神经干细胞分泌组:解锁成人和衰老大脑再生能力的秘密钥匙

IF 2.7 Q3 CLINICAL NEUROLOGY
Soumia Abdellaoui , Lida Katsimpardi
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引用次数: 0

摘要

成人神经发生涉及静止神经干细胞(qNSCs)的激活,以产生新的神经元,这些神经元迁移并整合到现有的神经回路中。除了在神经发生中发挥作用外,成人NSCs还分泌生物活性化合物,统称为分泌组,有助于调节这一过程。然而,衰老和神经退行性疾病通过促进神经源性生态位内的促炎环境而损害神经发生。随着年龄的增长,NSCs变得越来越安静,导致其分泌活性下降——这是衰老的NSCs的标志。增强成人NSCs的功能具有恢复这些条件下脑功能的治疗潜力。具体而言,重新激活静止的NSCs并可能消除衰老的NSCs可以促进神经发生并改善衰老和神经退行性疾病的认知功能。在这篇综述中,我们探讨了成人NSCs及其分泌组在维持成年期和衰老期脑功能中的作用。对文献的全面分析揭示了NSCs及其分泌组如何影响神经发生,从激活和分化到整合到神经回路。在老年和神经退行性模型中靶向成人NSCs是一种很有前途的脑功能恢复策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Neural stem cell secretome: a secret key to unlocking the power of regeneration in the adult and aging brain
Adult neurogenesis involves the activation of quiescent neural stem cells (qNSCs) to generate new neurons, which migrate and integrate into existing neural circuits. In addition to their role in neurogenesis, adult NSCs also secrete bioactive compounds collectively known as the secretome, which contribute to the regulation of this process. However, aging and neurodegenerative diseases impair neurogenesis by promoting a pro-inflammatory environment within the neurogenic niche. With age, NSCs become increasingly quiescent, leading to a decline in their secretory activity— a hallmark of aged NSCs. Enhancing the function of adult NSCs holds therapeutic potential for restoring brain function under these conditions. Specifically, reactivating quiescent NSCs and possibly eliminating senescent ones can boost neurogenesis and improve cognitive function in aging and neurodegenerative diseases. In this review, we explore the role of adult NSCs and their secretome in sustaining brain function throughout adulthood and aging. A comprehensive analysis of the literature sheds light onto how NSCs and their secretome influence neurogenesis, from activation and differentiation to integration into neural circuits. Targeting adult NSCs in aged and neurodegenerative models presents a promising strategy for brain function restoration.
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来源期刊
Aging brain
Aging brain Neuroscience (General), Geriatrics and Gerontology
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