Acta radiologicaPub Date : 2026-02-01Epub Date: 2025-12-01DOI: 10.1177/02841851251399897
Sungjun Hwang, Jung Hoon Kim, Junghoan Park, Rae Rim Ryu
{"title":"Key preoperative findings for predicting vascular invasion and recurrence after conversion surgery after chemotherapy in pancreatic cancer.","authors":"Sungjun Hwang, Jung Hoon Kim, Junghoan Park, Rae Rim Ryu","doi":"10.1177/02841851251399897","DOIUrl":"10.1177/02841851251399897","url":null,"abstract":"<p><p>BackgroundPancreatic cancer has poor outcomes, with vascular invasion being a critical factor in determining resectability and prognosis. Accurate assessment of vascular invasion remains challenging.PurposeTo investigate the predictors of vascular invasion and recurrence-free survival (RFS) in patients with pancreatic cancer undergoing surgery after chemotherapy using computed tomography (CT) and histopathological data, and to evaluate the diagnostic performance of CT-based vascular scoring system.Material and MethodsWe retrospectively analyzed 98 patients with pancreatic cancer showing vascular encasement on CT who underwent chemotherapy before surgery. Two reviewers evaluated baseline and preoperative CT to assess resectability. Clinicohistopathological factors were assessed. RFS was analyzed using the Kaplan-Meier method. The predictors were identified using Cox proportional hazards and logistic regression models. A 3-point scoring system quantified vascular involvement at baseline and preoperative CT, with total scores combining both time points.ResultsOf the 98 patients, 32 (32.7%) had pathologically confirmed vascular invasion. Change in tumor size (odds ratio [OR]=3.1; <i>P</i> = 0.022), T stage (OR=15.4; <i>P</i> = 0.038), and perineural invasion (OR=13.2; <i>P</i> = 0.028) predicted vascular invasion. Total vascular scores strongly correlated with vascular invasion (areas under the curve=0.924 and 0.803). Median RFS was 21 months, influenced by lymph node involvement at baseline and preoperative CT (hazard ratio [HR]=2.3; <i>P</i> = 0.009 and HR=2.6; <i>P</i> = 0.013, respectively), tumor differentiation (HR=3.3; <i>P</i> = 0.047), and elevated CA 19-9 (HR=2.8; <i>P</i> = 0.019).ConclusionChanges in tumor size on CT, T stage, and perineural invasion predict vascular invasion. In addition, a CT-based scoring systems can accurately predict vascular invasion after chemotherapy.</p>","PeriodicalId":7143,"journal":{"name":"Acta radiologica","volume":" ","pages":"166-177"},"PeriodicalIF":1.1,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145647103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Acta radiologicaPub Date : 2026-02-01Epub Date: 2025-11-25DOI: 10.1177/02841851251398622
Su Young Yun, Young Jin Heo
{"title":"Deep learning-based super-resolution of contrast-enhanced volumetric interpolated breath-hold examination for evaluation of intracranial enhancing lesions.","authors":"Su Young Yun, Young Jin Heo","doi":"10.1177/02841851251398622","DOIUrl":"10.1177/02841851251398622","url":null,"abstract":"<p><p>BackgroundDeep learning (DL)-based reconstruction may decrease the scan time of three-dimensional (3D) T1-weighted (T1W) imaging without compromising image quality. However, DL-based super-resolution reconstruction of volumetric interpolated breath-hold examination (DL-VIBE) has not previously been applied to intracranial contrast-enhancing lesions.PurposeTo investigate the diagnostic performance of DL-VIBE and compare it with conventional 3D T1 magnetization-prepared rapid-acquisition gradient echo (MPRAGE) for assessing intracranial enhancing lesions.Material and MethodsIn this study, 97 patients (35 men, 62 women; mean age = 59.2 ± 15.3 years) who underwent both contrast-enhanced 3D T1W imaging in the same imaging session (1 min 49 s vs. 5 min 32 s) between May and December 2023 were retrospectively included. Two neuroradiologists independently evaluated image quality, gray-white matter differentiation, lesion conspicuity, and artifacts using a 5-point Likert scale. Quantitative metrics included the number and maximum diameter of enhancing lesions, contrast:noise ratio (CNR) of lesion-to-normal parenchyma (CNR<sub>lesion/parenchyma</sub>), and CNR of white:gray matter (CNR<sub>WM/GM</sub>).ResultsAlthough DL-VIBE demonstrated lower overall image quality and gray-white matter differentiation, it showed significantly higher CNR<sub>lesion/parenchyma</sub> and fewer motion and pulsation artifacts (<i>P</i> <0.001) than conventional MPRAGE. Furthermore, no significant differences were observed in the lesion conspicuity, number, or longest diameter of enhancing lesions between DL-VIBE and conventional MPRAGE (<i>P</i> >0.05).ConclusionDL-VIBE showed comparable diagnostic performance for intracranial enhancing lesions with reduced scan time compared to conventional MPRAGE, although it was limited by a lower image quality. Therefore, DL-VIBE represents a promising approach for the technical development of DL-based reconstruction in clinical practice.