Acta physiologica Hungarica最新文献_第6页

The role of gut hormones in appetite regulation (review). 肠道激素在食欲调节中的作用(综述)。

Acta physiologica Hungarica Pub Date : 2014-12-01 DOI: 10.1556/APhysiol.101.2014.4.1

G Marić, T Gazibara, I Zaletel, M Labudović Borović, N Tomanović, M Ćirić, Nela Puškaš

{"title":"The role of gut hormones in appetite regulation (review).","authors":"G Marić, T Gazibara, I Zaletel, M Labudović Borović, N Tomanović, M Ćirić, Nela Puškaš","doi":"10.1556/APhysiol.101.2014.4.1","DOIUrl":"https://doi.org/10.1556/APhysiol.101.2014.4.1","url":null,"abstract":"Eating process is an aggregate of complex and different forms of behavior. Its regulation is based on energy homeostasis and appetite control which includes two components: the homeostatic and the hedonistic control. Important signals in appetite regulation are gut-derived hormones. They are produced by enteroendocrine cells in response to nutrient and energy intake, and achieve their effects by influencing brain structures involved in food intake regulation. The key brain structure involved in this process is the hypothalamus. Gut hormones reach the hypothalamus from the circulation or by the vagal nerve via the nucleus of the solitary tract. Among gut peptides, ghrelin is the only orexigenic hormone, leading to an increase in food intake and body weight. All others, such as cholecystokinin, glucagon like peptide-1, oxyntomodulin, peptide tyrosine tyrosine or pancreatic polypeptide, are anorexigenic, leading to decrease in food intake. Also, gut-derived endocannabinoids exert orexigenic effect on appetite. Keeping in mind the growing problem of obesity, the crucial issue when considering gut derived peptides is to understand their mechanisms of acting because of potential role in clinical therapy, and discovering long-lasting gut peptides or their analogues, with no or minimal side effects. ","PeriodicalId":7167,"journal":{"name":"Acta physiologica Hungarica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1556/APhysiol.101.2014.4.1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32927247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 38

Protective effect of ghrelin in a rat model of celiac disease. 胃饥饿素对腹腔疾病大鼠模型的保护作用。

Acta physiologica Hungarica Pub Date : 2014-12-01 DOI: 10.1556/APhysiol.101.2014.4.5

L R Nikoukar, Fatemeh Nabavizadeh, S M Mohamadi, A Moslehi, G Hassanzadeh, H Nahrevanian, S Agah

{"title":"Protective effect of ghrelin in a rat model of celiac disease.","authors":"L R Nikoukar, Fatemeh Nabavizadeh, S M Mohamadi, A Moslehi, G Hassanzadeh, H Nahrevanian, S Agah","doi":"10.1556/APhysiol.101.2014.4.5","DOIUrl":"https://doi.org/10.1556/APhysiol.101.2014.4.5","url":null,"abstract":"Ghrelin is a gut hormone shown to have protective effects throughout the gastrointestinal tract. This study aims to investigate its protective effect in celiac disease induced in rats. Twenty-four rat pups were divided into 4 groups as follows: control, disease (1.5 mg/g intragastric gliadin), co-treatment (50 ng/g intraperitoneal ghrelin after gliadin gavage) and pretreatment (50 ng/g intraperitoneal ghrelin before gliadin gavage). Animals' weight gain was charted. Histological features assessed include villus length, villus width, crypt depth and number of intraepithelial lymphocytes. Tissue interferon-gamma was quantified by ELISA. ANOVA was used to compare results statistically. Results showed that villi were shortened in the diseased group, but were as long as the control in pretreatment and co-treatment groups. Crypt depth had increased in disease group, but turned to normal in co-treatment group. Number of intraepithelial lymphocytes was significantly higher in disease group than the control, while no difference was observed between co-treatment and control groups. Disease and control animals weighed equally at the end of the experiment, but ghrelin-treated animals had significantly gained more weight than these two. Interferon-gamma measurement revealed no significant difference among groups. We concluded administration of ghrelin led to histological improvement of celiac disease which was more obvious if administered after exposure to gliadin. ","PeriodicalId":7167,"journal":{"name":"Acta physiologica Hungarica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1556/APhysiol.101.2014.4.5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32927251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

