Dose dependent effects of serotonergic agents on anxiety.

Acta physiologica Hungarica Pub Date : 2014-12-01 DOI:10.1556/APhysiol.101.2014.4.9

M Kolcsar, Z Gáll, M T Dogaru

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引用次数: 7

Abstract

Unlabelled: The role of serotonin in depression and anxiety is still highly controversial. In this experiment the effect of two substances upon anxiety was studied in rats.

Methods: Forty adult (45-55 weeks old) male Wistar rats were used to study the following behavioral parameters on elevated plus maze test: open arm and closed arm entries; open arm, closed arm and central square activity duration, open arm preference and total distance traveled.

Results: A single injected dose of the antidepressant fluoxetine had no significant effect on animals' activity in the open-arm test, neither in a small dosage (5 mg/kgbw) nor in a higher one (10 mg/kgbw), whereas a single high dose of buspirone significantly impeded the open-arm activity of the rats. None of the substances influenced the general locomotor activity significantly, but the higher doses of buspirone mainly blocked the closed-arm entries and they even decreased the total distance traveled.

Conclusion: Acute fluoxetine and buspirone administration influenced the rats' behavior in the elevated plus-maze test in a dose dependent manner. Anxiolytic effects occur after small doses but anxiogenic-like effects were noticed in rodents when higher doses were used.

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血清素能剂对焦虑的剂量依赖性作用。

未标注:血清素在抑郁和焦虑中的作用仍然存在很大争议。本实验研究了两种物质对大鼠焦虑的影响。方法:选取40只成年雄性Wistar大鼠(45 ~ 55周龄)，研究其在高架+迷宫实验中的行为参数:张开臂和闭合臂进入;张开手臂，闭合手臂和中心广场活动时间，张开手臂偏好和总距离。结果:单次注射抗抑郁药氟西汀对动物在开臂试验中的活性没有显著影响，无论是小剂量(5 mg/kgbw)还是高剂量(10 mg/kgbw)，而单次高剂量丁螺环酮显著阻碍了大鼠的开臂活性。这些物质对一般运动活动的影响都不显著，但高剂量丁螺环酮主要阻断了闭臂入口，甚至减少了行走的总距离。结论:氟西汀和丁螺环酮急性给药对大鼠升高+迷宫实验行为具有剂量依赖性。小剂量后出现抗焦虑作用，但高剂量时在啮齿动物中出现类似焦虑的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta physiologica Hungarica 医学-生理学

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审稿时长

6.0 months