Aging brain最新文献

{"title":"The role of the parietal cortex in inhibitory processing in the vertical meridian: Evidence from elderly brain damaged patients","authors":"Pedro J. Fernández ,&nbsp;Ana B. Vivas ,&nbsp;Magdalena Chechlacz ,&nbsp;Luis J. Fuentes","doi":"10.1016/j.nbas.2022.100043","DOIUrl":"10.1016/j.nbas.2022.100043","url":null,"abstract":"<div><p>We explored the effects of parietal damage on inhibitory effects of visuospatial attention, inhibition of return (IOR) and inhibitory tagging (IT), in the vertical meridian. We combined a vertical spatial cue paradigm with a Stroop task employing three different temporal intervals between the spatial cue and the target (700, 1200 and 2000 ms) in two groups of patients, one with damage to the parietal cortex and underlying white matter (the parietal patients group) and the other with damage in other brain areas not including the parietal lobe (the control patient group), and a healthy control group. Healthy controls showed the expected inhibitory effects, IOR at the 700 and 1200 intervals and IT at the 1200 interval (as evidenced in a reduction in the magnitude of Stroop interference at the cued location). On the other hand, only the group of parietal patients showed delayed onset of inhibitory effects, IOR and IT appeared at the 1200 ms and 2000 ms intervals, respectively. These findings provide evidence for a role of the parietal cortex, and the underlying fibre tracts, in inhibitory processing in the vertical meridian, with damage to the parietal cortex altering the time course of attention-dependent inhibition.</p></div>","PeriodicalId":72131,"journal":{"name":"Aging brain","volume":"2 ","pages":"Article 100043"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/05/d5/main.PMC9997184.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9469570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional near infrared spectroscopy activation during an executive function task differs between healthy older and younger adults","authors":"Heather Kwan ,&nbsp;Vanessa Scarapicchia ,&nbsp;Drew Halliday ,&nbsp;Stuart MacDonald ,&nbsp;Jodie R. Gawryluk","doi":"10.1016/j.nbas.2022.100029","DOIUrl":"10.1016/j.nbas.2022.100029","url":null,"abstract":"<div><h3>Background</h3><p>Healthy aging can include declines in processing speed and executive function. Further research is needed to characterize the neurobiological underpinnings of these cognitive changes in older adulthood. The current study used functional near infrared spectroscopy (fNIRS), an optical neuroimaging technique, to examine differences in cerebral oxygenation between healthy older adults (OA) and younger adults (YA) during a measure of cognitive interference.</p></div><div><h3>Methods</h3><p>Thirty-four participants were sampled from two age groups: YA (mean age = 28.1 years, SD = 2.8, F = 9) and OA (mean age = 70.9 years, SD = 5.4, F = 9). Participants completed the Multi-Source Interference Task (MSIT), a measure of executive function with high and low-demand conditions, while undergoing fNIRS recordings using a TechEn CW6 system with 34-source-detector channels, situated over the prefrontal cortex. Functional activation patterns, accuracy, and reaction time were compared between and within groups for each condition.</p></div><div><h3>Results</h3><p>Behaviourally, during the control condition, OA and YA had comparable accuracy, although OA had significantly slower reaction times than YA. During the interference condition, OA had significantly lower accuracy and slower reaction times than YA. Results demonstrated a significant difference between groups with an age-related increase in HbO for OA in both conditions (p &lt; 0.05). Within groups, OA showed greater activation during the control condition, while YA demonstrated greater activation during the interference condition.</p></div><div><h3>Conclusions</h3><p>The findings suggest that OA recruit additional neural resources to achieve similar behavioural performance during low-level cognitive interference, but that compensation in OA may be insufficient to support behavioural performance at higher levels of interference.</p></div>","PeriodicalId":72131,"journal":{"name":"Aging brain","volume":"2 ","pages":"Article 100029"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ba/49/main.PMC9997178.