Streptozotocin-nicotinamide-induced rat model of type 2 diabetes (review). 链脲佐菌素-烟酰胺诱导的2型糖尿病大鼠模型(综述)。

Acta physiologica Hungarica Pub Date : 2014-12-01 DOI: 10.1556/APhysiol.101.2014.4.2

Asghar Ghasemi, S Khalifi, S Jedi

引用次数: 200

The analysis of transduction mechanisms associated with an acute action of homocysteine on isolated rat femoral artery. 同型半胱氨酸对离体大鼠股动脉急性作用的转导机制分析。

Acta physiologica Hungarica Pub Date : 2014-12-01 DOI: 10.1556/APhysiol.101.2014.4.6

Miroslav Radenković, D Djurić, R Janković, M Prostran

{"title":"The analysis of transduction mechanisms associated with an acute action of homocysteine on isolated rat femoral artery.","authors":"Miroslav Radenković, D Djurić, R Janković, M Prostran","doi":"10.1556/APhysiol.101.2014.4.6","DOIUrl":"https://doi.org/10.1556/APhysiol.101.2014.4.6","url":null,"abstract":"The present study was undertaken in order to examine transduction mechanism involved in the single application of 100 μM homocysteine (Hcy) on isolated rat femoral artery (RFA) rings equilibrated on the basal tone; to establish if a single application of 100 μM Hcy alters contractile effect of phenylephrine (Phe), or oppositely the relaxant effect of acetylcholine (ACh) or bradykinin (BK) after 60-min-long incubation of 100 μM Hcy; and finally to identify morphological changes on the vascular wall after a 24-h-long incubation of 100 μM Hcy. Hcy produced contractile response of intact RFA, which was increased after endothelial denudation, while decreased by urapidil (an α1 receptor blocker), nifedipine (a voltage-gated L-type Ca++ channel blocker) or indomethacin (a cyclooxygenase inhibitor). The initial RFA contraction evoked by Phe was further increased by the single addition of Hcy, which was not the case when ouabain (an inhibitor of Na+/K+-ATPase) was preincubated. After 60-min-long incubation of Hcy relaxant actions of ACh and BK were unaltered, equieffective and equipotent. A 24-h-long incubation of RFA rings with Hcy produced an impairment of vascular endothelium, expressed as a minor or more pronounced interruption of endothelial cells. ","PeriodicalId":7167,"journal":{"name":"Acta physiologica Hungarica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32927252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Changes in antioxidant enzymes and lipid peroxidation in extensor digitorum longus muscles of streptozotocin-diabetic rats may contribute to muscle atrophy. 链脲佐菌素糖尿病大鼠指长伸肌抗氧化酶和脂质过氧化的变化可能导致肌肉萎缩。

Acta physiologica Hungarica Pub Date : 2014-12-01 DOI: 10.1556/APhysiol.101.2014.007

