility: Age-related modulations in EEG activity","authors":"Margarita Darna , Christopher Stolz , Hannah-Sophia Jauch , Hendrik Strumpf , Jens-Max Hopf , Constanze I. Seidenbecher , Björn H. Schott , Anni Richter","doi":"10.1016/j.nbas.2025.100142","DOIUrl":"10.1016/j.nbas.2025.100142","url":null,"abstract":"<div><div>Cognitive flexibility, the ability to adapt one’s behaviour in changing environments, declines during aging. Electroencephalography (EEG) studies have implicated midfrontal theta oscillations in attentional set-shifting, a measure of cognitive flexibility. Little is known about the electrocortical underpinnings of set-shifting in aging. Here, we investigated aging effects on set-shifting performance by analysing theta power in 20 young (mean age: 22.5 ± 2.9 years) and 19 older (mean age: 69.4 ± 6.1 years) adults. Increasing shift difficulty (i.e., intra- vs. extra-dimensional shifts) elicited worse performance in both age groups, with older adults showing overall longer reaction times (RTs) and increased RT variability. Young adults exhibited amplified midfrontal theta power increases with higher shift difficulty whereas older adults showed overall lower theta power and no task-related midfrontal theta power modulation, indicating potentially distinct underlying neural mechanisms.</div></div>","PeriodicalId":72131,"journal":{"name":"Aging brain","volume":"8 ","pages":"Article 100142"},"PeriodicalIF":1.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144365585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neural stem cell secretome: a secret key to unlocking the power of regeneration in the adult and aging brain 神经干细胞分泌组：解锁成人和衰老大脑再生能力的秘密钥匙

IF 1.7

Aging brain Pub Date : 2025-01-01 DOI: 10.1016/j.nbas.2025.100144

Soumia Abdellaoui , Lida Katsimpardi

{"title":"Neural stem cell secretome: a secret key to unlocking the power of regeneration in the adult and aging brain","authors":"Soumia Abdellaoui , Lida Katsimpardi","doi":"10.1016/j.nbas.2025.100144","DOIUrl":"10.1016/j.nbas.2025.100144","url":null,"abstract":"<div><div>Adult neurogenesis involves the activation of quiescent neural stem cells (qNSCs) to generate new neurons, which migrate and integrate into existing neural circuits. In addition to their role in neurogenesis, adult NSCs also secrete bioactive compounds collectively known as the secretome, which contribute to the regulation of this process. However, aging and neurodegenerative diseases impair neurogenesis by promoting a pro-inflammatory environment within the neurogenic niche. With age, NSCs become increasingly quiescent, leading to a decline in their secretory activity— a hallmark of aged NSCs. Enhancing the function of adult NSCs holds therapeutic potential for restoring brain function under these conditions. Specifically, reactivating quiescent NSCs and possibly eliminating senescent ones can boost neurogenesis and improve cognitive function in aging and neurodegenerative diseases. In this review, we explore the role of adult NSCs and their secretome in sustaining brain function throughout adulthood and aging. A comprehensive analysis of the literature sheds light onto how NSCs and their secretome influence neurogenesis, from activation and differentiation to integration into neural circuits. Targeting adult NSCs in aged and neurodegenerative models presents a promising strategy for brain function restoration.</div></div>","PeriodicalId":72131,"journal":{"name":"Aging brain","volume":"8 ","pages":"Article 100144"},"PeriodicalIF":1.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144557571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

TOMM40 may mediate GFAP, neurofilament light Protein, pTau181, and brain morphometry in aging TOMM40可能在衰老过程中介导GFAP、神经丝轻蛋白、pTau181和脑形态计量学。

IF 1.7

Aging brain Pub Date : 2025-01-01 DOI: 10.1016/j.nbas.2024.100134

Robyn A. Honea , Heather Wilkins , Suzanne L. Hunt , Paul J. Kueck , Jeffrey M. Burns , Russell H. Swerdlow , Jill K. Morris

