Aging brain最新文献_第3页

Aging brain Pub Date : 2024-01-01 DOI: 10.1016/j.nbas.2024.100106

Lauren Revie, Claudia Metzler-Baddeley

{"title":"Age-related fornix decline predicts conservative response strategy-based slowing in perceptual decision-making","authors":"Lauren Revie, Claudia Metzler-Baddeley","doi":"10.1016/j.nbas.2024.100106","DOIUrl":"https://doi.org/10.1016/j.nbas.2024.100106","url":null,"abstract":"<div><p>Aging leads to response slowing but the underpinning cognitive and neural mechanisms remain elusive. We modelled older and younger adults’ response times (RT) from a flanker task with a diffusion drift model (DDM) and employed diffusion-weighted magnetic resonance imaging and spectroscopy to study neurobiological predictors of DDM components (drift-rate, boundary separation, non-decision time). Microstructural indices were derived from white matter pathways involved in visuo-perceptual and attention processing [optic radiation, inferior and superior longitudinal fasciculi (ILF, SLF), fornix]. Estimates of metabolite concentrations [N-acetyl aspartate (NAA), glutamate (Glx), and γ-aminobutyric acid (GABA), creatine (Cr), choline (Cho), myoinositol (mI)] were measured from occipital (OCC), anterior cingulate (ACC) and posterior parietal cortices (PPC). Age-related increases in RT, boundary separation, and non-decision time were observed with response conservatism acounting for RT slowing. Aging was associated with reductions in white matter microstructure (lower fractional anisotropy and restricted signal fraction, larger diffusivities) and in metabolites (NAA in ACC and PPC, Glx in ACC). Regression analyses identified brain regions involved in top-down (fornix, SLF, ACC, PPC) and bottom-up (ILF, optic radiation OCC) processing as predictors for DDM parameters and RT. Fornix FA was the strongest predictor for increases in boundary separation (beta = −0.8) and mediated the effects of age on RT. These findings demonstrate that response slowing in visual discrimination is driven by the adoption of a more conservative response strategy. Age-related fornix decline may result in noisier communication of contextual information from the hippocampus to anterior decision-making regions and thus contribute to the conservative response strategy shift.</p></div>","PeriodicalId":72131,"journal":{"name":"Aging brain","volume":"5 ","pages":"Article 100106"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S258995892400001X/pdfft?md5=3e196de7b04dfb9332521fa56c30b1da&pid=1-s2.0-S258995892400001X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139548591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sleep-memory relationships during brain aging 大脑衰老过程中的睡眠-记忆关系。

IF 1.7

Aging brain Pub Date : 2024-01-01 DOI: 10.1016/j.nbas.2024.100127

Deependra Kumar (Guest editor)

引用次数: 0

Sleep discrepancy and brain glucose metabolism in community-dwelling older adults 社区老年人的睡眠差异与脑葡萄糖代谢

IF 1.7

Aging brain Pub Date : 2024-01-01 DOI: 10.1016/j.nbas.2024.100130

Nadia Soh , Michael Weinborn , James D. Doecke , Rodrigo Canovas , Vincent Doré , Ying Xia , Jurgen Fripp , Kevin Taddei , Romola S. Bucks , Hamid R. Sohrabi , Ralph N. Martins , Melissa Ree , Stephanie R. Rainey-Smith