</p>","PeriodicalId":7143,"journal":{"name":"Acta radiologica","volume":" ","pages":"133-141"},"PeriodicalIF":1.1,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145601739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Acta radiologicaPub Date : 2026-02-01Epub Date: 2025-12-18DOI: 10.1177/02841851251387444
Johan Jendeberg, Alma Björkman, Pär Dahlman, Hampus Eklöf, Elisabeth Eriksson, Mikael Hellström, Susanna Holst, Amar Karalli, Henrik Leonhardt, Anders Magnusson, Edward Meurling, Christian Papatziamos Hjelle, Adam Sjögren, Rodica Tila, Jonas Wallström, Jenny Öman, Ulf Nyman
{"title":"Computed tomography urography in macroscopic hematuria: a retrospective study with implications for standard care pathway.","authors":"Johan Jendeberg, Alma Björkman, Pär Dahlman, Hampus Eklöf, Elisabeth Eriksson, Mikael Hellström, Susanna Holst, Amar Karalli, Henrik Leonhardt, Anders Magnusson, Edward Meurling, Christian Papatziamos Hjelle, Adam Sjögren, Rodica Tila, Jonas Wallström, Jenny Öman, Ulf Nyman","doi":"10.1177/02841851251387444","DOIUrl":"10.1177/02841851251387444","url":null,"abstract":"<p><p>BackgroundStandardized care pathway (SCP) for macrohematuria (patients aged ≥50 years) in Sweden includes four-phase computed tomography urography (CTU) before cystoscopy, but targeted SCP lead time for CTU (6 days)/treatment is fulfilled in <25% of patients.PurposeTo retrospectively analyze the incidence of CTU-diagnosed upper urinary tract (UUT), kidney and bladder tumors, calculi, radiation dose, and its implications for SCP.Material and MethodsA total of 4491 consecutive CTU reports on macrohematuria indication were reviewed, mainly during 2022 (86.6%) from nine radiology units: four regions, three university hospitals, and two private units. Tumor findings were verified via biopsy/cytology reports, CTU characteristics, and follow-up. Effective patient radiation doses were calculated.ResultsIn patients aged ≥50 years (n = 3915) the incidence of UUT/kidney/bladder tumors was 0.9%/1.0%/6.9%, respectively, and of calyceal, pelvic, ureteral, and bladder calculi was 13%, 2.0%, 2.7%, and 2.2%, respectively. Median effective dose was 12.9 mSv (range=10-22 mSv) in the six radiology units using four-phase CTU in 87%-100% of the examinations and 9-12 mSv in the three units using four-phase in 3%-53%.ConclusionThe limited incidence of UUT and kidney tumors diagnosed at CTU for macrohematuria necessitates a multidisciplinary discussion on how to improve SCP lead times for the vast majority with urothelial tumors, i.e. bladder tumors. Alternative diagnostic pathways such as cystoscopy and clinical risk evaluation before CTU should be contemplated. Additionally, there is a need to optimize radiation dose by reducing the number of CTU phases on one hand and without losing significant diagnostic accuracy on the other hand.</p>","PeriodicalId":7143,"journal":{"name":"Acta radiologica","volume":" ","pages":"227-236"},"PeriodicalIF":1.1,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145779798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Acta radiologicaPub Date : 2026-02-01Epub Date: 2025-11-18DOI: 10.1177/02841851251394561
Neslihan Merd, Demet Gündüz, Nur Kara Oğuz, Maksude Esra Kadıoğlu
{"title":"Evaluation of parameter changes in lateral lumbosacral radiography of patients with lumbar spinal stenosis in MRI.","authors":"Neslihan Merd, Demet Gündüz, Nur Kara Oğuz, Maksude Esra Kadıoğlu","doi":"10.1177/02841851251394561","DOIUrl":"10.1177/02841851251394561","url":null,"abstract":"<p><p>BackgroundMagnetic resonance imaging (MRI) is the gold standard for evaluating lumbar spinal stenosis (LSS); however, its high cost and potential overuse raise concerns. Although plain radiographs are more accessible and cost-effective, there is currently no established radiographic criterion for the diagnosis of LSS.PurposeTo investigate in 100 patients the effect of LSS on objective parameters reflected on radiographs and to adapt existing radiographic indices for the diagnosis of LSS.Material and MethodsBetween September 2017 and May 2018, a retrospective evaluation was