大蒜对链脲佐菌素诱导的糖尿病大鼠心脏组织氧化应激及组织病理学的预防作用。

Roya Naderi, G. Mohaddes, M. Mohammadi, A. Alihemmati, R. Badalzadeh, R. Ghaznavi, R. Ghyasi, S. Mohammadi
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引用次数: 22

摘要

由于氧化应激可引起或加重糖尿病的一些并发症,我们研究了大蒜在链脲佐菌素诱导的糖尿病大鼠血液和心脏中的保护作用。雄性Wistar大鼠28只,随机分为对照组、大蒜组、糖尿病组、糖尿病+大蒜组。研究了雄性大鼠腹腔注射链脲佐菌素(50 mg/kg)诱导糖尿病的方法。大鼠每周6天灌食新鲜大蒜匀浆(250 mg/kg),连续6周。6周末采集大鼠血液和心脏组织,测定谷胱甘肽过氧化物酶(GPx)、超氧化物歧化酶(SOD)、过氧化氢酶(CAT)、丙二醛(MDA)含量,并进行组织学评价。糖尿病的诱导增加了血液和心脏匀浆中的丙二醛水平。在用大蒜治疗的糖尿病大鼠中,血液和心脏匀浆中的丙二醛水平降低。大蒜对糖尿病大鼠血液及心脏匀浆中SOD、GPX、CAT含量均有升高。心肌组织病理学结果证实了大蒜对糖尿病大鼠的保护作用。因此,本研究表明大蒜可以有效调节链脲佐菌素诱导的糖尿病大鼠血液和心脏中的抗氧化剂状态。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Preventive effects of garlic (Allium sativum) on oxidative stress and histopathology of cardiac tissue in streptozotocin-induced diabetic rats.
Since some complications of diabetes mellitus may be caused or exacerbated by an oxidative stress, the protective effects of garlic (Allium sativum) were investigated in the blood and heart of streptozotocin-induced diabetic rats. Twenty-eight male Wistar rats were randomly divided into four groups: control, garlic, diabetic, and diabetic+garlic. Diabetes was induced by intraperitoneal (i.p.) injection of streptozotocin (50 mg/kg) in male rats. Rats were fed with raw fresh garlic homogenate (250 mg/kg) six days a week by gavage for a period of 6 weeks. At the end of the 6th week blood samples and heart tissues were collected and used for determination of glutathione peroxidase (GPx), superoxide dismutase (SOD), catalase (CAT), malondialdehyde (MDA) and histological evaluation. Induction of diabetes increased MDA levels in blood and homogenates of heart. In diabetic rats treated with garlic, MDA levels decreased in blood and heart homogenates. Treatment of diabetic rats with garlic increased SOD, GPX and CAT in blood and heart homogenates. Histopathological finding of the myocardial tissue confirmed a protective role for garlic in diabetic rats. Thus, the present study reveals that garlic may effectively modulate antioxidants status in the blood and heart of streptozotocin induced-diabetic rats.
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来源期刊
Acta physiologica Hungarica
Acta physiologica Hungarica 医学-生理学
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