Acta radiologicaPub Date : 2026-02-01Epub Date: 2025-11-27DOI: 10.1177/02841851251396564
Marko Frings, Abdullatif Kocak, Sivagurunathan Sutharsan, Michael Forsting, Christian Taube, Marcel Opitz, Matthias Welsner
{"title":"Advancements in monitoring paranasal sinuses among people with cystic fibrosis using photon-counting CT.","authors":"Marko Frings, Abdullatif Kocak, Sivagurunathan Sutharsan, Michael Forsting, Christian Taube, Marcel Opitz, Matthias Welsner","doi":"10.1177/02841851251396564","DOIUrl":"10.1177/02841851251396564","url":null,"abstract":"<p><p>BackgroundPeople diagnosed with cystic fibrosis (pwCF) who have chronic rhinosinusitis undergo low-dose computed tomography (LDCT) scans of the paranasal sinuses as a crucial component of their disease management.PurposeTo assess and compare the intra-individual image quality and radiation dose between photon-counting CT (PCCT) and CT scanners utilizing an energy-integrating detector system (EID-CT) with LD protocols for pwCF.Material and MethodsIn this retrospective study, 23 pwCF who underwent LD paranasal sinuses PCCT and who had previously undergone LD paranasal sinuses EID-CT were included. An intra-individual comparison of image quality and radiation dose was carried out. Three blinded radiologists rated overall image quality, image sharpness, and image noise using a 5-point Likert scale. The study measured the dose length product, the volumetric CT dose index, the effective dose, and the signal to noise ratio (SNR).ResultsThe cohort comprised 23 individuals (6 women [26%], 17 men [74%]; mean age = 36.7 years). PCCT achieved superior evaluations for image quality in comparison to EID-CT (mean = 5 vs. 3; <i>P</i> <0.001). Furthermore, PCCT exhibited diminished image noise (mean = 4 vs. 3; <i>P</i> <0.001). The mean SNR of the paranasal sinuses demonstrated an increase in PCCT as opposed to EID-CT (<i>P</i> <0.001). PCCT demonstrated a reduction of approximately 36% in effective dose compared to EID-CT (mean = 0.09 vs. 0.15 mSv; <i>P</i> <0.001).ConclusionPCCT scans of the paranasal sinuses offer superior image quality and substantially reduce radiation dose compared to EID-CT scans in pwCF, offering a safer and more effective imaging alternative compared to EID-CT for managing cystic fibrosis.</p>","PeriodicalId":7143,"journal":{"name":"Acta radiologica","volume":" ","pages":"157-165"},"PeriodicalIF":1.1,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145627643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Acta radiologicaPub Date : 2026-02-01Epub Date: 2025-12-18DOI: 10.1177/02841851251405785
Jun Gon Kim, Myung Sub Kim, Sang Yub Lee, Kwang Bo Park, Young Soo Do, Shin Seok Yang, Yang-Jin Park
{"title":"Factors influencing cardiomegaly and cardiac size changes after endovascular treatment in peripheral arteriovenous malformations.","authors":"Jun Gon Kim, Myung Sub Kim, Sang Yub Lee, Kwang Bo Park, Young Soo Do, Shin Seok Yang, Yang-Jin Park","doi":"10.1177/02841851251405785","DOIUrl":"10.1177/02841851251405785","url":null,"abstract":"<p><p>BackgroundAlthough prior studies on peripheral arteriovenous malformations (AVMs) have addressed diagnosis and treatment, the prevalence and risk factors for cardiomegaly remain underexplored.PurposeTo assess the prevalence of cardiomegaly in peripheral AVMs, identify associated factors, and evaluate changes in cardiac size and function following endovascular treatment.Material and MethodsA retrospective review was conducted on 437 patients treated for peripheral AVMs between 2000 and 2022 at a single vascular anomalies center. AVM types were classified according to the Cho-Do angiographic classification. Cardiomegaly was defined as a cardiothoracic ratio (CTR) >0.5 on chest radiographs. Factors associated with cardiomegaly and post-treatment changes in CTR and cardiac function were analyzed.ResultsCardiomegaly was observed in 108/437 (24.7%) patients. Multivariate analysis identified type I/II (vs. III) (<i>P</i> = 0.002), lesion diameter >10 cm (<i>P</i> = 0.013), and bone involvement (<i>P</i> = 0.021) as significant risk factors. Abdominopelvic (<i>P</i> <0.001) and thoracic-neck AVMs (<i>P</i> = 0.018) had higher cardiomegaly prevalence than extremity AVMs. Among the 108 patients with cardiomegaly, 84 underwent follow-up chest radiographs. The median CTR reduction rate was 8.9% (interquartile range [IQR] 4.1-15.8), with a significant decrease (<i>P</i> <0.001). Higher angiographic devascularization was associated with greater CTR reductions (<i>P</i> = 0.013). Echocardiography was selectively performed in patients with suspected cardiac involvement. Among 27 patients with both pre- and post-treatment echocardiography, 44% showed functional improvement.ConclusionAVM type, extent, location, and bone involvement were significant factors influencing cardiomegaly risk. Endovascular treatment was effective in reducing cardiac enlargement and functional improvement was observed in a subset of patients.