Addictive behaviors最新文献

{"title":"A prospective longitudinal analysis of opioid and stimulant use in American Indian and First Nations communities","authors":"Melissa Walls ,&nbsp;Dane Hautala ,&nbsp;Kelley J. Sittner ,&nbsp;Andrea Medley ,&nbsp;Ravyn Gibbs","doi":"10.1016/j.addbeh.2025.108456","DOIUrl":"10.1016/j.addbeh.2025.108456","url":null,"abstract":"<div><div>We describe stages of opioid and psychostimulant use (i.e., onset of use and progression to dependence) over the early life course within Indigenous communities where drug overdose impacts have been most extreme. This community-based participatory research includes 9 waves of survey data collected prior to and during the unfolding of the overdose epidemic in North America (2002–2017) on/near 8 distinct American Indian reservations or First Nation reserves. Substance use (psychostimulants, prescription pain pill misuse, and heroin) was assessed via structured diagnostic interviews. Discrete time survival analysis was used to estimate hazard rates for substance use initiation, dependence, and transitions from first use to dependence. Cumulative probability of lifetime use by age 27 years was 29 % for psychostimulants (e.g., methamphetamine), 35 % for prescription pain pills, and 22 % for heroin. New cases of prescription pain pill misuse peaked in the early 2000s, followed by rapid increases in psychostimulant and heroin use starting around 2008. We found that 37 %–51 % of drug users eventually met criteria for dependence, and progression from use to dependence was typically within one year for this sub-group. Socio-demographic factors were differentially associated with probability of substance use, depending on drug type. Findings highlight the critical need for culturally grounded prevention, harm reduction, and treatment strategies to address substance use inequities in Indigenous communities.</div></div>","PeriodicalId":7155,"journal":{"name":"Addictive behaviors","volume":"171 ","pages":"Article 108456"},"PeriodicalIF":3.6,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144889753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A multimethod examination of impulsivity and its association with gamma-aminobutyric acid (GABA), glutamate, and other neurometabolite levels in youth who do and do not use alcohol","authors":"Anna M. Porter ,&nbsp;Anna E. Kirkland ,&nbsp;Pamela L. Ferguson ,&nbsp;Brittney D. Browning ,&nbsp;Louise Mewton ,&nbsp;Lindsay M. Squeglia","doi":"10.1016/j.addbeh.2025.108452","DOIUrl":"10.1016/j.addbeh.2025.108452","url":null,"abstract":"<div><h3>Background</h3><div>Minimal research has examined neurochemical alterations underlying the relationship between impulsivity and alcohol use in youth. We examined associations between multimethod impulsivity measures and neurometabolite levels in youth who use alcohol compared to controls.</div></div><div><h3>Methods</h3><div>Using baseline data from two clinical trials with youth (age 16–22) who used alcohol (<em>N</em> = 82, 65 % female) and healthy controls (<em>N</em> = 22, 50 % female), we measured levels of glutamate-related metabolites (glutamate [Glu] and glutamate + glutamine [Glx]) and GABA, and other exploratory neurometabolites (glutathione, total N-acetylaspartate [tNAA], total choline-containing metabolites [tCho], and <em>myo</em>-inositol), in the dorsal anterior cingulate cortex using proton magnetic resonance spectroscopy. Trait impulsivity was measured via the Barratt Impulsiveness Scale (BIS-11), and behavioral impulsivity was measured via the D-KEFS Color-Word Interference Test and the Cash Choice Task.</div></div><div><h3>Results</h3><div>Compared to controls, youth who use alcohol had higher impulsivity on the BIS-11 attentional, non-planning, and motor subscales. There were no significant interactions between group (alcohol, control) and impulsivity variables in predicting Glu, Glx, or GABA levels. In exploratory analyses, better inhibitory control and lower non-planning impulsivity in youth who use alcohol was associated with higher glutathione levels; however, the opposite relationship was found for controls.</div></div><div><h3>Conclusions</h3><div>These preliminary findings suggest trait, but not behavioral, impulsivity is significantly associated with alcohol use in youth. Glutathione may have differential associations with distinct impulsivity constructs in youth who use alcohol compared to controls. Further research is needed to corroborate these associations and their implications for understanding the neurochemical basis of impulsivity and alcohol use in youth.