Acta radiologicaPub Date : 2025-02-01Epub Date: 2025-02-17DOI: 10.1177/02841851241297818
Ahmed A Bessar, Yasmin Ibrahim Libda, Maichael Talaat, Enjy Fathy Tantawy, Ahmed Ismail Heraiz, Manar A Bessar
{"title":"Comparison of the transradial and transfemoral approaches for uterine artery embolization: a randomized clinical trial.","authors":"Ahmed A Bessar, Yasmin Ibrahim Libda, Maichael Talaat, Enjy Fathy Tantawy, Ahmed Ismail Heraiz, Manar A Bessar","doi":"10.1177/02841851241297818","DOIUrl":"10.1177/02841851241297818","url":null,"abstract":"<p><p>BackgroundUterine artery embolization (UAE) is a procedure commonly used to control uterine bleeding or pain. While the procedure is traditionally performed through the transfemoral approach (TFA), the transradial approach (TRA) is another method.PurposeTo compare the effectiveness of the UAE using the TRA approach versus the TFA approach.Material and MethodsThis non-blinded, randomized clinical trial was conducted at a tertiary hospital between 1 January 2019 and 30 June 2022. A total of 42 female patients with abnormal uterine bleeding and/or pelvic pain from uterine fibroids were randomly assigned to either the TRA group or the TFA group. Data collected included demographic information, procedural details, patient satisfaction, and radiation metrics.ResultsThe TRA group had significantly lower numbers of microsphere vials used compared to the TFA group (<i>P</i> = 0.014). While there were no significant differences in procedure times (<i>P</i> = 0.058), fluoroscopic times (<i>P</i> = 0.117), or radiation doses (<i>P</i> = 0.466), the TRA approach was associated with a higher success rate in achieving bilateral UA catheterization and fewer instances of bilateral sheath insertion. Patient satisfaction scores were similar between the groups, with no statistically significant difference (<i>P</i> = 0.932). Minor adverse events such as local hematoma and color changes were more frequent in the TFA group, though these differences were not statistically significant.ConclusionAlthough both approaches were effective for the UAE, the TRA approach may be a viable alternative to the TFA due to its higher success rate in achieving bilateral catheterization, lower radiation doses, and shorter procedural times.</p>","PeriodicalId":7143,"journal":{"name":"Acta radiologica","volume":" ","pages":"165-173"},"PeriodicalIF":1.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143439464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Acta radiologicaPub Date : 2025-02-01Epub Date: 2025-01-23DOI: 10.1177/02841851241300328
Yu Jin, Xi Bai, Da Guo, Zhiwei Guo
{"title":"The prognostic impact of arterial spin labeling hyperperfusion in acute ischemic stroke: a systematic review and meta-analysis.","authors":"Yu Jin, Xi Bai, Da Guo, Zhiwei Guo","doi":"10.1177/02841851241300328","DOIUrl":"10.1177/02841851241300328","url":null,"abstract":"<p><p>Hyperperfusion is related to vessel recanalization, tissue reperfusion, and collateral circulation. To determine the prognostic impact of hyperperfusion after an acute ischemic stroke (AIS) identified by arterial spin labeling (ASL) cerebral blood flow. Studies published in PubMed, Embase, and Cochrane Library databases were searched. Studies assessing the diagnostic performance of ASL hyperperfusion after AIS were included. Functional prognosis, hemorrhagic transformation (HT), infarction volume, and penumbra salvage volume were evaluated. The standardized mean difference or risk ratio was pooled, implementing a random effect model. Multiple subgroup analyses were performed. Seven studies including 617 participants were included in this meta-analysis. ASL hyperperfusion in AIS was correlated well with symptom severity and outcome after 24 h National Institutes of Health Stroke Scale (NIHSS) and 90-day modified Rankin Scale (mRS). Earlier ASL hyperperfusion was associated with a smaller infarction volume and a larger penumbra salvage volume, while also indicating a higher risk of HT. In addition, in subgroup analysis, our results demonstrated that thrombolysis, mechanical thrombectomy treatment, early improvement of NIHSS, and involving infarction in cortical territory are associated with ASL hyperperfusion. ASL hyperperfusion was related to a favorable functional outcome but an increased risk of HT. Stroke patients with hyperperfusion showed smaller infarction volume and larger penumbra salvage volume than those with non-hyperperfusion.</p>","PeriodicalId":7143,"journal":{"name":"Acta radiologica","volume":" ","pages":"218-227"},"PeriodicalIF":1.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143021773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Acta radiologicaPub Date : 2025-02-01Epub Date: 2025-01-31DOI: 10.1177/02841851241298885
