J. Russell Ravenel , Amy E. Perkins , Angela Tomczik , Ana Defendini , Helen K. Strnad , Elena Varlinskaya , Terrence Deak , Robert L. Spencer
{"title":"与年龄相关的社交互动减少与特定脑区的 c-Fos 诱导减少有关,而与催产素受体表达谱无关","authors":"J. Russell Ravenel , Amy E. Perkins , Angela Tomczik , Ana Defendini , Helen K. Strnad , Elena Varlinskaya , Terrence Deak , Robert L. Spencer","doi":"10.1016/j.nbas.2024.100107","DOIUrl":null,"url":null,"abstract":"<div><p>Social behavior decreases with aging, and we have previously found a substantial decline in social investigative behavior of old female rats. In this study we examined the neural activation pattern (<em>c-Fos</em> mRNA) of young (3 month) and old (18 month) female rats after brief 10 min exposure to a novel female rat in order to identify forebrain regions that show selective age-related alterations in their neural response to social investigation. We also measured relative oxytocin receptor expression (<em>Oxtr</em> mRNA) as a possible factor in age-related declines in <em>c-Fos</em> induction after social interaction. Young rats exposed to a social partner had a greater <em>c-Fos</em> mRNA response than those exposed to novel context alone in the lateral septum and septohypothalamic area, with blunted increases evident in old rats. In addition, <em>c-Fos</em> mRNA levels in the lateral septum were positively correlated with social investigative behavior. Interestingly, age-related differences in <em>c-Fos</em> gene induction were unrelated to the local amount of <em>Oxtr</em> expression within specific brain regions, although we found an age-related decline in <em>Oxtr</em> expression in the ventromedial hypothalamus. This functional neuroanatomical characterization may point to certain brain regions that are especially sensitive to age-related declines associated with social interaction behavior.</p></div>","PeriodicalId":72131,"journal":{"name":"Aging brain","volume":null,"pages":null},"PeriodicalIF":1.7000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589958924000021/pdfft?md5=81a4a7da92868c991b73dd80046dea42&pid=1-s2.0-S2589958924000021-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Age-related decline in social interaction is associated with decreased c-Fos induction in select brain regions independent of oxytocin receptor expression profiles\",\"authors\":\"J. Russell Ravenel , Amy E. Perkins , Angela Tomczik , Ana Defendini , Helen K. Strnad , Elena Varlinskaya , Terrence Deak , Robert L. Spencer\",\"doi\":\"10.1016/j.nbas.2024.100107\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Social behavior decreases with aging, and we have previously found a substantial decline in social investigative behavior of old female rats. In this study we examined the neural activation pattern (<em>c-Fos</em> mRNA) of young (3 month) and old (18 month) female rats after brief 10 min exposure to a novel female rat in order to identify forebrain regions that show selective age-related alterations in their neural response to social investigation. We also measured relative oxytocin receptor expression (<em>Oxtr</em> mRNA) as a possible factor in age-related declines in <em>c-Fos</em> induction after social interaction. Young rats exposed to a social partner had a greater <em>c-Fos</em> mRNA response than those exposed to novel context alone in the lateral septum and septohypothalamic area, with blunted increases evident in old rats. In addition, <em>c-Fos</em> mRNA levels in the lateral septum were positively correlated with social investigative behavior. Interestingly, age-related differences in <em>c-Fos</em> gene induction were unrelated to the local amount of <em>Oxtr</em> expression within specific brain regions, although we found an age-related decline in <em>Oxtr</em> expression in the ventromedial hypothalamus. This functional neuroanatomical characterization may point to certain brain regions that are especially sensitive to age-related declines associated with social interaction behavior.</p></div>\",\"PeriodicalId\":72131,\"journal\":{\"name\":\"Aging brain\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.7000,\"publicationDate\":\"2024-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S2589958924000021/pdfft?md5=81a4a7da92868c991b73dd80046dea42&pid=1-s2.0-S2589958924000021-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Aging brain\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2589958924000021\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Aging brain","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2589958924000021","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
Age-related decline in social interaction is associated with decreased c-Fos induction in select brain regions independent of oxytocin receptor expression profiles
Social behavior decreases with aging, and we have previously found a substantial decline in social investigative behavior of old female rats. In this study we examined the neural activation pattern (c-Fos mRNA) of young (3 month) and old (18 month) female rats after brief 10 min exposure to a novel female rat in order to identify forebrain regions that show selective age-related alterations in their neural response to social investigation. We also measured relative oxytocin receptor expression (Oxtr mRNA) as a possible factor in age-related declines in c-Fos induction after social interaction. Young rats exposed to a social partner had a greater c-Fos mRNA response than those exposed to novel context alone in the lateral septum and septohypothalamic area, with blunted increases evident in old rats. In addition, c-Fos mRNA levels in the lateral septum were positively correlated with social investigative behavior. Interestingly, age-related differences in c-Fos gene induction were unrelated to the local amount of Oxtr expression within specific brain regions, although we found an age-related decline in Oxtr expression in the ventromedial hypothalamus. This functional neuroanatomical characterization may point to certain brain regions that are especially sensitive to age-related declines associated with social interaction behavior.