</div></div>","PeriodicalId":7155,"journal":{"name":"Addictive behaviors","volume":"171 ","pages":"Article 108452"},"PeriodicalIF":3.6,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144879945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hallucinogenic drug use and depression, psychological distress and suicidality among disabled adults in the US","authors":"Samantha M. Ross-Cypcar ,&nbsp;Justin A. Haegele ,&nbsp;Jeanette M. Garcia","doi":"10.1016/j.addbeh.2025.108454","DOIUrl":"10.1016/j.addbeh.2025.108454","url":null,"abstract":"<div><div>While recent nationally representative studies have evaluated the association between hallucinogen use and mental health events, little is known about these associations among disabled adults. Our primary aim was to use national data from the 2021, 2022, and 2023 National Survey on Drug Use and Health (NSDUH) to determine how past-year use of specific hallucinogens is associated with disabled adults reporting past-year SPD, MDE, and suicidality. A subsample of adults ages 18 to 50 years old (n = 107,781) was drawn from the 2021–2023 combined NSDUH dataset for this analysis. Descriptive analyzes generated weighted prevalence estimates for hallucinogen use and mental health outcomes, and crude odds ratios for experiencing a mental health outcome among past year hallucinogen users were estimated in comparison to non-hallucinogen users, stratified by disability status. The weighted prevalence of hallucinogen use in the past year was significantly higher among disabled (8.37 %) compared to nondisabled adults (4.86 %; p &lt; 0.0001). Among disabled adults who used hallucinogens in the past year, 48.87 % reported a major depressive episode, 68.93 % reported a serious psychological distress indicator, and 39.65 % reported suicidal thinking, planning, or attempt. About 4 % of disabled adults reported that hallucinogen use in the past year worsened or caused emotional or mental health problems. Findings provide evidence of differences to the degree that disabled adults are using hallucinogens in comparison to nondisabled adults using a nationally representative sample. These findings provide new data to help understand hallucinogen use in relation to mental health events among this population.</div></div>","PeriodicalId":7155,"journal":{"name":"Addictive behaviors","volume":"170 ","pages":"Article 108454"},"PeriodicalIF":3.6,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144829753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Warning label messages about the cancer risk associated with alcohol: Effects of causal language","authors":"Jackelyn B. Payne ,&nbsp;Jacob A. Rohde ,&nbsp;Carlos O. Garrido ,&nbsp;Emma Jesch ,&nbsp;William M.P. Klein ,&nbsp;David Berrigan ,&nbsp;Richard P. Moser ,&nbsp;Paul K.J. Han","doi":"10.1016/j.addbeh.2025.108453","DOIUrl":"10.1016/j.addbeh.2025.108453","url":null,"abstract":"<div><h3>Objectives</h3><div>To investigate the effects of causal language in warning messages about alcohol and cancer risk.</div></div><div><h3>Methods</h3><div>In an online factorial experiment conducted in 2023, 799 US adults were randomly assigned to view one of eight messages employing different combinations of causal verbs (e.g., “causes”) and modal verbs (e.g., “may”) to describe the alcohol-cancer relationship. Analyses compared the effects of causal language on perceptions of causal certainty, alcohol-related cancer risk, message credibility, message reactance, and alcohol consumption intentions.</div></div><div><h3>Results</h3><div>Causal language did not affect perceived causal certainty, perceived cancer risk, or alcohol consumption intentions, but decreased perceived message credibility and increased reactance. Modal language decreased perceived causal certainty and cancer risk, increased perceived credibility of messages containing “causes,” and decreased reactance to all messages.</div></div><div><h3>Conclusions</h3><div>Causal language in alcohol warning messages has complex, countervailing effects: higher-certainty causal verbs do not increase risk perceptions but increase negative reactance, whereas higher-uncertainty modal verbs decrease risk perceptions but also reactance. These results suggest causal language may pose potential tradeoffs for risk communication efforts, raising the need for caution and more research to understand its effects.