Acta radiologica最新文献

{"title":"Cystic-solid ADC difference on MRI for differentiating seromucinous borderline tumor from endometriosis-associated ovarian cancer.","authors":"Masanori Ishida, Akihiko Hayakawa, Shigehiro Hayashi, Yoichi Araki, Elly Arizono, Akitoshi Kanagawa, Yukari Wakabayashi, Motoki Nakai, Hirotaka Nishi, Kazuhiro Saito","doi":"10.1177/02841851261495789","DOIUrl":"https://doi.org/10.1177/02841851261495789","url":null,"abstract":"<p><p>BackgroundSeromucinous borderline tumor (SMBT) and endometriosis-associated ovarian cancer (EAOC) may show overlapping magnetic resonance imaging (MRI) features. Quantitative diffusion-weighted imaging may improve their preoperative differentiation.PurposeTo evaluate the diagnostic performance of the cystic-solid apparent diffusion coefficient difference (ΔADC) for differentiating SMBT from EAOC.Material and MethodsThis retrospective single-center study included 49 patients with pathologically confirmed SMBT (n = 14) or EAOC (n = 35) who underwent preoperative pelvic MRI. Apparent diffusion coefficient (ADC) values were measured in the cystic and solid components, and ΔADC was calculated as cystic ADC minus solid ADC. Receiver operating characteristic (ROC) analysis was performed with EAOC as the positive outcome.ResultsSMBT showed lower cystic ADC values and higher solid ADC values than EAOC, resulting in a smaller ΔADC. ΔADC and solid ADC yielded areas under the ROC curve of 0.924 (95% confidence interval (CI) 0.817-1.000) and 0.918 (95% CI 0.837-1.000), respectively. The difference was not statistically significant (<i>P</i> = 0.862). At the internally derived ΔADC cutoff of 0.529 ×10^-3 mm²/s, sensitivity was 94.3% (95% CI 80.8-99.3) and specificity was 92.9% (95% CI 66.1-99.8); because the cutoff was derived and evaluated in the same cohort, these performance estimates may be optimistic.ConclusionΔADC showed high diagnostic performance for differentiating SMBT from EAOC, but incremental diagnostic performance over solid ADC was not demonstrated. The internally derived cutoff and associated performance estimates require independent multicenter validation before clinical application.</p>","PeriodicalId":7143,"journal":{"name":"Acta radiologica","volume":" ","pages":"2841851261495789"},"PeriodicalIF":1.2,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149166181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improved liver and portal venous system enhancement with saline flush after contrast injection in portal venous phase computed tomography.","authors":"Tetsuro Kaga, Yoshifumi Noda, Mizuki Hirata, Nobuyuki Kawai, Ryosuke Suzuki, Hiroki Kato, Masayuki Matsuo","doi":"10.1177/02841851261483224","DOIUrl":"10.1177/02841851261483224","url":null,"abstract":"<p><p>BackgroundThe utility of saline flush in portal venous phase (PVP) contrast-enhanced computed tomography (CECT) for the liver remains controversial.PurposeTo investigate the effect of saline flush after contrast injection on liver and portal venous system enhancement in PVP CECT.Material and MethodsThe saline flush group prospectively included 97 consecutive patients (52 women; median age = 68 years) who underwent PVP CECT with saline flush. The control group retrospectively comprised 105 patients (63 women; median age = 65 years) who underwent PVP CECT without saline flush. Scanning protocols, including contrast injection protocol and scan timing (65 s), were standardized. In the saline flush group, 20 mL of saline, determined through a phantom study, was injected after contrast injection. Two radiologists measured increased CT attenuations (ΔHUs) of the liver, portal vein (PV), superior mesenteric vein (SMV), and splenic vein (SV), and compared them between the two groups. The proportions of cases with liver ΔHU above and below 50 HU were also compared.ResultsΔHUs were higher for the liver (69.4 HU vs. 64.4 HU; <i>P</i> = 0.004), PV (184.6 HU vs. 171.9 HU; <i>P</i> = 0.001), SMV (179.0 HU vs. 171.0 HU; <i>P</i> = 0.002), and SV (185.1 HU vs. 163.6 HU; <i>P</i> < 0.001) in the saline flush group than in the control group. The proportion of cases with liver ΔHU below 50 HU was not different between the two groups (5.2% in the saline flush group vs. 7.6% in the control group; <i>P</i> = 0.57).ConclusionSaline flush may increase liver and portal venous system enhancement on PVP CECT.