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9469571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gray matter network properties show distinct associations with CSF p-tau 181 levels and amyloid status in individuals without dementia","authors":"Luigi Lorenzini ,&nbsp;Silvia Ingala ,&nbsp;Viktor Wottschel ,&nbsp;Alle Meije Wink ,&nbsp;Henk JMM Mutsaerts ,&nbsp;Sven Haller ,&nbsp;Kaj Blennow ,&nbsp;John T. O'Brien ,&nbsp;B. Giovanni Frisoni ,&nbsp;Gael Chételat ,&nbsp;Pierre Payoux ,&nbsp;Pablo Martinez-Lage ,&nbsp;Adam Waldman ,&nbsp;Joanna Wardlaw ,&nbsp;Craig Ritchie ,&nbsp;Juan Domingo Gispert ,&nbsp;Pieter Jelle Visser ,&nbsp;Philip Scheltens ,&nbsp;Frederik Barkhof ,&nbsp;Betty M. Tijms","doi":"10.1016/j.nbas.2022.100054","DOIUrl":"10.1016/j.nbas.2022.100054","url":null,"abstract":"<div><p>Gray matter networks are altered with amyloid accumulation in the earliest stage of AD, and are associated with decline throughout the AD spectrum. It remains unclear to what extent gray matter network abnormalities are associated with hyperphosphorylated-tau (p-tau). We studied the relationship of cerebrospinal fluid (CSF) p-tau181 with gray matter networks in non-demented participants from the European Prevention of Alzheimer’s Dementia (EPAD) cohort, and studied dependencies on amyloid and cognitive status. Gray matter networks were extracted from baseline structural 3D T1w MRI. P-tau181 and abeta were measured with the Roche cobas Elecsys System. We studied the associations of CSF biomarkers levels with several network’s graph properties. We further studied whether the relationships of p-tau 181 and network measures were dependent on amyloid status and cognitive stage (CDR). We repeated these analyses for network properties at a regional level, where we averaged local network values across cubes within each of 116 areas as defined by the automated anatomical labeling (AAL) atlas. Amyloid positivity was associated with higher network size and betweenness centrality, and lower gamma, clustering and small-world coefficients. Higher CSF p-tau 181 levels were related to lower betweenness centrality, path length and lambda coefficients (all p &lt; 0.01). Three-way interactions between p-tau181, amyloid status and CDR were found for path length, lambda and clustering (all p &lt; 0.05): Cognitively unimpaired amyloid-negative participants showed lower path length and lambda values with higher CSF p-tau181 levels. Amyloid-positive participants with impaired cognition demonstrated lower clustering coefficients in association to higher CSF p-tau181 levels.</p><p>Our results suggest that alterations in gray matter network clustering coefficient is an early and specific event in AD.</p></div>","PeriodicalId":72131,"journal":{"name":"Aging brain","volume":"2 ","pages":"Article 100054"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/52/ca/main.PMC9997148.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9155243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fiber Ball white matter modeling reveals microstructural alterations in healthy brain aging","authors":"Siddhartha Dhiman ,&nbsp;Stephanie Fountain-Zaragoza ,&nbsp;Jens H. Jensen ,&nbsp;Maria Fatima Falangola ,&nbsp;Emilie T. McKinnon ,&nbsp;Hunter G. Moss ,&nbsp;Kathryn E. Thorn ,&nbsp;William J. Rieter ,&nbsp;Maria Vittoria Spampinato ,&nbsp;Paul J. Nietert ,&nbsp;Joseph A. Helpern ,&nbsp;Andreana Benitez","doi":"10.1016/j.nbas.2022.100037","DOIUrl":"10.1016/j.nbas.2022.100037","url":null,"abstract":"<div><p>Age-related white matter degeneration is characterized by myelin breakdown and neuronal fiber loss that preferentially occur in regions that myelinate later in development. Conventional diffusion MRI (dMRI) has demonstrated age-related increases in diffusivity but provides limited information regarding the tissue-specific changes driving these effects. A recently developed dMRI biophysical modeling technique, Fiber Ball White Matter (FBWM) modeling, offers enhanced biological interpretability by estimating microstructural properties specific to the intra-axonal and extra-axonal spaces. We used FBWM to illustrate the biological mechanisms underlying changes throughout white matter in healthy aging using data from 63 cognitively unimpaired adults ages 45–85 with no radiological evidence of neurodegeneration or incipient Alzheimer’s disease. Conventional dMRI and FBWM metrics were computed for two late-myelinating (genu of the corpus callosum and association tracts) and two early-myelinating regions (splenium of the corpus callosum and projection tracts). We examined the associations between age and these metrics in each region and tested whether age was differentially associated with these metrics in late- vs. early-myelinating regions. We found that conventional metrics replicated patterns of age-related increases in diffusivity in late-myelinating regions. FBWM additionally revealed specific intra- and extra-axonal changes suggestive of myelin breakdown and preferential loss of smaller-diameter axons, yielding <em>in vivo</em> corroboration of findings from histopathological studies of aged brains. These results demonstrate that advanced biophysical modeling approaches, such as FBWM, offer novel information about the microstructure-specific alterations contributing to white matter changes in healthy aging. These tools hold promise as sensitive indicators of early pathological changes related to neurodegenerative disease.