{"title":"Sleep discrepancy and brain glucose metabolism in community-dwelling older adults","authors":"Nadia Soh , Michael Weinborn , James D. Doecke , Rodrigo Canovas , Vincent Doré , Ying Xia , Jurgen Fripp , Kevin Taddei , Romola S. Bucks , Hamid R. Sohrabi , Ralph N. Martins , Melissa Ree , Stephanie R. Rainey-Smith","doi":"10.1016/j.nbas.2024.100130","DOIUrl":"10.1016/j.nbas.2024.100130","url":null,"abstract":"<div><div>Sleep discrepancy (negative discrepancy reflects worse self-reported sleep than objective measures, such as actigraphy, and positive discrepancy the opposite) has been linked to adverse health outcomes. This study is first to investigate the relationship between sleep discrepancy and brain glucose metabolism (assessed globally and regionally via positron emission tomography), and to evaluate the contribution of insomnia severity and depressive symptoms to any associations. Using data from cognitively unimpaired community-dwelling older adults (<em>N</em> = 68), cluster analysis was used to characterise sleep discrepancy (for total sleep time (TST), wake after sleep onset (WASO), and sleep efficiency (SE)), and logistic regression was used to explore sleep discrepancy’s associations with brain glucose metabolism, while controlling for insomnia severity and depressive symptoms. Lower glucose metabolism across multiple brain regions was associated with negative discrepancy for WASO and SE, and positive discrepancy for WASO only (large effect sizes; β ≥ 0.5). Higher glucose metabolism in the superior parietal and posterior cingulate regions was associated with negative discrepancy for TST (large effect sizes; β ≥ 0.5). These associations remained when controlling for insomnia severity and depressive symptoms, suggesting a unique role of sleep discrepancy as a potential early behavioural marker of brain health.</div></div>","PeriodicalId":72131,"journal":{"name":"Aging brain","volume":"6 ","pages":"Article 100130"},"PeriodicalIF":1.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142702199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of advanced maternal age on ischemic stroke vulnerability in aged rats: Investigating on blood-brain barrier permeability and gene expression 高龄产妇对老年大鼠缺血性中风易感性的影响血脑屏障通透性和基因表达研究

IF 1.7

Aging brain Pub Date : 2024-01-01 DOI: 10.1016/j.nbas.2024.100125

Samira Khayat , Hamed Fanaei

{"title":"Effect of advanced maternal age on ischemic stroke vulnerability in aged rats: Investigating on blood-brain barrier permeability and gene expression","authors":"Samira Khayat , Hamed Fanaei","doi":"10.1016/j.nbas.2024.100125","DOIUrl":"10.1016/j.nbas.2024.100125","url":null,"abstract":"<div><h3>Background</h3><p>Advanced maternal age (AMA), commonly defined as pregnancy at or above 35 years old. Based on the evidence, this trend has raised concerns about potential health consequences for mothers, particularly in relation to ischemic stroke. Studies suggest that AMA may be associated with a higher risk of ischemic stroke in women due to physiological changes that impact vascular health and increase cardiovascular risk factors. The aim of this study was to investigate the effect of AMA on the extent of damage after ischemic stroke in aged rats.</p></div><div><h3>Methods</h3><p>Female rats that gave birth at an old age (10 months) and at a young age (4 months) were subjected to ischemic stroke in old age (20 months) and subsequently compared.</p><p>We assessed neurological deficits, infarct volume, blood–brain barrier (BBB) permeability, TNF-alpha levels, total oxidant capacity, and gene expressions that play a role in BBB integrity (VEGF, Occludin, and MMP-9) following ischemic stroke.</p></div><div><h3>Results</h3><p>There were significantly elevated levels of MMP-9 expression and reduced levels of occludin in AMA rats. Additionally, AMA rats had significantly higher levels of TNF-alpha and total oxidant capacity after experiencing an ischemic stroke. AMA rats showed significantly higher brain water content (BBB permeability), infarct volume, and neurological deficits compared to young-aged pregnancies.</p></div><div><h3>Discussion</h3><p>Complex relationship between pregnancy-related physiological changes, aging, vascular gene expression, and inflammatory factors may play a role in the increased vulnerability observed in older pregnant rats. The similarities between pregnancy-related alterations and aging highlight the influence of advanced maternal age on susceptibility to ischemic stroke.</p></div>","PeriodicalId":72131,"journal":{"name":"Aging brain","volume":"6 ","pages":"Article 100125"},"PeriodicalIF":1.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589958924000215/pdfft?md5=7b4566b53176186acd157cec681dd15d&pid=1-s2.0-S2589958924000215-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142167329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Why women may be more prone to Alzheimer’s disease 为什么女性更容易罹患阿尔茨海默病