{"title":"TOMM40 may mediate GFAP, neurofilament light Protein, pTau181, and brain morphometry in aging","authors":"Robyn A. Honea , Heather Wilkins , Suzanne L. Hunt , Paul J. Kueck , Jeffrey M. Burns , Russell H. Swerdlow , Jill K. Morris","doi":"10.1016/j.nbas.2024.100134","DOIUrl":"10.1016/j.nbas.2024.100134","url":null,"abstract":"<div><div>A growing amount of data has implicated the <em>TOMM40</em> gene in the risk for Alzheimer’s disease (AD), neurodegeneration, and accelerated aging. No studies have investigated the relationship of <em>TOMM40</em> rs2075650 (‘650<em>)</em> on the structural complexity of the brain or plasma markers of neurodegeneration. We used a comprehensive approach to quantify the impact of <em>TOMM40</em> ‘650 on brain morphology and multiple cortical attributes in cognitively unimpaired (CU) individuals. We also tested whether the presence of the risk allele, G, of <em>TOMM40</em> ‘650 was associated with plasma markers of amyloid, tau, and neurodegeneration and if there were interactions with age and sex, controlling for the effects of <em>APOE</em> ε4. We found that the <em>TOMM40</em> ‘650 G-allele was associated with decreased sulcal depth, increased gyrification index, and decreased gray matter volume. NfL, GFAP, and pTau181 had independent and age-associated increases in individuals with a G-allele. Our data suggest that <em>TOMM40</em> ‘650 is associated with aging-related plasma biomarkers and brain structure variation in temporal-limbic circuits.</div></div>","PeriodicalId":72131,"journal":{"name":"Aging brain","volume":"7 ","pages":"Article 100134"},"PeriodicalIF":1.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11699468/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142933794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Testing the causal impact of plasma amyloid on total Tau using a genetically informative sample of adult male twins 使用成年男性双胞胎的遗传信息样本测试血浆淀粉样蛋白对总Tau蛋白的因果影响

IF 1.7

Aging brain Pub Date : 2025-01-01 DOI: 10.1016/j.nbas.2025.100139

Nathan A. Gillespie , Michael C. Neale , Matthew S. Panizzon , Ruth E. McKenzie , Xin M. Tu , Hong Xian , Chandra A. Reynolds , Michael J. Lyons , Robert A. Rissman , Jeremy A. Elman , Carol Franz , William S. Kremen

{"title":"Testing the causal impact of plasma amyloid on total Tau using a genetically informative sample of adult male twins","authors":"Nathan A. Gillespie , Michael C. Neale , Matthew S. Panizzon , Ruth E. McKenzie , Xin M. Tu , Hong Xian , Chandra A. Reynolds , Michael J. Lyons , Robert A. Rissman , Jeremy A. Elman , Carol Franz , William S. Kremen","doi":"10.1016/j.nbas.2025.100139","DOIUrl":"10.1016/j.nbas.2025.100139","url":null,"abstract":"<div><div>The amyloid cascade hypothesis predicts that amyloid-beta (Aβ) aggregation drives tau tangle accumulation. We tested competing causal and non-causal hypotheses regarding the direction of causation between Aβ40 and Aβ42 and total Tau (t-Tau) plasma biomarkers. Plasma Aβ40, Aβ42, t-Tau, and neurofilament light chain (NFL) were measured in 1,035 men (mean = 67.0 years) using Simoa immunoassays. Genetically informative twin modeling tested the direction of causation between Aβs and t-Tau. No clear evidence that Aβ40 or Aβ42 directly causes t-Tau was observed. Instead, the alternative causal hypotheses also fit the data well. In contrast, exploratory analyses suggested a causal impact of the Aβ biomarkers on NFL. Separately, reciprocal causation was observed between t-Tau and NFL. Plasma Aβ40 or Aβ42 do not appear to have a direct causal impact on t-Tau, though our use of total rather than phosphorylated tau was a limitation. In contrast, Aβ biomarkers appeared to causally impact NFL in cognitively unimpaired men in their late 60 s.</div></div>","PeriodicalId":72131,"journal":{"name":"Aging brain","volume":"7 ","pages":"Article 100139"},"PeriodicalIF":1.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144071353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Human adult hippocampal neurogenesis in health and disease 健康与疾病中的成人海马神经发生

IF 1.7

Aging brain Pub Date : 2025-01-01 DOI: 10.1016/j.nbas.2025.100145

MC. Alonso-Moreno , M. Gallardo-Caballero , AV. Prádanos-Senén , M. Llorens-Martín

引用次数: 0

No sex differences in the association between regional brain structure abnormalities and cognitive functioning in a geriatric memory clinic population 在老年记忆临床人群中，区域脑结构异常和认知功能之间的关联没有性别差异

IF 1.7

Aging brain Pub Date : 2025-01-01 DOI: 10.1016/j.nbas.2025.100137

A. Lamé , E.G. Thomas , S.A.J. van de Schraaf , C. Groot , C.H. Sudre , F. Barkhof , M. Muller , R. Ossenkoppele , H.F.M. Rhodius-Meester