performed on 100 patients who underwent lumbosacral MRI and lateral lumbosacral radiography for back and/or leg pain. LSS was confirmed in 50 patients, and various angles, measurements, and ratios were calculated on the radiographs of these patients.ResultsPelvic incidence (PI) was significantly higher in the LSS group (<i>P</i> = 0.029). Foraminal width (FW) and pedicle width (PW) were significantly lower at all levels in patients with spinal stenosis (<i>P</i> <0.001 and <i>P</i> <0.005). Sagittal vertebral body width (SBW):PW ratio was significantly higher at all levels in the LSS group (<i>P</i> <0.005). Receiver operating characteristic (ROC) analysis was performed for the parameters showing significant differences between the LSS and control groups. Cutoff values were calculated for each significant parameter and level, and among them, PW, FW, and SBW:PW showed relatively high sensitivity, specificity and accuracy.ConclusionPW, FW, and the SBW/PW ratio demonstrated high sensitivity and specificity in the diagnosis of LSS. These parameters may be useful for screening purposes; however, they are not sufficient on their own for clinical or surgical decision-making.</p>","PeriodicalId":7143,"journal":{"name":"Acta radiologica","volume":" ","pages":"108-114"},"PeriodicalIF":1.1,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145547660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Ultrasonography and fine-needle aspiration cytology of thyroid nodules: assessment of malignancy using the British Thyroid Association classification.","authors":"Serkan Oner, Rukiye Sumeyye Bakici, Zulal Oner, Harun Erol","doi":"10.1177/02841851251389051","DOIUrl":"10.1177/02841851251389051","url":null,"abstract":"<p><p>BackgroundThe widespread use of high-resolution ultrasonography (US) imaging has led to an increased detection of thyroid nodules, which are common in the general population.PurposeTo evaluate the correlation between ultrasonographic and pathological findings of thyroid nodules undergoing US-guided fine-needle aspiration (FNA) and assess the contribution of US features to malignancy prediction.Material and MethodsA total of 573 patients (137 men, 436 women; age range = 20-88 years) who underwent US-guided FNA were included. Nodule characteristics were recorded using the British Thyroid Association (BTA) U classification, and cytological results were assessed according to the Bethesda system. Logistic regression analysis (LRA) was performed to determine the relationship between US features and malignancy.ResultsThe distribution of nodules in U2, U3, U4, and U5 categories was 212, 171, 84, and 36, respectively, with corresponding Bethesda (2-6) classifications of 287, 159, 18, 27, and 12. Malignancy rates (Bethesda 4-6) were 0%, 10%, 28.6%, and 44.5%, respectively. Hypoechogenicity (relative to muscle), internal vascularization, and microcalcifications were significantly associated with malignancy (<i>P</i> <0.05). LRA achieved an 85.5% accuracy in malignancy prediction.ConclusionUS features in the BTA U classification align with pathological findings. Hypoechoic solid nodules, central vascularization, and microcalcifications should raise suspicion for malignancy in the differential diagnosis of thyroid nodules. These study findings highlight the strong association between vascularity in the BTA classification and malignancy, suggesting its potential role in risk stratification.</p>","PeriodicalId":7143,"journal":{"name":"Acta radiologica","volume":" ","pages":"75-84"},"PeriodicalIF":1.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145436972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Evaluation of the effectiveness of a tunnel-shaped radiation shielding system in CT-guided interventions: Reduction of scattered radiation in phantom experiment.","authors":"Miyuki Nakatani, Shuji Kariya, Yasuyuki Ono, Takuji Maruyama, Yutaka Ueno, Noboru Tanigawa","doi":"10.1177/02841851251389937","DOIUrl":"10.1177/02841851251389937","url":null,"abstract":"<p><p>BackgroundComputed tomography (CT) fluoroscopy provides high-resolution images and is widely used for safe and accurate procedures, but it exposes operators to high radiation doses.PurposeTo develop and evaluate a tunnel-shaped shielding system to reduce operator exposure to scattered radiation during CT fluoroscopy-guided procedures.Material and MethodsThe shield, designed based on scattered radiation distribution, consists of a semi-cylindrical leaded acrylic part and a bottom plate with a non-lead shielding board surrounding the