Jin Ding, Huanzhi Ding, Ximing Wang
{"title":"An in vitro study of contrast agent optimization for MR hysterosalpingography.","authors":"Jin Ding, Huanzhi Ding, Ximing Wang","doi":"10.1177/02841851241298885","DOIUrl":"10.1177/02841851241298885","url":null,"abstract":"<p><p>BackgroundGadolinium-iodine mixed contrast agents can significantly improve the visualization of the fallopian tubes in magnetic resonance hysterosalpingography (MR-HSG). However, the mixing ratio of gadolinium-iodine contrast agents has not yet been standardized.PurposeTo explore the optimal mixing ratio of gadolinium-iodine contrast agents suitable for MR-HSG.Material and MethodsA total of 16 mixing ratios of gadolinium and saline mixtures (Gd-NS), gadolinium and iopromide mixtures (Gd-I370), and gadolinium and iodixanol mixtures (Gd-I320) were formulated for an in vitro study. These mixed contrast agents were scanned on 1.5 T and 3.0 T using T1 contrast enhancement sequences. For qualitative assessment, contrast agent imaging quality was graded on a subjective 3-point scale (good, moderate, and poor). For the quantitative evaluation, differences in the signal intensity (SI) of the three contrast agents, as well as the SI variations between 1.5 T and 3.0 T, were compared.ResultsGd-I370 and Gd-I320 exhibited the highest SI and good image at a 1:300 ratio on 1.5 T and a 1:200 ratio on 3.0 T. The difference in the SI among the three contrast agents was not statistically significant at 1.5 T (<i>P </i>> 0.05). At 3.0 T, the comparison between the SIs of Gd-I370 and Gd-I320 was not statistically significant (<i>P </i>> 0.05). The SIs of contrast agents on 3.0 T were higher than those on 1.5 T (<i>P </i>< 0.05).ConclusionA gadolinium-iodine contrast agent with a 1:300 mixing ratio may be more suitable for 1.5 T MR-HSG, while a 1:200 mixing ratio may be more suitable for 3.0 T MR-HSG. Additionally, the contrast agent SI is higher on 3.0 T than on 1.5 T.</p>","PeriodicalId":7143,"journal":{"name":"Acta radiologica","volume":" ","pages":"192-197"},"PeriodicalIF":1.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143062956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Acta radiologicaPub Date : 2025-01-24DOI: 10.1177/02841851241313022
Kemal Erol, Ezgi Akyildiz Tezcan, Seyit Erol
{"title":"Piriformis muscle abnormalities in sacroiliac MRI of patients with axial spondyloarthritis.","authors":"Kemal Erol, Ezgi Akyildiz Tezcan, Seyit Erol","doi":"10.1177/02841851241313022","DOIUrl":"https://doi.org/10.1177/02841851241313022","url":null,"abstract":"<p><strong>Background: </strong>Piriformis syndrome, an often-overlooked cause of sciatica, commonly presents as chronic gluteal pain and poses a diagnostic challenge, particularly in patients with axial spondyloarthritis (axSpA).</p><p><strong>Purpose: </strong>To examine piriformis muscle abnormalities on sacroiliac magnetic resonance imaging (MRI) and their association with clinical outcomes in patients with axSpA.</p><p><strong>Material and methods: </strong>This cross-sectional study included 100 axSpA patients (50 radiographic [r-axSpA], 50 non-radiographic [nr-axSpA]), classified by the 2009 ASAS Axial Spondyloarthritis criteria, who underwent MRI evaluations of the sacroiliac joints over a 6-month period. Piriformis evaluation included the measurement of muscle size, signal intensity, and the assessment of fatty infiltration. Sciatic neuritis was assessed by identifying enlarged sciatic nerves or increased signal intensity. Data collection included demographic details, disease activity, and functionality parameters. Statistical analysis was performed using appropriate methods, with <i>P</i> < 0.05 indicating significance.</p><p><strong>Results: </strong>Piriformis syndrome findings were identified in 10% of patients, with a slightly higher incidence in r-axSpA patients (12%) compared to nr-axSpA patients (8%); however, this difference was not statistically significant (<i>P</i> = 0.739). Patients with these MRI findings had significantly higher disease activity, as indicated by the Ankylosing Spondylitis Disease Activity Score with C-reactive protein (3.5 vs. 2.82; <i>P</i> = 0.015), and greater functional impairment, measured by the Bath Ankylosing Spondylitis Functional Index (5.45 vs. 2.7; <i>P</i> = 0.041).</p><p><strong>Conclusion: </strong>This study highlights the presence of MRI findings associated with piriformis syndrome among axSpA patients, which are linked to increased disease activity and reduced function. Recognizing piriformis syndrome as a co-morbidity may improve diagnosis and treatment, leading to better patient outcomes.</p>","PeriodicalId":7143,"journal":{"name":"Acta radiologica","volume":" ","pages":"2841851241313022"},"PeriodicalIF":1.1,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143027751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Acta radiologicaPub Date : 2025-01-23DOI: 10.1177/02841851241313026