</p>","PeriodicalId":7143,"journal":{"name":"Acta radiologica","volume":" ","pages":"849-858"},"PeriodicalIF":1.2,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148872613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utility of 3D-printed models in preoperative simulation and spatial recognition for cavernous sinus dural arteriovenous fistulas.","authors":"Hirotaka Sagawa, Shoko Fujii, Kyohei Fujita, Satoru Takahashi, Sakyo Hirai, Kazutaka Sumita","doi":"10.1177/02841851251395712","DOIUrl":"10.1177/02841851251395712","url":null,"abstract":"<p><p>BackgroundTransvenous embolization is the standard treatment for cavernous sinus dural arteriovenous fistulas (CS DAVFs). In some patients with CS DAVFs, selective embolization is possible if the shunted pouches can be accurately identified, avoiding the risk of cranial nerve damage due to excess coil use.PurposeTo evaluate the utility of three-dimensional (3D)-printed models in enhancing the spatial understanding of shunted pouches and approach routes and facilitating selective embolization for CS DAVFs.Material and MethodsThe 3D-printed models of the CS of five patients with CS DAVFs treated between 2022 and 2024 were printed with fused deposition modeling 3D printers using 3D data from 3D digital subtraction angiography (3D-DSA). Shunted pouches were identified using high-resolution cone-beam computed tomography and four-dimensional DSA. Embolization procedures were planned based on the tactile and spatial understanding provided by 3D-DSA and 3D-printed models. Five patients treated between 2018 and 2022 without 3D-printed models were used as controls.ResultsComplete shunt obliteration was observed in all five patients whose CS was 3D-printed. Two patients were treated successfully with selective embolization of the shunted pouch alone and three patients required additional partial sinus packing. In the control group, selective embolization was possible in only one patient, and only two patients achieved complete obliteration, including one requiring retreatment due to early recanalization.ConclusionThe use of 3D-printed models for CS DAVFs treatment may improve shunt point recognition and facilitate effective selective embolization.</p>","PeriodicalId":7143,"journal":{"name":"Acta radiologica","volume":" ","pages":"804-810"},"PeriodicalIF":1.2,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148700489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MRI-based radiomics for non-invasive prediction of histopathological and immunohistochemical features in ductal carcinoma in situ: Implications for risk stratification.","authors":"Aziz Anıl Tan, Amir Bakhshandehpour, Ümran Esen, Jale Karakaya, Gamze Durhan","doi":"10.1177/02841851261472084","DOIUrl":"10.1177/02841851261472084","url":null,"abstract":"<p><p>BackgroundDifferentiating the immunohistochemical and histopathological features of ductal carcinoma in situ (DCIS) lesions is critical to potentially enable future tailored treatment options and de-escalation strategies.PurposeTo investigate the potential of magnetic resonance imaging (MRI) radiomics for the non-invasive prediction of estrogen receptor (ER), progesterone receptor (PR), grade, microcalcification, and comedonecrosis in DCIS lesions, which may provide implications for risk stratification.Material and MethodsThis single-center retrospective study included 75 DCIS patients who had undergone pre-treatment MRI and were diagnosed through surgical pathology at our hospital between January 2010 and December 2023. The 75 segmented lesions were categorized into subgroups based on ER, PR, comedonecrosis, microcalcification status, and grade. Model performance was then assessed. Manual segmentation was performed on the second phase of dynamic contrast-enhanced T1 MRI. The BORUTA method was employed for feature selection. Using the selected features, the classification performance of various models was examined to determine if DCIS could be differentiated across the five subgroups.ResultsIn total, 75 patients with DCIS (74 women; mean age=49.36±11.28 years) were evaluated. Effective discrimination in subgroups was as follows: comedonecrosis, <i>n</i>=5; grade, <i>n</i>=1; ER, <i>n</i>=3; and PR, <i>n</i>=5. Radiomic model performance varied across subgroups, with F1 scores observed in the subgroups: ER, 0.8293-0.9091; PR, 0.7796-1; grade, 0.9051-0.9538; microcalcification, 0.9126-0.9895; and comedonecrosis, 0.8247-1.ConclusionMRI radiomics demonstrates significant potential in non-invasively differentiating key immunohistochemical and histopathological features of DCIS. This approach may provide complementary information for DCIS characterization and risk stratification, although further validation is required before clinical implementation.