</div></div>","PeriodicalId":7155,"journal":{"name":"Addictive behaviors","volume":"170 ","pages":"Article 108453"},"PeriodicalIF":3.6,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144867250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and validation of the time perspective scale of perceived benefits and harms of internet gaming among adolescents in China","authors":"Siman Li ,&nbsp;Mengni Du ,&nbsp;Xin Yi ,&nbsp;Hongsheng Yang ,&nbsp;Liping Yang ,&nbsp;Hongtao Shao ,&nbsp;Anise M.S. Wu ,&nbsp;Phoenix K.H. Mo ,&nbsp;Dong-wu Xu ,&nbsp;Pinpin Zheng ,&nbsp;Deborah Baofeng Wang ,&nbsp;Joseph T.F. Lau ,&nbsp;Yanqiu Yu","doi":"10.1016/j.addbeh.2025.108449","DOIUrl":"10.1016/j.addbeh.2025.108449","url":null,"abstract":"<div><h3>Background and aims</h3><div>Gaming-specific maladaptive cognitions were critical determinants of internet gaming disorder (IGD). This study was novel to develop and validate the Time Perspective Scale of Perceived Benefits and Harms of Internet Gaming (TPS-PBHIG) by integrating the concepts of present- and future-oriented time perspectives, perceived benefits, and perceived harms of internet gaming.</div></div><div><h3>Methods</h3><div>Item generation was conducted by using both inductive (focus group interviews among adolescents) and deductive (comprehensive literature review) approaches. Content validity was examined by both item-level and scale-level indicators. Comprehensive psychometric properties were then examined in a validation sample of 1,000 middle school students in Taizhou, Rui’an, and Yiwu, China, with an anonymous, structured survey (March/April 2024).</div></div><div><h3>Results</h3><div>The TPS-PBHIG included 21 items, demonstrating satisfactory content validity regarding clarity, relevance, and importance. In the validation sample, both exploratory and confirmatory factor analyses confirmed a 4-factor model (perceived immediate personal and social benefits, perceived future personal and social benefits, perceived personal harms, and perceived social harms). The scale/subscales of TPS-PBHIG in general showed satisfactory psychometric properties, including the absence of ceiling/floor effects, internal consistency, convergent validity, and divergent validity. Perceived immediate/future benefits were positively correlated with both IGD and gaming time, while perceived personal/social harms were significantly correlated with IGD, but not gaming time.</div></div><div><h3>Discussion and conclusions</h3><div>The TPS-PBHIG developed in this study provides a reliable and valid tool to assess perceived benefits and harms of internet gaming in both present-oriented and future-oriented time perspectives among Chinese adolescents.</div></div>","PeriodicalId":7155,"journal":{"name":"Addictive behaviors","volume":"170 ","pages":"Article 108449"},"PeriodicalIF":3.6,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144829754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The gateway effect of cigarette, e-cigarette, cigar, and alcohol use vs. Cannabis use","authors":"Yan Wang ,&nbsp;Patricia A. Cavazos-Rehg ,&nbsp;Yuxian Cui ,&nbsp;Morgan Speer ,&nbsp;Cassidy R. LoParco ,&nbsp;Darcey M. McCready ,&nbsp;Y. Tony Yang ,&nbsp;Carla J. Berg","doi":"10.1016/j.addbeh.2025.108451","DOIUrl":"10.1016/j.addbeh.2025.108451","url":null,"abstract":"<div><h3>Background</h3><div>While the gateway hypothesis suggests that using tobacco and alcohol increases likelihood of initiating cannabis, cannabis use may precede and increase other substance use. We examined gateway effects of cigarettes, e-cigarettes, cigars, and alcohol on cannabis use, and reverse associations.</div></div><div><h3>Methods</h3><div>We analyzed 2023 survey data from 4,031 US young adults (M_age = 26.29, 60 % female, 19 % Hispanic, 14 % Black, 14 % Asian). Discrete-time survival analysis assessed hazards of initiating cannabis based on self-reported age of initiating other substances, and vice versa. Time(age)-lagged predictors indicated whether participants had initiated the other substances by one year younger, accounting for sociodemographics; state non-medical cannabis laws; lifetime depression, anxiety, or attention deficit disorder [ADD]) diagnoses; and personality characteristics.