Hans Peter Bögl, Jörg Schilcher
{"title":"Identification of subtrochanteric and femoral shaft fractures as atypical femur fractures on radiology reports.","authors":"Hans Peter Bögl, Jörg Schilcher","doi":"10.1177/02841851241313026","DOIUrl":"https://doi.org/10.1177/02841851241313026","url":null,"abstract":"<p><strong>Background: </strong>Bisphosphonate-associated stress fractures, atypical femur fractures (AFF), are a rare subgroup of femoral stress fractures. Their correct and early diagnosis is imperative for appropriate treatment.</p><p><strong>Purpose: </strong>To investigate the sensitivity of written radiology reports to mention radiographic features of AFF, depending on the time period and academic level of the hospital.</p><p><strong>Material and methods: </strong>We used 171 patients, aged 55 years or older, who sustained an AFF between 2008 and 2010 (early period) identified through the Swedish National Patient Register and radiographic review and 104 patients identified through the Swedish Fracture Register between 2015 and 2018 (late period). Plain radiographs were extracted from 72 radiology departments in Sweden and individually re-reviewed and classified based on the American Society for Bone and Mineral Research case definition for AFF. Radiology reports were viewed for mentioning AFF or stress/insufficiency features (true positives). The number of true positives was compared with the number of false positives for both periods using non-parametric statistics and using the gold standard as reference.</p><p><strong>Results: </strong>We obtained 98 of the possible 171 reports with 7% of true positives for the early period and 77 of the possible 104 reports with 27% true positives for the late period (<i>P</i> < 0.001). The level of improvement over time was independent of the academic level of the hospital.</p><p><strong>Conclusion: </strong>Despite improvements over time, written radiology reports seldom mention AFF features. Clinicians, specifically orthopedic surgeons, are encouraged to contribute to a correct and early diagnosis to tailor treatment, while awaiting improvements in radiology reports.</p>","PeriodicalId":7143,"journal":{"name":"Acta radiologica","volume":" ","pages":"2841851241313026"},"PeriodicalIF":1.1,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143021769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Acta radiologicaPub Date : 2025-01-21DOI: 10.1177/02841851241313108
Di Geng, Liu-Ning Zhu, Jun Liu, Xian-Ce Zhao, Yi-Shi Wang, Xiao-Quan Xu, Fei-Yun Wu
{"title":"Time-dependent diffusion magnetic resonance imaging for the analysis of parotid gland tumors.","authors":"Di Geng, Liu-Ning Zhu, Jun Liu, Xian-Ce Zhao, Yi-Shi Wang, Xiao-Quan Xu, Fei-Yun Wu","doi":"10.1177/02841851241313108","DOIUrl":"https://doi.org/10.1177/02841851241313108","url":null,"abstract":"<p><strong>Background: </strong>Different parotid tumors differ in terms of treatment strategies due to their distinct biological behaviors. Time-dependent diffusion magnetic resonance imaging (t<sub>d</sub>-dMRI) can characterize and quantify the cytological indexes, and then aid the differential diagnosis of various tumors. However, the value of t<sub>d</sub>-dMRI in the analysis of parotid gland tumors remains unclear.</p><p><strong>Purpose: </strong>To investigate the value of quantitative parameters derived from t<sub>d</sub>-dMRI in the analysis of parotid gland tumors.</p><p><strong>Material and methods: </strong>In total, 39 patients with parotid gland tumors were prospectively enrolled, including 24 patients with polymorphic adenomas (PAs), eight with Warthin's tumors (WTs), and seven with malignant tumors (MTs). T<sub>d</sub>-dMRI was performed for preoperative evaluation. Intracellular volume fraction (<i>V</i><sub>in</sub>), mean cell size (<i>d</i>), extracellular diffusion coefficient (<i>D</i><sub>ex</sub>), and cellularity were obtained based on the Imaging Microstructural Parameters Using Limited Spectrally Edited Diffusion model, and compared among the three groups. One-way ANOVA, Kruskal-Wallis test, and receiver operating characteristic (ROC) curve analysis were performed for further statistical analysis as appropriate.