{"title":"No sex differences in the association between regional brain structure abnormalities and cognitive functioning in a geriatric memory clinic population","authors":"A. Lamé , E.G. Thomas , S.A.J. van de Schraaf , C. Groot , C.H. Sudre , F. Barkhof , M. Muller , R. Ossenkoppele , H.F.M. Rhodius-Meester","doi":"10.1016/j.nbas.2025.100137","DOIUrl":"10.1016/j.nbas.2025.100137","url":null,"abstract":"<div><div>Differences between men and women in cognitive impairment and neurodegeneration are not yet well understood. Although sex differences in brain structure abnormalities, including white matter hyperintensities (WMH) and grey matter (GM) atrophy, have been associated with cognitive decline in the ageing population, the evidence is limited and inconclusive. Therefore, we explored sex differences in brain structure abnormalities and in the association between brain structure abnormalities and cognitive functioning. We analyzed global and regional volumetric measures of WMH and GM of 475 patients visiting an academic geriatric memory clinic in the Netherlands with multiple linear regression analyses. For both global and regional WMH and GM, we found no sex differences in brain structure abnormalities. We also found no interaction of sex on the association between brain structure abnormalities and cognitive functioning. We reflect on using a binary classification of men and women based on sex in this study, which might overlook individual differences and does not elucidate gender-related factors that influence health and risk of pathology. Future studies should focus on exploring the relationship between sex and gender on brain structure and cognitive functioning beyond this binary model, by including more data on social context, more diverse populations and using intersectional approaches.</div></div>","PeriodicalId":72131,"journal":{"name":"Aging brain","volume":"7 ","pages":"Article 100137"},"PeriodicalIF":1.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143902418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Complex span measures of working memory do not mediate the effects of age on the P3 and N400 ERPs 工作记忆的复杂广度测量不介导年龄对P3和N400 erp的影响

IF 1.7

Aging brain Pub Date : 2025-01-01 DOI: 10.1016/j.nbas.2025.100140

Jasmin Joshi, Chandlyr M. Denaro, Alan A. Hartley, Catherine L. Reed

{"title":"Complex span measures of working memory do not mediate the effects of age on the P3 and N400 ERPs","authors":"Jasmin Joshi, Chandlyr M. Denaro, Alan A. Hartley, Catherine L. Reed","doi":"10.1016/j.nbas.2025.100140","DOIUrl":"10.1016/j.nbas.2025.100140","url":null,"abstract":"<div><div>Working memory (WM), the temporary maintenance of a limited amount of information in an accessible state, is required for the performance of many tasks. Studies have shown that WM demands are related to the neural processing of tasks requiring attention: Age affects the ERP components associated with WM context updating processes in the visual oddball task (P3) and semantic processing in the word-pair judgment task (N400). This study investigated whether WM capacity measured by complex span tasks mediates the effects of age on these ERPs. Younger adults (YA, n = 44, ages 18–23 yr) and older adults (OA, n = 41, ages 69–89 yr) completed operation, reading, and symmetry complex span tasks and two ERP tasks (P3/visual oddball; N400/word-pair judgment). Results showed age-related differences for all complex span tests. Principal components analysis of these tests showed a single factor for both groups, so a combined WM capacity factor score was created. Regressions of age group and WM factor score on P3 and N400 amplitudes and latencies showed that OAs had relatively lower amplitudes and longer latencies. However complex span was not related to P3 or N400 amplitudes or latencies and that result was the same for younger and older adults; that is, complex span did not mediate the age effects. WM processes indexed by the P3 and N400 components appear to be different from those elicited by complex span tasks. Attentional control processes of WM influence oddball and semantic judgement tasks more than storage components.</div></div>","PeriodicalId":72131,"journal":{"name":"Aging brain","volume":"7 ","pages":"Article 100140"},"PeriodicalIF":1.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143922898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sex differences in the association between episodic memory residual reserve index and change in executive function 情景记忆剩余储备指数与执行功能变化相关性的性别差异

IF 2.7

Aging brain Pub Date : 2025-01-01 DOI: 10.1016/j.nbas.2025.100146

Cheyenne Chooi , Brandon E. Gavett , David Ames , Paul Maruff , Vincent Doré , Victor L. Villemagne , Pierrick Bourgeat , Ying Xia , Colin L. Masters , Ralph N. Martins , Kevin Taddei , Christopher C. Rowe , Michael Weinborn , Stephanie R. Rainey-Smith