patient. Radiation doses were measured with and without the shield using patient and operator phantoms. Dosimeters were placed at 10 locations on the operator phantom, including the eye lens, thyroid, chest, abdomen, pelvis, legs, patient-side armpit, and needle-holding hand. Percentage reductions in radiation exposure were calculated.ResultsThe tunnel-shaped shield significantly reduced radiation exposure, with dose reductions of 83%-100% at the eye lens, 88%-96% at the thyroid, 84%-95% at the upper chest, 84%-92% at the lower chest, 88%-94% at the abdomen, 91%-94% at the pelvis, 57%-68% at the upper leg, 44%-83% at the lower leg, 90%-94% at the patient-side armpit, and 73%-86% at the needle-holding hand. All reductions were statistically significant.ConclusionPhantom experiments demonstrated that the tunnel-shaped shielding system effectively reduces operator exposure to scattered radiation during CT fluoroscopy-guided procedures.</p>","PeriodicalId":7143,"journal":{"name":"Acta radiologica","volume":" ","pages":"85-95"},"PeriodicalIF":1.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145457134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Diagnostic performance of contrast-enhanced spectral mammography in the evaluation of suspicious microcalcifications without associated mass.","authors":"Eda Elverici, Seçil Gündoğdu, Leman Gunbey Karabekmez, Serra Kayaçetin, Buket Altun Özdemir, Muhammet Batuhan Gökhan, Arzu Özsoy","doi":"10.1177/02841851251380868","DOIUrl":"10.1177/02841851251380868","url":null,"abstract":"<p><p>BackgroundContrast-enhancing magnetic resonance imaging is an expensive examination compared to contrast-enhanced spectral mammography (CESM) and cannot show microcalcifications.PurposeTo investigate the diagnostic performance of CESM for malignancy with microcalcifications alone and the relationship between tumor immunohistochemistry findings and tumor grade.Material and MethodsA total of 117 patients with suspected microcalcification at CESM were applied to our hospital between January 2022 and May 2024. Patients with accompanying mass and architectural distortion (n = 9) and the ones lacking pathology results (n = 11) were excluded. Patients with CESM and histopathological diagnosis (n = 97) were evaluated retrospectively. Mammography images were analyzed according to the American College of Radiology Breast Imaging-Reporting and Data System lexicon.ResultsIn our study, the diagnostic value of the presence of contrast enhancement in CESM was high in the evaluation of suspicious breast microcalcifications. Malignant pathology was detected in all of the microcalcifications with high-risk morphology. In addition, all of the microcalcifications that enhanced in solid and ground-glass form were invasive ductal carcinoma. However, no significant relationship was found between immunohistochemical parameters (ER, PR, CerB2, Ki-67 and grade) and enhancement in CESM. The highest enhancement rate among malignant subtypes was detected in the luminal B group.ConclusionCESM is useful to reduce the number of unnecessary benign biopsies with suspicious microcalcifications in the breast, and provides an important contribution to the radiologist's biopsy decision by simultaneously showing the morphological features of the microcalcification and the contrast enhancement information.</p>","PeriodicalId":7143,"journal":{"name":"Acta radiologica","volume":" ","pages":"34-42"},"PeriodicalIF":1.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145237574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Acta radiologicaPub Date : 2026-01-01Epub Date: 2025-11-04DOI: 10.1177/02841851251389575
Bahareh Abdolalizadeh, Nikolai Madrid Scheller, Marina Lunetcas, Oscar Rosenkrantz, Samir Jawad, Thomas Skaarup Kristensen, Thomas Axelsen, Carsten Palnæs Hansen, Caroline Ewertsen
{"title":"Pancreatic IPMN in clinical practice: descriptive analysis of 1082 patients referred to multidisciplinary evaluation.","authors":"Bahareh Abdolalizadeh, Nikolai Madrid Scheller, Marina Lunetcas, Oscar Rosenkrantz, Samir Jawad, Thomas Skaarup Kristensen, Thomas Axelsen, Carsten Palnæs Hansen, Caroline Ewertsen","doi":"10.1177/02841851251389575","DOIUrl":"10.1177/02841851251389575","url":null,"abstract":"<p><p>BackgroundIntraductal papillary mucinous neoplasms (IPMNs) of the pancreas are cystic lesions with varying malignant potential requiring long-term surveillance. However, optimal surveillance strategies remain debated.PurposeTo evaluate imaging and demographic characteristics of IPMN patients referred