</p>","PeriodicalId":7143,"journal":{"name":"Acta radiologica","volume":" ","pages":"208-216"},"PeriodicalIF":1.1,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145772910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Acta radiologicaPub Date : 2026-02-01Epub Date: 2025-11-25DOI: 10.1177/02841851251393798
Klara Sahlén, Pär Dahlman, Per Liss, Maria Lönnemark, Monica Segelsjö, Anders Magnusson
{"title":"Patient-reported symptoms at follow-up after a ureteral colic attack as an indication of spontaneous stone passage/remaining ureteral stone or presence of urinary tract obstruction.","authors":"Klara Sahlén, Pär Dahlman, Per Liss, Maria Lönnemark, Monica Segelsjö, Anders Magnusson","doi":"10.1177/02841851251393798","DOIUrl":"10.1177/02841851251393798","url":null,"abstract":"<p><p>BackgroundPatient-reported symptoms is considered a possible alternative to computed tomography (CT) for the evaluation of remaining ureteral stones at follow-up after a ureteral colic attack.PurposeTo investigate patient-reported symptoms at follow-up after a ureteral colic attack in patients with a remaining ureteral stone and to assess the association of symptoms with degree of urinary obstruction.Material and MethodsThis was a prospective study of 81 patients (68 men, 13 women; mean age = 59 years; age range = 23-88 years) referred for a follow-up CT after a ureteral colic attack with a remaining unilateral ureteral stone. A dynamic enhanced scan defined urinary obstruction. Stone size was the largest diameter of three multiplanar reformatations (axial, coronal, sagittal). Stone location was registered as proximal, mid-ureter or distal. Symptoms were registered in standardized questionnaires by the patient at the time of the follow-up.ResultsIn total, 43/81 (53%) patients reported symptoms. Obstruction of any degree was present in 16 (20%) patients. In 7 (100%) patients with moderate-severe obstruction reported discomfort attributed to the stone. In patients with mild obstruction, 5 (56%) reported discomfort; in patients with no obstruction, 31 (48%) reported discomfort.ConclusionAlmost half of the patients at follow-up reported no discomfort despite having a stone in the ureter. A significant association was found between a higher degree of obstruction and reported symptoms. Asymptomatic stones and silent partial obstruction could be missed based on reported symptoms. Imaging is still required to evaluate stone passage at follow-up after a ureteral colic attack.</p>","PeriodicalId":7143,"journal":{"name":"Acta radiologica","volume":" ","pages":"151-156"},"PeriodicalIF":1.1,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12886557/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145601734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Feasibility and efficacy of a thermal ablation device utilizing a nitinol-based coil.","authors":"Fuyuki Nagano, Akitoshi Inoue, Shohei Chatani, Yugo Imai, Akinaga Sonoda, Norihisa Nitta, Ken-Ichi Mukaisho, Naotake Nakamura, Yoshiyuki Watanabe","doi":"10.1177/02841851251396571","DOIUrl":"10.1177/02841851251396571","url":null,"abstract":"<p><p>BackgroundA fibrous actuator, composed of a nitinol-based coil memory alloy, functions as a flexible coil under normal conditions. It contracts and generates heat when activated with an electric current. This property makes it a promising candidate for use as an interventional thermal device.PurposeTo evaluate the thermal effects of a nitinol coil ablation device on liver tissue and the intrahepatic portal vein.Material and MethodsAn in vitro experiment using bovine resected liver was performed. Ten Japanese white rabbits were divided equally into two groups (0.6-W and 1.1-W) based on electric power settings. Ablation was performed in three liver regions for each rabbit. Ablated areas were measured using fat-suppressed T1-weighted imaging following gadolinium administration and histological examination with hematoxylin and eosin staining. For the intrahepatic