肠道激素在食欲调节中的作用(综述)。

G Marić, T Gazibara, I Zaletel, M Labudović Borović, N Tomanović, M Ćirić, Nela Puškaš
{"title":"肠道激素在食欲调节中的作用(综述)。","authors":"G Marić,&nbsp;T Gazibara,&nbsp;I Zaletel,&nbsp;M Labudović Borović,&nbsp;N Tomanović,&nbsp;M Ćirić,&nbsp;Nela Puškaš","doi":"10.1556/APhysiol.101.2014.4.1","DOIUrl":null,"url":null,"abstract":"<p><p>Eating process is an aggregate of complex and different forms of behavior. Its regulation is based on energy homeostasis and appetite control which includes two components: the homeostatic and the hedonistic control. Important signals in appetite regulation are gut-derived hormones. They are produced by enteroendocrine cells in response to nutrient and energy intake, and achieve their effects by influencing brain structures involved in food intake regulation. The key brain structure involved in this process is the hypothalamus. Gut hormones reach the hypothalamus from the circulation or by the vagal nerve via the nucleus of the solitary tract. Among gut peptides, ghrelin is the only orexigenic hormone, leading to an increase in food intake and body weight. All others, such as cholecystokinin, glucagon like peptide-1, oxyntomodulin, peptide tyrosine tyrosine or pancreatic polypeptide, are anorexigenic, leading to decrease in food intake. Also, gut-derived endocannabinoids exert orexigenic effect on appetite. Keeping in mind the growing problem of obesity, the crucial issue when considering gut derived peptides is to understand their mechanisms of acting because of potential role in clinical therapy, and discovering long-lasting gut peptides or their analogues, with no or minimal side effects. </p>","PeriodicalId":7167,"journal":{"name":"Acta physiologica Hungarica","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2014-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1556/APhysiol.101.2014.4.1","citationCount":"38","resultStr":"{\"title\":\"The role of gut hormones in appetite regulation (review).\",\"authors\":\"G Marić,&nbsp;T Gazibara,&nbsp;I Zaletel,&nbsp;M Labudović Borović,&nbsp;N Tomanović,&nbsp;M Ćirić,&nbsp;Nela Puškaš\",\"doi\":\"10.1556/APhysiol.101.2014.4.1\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Eating process is an aggregate of complex and different forms of behavior. Its regulation is based on energy homeostasis and appetite control which includes two components: the homeostatic and the hedonistic control. Important signals in appetite regulation are gut-derived hormones. They are produced by enteroendocrine cells in response to nutrient and energy intake, and achieve their effects by influencing brain structures involved in food intake regulation. The key brain structure involved in this process is the hypothalamus. Gut hormones reach the hypothalamus from the circulation or by the vagal nerve via the nucleus of the solitary tract. Among gut peptides, ghrelin is the only orexigenic hormone, leading to an increase in food intake and body weight. All others, such as cholecystokinin, glucagon like peptide-1, oxyntomodulin, peptide tyrosine tyrosine or pancreatic polypeptide, are anorexigenic, leading to decrease in food intake. Also, gut-derived endocannabinoids exert orexigenic effect on appetite. Keeping in mind the growing problem of obesity, the crucial issue when considering gut derived peptides is to understand their mechanisms of acting because of potential role in clinical therapy, and discovering long-lasting gut peptides or their analogues, with no or minimal side effects. </p>\",\"PeriodicalId\":7167,\"journal\":{\"name\":\"Acta physiologica Hungarica\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2014-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1556/APhysiol.101.2014.4.1\",\"citationCount\":\"38\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Acta physiologica Hungarica\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1556/APhysiol.101.2014.4.1\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta physiologica Hungarica","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1556/APhysiol.101.2014.4.1","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 38

摘要

进食过程是复杂而不同的行为形式的集合。它的调节是基于能量稳态和食欲控制,包括两个组成部分:稳态和享乐控制。调节食欲的重要信号是肠道分泌的激素。它们是由肠内分泌细胞响应营养和能量摄入而产生的,通过影响参与食物摄入调节的大脑结构来实现其作用。参与这一过程的关键大脑结构是下丘脑。肠道激素通过循环或迷走神经经孤立束核到达下丘脑。在肠道肽中,胃饥饿素是唯一的促氧激素,导致食物摄入量增加和体重增加。所有其他的,如胆囊收缩素、胰高血糖素类肽-1、氧调蛋白、肽酪氨酸酪氨酸或胰腺多肽,都是厌氧性的,导致食物摄入量减少。此外,肠源性内源性大麻素对食欲有增氧作用。考虑到日益严重的肥胖问题,考虑肠道衍生肽时的关键问题是了解其作用机制,因为它们在临床治疗中具有潜在作用,并发现持久的肠道肽或其类似物,没有或最小的副作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The role of gut hormones in appetite regulation (review).

Eating process is an aggregate of complex and different forms of behavior. Its regulation is based on energy homeostasis and appetite control which includes two components: the homeostatic and the hedonistic control. Important signals in appetite regulation are gut-derived hormones. They are produced by enteroendocrine cells in response to nutrient and energy intake, and achieve their effects by influencing brain structures involved in food intake regulation. The key brain structure involved in this process is the hypothalamus. Gut hormones reach the hypothalamus from the circulation or by the vagal nerve via the nucleus of the solitary tract. Among gut peptides, ghrelin is the only orexigenic hormone, leading to an increase in food intake and body weight. All others, such as cholecystokinin, glucagon like peptide-1, oxyntomodulin, peptide tyrosine tyrosine or pancreatic polypeptide, are anorexigenic, leading to decrease in food intake. Also, gut-derived endocannabinoids exert orexigenic effect on appetite. Keeping in mind the growing problem of obesity, the crucial issue when considering gut derived peptides is to understand their mechanisms of acting because of potential role in clinical therapy, and discovering long-lasting gut peptides or their analogues, with no or minimal side effects.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Acta physiologica Hungarica
Acta physiologica Hungarica 医学-生理学
自引率
0.00%
发文量
0
审稿时长
6.0 months
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信