to our multidisciplinary team (MDT) conference over a 5-year period, and to determine the frequency and histopathological outcomes of surgical resections.Material and MethodsWe assessed a cohort of all patients referred to the weekly IPMN MDT conference between 1 January 2019 and 31 December 2023. Using electronic health records, we linked information from imaging records with clinical characteristics. Outcomes included imaging features, presence and development of worrisome features (WFs), and surgical interventions.ResultsDuring the study period, 1082 patients were eligible for inclusion in the study cohort. The majority were female (57.1%) and mean age at entry was 69.8 years. Branch duct IPMN was the most common subtype (95.3%). At baseline, WFs were present in 207 (19.1%) patients and an additional 47 (4.1%) patients developed WFs during follow-up. Rapid cyst growth was observed in 6.8% using the Fukuoka criteria and 10.3% using the updated Kyoto 2024 criteria. Surgical resection was performed in 62 (5.7%) patients, of whom 31 (2.9%) had malignant transformation or high-grade dysplasia.ConclusionMalignant transformation was uncommon among our IPMN patients. WFs and rapid cyst growth were not consistent predictors. These findings support more individualized and less intensive surveillance.</p>","PeriodicalId":7143,"journal":{"name":"Acta radiologica","volume":" ","pages":"67-74"},"PeriodicalIF":1.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145437010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Acta radiologicaPub Date : 2026-01-01Epub Date: 2026-01-21DOI: 10.1177/02841851261416844
{"title":"CORRIGENDUM to \"Deep learning powered breast ultrasound to improve characterization of breast masses: a prospective study\".","authors":"","doi":"10.1177/02841851261416844","DOIUrl":"https://doi.org/10.1177/02841851261416844","url":null,"abstract":"","PeriodicalId":7143,"journal":{"name":"Acta radiologica","volume":"67 1","pages":"96"},"PeriodicalIF":1.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146008140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Deep learning powered breast ultrasound to improve characterization of breast masses: a prospective study.","authors":"Veenu Singla, Dollphy Garg, Sapna Negi, Nandita Mehta, T Pallavi, Sonam Choudhary, Abhik Dhiman","doi":"10.1177/02841851251377927","DOIUrl":"10.1177/02841851251377927","url":null,"abstract":"<p><p>BackgroundThe diagnostic performance of ultrasound (US) is heavily reliant on the operator's expertise. Advances in artificial intelligence (AI) have introduced deep learning (DL) tools that detect morphology beyond human perception, providing automated interpretations.PurposeTo evaluate Smart-Detect (S-Detect), a DL tool, for its potential to enhance diagnostic precision and standardize US assessments among radiologists with varying levels of experience.Material and MethodsThis prospective observational study was conducted between May and November 2024. US and S-Detect analyses were performed by a breast imaging fellow. Images were independently analyzed by five radiologists with varying experience in breast imaging (<1 year-15 years). Each radiologist assessed the images twice: without and with S-Detect. ROC analyses compared the diagnostic performance. True downgrades and upgrades were calculated to determine the biopsy reduction with AI assistance. Kappa statistics assessed radiologist agreement before and after incorporating S-Detect.ResultsThis study analyzed 230 breast masses from 216 patients. S-Detect demonstrated high specificity (92.7%), PPV (92.9%), NPV (87.9%), and accuracy (90.4%). It enhanced less experienced radiologists' performance, increasing the sensitivity (85% to 93.33%), specificity (54.5% to 73.64%), and accuracy (70.43% to 83.91%; <i>P</i> <0.001). AUC significantly increased for the less experienced radiologists (0.698 to 0.835 <i>P</i> <0.001), with no significant gains for the expert radiologist. It also reduced variability in assessment between radiologists with an increase in kappa agreement (0.459-0.696) and enabled significant downgrades, reducing unnecessary biopsies.ConclusionThe DL tool improves diagnostic accuracy, bridges the expertise gap, reduces reliance on invasive procedures, and enhances consistency in clinical decisions among radiologists.</p>","PeriodicalId":7143,"journal":{"name":"Acta radiologica","volume":" ","pages":"13-23"},"PeriodicalIF":1.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145147263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}