Koji Nonaka, S Une, N Tatsuta, K Ito, J Akiyama

{"title":"Changes in antioxidant enzymes and lipid peroxidation in extensor digitorum longus muscles of streptozotocin-diabetic rats may contribute to muscle atrophy.","authors":"Koji Nonaka, S Une, N Tatsuta, K Ito, J Akiyama","doi":"10.1556/APhysiol.101.2014.007","DOIUrl":"https://doi.org/10.1556/APhysiol.101.2014.007","url":null,"abstract":"We investigated muscle atrophy, major antioxidant enzymes and lipid peroxidation in the extensor digitorum longus (EDL, predominantly fast fibers) and soleus (predominantly slow fibers) muscle of streptozotocin-diabetic rats. Female Wistar rats were divided into a control (n = 5) and streptozotocin-induced diabetic group (n = 5). Eight weeks after diabetes induction the EDL and soleus muscles were removed and catalase (CAT), glutathione peroxidase (GPX) and superoxide dismutase activity (SOD), and thiobarbituric acid reactive substances (TBARS) levels measured. The CAT activity increased in both the EDL and soleus muscles of the diabetic rats (p < 0.01), whereas the GPX and SOD activities were increased only in the EDL muscle (p < 0.01 and p < 0.05). The TBARS levels were only increased in the EDL muscle of the diabetic rats (p < 0.01). Both muscles showed significant atrophy but the EDL muscle elicited the greatest atrophy. In conclusion, it appears that adaptive responses to oxidative stress were adequate in the soleus muscle, but not in the EDL muscle, of diabetic rats. Thus fast twitch muscle fibers may be more susceptible to oxidative stress than slow twitch muscle fibers and this may contribute to muscle atrophy under diabetic conditions. ","PeriodicalId":7167,"journal":{"name":"Acta physiologica Hungarica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1556/APhysiol.101.2014.007","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32651731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Reproducibility of peak power output during a 10-s cycling maximal effort using different sampling rates. 使用不同采样率在10秒循环最大努力期间峰值功率输出的再现性。

Acta physiologica Hungarica Pub Date : 2014-12-01 DOI: 10.1556/APhysiol.101.2014.009

J P Duarte, Manuel J Coelho-E-Silva, V Severino, D Martinho, L Luz, J R Pereira, R Baptista, J Valente-Dos-Santos, A M Machado-Rodrigues, V Vaz, A Cupido-Dos-Santos, J Martín-Hernández, S P Cumming, R M Malina

{"title":"Reproducibility of peak power output during a 10-s cycling maximal effort using different sampling rates.","authors":"J P Duarte, Manuel J Coelho-E-Silva, V Severino, D Martinho, L Luz, J R Pereira, R Baptista, J Valente-Dos-Santos, A M Machado-Rodrigues, V Vaz, A Cupido-Dos-Santos, J Martín-Hernández, S P Cumming, R M Malina","doi":"10.1556/APhysiol.101.2014.009","DOIUrl":"https://doi.org/10.1556/APhysiol.101.2014.009","url":null,"abstract":"The study was aimed to investigate the reproducibility of performance parameters obtained from 10-s maximal cycling effort against different braking forces in young adult athletes. The sample (n = 48) included male athletes aged 18.9-29.9 years (175.5 ± 6.9 cm, 76.2 ± 10.1 kg). The exercise protocol was performed in a cycle-ergometer against a random braking force (4% to 11% of body mass). Intra-individual variation was examined from repeated tests within one week. Descriptive statistics were computed and differences between sessions were tested using paired t-test. The coefficient of correlation between repeated measures, technical error of measurement (TEM), coefficient of variation and ICC were calculated. Agreement between trials was examined using the Bland-Altman procedure. Mean values of peak power were relatively stable when obtained from sampling rates of 50 Hz and ranged between 1068 watt and 1082 watt (t(47) = 1.149, p = 0.256, ES-r = 0.165) or while corresponding to a sampling rate of 1 Hz (t(47) = 0.742, p = 0.462, ES-r = 0.107). Correlations between repeated measures were high (+0.907, 95% CI: +0.839 to +0.947) and TEM about 59.3 watt (%CV = 5.52%; ICC = 0.951, 95% CI: 0.912 to 0.972). The present study suggests that reproducibility of peak power in male adult athletes tended to be acceptable and within individual error appeared unrelated to braking force. ","PeriodicalId":7167,"journal":{"name":"Acta physiologica Hungarica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1556/APhysiol.101.2014.009","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32651733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Dose dependent effects of serotonergic agents on anxiety. 血清素能剂对焦虑的剂量依赖性作用。