</div></div><div><h3>Results</h3><div>Lifetime use was: 68 % for cannabis, 45 % cigarettes, 49 % e-cigarettes, 31 % cigars, and 85 % alcohol. Past-year cigarette, e-cigarette, cigar, and alcohol initiation increased hazards of initiating cannabis (adjusted Hazard Ratio, aHR = 3.78, 95 %CI = 3.39–4.22; aHR = 2.17, 95 %CI = 1.86–2.53; aHR = 2.90, 95 %CI = 2.45–3.43; aHR = 3.41, 95 %CI = 3.11–3.75, respectively). Past-year cannabis initiation increased hazards of other substance initiation (cigarettes: aHR = 3.51, 95 %CI = 3.11–3.96; e-cigarettes: aHR = 3.73, 95 %CI = 3.34–4.17; cigars: aHR = 3.66, 95 %CI = 3.20–4.18; alcohol: aHR = 3.07, 95 %CI = 2.73–3.45). Associations were generally stronger when initiation occurred at ages 5–18 vs. &gt; 18. Depression predicted cannabis initiation; anxiety and ADD predicted e-cigarette initiation. Certain personality characteristics were protective against initiation (agreeableness and conscientiousness for each, openness for cigarettes and cigars, emotional stability for cannabis, cigarettes, and cigars); extraversion increased hazards of initiating cannabis and e-cigarettes.</div></div><div><h3>Conclusions</h3><div>Interventions should target underlying mechanisms influencing the use of various substances, such as mental health and personality characteristics, especially among adolescents.</div></div>","PeriodicalId":7155,"journal":{"name":"Addictive behaviors","volume":"170 ","pages":"Article 108451"},"PeriodicalIF":3.6,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144810442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A longitudinal investigation of sports betting legalization’s influence on problem gambling","authors":"Tiange Xu ,&nbsp;Joshua B. Grubbs ,&nbsp;Shane W. Kraus","doi":"10.1016/j.addbeh.2025.108448","DOIUrl":"10.1016/j.addbeh.2025.108448","url":null,"abstract":"<div><div>As sports betting legalization expands across the United States, understanding its effects on problem gambling remains crucial for evidence-based policy development. This longitudinal study tracked 112 American sports bettors over two years using a natural experimental design, comparing problem gambling severity between participants in states that legalized sports betting during the study period versus those in states maintaining prohibitions. Mixed-effects negative binomial regression revealed no significant interaction between time and legalization status. However, equivalence testing failed to demonstrate that legalization’s effect was practically negligible, leaving the true impact uncertain. Demographic analysis identified significant risk factors, with younger age and single marital status predicting higher problem gambling severity. These findings underscore the need for targeted protective measures for vulnerable demographic groups within regulatory frameworks in newly legalized jurisdictions.</div></div>","PeriodicalId":7155,"journal":{"name":"Addictive behaviors","volume":"170 ","pages":"Article 108448"},"PeriodicalIF":3.6,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144771562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal analysis of e-cigarette and cannabis dual use in an Ohio sample of adolescents and young adults","authors":"Vitoria B. Spinola ,&nbsp;Jill M. Singer ,&nbsp;Elizabeth G. Klein ,&nbsp;Theodore L. Wagener ,&nbsp;Marielle C. Brinkman ,&nbsp;Alayna P. Tackett ,&nbsp;Bo Lu ,&nbsp;Dylan D. Wagner ,&nbsp;Loren E. Wold ,&nbsp;Megan E. Roberts","doi":"10.1016/j.addbeh.2025.108444","DOIUrl":"10.1016/j.addbeh.2025.108444","url":null,"abstract":"<div><div>Adolescents and young adults (AYA) who vape e-cigarettes are likely to use cannabis (“dual use”), but little research has examined factors influencing future use pattern-. Using longitudinal data from 551 Ohio AYA (aged 15–24) who reported past-3-month e-cigarette use, we explored associations between baseline dual use and continued e-cigarette and cannabis use one year later, adjusting for sociodemographic factors. At baseline, 42.3 % of participants reported past-30-day cannabis use, indicating a high prevalence of dual use within this sample. Logistic regressions revealed that past-30-day tobacco use predicted continued e-cigarette use (OR = 1.97), but dual use at baseline was not a significant predictor. However, baseline dual use (OR = 4.58), lifetime cannabis use (OR = 3.91), and Sexual and Gender Minority status (OR = 2.57) significantly predicted continued cannabis use. These findings highlight the importance of addressing dual use in prevention efforts, as dual use at baseline was a strong predictor of continued cannabis use one year later—particularly among historically marginalized groups and those with prior cannabis exposure.