</p>","PeriodicalId":7143,"journal":{"name":"Acta radiologica","volume":" ","pages":"841-848"},"PeriodicalIF":1.2,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148823870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Late gadolinium-enhanced cardiac MRI and C-reactive protein for predicting clinical prognosis of acute myocarditis in adults.","authors":"Xiayun Shi, Yunfei Wang, Zhongman Zhang, Tianle Wang, Xiaomei Zhu","doi":"10.1177/02841851261477088","DOIUrl":"10.1177/02841851261477088","url":null,"abstract":"<p><p>BackgroundThe relationship between acute myocardial injury and prognosis in acute myocarditis (AM) is unclear.PurposeTo evaluate myocardial injury characteristics by cardiovascular magnetic resonance (CMR) tissue parameters and their impact on adverse outcomes of AM patients.Material and MethodsThis retrospective study enrolled 41 patients with fulminant myocarditis (FM, including 17 FM patients without mechanical circulatory support [MCS] and 24 FM patients with MCS) and 35 patients with non-fulminant myocarditis (non-FM). Cine, mapping (native T1, T2, and post-T1), and late gadolinium enhancement (LGE) of the left ventricle were performed during CMR. Adverse clinical outcomes consisted of a primary endpoint, major adverse cardiovascular events (MACEs), and a secondary endpoint, a decline in functional status (defined as New York Heart Association [NYHA] functional classes II-IV).ResultsCompared with patients with non-FM, those in FM with MCS exhibited increased native T1 (<i>P</i> = 0.001), extracellular volume (ECV) (<i>P</i> = 0.018), and LGE (<i>P</i> = 0.005) values. After adjusting for the clinical variables (CRP > 67.9 mg/dL), LGE > 8.4% remained independently associated with adverse clinical outcomes and improved the predicting ability of the model (C-statistic improved from 0.74 to 0.82).ConclusionThe burden of necrosis and fibrosis was greatest in FM with MCS, while edema was similar across groups. Higher LGE% adds incremental prognostic value. A new classification using CRP and LGE improved prediction of adverse outcomes. Thus, CMR evaluation of myocardial injury extent offers variable information to improve risk stratification in FM.</p>","PeriodicalId":7143,"journal":{"name":"Acta radiologica","volume":" ","pages":"811-821"},"PeriodicalIF":1.2,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148786834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acta Radiologica Prizes 2025: Xenia Forsselliana 2025 and the International Scientific Prize.","authors":"Lars Lonn, Janne Nurminen","doi":"10.1177/02841851261465096","DOIUrl":"https://doi.org/10.1177/02841851261465096","url":null,"abstract":"","PeriodicalId":7143,"journal":{"name":"Acta radiologica","volume":"67 10","pages":"801-803"},"PeriodicalIF":1.2,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149011905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Danish Pancreatic Cancer Group consensus guidelines on the management of pancreatic IPMN.","authors":"Bahareh Abdolalizadeh, Claus Fristrup, Lars Peter Larsen, Eva Fallentin, Caroline Ewertsen","doi":"10.1177/02841851261477089","DOIUrl":"10.1177/02841851261477089","url":null,"abstract":"<p><p>BackgroundIntraductal papillary mucinous neoplasms (IPMNs) are the most common pancreatic cystic neoplasms and are increasingly detected incidentally. Although they carry malignant potential, most lesions follow an indolent course, creating a clinical challenge in balancing early cancer detection with the risks of overtreatment. Existing international guidelines differ in surveillance strategies, thresholds for intervention, and recommendations for discontinuation.PurposeTo present Danish