大脑结构变异与老年人思维理论的个体差异

IF 1.7 Q3 CLINICAL NEUROLOGY
Yuki Otsuka , Ryusuke Nakai , Miho Shizawa , Shoji Itakura , Ayumi Sato , Nobuhito Abe
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引用次数: 0

摘要

心智理论(ToM)并没有受到衰老的实质性影响,这表明出现了各种补偿机制。为了确定老年人中服务于心智理论的大脑区域,我们使用基于体素的形态计量学(VBM)和基于束的空间统计学(TBSS)研究了大脑结构的个体差异与心智理论测试(RMET)成绩的关联,RMET是一种广泛使用的心智理论测量方法。VBM 分析显示,RMET 分数与灰质(GM)体积之间仅在右侧颞中回存在显著正相关,而该区域与社会认知有关联。另外,TBSS显示,RMET得分与广泛的白质(WM)束的分数各向异性(FA)值之间存在显著的正相关,其中包括双侧钩状束,该区域以前曾与年轻人的RMET表现有关。我们推测,WM完整性的个体差异对老年人ToM的影响很大,而GM体积的个体差异的影响则相对有限。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Brain structure variation and individual differences in theory of mind among older adults

The theory of mind (ToM) is not substantially influenced by aging, suggesting the emergence of various compensatory mechanisms. To identify brain regions subserving ToM in older adults, we investigated the associations of individual differences in brain structure with performance on the Reading the Mind in the Eyes Test (RMET), a widely used measure of ToM, using voxel-based morphometry (VBM) and tract-based spatial statistics (TBSS). In contrast to findings obtained from young adults, where multiple cortical regions are implicated in ToM, VBM analysis revealed a significant positive correlation between RMET score and gray matter (GM) volume only in the right middle temporal gyrus, a region implicated in social cognition. Alternatively, TBSS revealed significant positive correlations between RMET score and the fractional anisotropy (FA) values in widespread white matter (WM) tracts, including the bilateral uncinate fasciculus, a region previously linked to RMET performance in young adults. We speculate that individual differences in WM integrity are strong influences on ToM among older adults, whereas the impact of individual differences in GM volumes is relatively limited.

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来源期刊
Aging brain
Aging brain Neuroscience (General), Geriatrics and Gerontology
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