Human adult hippocampal neurogenesis in health and disease

IF 2.7 Q3 CLINICAL NEUROLOGY
MC. Alonso-Moreno , M. Gallardo-Caballero , AV. Prádanos-Senén , M. Llorens-Martín
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Abstract

The mammalian hippocampus generates new dentate granule cells (DGCs) throughout life. This process, named adult hippocampal neurogenesis (AHN), participates in hippocampal functions such as memory and mood regulation. Moreover, AHN is impaired in mouse models and patients with neurodegenerative and psychiatric disorders. Additionally, physiological aging targets AHN and the integrity of the hippocampal neurogenic niche. This perspective review aims to discuss the regulation of human AHN in patients with neurodegenerative and psychistric conditions. Moreover, we will address key adaptations of human AHN and the neurogenic niche in response to physiological aging.
健康与疾病中的成人海马神经发生
哺乳动物海马在一生中产生新的齿状颗粒细胞(DGCs)。这个过程被称为成人海马神经发生(AHN),参与海马功能,如记忆和情绪调节。此外,AHN在小鼠模型和神经退行性疾病和精神疾病患者中受损。此外,生理衰老的目标是AHN和海马神经源性生态位的完整性。本综述旨在探讨人类AHN在神经退行性和精神疾病患者中的调节作用。此外,我们将讨论人类AHN和神经源性生态位对生理衰老的关键适应。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Aging brain
Aging brain Neuroscience (General), Geriatrics and Gerontology
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