</p><p><strong>Results: </strong>Significant differences were found in all t<sub>d</sub>-dMRI-derived indexes among PAs, WTs, and MTs (all <i>P</i> < 0.05). <i>V</i><sub>in</sub> was the sole parameter with significant differences for all sub-group comparisons (PAs vs. WTs, <i>P</i> < 0.001; PAs vs. MTs, <i>P</i> = 0.031; WTs vs. MTs, <i>P</i> = 0.047). With <i>V</i><sub>in</sub> values of 0.267, 0.231, and 0.260 as threshold, respectively, optimal performance levels were obtained for differentiating PAs from WTs (area under the ROC curve [AUC]=0.932, sensitivity=0.917, and specificity=0.875), PAs from MTs (AUC=0.744, sensitivity=0.833, and specificity=0.714), and WTs from MTs (AUC=0.750, sensitivity=0.875, and specificity=0.714).</p><p><strong>Conclusion: </strong>Microstructural parameters derived from t<sub>d</sub>-dMRI, especially <i>V</i><sub>in</sub>, might be promising imaging biomarkers for characterizing parotid gland tumors.</p>","PeriodicalId":7143,"journal":{"name":"Acta radiologica","volume":" ","pages":"2841851241313108"},"PeriodicalIF":1.1,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142998336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Acta radiologicaPub Date : 2025-01-01DOI: 10.1177/02841851251313643
Søren Rafael Rafaelsen
{"title":"Welcoming the new Editor-in-Chief of <i>Acta Radiologica</i>: Lars Lönn.","authors":"Søren Rafael Rafaelsen","doi":"10.1177/02841851251313643","DOIUrl":"https://doi.org/10.1177/02841851251313643","url":null,"abstract":"","PeriodicalId":7143,"journal":{"name":"Acta radiologica","volume":"66 1","pages":"4-5"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143078186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Acta radiologicaPub Date : 2025-01-01Epub Date: 2024-11-21DOI: 10.1177/02841851241296029
Dan Yang, Yike Ren, Guanying Wang, Chunhong Wang
{"title":"Diffusion-weighted imaging based on intravoxel incoherent motion: correlation with molecular prognostic factors and subtypes in breast cancer.","authors":"Dan Yang, Yike Ren, Guanying Wang, Chunhong Wang","doi":"10.1177/02841851241296029","DOIUrl":"10.1177/02841851241296029","url":null,"abstract":"<p><strong>Background: </strong>Intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI), which indicates biological tissue attributes, may be applied to accurately assess breast tumors.</p><p><strong>Purpose: </strong>To analyze the IVIM parameters of different molecular prognostic factors and subtypes to find out whether there are any connections.</p><p><strong>Material and methods: </strong>A total of 181 patients enrolled in this retrospective study had preoperative magnetic resonance imaging (MRI) examinations, and pathologies were verified as breast cancers. Regions of interest were placed at all slices of the parameter maps (D, tissue diffusivity; ADC, apparent diffusion coefficient; f, perfusion fraction; and D*, pseudo-diffusivity maps) of IVIM and generated parameter values to be used for comparative analysis among molecular prognostic factors and subtypes.</p><p><strong>Results: </strong>D and ADC were greater in estrogen receptor (ER)-negative, human epidermal growth factor receptor 2 (HER2)-positive, and Ki67-low expression groups (all <i>P</i> values < 0.05). The progesterone receptor (PR)-negative group had a higher D value (<i>P</i> < 0.05). f was larger in the lymph node metastasis-negative group and the PR-positive group (<i>P</i> = 0.012 and 0.046, respectively). Among breast cancer subtypes, D and ADC were different between the HER2-overexpression and the Luminal B (HER2-negative) subtypes (<i>P</i> = 0.019 and 0.028, respectively). The difference in D between the luminal and non-luminal subtypes was statistically significant (<i>P</i> = 0.008). The triple-negative subtype significantly differs from the other subtypes in D* and f (<i>P</i> = 0.012 and 0.016, respectively).</p><p><strong>Conclusion: </strong>IVIM-related metrics exhibited relationships with breast cancer molecular prognosis factors and subtypes.</p>","PeriodicalId":7143,"journal":{"name":"Acta radiologica","volume":" ","pages":"35-41"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142680541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Acta radiologicaPub Date : 2025-01-01Epub Date: 2024-11-18DOI: 10.1177/02841851241292810
Ye Eun Lee, Kun Yung Kim, Young-Min Han