</div></div>","PeriodicalId":7155,"journal":{"name":"Addictive behaviors","volume":"170 ","pages":"Article 108444"},"PeriodicalIF":3.6,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144766435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Race and ethnicity differences in the association between the sensory experience and appeal of e-cigarette products: A pooled analysis of four within-subject experiments","authors":"Tyler B. Mason ,&nbsp;Dae-Hee Han ,&nbsp;Melissa Wong ,&nbsp;Dayoung Bae ,&nbsp;Alyssa F. Harlow ,&nbsp;Adam M. Leventhal","doi":"10.1016/j.addbeh.2025.108447","DOIUrl":"10.1016/j.addbeh.2025.108447","url":null,"abstract":"<div><div>We pooled data from four product appeal testing experiments to examine whether associations of sensory attribute ratings (i.e., sweet, smooth, bitter, and harsh) of e-cigarettes with product appeal are moderated by race/ethnicity. Non-Hispanic White (<em>n</em> = 174), Black (<em>n</em> = 99), Asian (<em>n</em> = 34), Hispanic (<em>n</em> = 29), another race (<em>n</em> = 13), and multiracial (<em>n</em> = 56) adult tobacco product users completed product appeal testing. Participants self-administrated standardized doses of 8–40 different e-cigarette products (depending on the experiment) and rated the products’ sensory attributes and appeal. Multilevel models examined race/ethnicity as a moderator of the association of sensory attributes with appeal, using analyses partitioning between- and within-subjects variance. Product-specific (within-subjects) variance in sweetness was associated with enhanced e-cigarette appeal less strongly for Black vs. non-Hispanic White participants. Product-specific smoothness enhanced e-cigarette appeal more strongly for multiracial vs. non-Hispanic White participants. Product-specific bitterness reduced e-cigarette appeal more strongly for Hispanic vs. non-Hispanic White participants. Product-specific harshness reduced e-cigarette appeal and product-specific smoothness enhanced appeal less for Asian compared to non-Hispanic White participants. Regulatory restrictions on additives that suppress the harsh or bitter qualities of e-cigarettes may deter Hispanic adults from e-cigarettes but may be less likely to deter Asian adults. Black adults perceived appeal was less related to sweetness and thus may be more responsive to regulations outside of bans on sweet additives.</div></div>","PeriodicalId":7155,"journal":{"name":"Addictive behaviors","volume":"170 ","pages":"Article 108447"},"PeriodicalIF":3.6,"publicationDate":"2025-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144756845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characteristics of adolescent cannabis use and social context predicting problematic use: A decision tree analysis","authors":"Katelyn Battista ,&nbsp;Slim Haddad ,&nbsp;Scott T. Leatherdale ,&nbsp;Richard Bélanger","doi":"10.1016/j.addbeh.2025.108445","DOIUrl":"10.1016/j.addbeh.2025.108445","url":null,"abstract":"<div><div>Identifying characteristics of adolescent cannabis use and the surrounding social context that may predict problematic use is important for delivering harm-reduction approaches in both clinical and public health settings. We used a decision tree analysis to identify combinations of various use characteristics (e.g., frequency, mode, duration, initiation age, polysubstance use) and social context risk factors (e.g., peer and household use, solitary use, ease of access) characterizing the highest risk groups for three indicators of problematic use (unsuccessful quit attempt, excessive use, feeling addicted). We analyzed data from 8,915 cannabis ever-users from a large sample of secondary school students (mean age 15.5) in Québec, Canada, who completed the COMPASS survey. Using cannabis at least 2–4 times per month was the most important predictor of problematic use and independently characterized the highest risk groups. Initiating use before age 14 and engaging in solitary use also predicted increased problematic use risk among adolescents whose sustained past-year use did not meet the 2–4 times per month threshold. No sociodemographic differentiation emerged among high-risk groups. When screening for risky cannabis use or promoting safer cannabis behaviours among adolescents, health care providers and public health groups should consider factors with the greatest potential to influence detrimental trajectories among this age group.</div></div>","PeriodicalId":7155,"journal":{"name":"Addictive behaviors","volume":"170 ","pages":"Article 108445"},"PeriodicalIF":3.6,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144748770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}