威利斯圈脉动分析

IF 1.7 Q3 CLINICAL NEUROLOGY
Henning U. Voss , Qolamreza R. Razlighi
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引用次数: 0

摘要

目的评估脑血流搏动成像在老龄化研究中的现象学意义。方法用采样率为 100 毫秒的超快速核磁共振成像和同步采集的脉搏氧饱和度数据对 38 名 20 至 72 岁的受试者(24 名女性)进行成像。其中,28 名受试者的核磁共振成像和脉搏数据合格,16 名受试者的年龄在 20 至 28 岁之间,12 名受试者的年龄在 61 至 72 岁之间。采用最近开发的分析相位投影法提取血容量波形,对威利斯圈的脉搏振幅进行了评估。威利斯圈的脉搏振幅随年龄的增长而显著增加(p = 0.01),但与性别、心率和核磁共振成像时的头部运动无关。讨论与结论老年人威利斯圈脉搏波振幅的增加表明脑血液搏动成像在老龄化研究中具有现象学意义。脉搏波幅增大的生理原因(脉压增高与动脉形态变化、心脏引起的脉搏波形重塑以及与脑脊液搏动的可能相互作用)还需要进一步研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Pulsatility analysis of the circle of Willis

Purpose

To evaluate the phenomenological significance of cerebral blood pulsatility imaging in aging research.

Methods

N = 38 subjects from 20 to 72 years of age (24 females) were imaged with ultrafast MRI with a sampling rate of 100 ms and simultaneous acquisition of pulse oximetry data. Of these, 28 subjects had acceptable MRI and pulse data, with 16 subjects between 20 and 28 years of age, and 12 subjects between 61 and 72 years of age. Pulse amplitude in the circle of Willis was assessed with the recently developed method of analytic phase projection to extract blood volume waveforms.

Results

Arteries in the circle of Willis showed pulsatility in the MRI for both the young and old age groups. Pulse amplitude in the circle of Willis significantly increased with age (p = 0.01) but was independent of gender, heart rate, and head motion during MRI.

Discussion and conclusion

Increased pulse wave amplitude in the circle of Willis in the elderly suggests a phenomenological significance of cerebral blood pulsatility imaging in aging research. The physiologic origin of increased pulse amplitude (increased pulse pressure vs. change in arterial morphology vs. re-shaping of pulse waveforms caused by the heart, and possible interaction with cerebrospinal fluid pulsatility) requires further investigation.

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来源期刊
Aging brain
Aging brain Neuroscience (General), Geriatrics and Gerontology
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