链脲佐菌素-烟酰胺诱导的2型糖尿病大鼠模型(综述)。

Asghar Ghasemi, S Khalifi, S Jedi
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引用次数: 200

摘要

糖尿病是世界五大死亡原因之一,2型糖尿病的发病率高于1型糖尿病。无副作用的糖尿病管理仍然是一个挑战,因此需要研究新的策略。由于人体研究的困难,糖尿病的动物模型是为此目的有用的研究工具,而2型糖尿病的啮齿动物模型是首选。本研究的目的是对链脲佐菌素和烟酰胺诱导的大鼠2型糖尿病最常用的模型之一进行综述,并考虑其在人类糖尿病研究中的优缺点。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Streptozotocin-nicotinamide-induced rat model of type 2 diabetes (review).

Diabetes is one of the five leading causes of death in the world, with type 2 diabetes occurring more frequently than type 1. Management of diabetes without side effects is still a challenge and therefore new strategies need to be examined. Because of difficulties in human research, animal models of diabetes are useful research tools for this purpose and rodent models of type 2 diabetes are the first choice. The aim of this study is an overview on one of the most frequently used models of type 2 diabetes in rat, induced by streptozotocin and nicotinamide, considering its advantages and disadvantages for diabetes research in humans.

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来源期刊
Acta physiologica Hungarica
Acta physiologica Hungarica 医学-生理学
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