IF 1.7

Aging brain Pub Date : 2024-01-01 DOI: 10.1016/j.nbas.2024.100121

Sadashiva K. Pai

引用次数: 0

Visual contrast sensitivity is associated with community structure integrity in cognitively unimpaired older adults: the Brain Networks and Mobility (B-NET) Study 视觉对比敏感度与认知能力未受损的老年人群落结构完整性相关：脑网络与移动性（B-NET）研究

IF 1.7

Aging brain Pub Date : 2024-01-01 DOI: 10.1016/j.nbas.2024.100122

Alexis D. Tanase , Haiying Chen , Michael E. Miller , Christina E. Hugenschmidt , Jeff D. Williamson , Stephen B. Kritchevsky , Paul J. Laurienti , Atalie C. Thompson

{"title":"Visual contrast sensitivity is associated with community structure integrity in cognitively unimpaired older adults: the Brain Networks and Mobility (B-NET) Study","authors":"Alexis D. Tanase , Haiying Chen , Michael E. Miller , Christina E. Hugenschmidt , Jeff D. Williamson , Stephen B. Kritchevsky , Paul J. Laurienti , Atalie C. Thompson","doi":"10.1016/j.nbas.2024.100122","DOIUrl":"10.1016/j.nbas.2024.100122","url":null,"abstract":"<div><p>Older adults with impairment in contrast sensitivity (CS), the ability to visually perceive differences in light and dark, are more likely to demonstrate limitations in mobility function, but the mechanisms underlying this relationship are poorly understood. We sought to determine if functional brain networks important to visual processing and mobility may help elucidate possible neural correlates of this relationship. This cross-sectional analysis utilized functional MRI both at rest and during a motor imagery (MI) task in 192 community-dwelling, cognitively-unimpaired older adults <span><math><mo>≥</mo></math></span> 70 years of age from the Brain Networks and Mobility study (B-NET). Brain networks were partitioned into network communities, groups of regions that are more interconnected with each other than the rest of the brain, the spatial consistency of the communities for multiple brain subnetworks was assessed. Lower baseline binocular CS was significantly associated with degraded sensorimotor network (SMN) community structure at rest. During the MI task, lower binocular CS was significantly associated with degraded community structure in both the visual (VN) and default mode network (DMN). These findings may suggest shared neural pathways for visual and mobility dysfunction that could be targeted in future studies.</p></div>","PeriodicalId":72131,"journal":{"name":"Aging brain","volume":"6 ","pages":"Article 100122"},"PeriodicalIF":1.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589958924000185/pdfft?md5=25af366b1c6e9bcd719b3cd70dc80f4f&pid=1-s2.0-S2589958924000185-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141951133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Protein quality control gone awry in Alzheimer’s 阿尔茨海默氏症的蛋白质质量控制出了问题

Aging brain Pub Date : 2024-01-01 DOI: 10.1016/j.nbas.2024.100113

Sadashiva K. Pai

引用次数: 0

Intrinsic functional connectivity strength of SuperAgers in the default mode and salience networks: Insights from ADNI SuperAgers 在默认模式和显著性网络中的内在功能连接强度：来自 ADNI 的启示

Aging brain Pub Date : 2024-01-01 DOI: 10.1016/j.nbas.2024.100114

Haley E. Keenan , Alexis Czippel , Sepideh Heydari , Jodie R. Gawryluk , Erin L. Mazerolle , for the Alzheimer's Disease Neuroimaging Initiative

