Acta physiologica Hungarica最新文献

Noscapine protects OLN-93 oligodendrocytes from ischemia-reperfusion damage: Calcium and nitric oxide involvement. 诺斯平保护OLN-93少突胶质细胞免受缺血再灌注损伤:钙和一氧化氮的参与。

Acta physiologica Hungarica Pub Date : 2015-12-21 DOI: 10.1556/036.102.2015.4.2

S. Nadjafi, S. Ebrahimi, N. Rahbar‐Roshandel

{"title":"Noscapine protects OLN-93 oligodendrocytes from ischemia-reperfusion damage: Calcium and nitric oxide involvement.","authors":"S. Nadjafi, S. Ebrahimi, N. Rahbar‐Roshandel","doi":"10.1556/036.102.2015.4.2","DOIUrl":"https://doi.org/10.1556/036.102.2015.4.2","url":null,"abstract":"This study was carried out to evaluate the effects of noscapine, a benzylisoquinoline alkaloid from opium poppy, on oligodendrocyte during ischemia/reperfusion-induced excitotoxic injury. Changes in intracellular calcium levels due to chemical ischemia and nitric oxide (NO) production during ischemia/reperfusion were evaluated as the hallmarks of ischemia-derived excitotoxic event. OLN-93 cell line (a permanent immature rat oligodendrocyte) was used as a model of oligodendrocyte. 30- or 60-minute-oxygen-glucose deprivation/24 hours reperfusion were used to induce excitotoxicity. MTT (3-[4,5-Dimethylthiazol-2-yl]-2,5-diphenyl-tetrazolium bromide) assay was used to evaluate cell viability. Ratiometric fluorescence microscopy using Ca(2+)-sensitive indicator Fura-2/AM was utilized to assess intracellular calcium levels. NO production was evaluated by Griess method. Noscapine (4 μM) significantly attenuated intracellular Ca(2+) elevation (P < 0.001). Also, noscapine significantly decreased NO production during a 30-minute oxygen-glucose deprivation/reperfusion (P < 0.01). The inhibitory effect of noscapine (4 μM) on intracellular Ca(2+) was greater than ionotropic glutamate receptors antagonists. Noscapine is protective against ischemia/reperfusion-induced excitotoxic injury in OLN-93 oligodendrocyte. This protective effect seems to be related to attenuation of intracellular Ca(2+) overload and NO production.","PeriodicalId":7167,"journal":{"name":"Acta physiologica Hungarica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1556/036.102.2015.4.2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67628096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Polar OwnIndex is not a reliable indicator of aerobic training status. Polar OwnIndex不是有氧训练状态的可靠指标。

Acta physiologica Hungarica Pub Date : 2015-12-21 DOI: 10.1556/036.102.2015.4.9

F. Köteles, Z. Dömötör, T. Berkes, R. Szemerszky

{"title":"Polar OwnIndex is not a reliable indicator of aerobic training status.","authors":"F. Köteles, Z. Dömötör, T. Berkes, R. Szemerszky","doi":"10.1556/036.102.2015.4.9","DOIUrl":"https://doi.org/10.1556/036.102.2015.4.9","url":null,"abstract":"Polar watches with heart rate monitoring function have become popular among recreational and professional athletes. In addition to monitoring functions, they calculate a specific index called OwnIndex which is claimed to measure aerobic training status. The current research attempted to shed light on the factors determining the OwnIndex. In Study 1, OwnIndex calculated by the RS-400 Polar watch was estimated using anthropometric (gender, age, height, weight), cardiovascular (resting HR, RMSSD), and exercise-related (maximal oxygen uptake, self-reported physical activity) data of 45 young adults. In Study 2, the OwnIndex was measured in 21 young adults twice, first with self-reported physical activity set to the lowest, then to the highest value. In the regression analysis (Study 1), the only significant predictor of OwnIndex was self-reported physical activity (R² = 0.883; β = 0.915, p < 0.001). A significant difference with a large effect size (t(20) = -16.657, p <0.001, d = 3.635) and no significant correlation (r = -0.32; p = 0.155) were found between the OwnIndices calculated with different levels of activity in Study 2. As anthropometric and cardiac variables play a practically negligible role in the calculation of the OwnIndex, it cannot be considered an appropriate measure of aerobic fitness.","PeriodicalId":7167,"journal":{"name":"Acta physiologica Hungarica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1556/036.102.2015.4.9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67628299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Lactation protects against myocardial ischemia-reperfusion injury in rats. 哺乳对大鼠心肌缺血再灌注损伤的保护作用。