multidisciplinary consensus recommendations for the evaluation, surveillance, and management of pancreatic intraductal papillary mucinous neoplasms.Material and MethodsThe Danish Pancreatic Cancer Group consensus was developed by a multidisciplinary working group comprising radiologists and pancreatic surgeons. Recommendations were based on a narrative review of the literature, existing international guidelines, and clinical experience within a centralized healthcare setting. Consensus was achieved through iterative discussions without a formal Delphi process.RecommendationsMagnetic resonance imaging with MR cholangiopancreatography (MRI/MRCP) is recommended as the primary modality for diagnosis and surveillance, with computed tomography and endoscopic ultrasound used selectively. Risk stratification is based on high-risk stigmata and worrisome features, with emphasis on interval changes during follow-up. Surveillance strategies are primarily size-based and individualized according to patient age, comorbidities, and surgical eligibility. Surgical evaluation is recommended for cysts larger than 30 mm and for main-duct or mixed-type IPMNs with high-risk features, while a more selective approach is applied to branch-duct IPMN. Discontinuation of surveillance is supported in selected patients with stable disease, particularly in older individuals.ConclusionThe Danish multidisciplinary consensus provides a pragmatic, risk-adapted approach to IPMN management, emphasizing individualized care, multidisciplinary decision-making, and avoidance of unnecessary investigations and surgical overtreatment.</p>","PeriodicalId":7143,"journal":{"name":"Acta radiologica","volume":" ","pages":"859-867"},"PeriodicalIF":1.2,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148872630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CT-based cross-center risk stratification of pure ground-glass nodules incorporating domain style-aware correction.","authors":"Kang Qi, Chao Fan, Yongzheng Yao, Xiaoyu Zhuang, Haibo Liu, Xibin Jia, Gang Lin","doi":"10.1177/02841851261481162","DOIUrl":"10.1177/02841851261481162","url":null,"abstract":"<p><p>BackgroundPure ground-glass nodules (pGGNs) are increasingly detected on chest CT. Although most exhibit indolent behavior, a subset may harbor invasive features before obvious radiological progression, making early risk stratification clinically important.PurposeTo develop and externally validate a CT-based deep learning model with domain adaptation for cross-center risk stratification of pGGNs.Material and MethodsThis retrospective multicenter study included 1235 surgically confirmed pGGNs from two institutions. A deep learning model incorporating domain style-aware correction was developed to differentiate AAH/AIS-like lesions from MIA/IAC-like lesions using preoperative CT images. Data from one center were used for training and internal validation, and an independent external cohort was used for validation. Model performance was evaluated using AUC, accuracy, calibration, and decision curve analysis.ResultsThe model achieved an AUC of 0.93 and an accuracy of 90.4% in the internal validation set. In the external validation set, the AUC was 0.88 with an accuracy of 81.7%, demonstrating good cross-center generalization. Domain adaptation improved external AUC from 0.85 to 0.88. Calibration analysis showed good agreement between predicted and observed probabilities. Decision curve analysis indicated higher net benefit compared with treat-all and treat-none strategies across a range of thresholds.ConclusionThe proposed model demonstrates robust performance across centers and may serve as a noninvasive tool to support individualized surveillance strategies for patients with pGGNs.