</p></div>","PeriodicalId":72131,"journal":{"name":"Aging brain","volume":"2 ","pages":"Article 100037"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d6/fe/main.PMC9624504.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9072374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multisensory integration precision is associated with better cognitive performance over time in older adults: A large-scale exploratory study","authors":"Rebecca J. Hirst ,&nbsp;Annalisa Setti ,&nbsp;Céline De Looze ,&nbsp;Rose Anne Kenny ,&nbsp;Fiona N. Newell","doi":"10.1016/j.nbas.2022.100038","DOIUrl":"10.1016/j.nbas.2022.100038","url":null,"abstract":"<div><p>Age-related sensory decline impacts cognitive performance and exposes individuals to a greater risk of cognitive decline. Integration across the senses also changes with age, yet the link between multisensory perception and cognitive ageing is poorly understood. We explored the relationship between multisensory integration and cognitive function in 2875 adults aged 50 + from The Irish Longitudinal Study on Ageing. Multisensory integration was assessed at several audio-visual temporal asynchronies using the Sound Induced Flash Illusion (SIFI). More precise integration (i.e. less illusion susceptibility with larger temporal asynchronies) was cross-sectionally associated with faster Choice Response Times and Colour Trail Task performance, and fewer errors on the Sustained Attention to Response Task. We then used k-means clustering to identify groups with different 10-year cognitive trajectories on measures available longitudinally; delayed recall, immediate recall and verbal fluency. Across measures, groups with consistently higher performance trajectories had more precise multisensory integration. These findings support broad links between multisensory integration and several cognitive measures, including processing speed, attention and memory, rather than association with any specific subdomain.</p></div>","PeriodicalId":72131,"journal":{"name":"Aging brain","volume":"2 ","pages":"Article 100038"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/68/e7/main.PMC9997173.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9095537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship between cardiovascular risk and lifestyle activities on hippocampal volumes in normative aging","authors":"Vanessa Scarapicchia ,&nbsp;Stuart MacDonald ,&nbsp;Jodie R. Gawryluk","doi":"10.1016/j.nbas.2022.100033","DOIUrl":"10.1016/j.nbas.2022.100033","url":null,"abstract":"<div><h3>Background</h3><p>Despite the life-course perspective of popular aging models, few studies on healthy aging to date have examined both younger and older adulthood. The current study examined how cumulative vascular risk factors and self-reported levels of physical, social, and cognitive activity are associated with differences in hippocampal volumes in healthy younger and older adults.</p></div><div><h3>Methods</h3><p>34 neurologically healthy participants were separated into two age cohorts: a younger adult group (age 25–35, n = 17) and an older adult group (age 65–82, n = 17). Participants underwent a 3 T T1 MRI and completed a series of questionnaires. Voxel-based morphometry examined whole-brain grey matter density differences between groups. Hippocampal volumes were computed. Analyses examined the association between hippocampal volumes, cumulative vascular risk, and self-reported levels of physical, social, and cognitive activity, both within and across groups.</p></div><div><h3>Results</h3><p>Between-group comparisons revealed greater cortical atrophy in older relative to young adults in regions including the left and right hippocampus and temporal fusiform cortex. Across-group analyses revealed a significant negative association between cardiovascular risk scores and bilateral hippocampal volumes across age groups. A significant negative association was identified between frequency of social activities and bilateral hippocampal volumes in older adults only. No significant associations were found between left or right hippocampal volumes and total, cognitive, or physical activities in both within- and across-group analyses.