{"title":"Factors related to acute kidney injury after AngioJet rheolytic thrombectomy.","authors":"Ye Eun Lee, Kun Yung Kim, Young-Min Han","doi":"10.1177/02841851241292810","DOIUrl":"10.1177/02841851241292810","url":null,"abstract":"<p><strong>Background: </strong>AngioJet rheolytic thrombectomy is associated with a higher risk of acute kidney injury due to its potential for inducing mechanical harm and intravascular hemolysis. However, previous studies have focused on a single disease entity.</p><p><strong>Purpose: </strong>To identify predictors associated with acute kidney injury after AngioJet rheolytic thrombectomy across a range of disease entities.</p><p><strong>Material and methods: </strong>A total of 95 patients who underwent AngioJet rheolytic thrombectomy between October 2018 and April 2023 were retrospectively reviewed. In total, 11 patients were excluded due to the absence of a postprocedural serum creatinine test within 72 h; finally, 84 patients were included. Acute kidney injury was defined as a ≥1.5-fold increase or ≥0.3 mg/dL rise in serum creatinine within 72 h after the procedure. Univariate and multivariate analysis were performed to identify risk factors for acute kidney injury.</p><p><strong>Results: </strong>Technical and clinical success were achieved in all patients (84/84, 100%). Of the 84 patients (40 men [47.6%], 44 women [52.4%]; mean age = 67.2 ± 15.9 years), 15 (17.8%) had developed acute kidney injury. Multivariate analysis showed concurrent malignancy (odds ratio [OR] = 42.231, 95% confidence interval [CI] = 2.332-764.693; <i>P</i> = 0.011) and AngioJet rheolytic thrombectomy in arterial system (OR = 24.109, 95% CI = 1.319-440.551; <i>P</i> = 0.032) as statistically significant predictors of acute kidney injury.</p><p><strong>Conclusions: </strong>AngioJet rheolytic thrombectomy is a potential risk for acute kidney injury. Concurrent malignancy and AngioJet rheolytic thrombectomy in the arterial system are independent predictors of acute kidney injury.</p>","PeriodicalId":7143,"journal":{"name":"Acta radiologica","volume":" ","pages":"120-124"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142646778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Acta radiologicaPub Date : 2025-01-01Epub Date: 2024-11-22DOI: 10.1177/02841851241297207
Siting Zang, Yu Pan, Miao Chen, Gang Zhang
{"title":"Different iron distribution patterns in Parkinson's disease and its motor subtypes: a quantitative susceptibility mapping study.","authors":"Siting Zang, Yu Pan, Miao Chen, Gang Zhang","doi":"10.1177/02841851241297207","DOIUrl":"10.1177/02841851241297207","url":null,"abstract":"<p><strong>Background: </strong>This study utilized quantitative susceptibility mapping (QSM) to evaluate magnetic susceptibility of brain nuclei in Parkinson's disease (PD).</p><p><strong>Purpose: </strong>To explore iron deposition patterns in PD and ascertain if these patterns can distinguish between motor subtypes.</p><p><strong>Material and methods: </strong>This study enrolled 30 healthy controls and 34 patients with PD categorized mainly into postural instability and gait disorder (PIGD) (n = 12) and tremor dominance (TD) (n = 16). A total of 18 regions of interest were delineated, and a comprehensive classification of nuclei was conducted, including the differentiation of globus pallidus (GP) into its external (GPe) and internal (GPi) segments. All participants underwent brain magnetic resonance imaging.</p><p><strong>Results: </strong>Notable differences in magnetic susceptibility were identified in bilateral substantia nigra pars reticulate (SNr) and substantia nigra pars compacta (SNc) between PD and HC. Significant differences in QSM values of bilateral GPe, SNr, and SNc-R were found between TD and PIGD. The susceptibility values of bilateral putamen (PUT) were positively correlated with MDS-UPDRSIII score and Hoehn-Yahr scale in PD. QSM values of bilateral PUT and SNc-L showed associations with MDS-UPDRSIII score in TD. QSM values showed associations with MDS-UPDRSIII in bilateral PUT and Hoehn-Yahr scale in PUT-L and TH-L in PIGD.</p><p><strong>Conclusion: </strong>Pathologic iron deposition exhibits variability across nuclei of PD, with age also influencing this distribution. SN may be meaningful in identifying different subtypes of PD, such as differentiating PD from HC in the future.</p>","PeriodicalId":7143,"journal":{"name":"Acta radiologica","volume":" ","pages":"99-106"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142685755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}