Acta physiologica Hungarica Pub Date : 2014-12-01 DOI: 10.1556/APhysiol.101.2014.4.9

M Kolcsar, Z Gáll, M T Dogaru

{"title":"Dose dependent effects of serotonergic agents on anxiety.","authors":"M Kolcsar, Z Gáll, M T Dogaru","doi":"10.1556/APhysiol.101.2014.4.9","DOIUrl":"https://doi.org/10.1556/APhysiol.101.2014.4.9","url":null,"abstract":"Unlabelled: The role of serotonin in depression and anxiety is still highly controversial. In this experiment the effect of two substances upon anxiety was studied in rats.Methods: Forty adult (45-55 weeks old) male Wistar rats were used to study the following behavioral parameters on elevated plus maze test: open arm and closed arm entries; open arm, closed arm and central square activity duration, open arm preference and total distance traveled.Results: A single injected dose of the antidepressant fluoxetine had no significant effect on animals' activity in the open-arm test, neither in a small dosage (5 mg/kgbw) nor in a higher one (10 mg/kgbw), whereas a single high dose of buspirone significantly impeded the open-arm activity of the rats. None of the substances influenced the general locomotor activity significantly, but the higher doses of buspirone mainly blocked the closed-arm entries and they even decreased the total distance traveled.Conclusion: Acute fluoxetine and buspirone administration influenced the rats' behavior in the elevated plus-maze test in a dose dependent manner. Anxiolytic effects occur after small doses but anxiogenic-like effects were noticed in rodents when higher doses were used.","PeriodicalId":7167,"journal":{"name":"Acta physiologica Hungarica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32927253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Correlations of psycho-physiological parameters influencing the physical fitness of aged women. 影响老年妇女体质的心理生理参数的相关性。

Acta physiologica Hungarica Pub Date : 2014-12-01 DOI: 10.1556/APhysiol.101.2014.005

É Bretz, D É Kóbor-Nyakas, K J Bretz, N Hrehuss, Z Radák, Csaba Nyakas

{"title":"Correlations of psycho-physiological parameters influencing the physical fitness of aged women.","authors":"É Bretz, D É Kóbor-Nyakas, K J Bretz, N Hrehuss, Z Radák, Csaba Nyakas","doi":"10.1556/APhysiol.101.2014.005","DOIUrl":"https://doi.org/10.1556/APhysiol.101.2014.005","url":null,"abstract":"Regular assessment of psycho-physiological parameters in aged subjects helps to clarify physical and mental conditions which are important in the prevention of health-endangering events to assure a healthy aging. Thirty older care female residents consented voluntarily to participate in the study. The somatic and psycho-physiological parameters recorded were handgrip force, disjunctive reaction time, balance control and whole body movement coordination, the electrocardiogram and heart rate variability. Significant correlations were found between (a) reaction time and balance control efficiency (r = -0.567, p < 0.009), (b) reaction time and movement coordination accuracy (r = -0.453, p < 0.045), (c) cardiac state and movement coordination accuracy (r = 0.545, p < 0.016), (d) cardiac stress and cardiac state (r = -0.495, p < 0.031), and (e) cardiac stress and force (r = -0.822, p < 0.045). In conclusion, for the aim of establishing basic battery tests for assessing psycho-physiological condition of physical fitness our results emphasize the importance of systematic physical activity, endurance and strength training supporting muscle force, balance control and whole-body movement coordination, in addition to improving the cardiac stress index level. The strong interrelation among these parameters allows the drawing of a more complete view regarding the health condition of aged individuals. ","PeriodicalId":7167,"journal":{"name":"Acta physiologica Hungarica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32651730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

The slope of the VO2 slow component is associated with exercise intolerance during severe-intensity exercise. 在高强度运动中，VO2慢速组分的斜率与运动不耐受有关。

Acta physiologica Hungarica Pub Date : 2014-12-01 DOI: 10.1556/APhysiol.101.2014.4.13