</p></div><div><h3>Conclusion</h3><p>Greater cumulative vascular risk is associated with smaller hippocampal volumes across age cohorts. Findings suggest that social activities with low cognitive load may not be beneficial to structural brain outcomes in older age.</p></div>","PeriodicalId":72131,"journal":{"name":"Aging brain","volume":"2 ","pages":"Article 100033"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f7/5a/main.PMC9999441.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9102678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of endogenous estrogen on a network model of female brain integrity","authors":"Janelle T. Foret ,&nbsp;Marie Caillaud ,&nbsp;Drew D. Gourley ,&nbsp;Maria Dekhtyar ,&nbsp;Hirofumi Tanaka ,&nbsp;Andreana P. Haley","doi":"10.1016/j.nbas.2022.100053","DOIUrl":"10.1016/j.nbas.2022.100053","url":null,"abstract":"<div><p>Recent reports document sex differences in midlife brain integrity and metabolic health, such that more relationships are detectable between metabolic syndrome (MetS) components and markers of brain health in females than in males. Midlife is characterized by a rapid decrease in endogenous estrogen levels for women which is thought to increase risk for cardiometabolic disease and neurocognitive decline. Our study used network models, designed to explore the interconnectedness and organization of relationships among many variables at once, to compare the influence of endogenous estrogen and chronological age on a network of brain and metabolic health in order to investigate the utility of estrogen as a biomarker for brain vulnerability. Data were analyzed from 82 females (ages 40–62). Networks consisted of known biomarkers of risk for late-life cognitive decline: the five components of MetS; Brain-predicted age difference calculated on gray and white matter volume; white matter hyperintensities; Default Mode Network functional connectivity; cerebral concentrations of <em>N</em>-acetyl aspartate, glutamate and myo-inositol; and serum concentrations of estradiol. A second network replaced estradiol with chronological age. Expected influence (EI) of estradiol on the network was −1.190, relative to chronological age at −0.524, indicating that estradiol had a stronger expected influence over the network than age. A negative expected influence indicates that higher levels of estradiol would be expected to decrease the number of relationships in the model, which is thought to indicate lower risk. Overall, levels of estradiol appear more influential than chronological age at midlife for relationships between brain integrity and metabolic health.</p></div>","PeriodicalId":72131,"journal":{"name":"Aging brain","volume":"2 ","pages":"Article 100053"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/2d/00/main.PMC9997143.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9453774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brain and cognitive ageing: The present, and some predictions (…about the future)","authors":"Simon R. Cox ,&nbsp;Ian J. Deary","doi":"10.1016/j.nbas.2022.100032","DOIUrl":"10.1016/j.nbas.2022.100032","url":null,"abstract":"<div><p>Experiencing decline in one’s cognitive abilities is among the most feared aspects of growing old <span>[53]</span>. Age-related cognitive decline carries a huge personal, societal, and financial cost both in pathological ageing (such as dementias) and also within the non-clinical majority of the population. A projected 152 million people worldwide will suffer from dementia by 2050 <span>[3]</span>. The early stages of cognitive decline are much more prevalent than dementia, and can still impose serious limitations of performance on everyday activities, independence, and quality of life in older age <span>[5]</span>, <span>[60]</span>, <span>[80]</span>. Cognitive decline also predicts poorer health, adherence to medical regimens, and financial decision-making, and can herald dementia, illness, and death <span>[6]</span>, <span>[40]</span>. Of course, when seeking to understand why some people experience more severe cognitive ageing than others, researchers have turned to the organ of thinking for clues about the nature, possible mechanisms, and determinants that might underpin more and less successful cognitive agers. However, that organ is relatively inaccessible, a limitation partly alleviated by advances in neuroimaging. Here we discuss lessons for cognitive and brain ageing that have come from neuroimaging research (especially structural brain imaging), what neuroimaging still has left to teach us, and our views on possible ways forward in this multidisciplinary field.