Acta physiologica Hungarica Pub Date : 2015-12-21 DOI: 10.1556/036.102.2015.4.4

S. Shekarforoush, F. Safari

{"title":"Lactation protects against myocardial ischemia-reperfusion injury in rats.","authors":"S. Shekarforoush, F. Safari","doi":"10.1556/036.102.2015.4.4","DOIUrl":"https://doi.org/10.1556/036.102.2015.4.4","url":null,"abstract":"Some researchers have reported that lactation is effective in reducing cardiovascular disease risk factors. The purpose of this study was to investigate whether lactation may improve intrinsic tolerance against ischemia reperfusion (IR) injury. The rats were randomly divided into two groups (n = 8 in each group). In the lactation (Lact) group, the surgery was performed on postpartum day 21 (at the end of lactation period) and the results were compared with those of virgin female rats (control group). Cardiac IR injury was induced by means of left anterior descending coronary artery occlusion for 30 min followed by reperfusion for 120 min. Infarct size was measured using the staining agent 2,3,5-triphenyltetrazolium chloride. At the end of the experiment, Mean arterial pressure in the control group was significantly lower than that in the Lact group. Myocardial infarct size was significantly reduced in the Lact group (23 ± 3% vs. 45 ± 8%, p < 0.05 in the control group). Lactation reduced the extent of myocardial injury induced by ischemia and reperfusion. So, lactation may increase cardiac tolerance to ischemic injury.","PeriodicalId":7167,"journal":{"name":"Acta physiologica Hungarica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1556/036.102.2015.4.4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67627794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

ACE and ACTN3 genes polymorphisms among female Hungarian athletes in the aspect of sport disciplines. 匈牙利女运动员ACE和ACTN3基因在运动学科方面的多态性

Acta physiologica Hungarica Pub Date : 2015-12-21 DOI: 10.1556/036.102.2015.4.12

E. Bosnyák, E. Trájer, A. Udvardy, Z. Komka, A. Protzner, T. Kováts, I. Györe, M. Tóth, J. Pucsok, M. Szmodis

{"title":"ACE and ACTN3 genes polymorphisms among female Hungarian athletes in the aspect of sport disciplines.","authors":"E. Bosnyák, E. Trájer, A. Udvardy, Z. Komka, A. Protzner, T. Kováts, I. Györe, M. Tóth, J. Pucsok, M. Szmodis","doi":"10.1556/036.102.2015.4.12","DOIUrl":"https://doi.org/10.1556/036.102.2015.4.12","url":null,"abstract":"The aim of the study was to determine the importance of two sport-associated gene polymorphisms, alpha-actinin-3 R577X (ACTN3) and angiotensin-converting enzyme I/D (ACE), among Hungarian athletes in different sports. The examination was carried out only on women (n = 100). Sport-specific groups were formed in order to guarantee the most homogeneous clusters. Human genomic DNA was isolated from blood, and genotyping was performed by polymerase chain reaction. To measure the differences between the participating groups, Chi-squared test was performed using Statistica 9.0 for Windows® (significance level: p < 0.05). In comparing the ACE I/D allele frequencies, significant difference was detected between water polo (I = 61.11%; D = 38.89%) and combat sports (I = 35.71%, D = 64.29%) athletes (p < 0.03). There was no statistical difference when ACE I/D alleles in combat sports and kayaking/rowing (p > 0.05) were compared. A similarity was detectable in the I allele frequencies of the water polo (61.11%) and kayaking/rowing (56.67%) groups. The ACTN3 R/X polymorphism showed no differences in comparison with the sport groups. R allele frequencies were higher in every group compared to the X allele. The potential significance of the ACE I allele in sports of an aerobic nature was not clearly confirmed among Hungarian athletes.","PeriodicalId":7167,"journal":{"name":"Acta physiologica Hungarica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1556/036.102.2015.4.12","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67627961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Low dietary zinc intake attenuates the efficacy of 2,4-thiazolidinedione on reducing hyperglycemia in db/db mice (Short communication). 低锌摄入量降低2,4-噻唑烷二酮降低db/db小鼠高血糖的功效(短通讯)。