{"title":"Sex differences in the association between episodic memory residual reserve index and change in executive function","authors":"Cheyenne Chooi , Brandon E. Gavett , David Ames , Paul Maruff , Vincent Doré , Victor L. Villemagne , Pierrick Bourgeat , Ying Xia , Colin L. Masters , Ralph N. Martins , Kevin Taddei , Christopher C. Rowe , Michael Weinborn , Stephanie R. Rainey-Smith","doi":"10.1016/j.nbas.2025.100146","DOIUrl":"10.1016/j.nbas.2025.100146","url":null,"abstract":"<div><div>Sex differences in cognitive reserve might contribute to females being disproportionately affected by Alzheimer’s disease (AD). We investigated sex differences in the protective effects of cognitive reserve, and whether brain beta-amyloid accounts for differences. Older adults (n = 997 from the Australian Imaging, Biomarkers and Lifestyle Study of Ageing) diagnosed as Cognitively Normal, Mild Cognitive Impairment, or AD at baseline were assessed every 18 months for up to a maximum of seven visits. Cognitive reserve was calculated from the variance in episodic memory not explained by demographic or brain measures. Executive functioning (EF) intercept and slope were regressed onto the main and interaction effects of cognitive reserve x brain integrity x sex, plus covariates (age, number of <em>APOE</em> ε4 alleles). A three-way interaction was observed between cognitive reserve, brain integrity, and sex on the EF slope. Females benefitted more than males from the protective effects of cognitive reserve at low levels of brain integrity. Sex differences in the protective effect of cognitive reserve were not moderated by brain beta-amyloid burden.</div></div>","PeriodicalId":72131,"journal":{"name":"Aging brain","volume":"8 ","pages":"Article 100146"},"PeriodicalIF":2.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144739254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identification of novel candidate loci for Alzheimer’s disease and related dementias by leveraging the shared genetic basis with hippocampal volume 利用与海马体积共享的遗传基础，鉴定阿尔茨海默病和相关痴呆的新候选基因座

IF 2.7

Aging brain Pub Date : 2025-01-01 DOI: 10.1016/j.nbas.2025.100147

Chenyang Jiang , Sven J. van der Lee , Niccolò Tesi , Wiesje M. van der Flier , Betty M. Tijms , Lianne M. Reus

{"title":"Identification of novel candidate loci for Alzheimer’s disease and related dementias by leveraging the shared genetic basis with hippocampal volume","authors":"Chenyang Jiang , Sven J. van der Lee , Niccolò Tesi , Wiesje M. van der Flier , Betty M. Tijms , Lianne M. Reus","doi":"10.1016/j.nbas.2025.100147","DOIUrl":"10.1016/j.nbas.2025.100147","url":null,"abstract":"<div><div>Alzheimer’s disease and related dementias (ADRD) are complex neurodegenerative disorders of which the genetic basis remains incompletely understood. Hippocampal volume loss is a core hallmark of AD. Hippocampal volume also has a strong heritable component and its genetic underpinnings may help us to understand the complex biological mechanism underlying ADRD. To identify shared genetic risk loci across late-onset ADRD and bilateral hippocampal volumes, we conducted a cross-trait analysis of existing GWAS data on the two traits using the conjunctional false discovery rate (conjFDR) framework. Functional annotation and phenome-wide association studies (PheWAS) were performed on the identified shared loci to characterize their biological relevance. We identified 11 unique lead genetic loci, of which 7 loci showed discordant directional effects (loci associated with increased risk for ADRD and smaller hippocampal volumes). We found that <em>SHARPIN</em> and <em>TNIP1</em> genes play a role in ADRD by affecting hippocampal volumes. In addition, we observed 9 novel ADRD-hippocampus loci in genes previously implicated in AD (<em>IGIP</em> and <em>ACE</em>) and novel ADRD-genes (<em>KCTD13</em>, <em>HINT1</em>, <em>SH3TC2</em>, <em>FAM53B</em>, <em>TPM1</em>, <em>IL34</em> and <em>SSH2</em>). PheWAS results show that most shared loci associated with neuroimaging measurements, white blood cell markers, red blood cell markers, and lipids. This study shows a shared genetic basis between ADRD and bilateral hippocampal volumes. By integrating summary statistics for these two traits, we identified both novel and previously reported ADRD-hippocampus loci. Functional analysis highlights the role of immune cells and lipid markers in the shared loci, suggesting a shared neurobiological basis for ADRD and bilateral hippocampal volumes.</div></div>","PeriodicalId":72131,"journal":{"name":"Aging brain","volume":"8 ","pages":"Article 100147"},"PeriodicalIF":2.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144724673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0