</p></div>","PeriodicalId":72131,"journal":{"name":"Aging brain","volume":"2 ","pages":"Article 100032"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9997131/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9666378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Capillary function progressively deteriorates in prodromal Alzheimer’s disease: A longitudinal MRI perfusion study","authors":"Lasse S. Madsen ,&nbsp;Rune B. Nielsen ,&nbsp;Peter Parbo ,&nbsp;Rola Ismail ,&nbsp;Irene K. Mikkelsen ,&nbsp;Hanne Gottrup ,&nbsp;Leif Østergaard ,&nbsp;David J. Brooks ,&nbsp;Simon F. Eskildsen","doi":"10.1016/j.nbas.2022.100035","DOIUrl":"10.1016/j.nbas.2022.100035","url":null,"abstract":"<div><p>Cardiovascular risk factors are associated with the development of Alzheimer’s disease (AD), and increasing evidence suggests that cerebral microvascular dysfunction plays a vital role in the disease progression. Using magnetic resonance imaging, we investigated the two-year changes of the cerebral microvascular blood flow in 11 mild cognitively impaired (MCI) patients with prodromal AD compared to 12 MCI patients without evidence of AD and 10 cognitively intact age-matched controls. The pAD-MCI patients displayed widespread deterioration in microvascular cerebral perfusion associated with capillary dysfunction. No such changes were observed in the other two groups, suggesting that the dysfunction in capillary perfusion is linked to the AD pathophysiology. The observed capillary dysfunction may limit local oxygenation in AD leading to downstream β-amyloid aggregation, tau hyperphosphorylation, neuroinflammation and neuronal dysfunction. The findings are in agreement with the capillary dysfunction hypothesis of AD, suggesting that increasing heterogeneity of capillary blood flow is a primary pathological event in AD.</p></div>","PeriodicalId":72131,"journal":{"name":"Aging brain","volume":"2 ","pages":"Article 100035"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/98/52/main.PMC9997144.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9155236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cerebral topography of vesicular cholinergic transporter changes in neurologically intact adults: A [18F]FEOBV PET study","authors":"Prabesh Kanel ,&nbsp;Sygrid van der Zee ,&nbsp;Carlos A. Sanchez-Catasus ,&nbsp;Robert A. Koeppe ,&nbsp;Peter J.H. Scott ,&nbsp;Teus van Laar ,&nbsp;Roger L. Albin ,&nbsp;Nicolaas I. Bohnen","doi":"10.1016/j.nbas.2022.100039","DOIUrl":"10.1016/j.nbas.2022.100039","url":null,"abstract":"<div><p>Acetylcholine plays a major role in brain cognitive and motor functions with regional cholinergic terminal loss common in several neurodegenerative disorders. We describe age-related declines of regional cholinergic neuron terminal density <em>in vivo</em> using the positron emission tomography (PET) ligand [¹⁸F](–)5-Fluoroethoxybenzovesamicol ([¹⁸F]FEOBV), a vesamicol analogue selectively binding to the vesicular acetylcholine transporter (VAChT). A total of 42 subjects without clinical evidence of neurologic disease (mean 50.55 [range 20–80] years, 24 Male/18 Female) underwent [¹⁸F]FEOBV brain PET imaging. We used SPM based voxel-wise statistical analysis to perform whole brain voxel-based parametric analysis (family-wise error corrected, FWE) and to also extract the most significant clusters of regions correlating with aging with gender as nuisance variable. Age-related VAChT binding reductions were found in primary sensorimotor cortex, visual cortex, caudate nucleus, anterior to mid-cingulum, bilateral insula, <em>para</em>-hippocampus, hippocampus, anterior temporal lobes/amygdala, dorsomedial thalamus, metathalamus, and cerebellum (gender and FWE-corrected, P &lt; 0.05). These findings show a specific topographic pattern of regional vulnerability of cholinergic nerve terminals across multiple cholinergic systems accompanying aging.</p></div>","PeriodicalId":72131,"journal":{"name":"Aging brain","volume":"2 ","pages":"Article 100039"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589958922000111/pdfft?md5=c347c31ab362a604e61be2588ede41b2&pid=1-s2.0-S2589958922000111-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46197838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}