Acta physiologica Hungarica Pub Date : 2015-12-21 DOI: 10.1556/036.102.2015.4.13

Y.-M. Song, H. Hsu, M.-D. Chen

引用次数: 0

Correlation between erythropoietin serum levels and erythrocyte susceptibility to lipid peroxidation in elderly with type 2 diabetes. 老年2型糖尿病患者血清促红细胞生成素水平与红细胞脂质过氧化易感性的相关性

Acta physiologica Hungarica Pub Date : 2015-12-21 DOI: 10.1556/036.102.2015.4.7

D. Gradinaru, D. Margină, M. Ilie, C. Borșa, C. Ionescu, G. Prada

{"title":"Correlation between erythropoietin serum levels and erythrocyte susceptibility to lipid peroxidation in elderly with type 2 diabetes.","authors":"D. Gradinaru, D. Margină, M. Ilie, C. Borșa, C. Ionescu, G. Prada","doi":"10.1556/036.102.2015.4.7","DOIUrl":"https://doi.org/10.1556/036.102.2015.4.7","url":null,"abstract":"Erythropoietin (EPO), a key hormone involved in red blood cell formation has been recently acknowledged for its pleiotropic actions and protective role in ageing and various pathological conditions concurrent with oxidative stress, vascular diseases and metabolic abnormalities such as diabetes mellitus. The aim of the study was to evaluate the relationship between circulating erythropoietin levels and oxidative stress biomarkers, in elderly with type 2 diabetes (T2DM). The study was carried out in 67 subjects with T2DM (69 ± 5 years; n = 37) without anemia, and aged-matched controls (70 ± 6 years; n = 30). EPO serum levels, erythrocyte susceptibility to lipid peroxidation (ESP) and total antioxidant capacity (TAC) were evaluated. Lower EPO levels (p < 0.01) and higher ESP values (p < 0.001) were found in T2DM group, compared to healthy subjects. EPO levels showed significant negative associations with ESP, both in T2DM subjects (r = -0.565; p < 0.001) and in all study population (r = -0,600; p < 0,001; n = 67). In conclusion, we provide new data regarding the cytoprotective effect of EPO exerted at systemic level on erythrocyte membrane, in the particular state of impaired glucose metabolism associated with oxidative stress, in the elderly.","PeriodicalId":7167,"journal":{"name":"Acta physiologica Hungarica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1556/036.102.2015.4.7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67628430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Comparative animal study of the antinociceptive efficacy of lamotrigine and gabapentin for the management of pain. 拉莫三嗪和加巴喷丁治疗疼痛的动物对照研究。