L F Barbosa, C C Greco, Benedito Sérgio Denadai

{"title":"The slope of the VO2 slow component is associated with exercise intolerance during severe-intensity exercise.","authors":"L F Barbosa, C C Greco, Benedito Sérgio Denadai","doi":"10.1556/APhysiol.101.2014.4.13","DOIUrl":"https://doi.org/10.1556/APhysiol.101.2014.4.13","url":null,"abstract":"The aim of this study was to analyze the relationship between the slope of the VO2 slow component (VO2sc) and exercise tolerance (tlim) during constant-work-rate (CWR) exercise performed within the severe intensity domain. Fifteen active subjects (VO2max = 41.2 ± 5.1 ml.kg-1.min-1) performed the following tests: 1) an incremental test to determine the VO2max and the work rate associated with the VO2max (IVO2max) and; 2) two CWR transitions at 95% of the IVO2max to determine the slope of the VO2 slow component and the tlim. Three tlims were obtained: tlim1 = CWR1; tlim2 = CWR2; and tlim1+2 = (CWR1 + CWR2) / 2. There was no significant difference between the VO2max (3271.7 ± 410.7 mL·min-1) and VO2peak obtained during the CWR tests (CWR1 = 3356.3 ± 448.8 mL·min-1, CWR2 = 3362.2 ± 393.4 mL·min-1, p > 0.05). Significant correlations (p < 0.05) were found among the VO2sc kinetics and tlim1 (r = -0.53), tlim2 (r = -0.49) and tlim1+2 (r = -0.55). Thus, exercise tolerance during CWR performed within the severe intensity domain is partially explained by the slope of the VO2 slow component.","PeriodicalId":7167,"journal":{"name":"Acta physiologica Hungarica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1556/APhysiol.101.2014.4.13","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32928764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Acta physiologica Hungarica Pub Date : 2014-12-01 DOI: 10.1556/APhysiol.101.2014.006

Takashi Abe, J P Loenneke, R S Thiebaud, M Ogawa, N Mitsukawa

{"title":"Age-related site-specific muscle loss in the thigh and zigzag walking performance in older men and women.","authors":"Takashi Abe, J P Loenneke, R S Thiebaud, M Ogawa, N Mitsukawa","doi":"10.1556/APhysiol.101.2014.006","DOIUrl":"https://doi.org/10.1556/APhysiol.101.2014.006","url":null,"abstract":"To investigate the relationships between site-specific muscle loss in the thigh, muscle quality and zigzag walking performance, 40 men and 41 women aged 65-79 years had muscle thickness (MTH) measured by ultrasound at nine sites on the anterior and posterior aspects of the body. Skeletal muscle mass (SM) was estimated from an ultrasound-derived prediction equation. Site-specific thigh sarcopenia was calculated using ultrasound-measured MTH at the anterior/posterior aspects of the thigh (AP-MTH ratio). Zigzag walking time (ZWT) and maximum isometric knee extension (KE) and flexion (KF) torques were measured. Muscle quality (torque/thigh SM) and knee joint strength index (torque/body mass) were calculated. There were no significant correlations between SM index and ZWT. However, AP-MTH ratio was inversely correlated (P < 0.05) to ZWT in men (r = -0.335) and women (r = -0.309). ZWT was also inversely correlated (P < 0.05) to KE-strength index in both sexes (men, r = -0.328; women, r = -0.372). Similarly, ZWT was correlated to KF-strength index (r = -0.497) and muscle quality (r = -0.322) in women, but not in men. After adjusting for age, height and body mass, AP-MTH ratio was inversely correlated to ZWT in men (r = -0.325) and tended to be correlated to ZWT in women (r = -0.263). Zigzag walking performance may be associated with site-specific thigh sarcopenia in older men and women.","PeriodicalId":7167,"journal":{"name":"Acta physiologica Hungarica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1556/APhysiol.101.2014.006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32651732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6