</p>","PeriodicalId":7143,"journal":{"name":"Acta radiologica","volume":" ","pages":"868-879"},"PeriodicalIF":1.2,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148885939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CT-derived composite coronary wall thickness as a marker of early vessel wall remodeling in patients with CAD-RADS 0-2.","authors":"Safiye Sanem Dereli Bulut, Gorkem Karamustafao, Cengiz Sabanoglu, Zakir Sakci","doi":"10.1177/02841851261478938","DOIUrl":"10.1177/02841851261478938","url":null,"abstract":"<p><p>BackgroundEarly coronary atherosclerosis may involve vessel wall remodeling before significant luminal stenosis develops. Coronary computed tomography angiography (CCTA) may enable assessment of vessel wall geometry using composite measurements derived from luminal and outer vessel boundaries.PurposeTo evaluate composite coronary wall thickness (TWT) using a CCTA-based virtual intravascular ultrasound (IVUS) approach in patients with CAD-RADS 0-2 and to assess its associations with cardiovascular risk factors, coronary calcium burden, positive remodeling, and CAD-RADS category.Material and MethodsThis retrospective single-center study included 234 patients (129 men, 105 women; mean age = 57 ± 11 years) who underwent clinically indicated CCTA between January 2023 and September 2025 and were classified as CAD-RADS 0-2. TWT was measured using a virtual IVUS-based reconstruction in proximal and mid segments of the left main, left anterior descending, left circumflex, and right coronary arteries. Associations between TWT and clinical or imaging variables were evaluated using multivariable regression and segment-level mixed-effects models.ResultsTWT was significantly higher in proximal than mid coronary segments (<i>P</i> < 0.001). Hypertension, LDL cholesterol, and positive remodeling were independently associated with increased TWT (<i>P</i> < 0.05), whereas diabetes mellitus was not. TWT independently predicted higher CAD-RADS category (odds ratio = 2.41; <i>P</i> = 0.003) and showed good discriminative performance (area under the curve = 0.81). Moderate correlations were observed between TWT and coronary calcium burden (r = 0.40-0.60; <i>P</i> < 0.001).ConclusionCCTA-derived TWT is associated with CAD-RADS category, cardiovascular risk factors, and coronary calcium burden, reflecting early vessel wall remodeling preceding overt luminal disease.</p>","PeriodicalId":7143,"journal":{"name":"Acta radiologica","volume":" ","pages":"822-830"},"PeriodicalIF":1.2,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148817083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Added value of dual-energy CT to ultrasound assessment for AJCC 8th staging of papillary thyroid carcinoma.","authors":"Yu Hu, Xiao-Quan Xu, Wen-Ting Ma, Ao Li, Yan Zhou, Yong-Kang Xu, Fei-Yun Wu","doi":"10.1177/02841851261477082","DOIUrl":"10.1177/02841851261477082","url":null,"abstract":"<p><p>BackgroundAccurate staging is crucial for guiding treatment decisions and surgical planning in papillary thyroid carcinoma (PTC).PurposeTo determine whether dual-energy computed tomography (DECT) can improve the accuracy of ultrasound (US) assessment for the 8th edition of the American Joint Committee on Cancer (AJCC) staging of PTC.Material and MethodsThis retrospective study included 325 patients with PTC who underwent US and DECT before radical thyroidectomy. Using pathological results as the reference standard, the diagnostic accuracy of US, DECT, and US + DECT assessments for primary tumor (pT), regional lymph node (pN), and AJCC 8th staging were compared. McNemar's test was used for head-to-head accuracy comparisons between DECT or US + DECT and US. Inter-observer agreement was assessed using intraclass correlation coefficients (ICCs).ResultsDECT showed significantly higher accuracy than US in pT evaluation (0.754 vs. 0.628; <i>P</i> < 0.001). DECT showed slightly higher accuracy than US in pN evaluation (0.662 vs. 0.652; <i>P</i> = 0.250). Combining DECT and US led to higher accuracy than US alone for both pT (0.655 vs. 0.628; <i>P</i> = 0.004) and pN (0.686 vs 0.652; <i>P</i> = 0.001) evaluation, specifically in T3b tumors (odds ratio [OR] 2.024; <i>P</i> = 0.043), T4 tumors (OR 8.125; <i>P</i> = 0.005), and N1b nodules (OR 2.027; <i>P</i> = 0.045). Combining DECT and US was associated with 95% higher odds of accuracy than US alone in AJCC 8th Stage II evaluation (OR 10.000; <i>P</i> = 0.041).ConclusionCombining DECT and US can improve US evaluation of pT and pN of PTC and the identification of Stage II PTC.</p>","PeriodicalId":7143,"journal":{"name":"Acta radiologica","volume":" ","pages":"831-840"},"PeriodicalIF":1.2,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148817050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}