{"title":"Intrinsic functional connectivity strength of SuperAgers in the default mode and salience networks: Insights from ADNI","authors":"Haley E. Keenan , Alexis Czippel , Sepideh Heydari , Jodie R. Gawryluk , Erin L. Mazerolle , for the Alzheimer's Disease Neuroimaging Initiative","doi":"10.1016/j.nbas.2024.100114","DOIUrl":"https://doi.org/10.1016/j.nbas.2024.100114","url":null,"abstract":"<div><p>There exists a group of older individuals who appear to be resistant to age-related memory decline. These “SuperAgers” have been shown to demonstrate preservation of cortical thickness and functional connectivity strength across the cortex which positively correlates with memory performance. Over the last decade, roughly 30 articles have been published regarding SuperAgers; however, to our knowledge, no replications of these studies have been published. The current study sought to conceptually replicate Zhang and colleagues’ (2020) findings that SuperAgers demonstrate stronger intrinsic functional connectivity within the default mode (DMN) and salience networks (SN), and that connectivity strength within these networks correlates with memory performance. We identified 20 SuperAgers and 20 matched Normal Agers in the control cohort of the Alzheimer’s Disease Neuroimaging Initiative (ADNI) database. We compared the functional connectivity strength of the DMN and SN between these groups, and used the Rey Auditory Verbal Learning Test (RAVLT) to evaluate correlations between functional connectivity and memory performance. Our results did not replicate Zhang and colleagues’ (2020) results, as we found negligible differences between SuperAgers and Normal Agers in the DMN and SN, and no significant correlations between functional connectivity and memory performance after accounting for multiple comparisons. More replications are needed to confirm existing work. In addition, more research with larger SuperAger samples and more consistent definitions of SuperAging is needed, so that we can better understand this remarkable group of older adults.</p></div>","PeriodicalId":72131,"journal":{"name":"Aging brain","volume":"5 ","pages":"Article 100114"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589958924000100/pdfft?md5=9dcf31d863b6e46a018ab3c41bc0d9fd&pid=1-s2.0-S2589958924000100-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140181075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Daily fluctuations in blood glucose with normal aging are inversely related to hippocampal synaptic mitochondrial proteins 正常衰老过程中血糖的每日波动与海马突触线粒体蛋白成反比

Aging brain Pub Date : 2024-01-01 DOI: 10.1016/j.nbas.2024.100116

Paul W. Braunstein , David J. Horovitz , Andreina M. Hampton , Fiona Hollis , Lori A. Newman , Reilly T. Enos , Joseph A. McQuail

{"title":"Daily fluctuations in blood glucose with normal aging are inversely related to hippocampal synaptic mitochondrial proteins","authors":"Paul W. Braunstein , David J. Horovitz , Andreina M. Hampton , Fiona Hollis , Lori A. Newman , Reilly T. Enos , Joseph A. McQuail","doi":"10.1016/j.nbas.2024.100116","DOIUrl":"https://doi.org/10.1016/j.nbas.2024.100116","url":null,"abstract":"<div><p>Defective brain glucose utilization is a hallmark of Alzheimer’s disease (AD) while Type II diabetes and elevated blood glucose escalate the risk for AD in later life. Isolating contributions of normal aging from coincident metabolic or brain diseases could lead to refined approaches to manage specific health risks and optimize treatments targeted to susceptible older individuals. We evaluated metabolic, neuroendocrine, and neurobiological differences between young adult (6 months) and aged (24 months) male rats. Compared to young adults, blood glucose was significantly greater in aged rats at the start of the dark phase of the day but not during the light phase. When challenged with physical restraint, a potent stressor, aged rats effected no change in blood glucose whereas blood glucose increased in young adults. Tissues were evaluated for markers of oxidative phosphorylation (OXPHOS), neuronal glucose transport, and synapses. Outright differences in protein levels between age groups were not evident, but circadian blood glucose was inversely related to OXPHOS proteins in hippocampal synaptosomes, independent of age. The neuronal glucose transporter, GLUT3, was positively associated with circadian blood glucose in young adults whereas aged rats tended to show the opposite trend. Our data demonstrate aging increases daily fluctuations in blood glucose and, at the level of individual differences, negatively associates with proteins related to synaptic OXPHOS. Our findings imply that glucose dyshomeostasis may exacerbate metabolic aspects of synaptic dysfunction that contribute to risk for age-related brain disorders.</p></div>","PeriodicalId":72131,"journal":{"name":"Aging brain","volume":"5 ","pages":"Article 100116"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589958924000124/pdfft?md5=13b60ffa88deb82548b3cfe52fde3e2f&pid=1-s2.0-S2589958924000124-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140346991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Innate immunity in brain aging and neurodegeneration 脑衰老和神经退行性病变中的先天性免疫

Aging brain Pub Date : 2024-01-01 DOI: 10.1016/j.nbas.2024.100108

Sadashiva K. Pai

引用次数: 0