Acta physiologica Hungarica Pub Date : 2015-12-21 DOI: 10.1556/036.102.2015.4.3

A. Szabó, I. Bocșan, Ş. Suciu, A. Buzoianu

{"title":"Comparative animal study of the antinociceptive efficacy of lamotrigine and gabapentin for the management of pain.","authors":"A. Szabó, I. Bocșan, Ş. Suciu, A. Buzoianu","doi":"10.1556/036.102.2015.4.3","DOIUrl":"https://doi.org/10.1556/036.102.2015.4.3","url":null,"abstract":"UNLABELLED\u0000Pain relief using drugs with high efficacy provides significant improvement in the patients' lives. Drugs like lamotrigine (LTG) and gabapentin (GBP) have the ability to overcome the symptoms of neuropathic pain.\u0000\u0000\u0000AIM\u0000The present study offers a comparative analysis of LTG and GBP efficacy in a rat model of nociceptive pain after single administration.\u0000\u0000\u0000METHOD\u0000Sixty-three Wistar-Bratislava rats randomized into 7 groups were included: a control group treated with saline solution and 6 groups treated with different doses of LTG and GBP. Nociceptive responses to thermal and mechanical stimulations were evaluated before and after drug administration, at different time intervals, using paw pressure and hot plate tests. The obtained data were statistically analyzed, with significance at p value < 0.05.\u0000\u0000\u0000RESULTS\u0000LTG 100 mg/kg and 50 mg/kg presented a significant analgesic effect in both mechanical and thermal tests, 1 and 2 hours after administration. GBP 100 mg/kg increased latency time in hot plate test. The effect of both anticonvulsant drugs occurred rapidly after administration, but had a short duration.\u0000\u0000\u0000CONCLUSIONS\u0000LTG and GBP had an analgesic effect in a single dose administration. The effect of LTG was more evident since it was observed in both tests. Their effect was dose dependent.","PeriodicalId":7167,"journal":{"name":"Acta physiologica Hungarica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1556/036.102.2015.4.3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67627782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

The acute muscular effects of cycling with and without different degrees of blood flow restriction. 有和没有不同程度的血流限制的骑车的急性肌肉效应。

Acta physiologica Hungarica Pub Date : 2015-12-21 DOI: 10.1556/036.102.2015.4.10

D. Kim, J. Loenneke, R. Thiebaud, T. Abe, M. Bemben

{"title":"The acute muscular effects of cycling with and without different degrees of blood flow restriction.","authors":"D. Kim, J. Loenneke, R. Thiebaud, T. Abe, M. Bemben","doi":"10.1556/036.102.2015.4.10","DOIUrl":"https://doi.org/10.1556/036.102.2015.4.10","url":null,"abstract":"The aim was to compare the acute effects of work matched high intensity (75% peak aerobic capacity) aerobic exercise to low intensity (40% peak aerobic capacity) aerobic exercise with different degrees of blood flow restriction (BFR) [40% estimated arterial occlusion (40 BFR) and 60% estimated arterial occlusion (60 BFR)] on variables previously hypothesized to be important for muscle adaptation. There were no meaningful changes in torque. Anterior thigh muscle thickness was increased from baseline with high intensity cycling and 40 BFR (~2 mm increase, p ≤ 0.008). A significant increase in lactate occurred in all exercise conditions but was greatest with high intensity cycling (~5.4 mmol/L increase). Muscle activation was significantly higher with high intensity cycling compared to low intensity cycling with BFR, regardless of pressure (~25% vs. ~12% MVC). Mean power frequency was not different between conditions but did increase from the first 5 minutes of exercise to the last 5 minutes (93% vs. 101%, p < 0.001). Ratings of perceived exertion (RPE) were higher with high intensity cycling but discomfort was similar between conditions. We wish to suggest that high intensity cycling produces greater muscular stress than that observed with work matched low intensity cycling in combination with BFR.","PeriodicalId":7167,"journal":{"name":"Acta physiologica Hungarica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1556/036.102.2015.4.10","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67627917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16

Preventive effects of garlic (Allium sativum) on oxidative stress and histopathology of cardiac tissue in streptozotocin-induced diabetic rats. 大蒜对链脲佐菌素诱导的糖尿病大鼠心脏组织氧化应激及组织病理学的预防作用。

Acta physiologica Hungarica Pub Date : 2015-12-21 DOI: 10.1556/036.102.2015.4.5

Roya Naderi, G. Mohaddes, M. Mohammadi, A. Alihemmati, R. Badalzadeh, R. Ghaznavi, R. Ghyasi, S. Mohammadi

{"title":"Preventive effects of garlic (Allium sativum) on oxidative stress and histopathology of cardiac tissue in streptozotocin-induced diabetic rats.","authors":"Roya Naderi, G. Mohaddes, M. Mohammadi, A. Alihemmati, R. Badalzadeh, R. Ghaznavi, R. Ghyasi, S. Mohammadi","doi":"10.1556/036.102.2015.4.5","DOIUrl":"https://doi.org/10.1556/036.102.2015.4.5","url":null,"abstract":"Since some complications of diabetes mellitus may be caused or exacerbated by an oxidative stress, the protective effects of garlic (Allium sativum) were investigated in the blood and heart of streptozotocin-induced diabetic rats. Twenty-eight male Wistar rats were randomly divided into four groups: control, garlic, diabetic, and diabetic+garlic. Diabetes was induced by intraperitoneal (i.p.) injection of streptozotocin (50 mg/kg) in male rats. Rats were fed with raw fresh garlic homogenate (250 mg/kg) six days a week by gavage for a period of 6 weeks. At the end of the 6th week blood samples and heart tissues were collected and used for determination of glutathione peroxidase (GPx), superoxide dismutase (SOD), catalase (CAT), malondialdehyde (MDA) and histological evaluation. Induction of diabetes increased MDA levels in blood and homogenates of heart. In diabetic rats treated with garlic, MDA levels decreased in blood and heart homogenates. Treatment of diabetic rats with garlic increased SOD, GPX and CAT in blood and heart homogenates. Histopathological finding of the myocardial tissue confirmed a protective role for garlic in diabetic rats. Thus, the present study reveals that garlic may effectively modulate antioxidants status in the blood and heart of streptozotocin induced-diabetic rats.","PeriodicalId":7167,"journal":{"name":"Acta physiologica Hungarica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1556/036.102.2015.4.5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67627936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 22

Effect of 6 weeks of whole body vibration training on total and segmental body composition in healthy young adults. 6周全身振动训练对健康青年整体和部分身体组成的影响。

Acta physiologica Hungarica Pub Date : 2015-12-21 DOI: 10.1556/036.102.2015.4.11

J. Rubio-Arias, Paula Esteban, F. Martínez, D. Ramos-Campo, Susana Mendizábal, D. Berdejo-del-Fresno, J. Jiménez-Díaz

{"title":"Effect of 6 weeks of whole body vibration training on total and segmental body composition in healthy young adults.","authors":"J. Rubio-Arias, Paula Esteban, F. Martínez, D. Ramos-Campo, Susana Mendizábal, D. Berdejo-del-Fresno, J. Jiménez-Díaz","doi":"10.1556/036.102.2015.4.11","DOIUrl":"https://doi.org/10.1556/036.102.2015.4.11","url":null,"abstract":"The applied use of new technologies to enhance performance and improve health has been increasing. Initially, whole body vibration training (WBVT) was used as system to improve elite athlete performance. However, this is also used to improve body composition, especially there is a great attention on the effectiveness of WBVT to reduce fat and body weight, with a potential increase in muscle tissue. The aim of this study was to investigate the effects of a 6-week vibration-training program on total and segmental body composition in a group of physically healthy participants. The final study sample included 64 healthy young adults. Subjects were randomly allocated into the control group (CG: n = 26; 16 males and 10 females) and the experimental group (EGWBVT: n = 38; 19 males and 19 females). The program lasted six weeks with a frequency of three sessions per week and each session varied in intensity. There were not found statistically significant differences in any of the body composition variables analysed. This study suggests that a six-week vibration-training program with an increasing intensity (7.2 g-32.6 g) in healthy young adults that are not overweight did not alter total and segmental body composition.","PeriodicalId":7167,"journal":{"name":"Acta physiologica Hungarica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1556/036.102.2015.4.11","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67627950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6