portal vein ablation, nine rabbits were assigned to the ablation group and eight rabbits served as controls. Portography was conducted before and after the procedure.ResultsIn vitro, temperature increases at ablation site and at 5-, 10-, and 15-mm distances and ellipsoid-shaped ablated area were proportional to electric power. In the in vivo experiment, the 1.1-W group exhibited significantly greater ablation effects compared to the 0.6-W group, as measured by magnetic resonance imaging (50.6 vs. 22.7 mm²; <i>P</i> <0.001) and histopathology (38.9 vs. 21.7 mm²; <i>P</i> = 0.001). Nearly complete occlusion (>80% stenosis) was more frequently observed in the ablation group (72.2% vs. 22.2%; <i>P</i> = 0.007).ConclusionThe thermal ablation device utilizing a nitinol coil demonstrated effective liver ablation. Furthermore, it shows potential for customization in endovascular ablation applications.</p>","PeriodicalId":7143,"journal":{"name":"Acta radiologica","volume":" ","pages":"178-187"},"PeriodicalIF":1.1,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145647048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Prediction of MYCN amplification status in neuroblastoma using radiomics: a systematic review and meta-analysis.","authors":"Xinru Kuang, Xiaoquan Xu, Fei Teng, Dapeng Li, Feiyun Wu","doi":"10.1177/02841851251403127","DOIUrl":"10.1177/02841851251403127","url":null,"abstract":"<p><p>BackgroundMYCN gene amplification is associated with poor prognosis in neuroblastoma (NB) patients; however, its detection relies on the invasive fluorescence in situ hybridization technique. Radiomics can non-invasively predict MYCN gene amplification by extracting high-dimensional features from medical images.PurposeTo systematically review and meta-analyze the performance of radiomics models in predicting MYCN gene amplification status in NB patients.Material and MethodsAs of 18 March 2025, a systematic search was performed for original literature on the prediction of MYCN amplification in NB patients using radiomics models in the following databases: PubMed, Embase, Web of Science, and Cochrane Library. The quality of the literature was assessed using the QUADAS-2 and Radiomics Quality Score (RQS) tools. The meta-analysis was performed using the random-effects model.ResultsThis research ultimately included nine articles (899 patients), from which data could be extracted for both radiomics-only models and combined models that integrate radiomic features with other predictors. The radiomics-only model demonstrated pooled sensitivity of 0.85 (95% confidence interval [CI] = 0.77-0.91) and specificity of 0.86 (95% CI = 0.79-0.90), while the combined model showed a sensitivity of 0.81 (95% CI = 0.75-0.87) and specificity of 0.92 (95% CI = 0.87-0.95). Summary receiver operating characteristic (SROC) curve yielded an area under ROC curve of 0.92 ± 0.02 for the radiomics-only model and 0.94 ± 0.02 for the combined model. No evidence of publication bias was found.ConclusionsRadiomics might be one promising approach for predicting MYCN gene amplification in patients with NB.</p>","PeriodicalId":7143,"journal":{"name":"Acta radiologica","volume":" ","pages":"217-226"},"PeriodicalIF":1.1,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145772971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Acta radiologicaPub Date : 2026-02-01Epub Date: 2025-12-23DOI: 10.1177/02841851251407343
Sungeun Park, Mi Hye Yu, Hee Sun Park, Sung Il Jung, Young Jun Kim
{"title":"MRI radiomics model using T2-weighted imaging sequences to differentiate small hepatic metastases and hemangiomas.","authors":"Sungeun Park, Mi Hye Yu, Hee Sun Park, Sung Il Jung, Young Jun Kim","doi":"10.1177/02841851251407343","DOIUrl":"10.1177/02841851251407343","url":null,"abstract":"<p><p>BackgroundDifferentiating small hepatic metastases from hemangiomas can be challenging on visual assessment.PurposeTo evaluate the diagnostic performance of magnetic resonance imaging (MRI) radiomics models based on T2-weighted (T2W) imaging in differentiating small hepatic metastases from hemangiomas.Material and MethodsThis retrospective study included patients with small (≤2 cm) hepatic metastases from colorectal cancer or hemangiomas who underwent liver MRI between August 2018 and January 2024. Datasets were divided into training, internal, and external validation sets based on MRI scanner type. Manual segmentation was performed on conventional T2W, heavily T2W, and fat-suppressed (FS)-T2W imaging. Random forest models were developed using 10-fold cross-validation on 10 selected radiomics features. AUCs were calculated to evaluate model performance. Before segmentation, each hepatic lesion in the validation sets was categorized into metastasis, hemangioma, or indeterminate lesion according to visual assessment on T2W imaging by two radiologists in consensus.ResultsA total of 285 patients (148 men; mean age=55.8 ± 12.5 years) were included: training (140 patients: 151 metastases, 155 hemangiomas), internal (86 patients: 87 metastases, 80 hemangiomas), and external (59 patients: 37 metastases, 69 hemangiomas) validation sets. AUCs for conventional/heavily/FS-T2W imaging were 0.976/0.972/0.946 (training), 0.979/0.991/0.989 (internal validation), and 0.969/0.976/0.809 (external validation), respectively. Among visually indeterminate lesions, 6/7 lesions in the internal validation set and 5/8 lesions in the external validation set were correctly classified using radiomics scores.ConclusionRadiomics models based on T2W imaging exhibit excellent performance in differentiating small hepatic metastases from hemangiomas and may contribute to the correct classification of visually indeterminate hepatic lesions.</p>","PeriodicalId":7143,"journal":{"name":"Acta radiologica","volume":" ","pages":"237-249"},"PeriodicalIF":1.1,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145809119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Distinctive MRI findings and clinical correlations in pediatric idiopathic intracranial hypertension: optic nerve sheath dilatation and scleral flattening as diagnostic indicators.","authors":"Begumhan Baysal, Mahmut Bilal Dogan, Ozlem Turkyılmaz, Elif Yuksel Karatoprak, Fehim Esen","doi":"10.1177/02841851251395724","DOIUrl":"10.1177/02841851251395724","url":null,"abstract":"<p><p>BackgroundIdiopathic intracranial hypertension (IIH) in the pediatric population is a rare disease, and imaging is important in its diagnostic criteria.PurposeTo elucidate distinctive magnetic resonance imaging (MRI) findings of pediatric IIH and their correlation with clinical manifestations.Material and MethodsA total of 41 pediatric patients diagnosed with IIH and a control group consisting of 40 healthy children were retrospectively analyzed. Clinical parameters (body mass index, papilledema, cerebrospinal fluid [CSF] pressure), visual acuity, visual fields, and MRI findings were assessed. Statistical analysis was performed using SPSS 21.0 software.ResultsThe mean age was 12.4 ± 3.4 years, with 78% presenting with headaches and 24% with nausea and/or vomiting. MRI findings revealed optic nerve sheath dilatation (51.2%), posterior scleral flattening (43.9%), optic nerve tortuosity (19.5%), pituitary flattening (34.1%), and optic disc bulging (29.3%). Optic nerve sheath dilatation correlated with high CSF pressure. Scleral flattening correlated with elevated intracranial pressure, papilledema, and visual field defects. Optic disc bulging correlated with elevated papilledema and visual field defects also.ConclusionThis study highlights the diagnostic significance of optic nerve sheath dilatation and scleral flattening in pediatric IIH. Scleral flattening may be an important marker for optic nerve damage.</p>","PeriodicalId":7143,"journal":{"name":"Acta radiologica","volume":" ","pages":"124-132"},"PeriodicalIF":1.1,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145572858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Acta radiologicaPub Date : 2026-02-01Epub Date: 2025-11-25DOI: 10.1177/02841851251394540
Flemming Kromann Nielsen, Anne Grethe Jurik, Lars Lindgren, Niels Egund
{"title":"Tibiofemoral joint space width in semiflexed standing position: no difference by weightbearing on one or two knees by manual and computerized measurements.","authors":"Flemming Kromann Nielsen, Anne Grethe Jurik, Lars Lindgren, Niels Egund","doi":"10.1177/02841851251394540","DOIUrl":"10.1177/02841851251394540","url":null,"abstract":"<p><p>BackgroundSingle knee weightbearing (SKW) radiographs are considered more accurate for detecting minimal joint space width (mJSW) than double knee weightbearing (DKW) but have not been compared using a standardized method.PurposeTo compare medial and lateral tibiofemoral mJSW between SKW and DKW radiographs using manual and computerized measurements.Material and MethodsStandardized posteroanterior radiographs of both knees were obtained from 98 patients with knee pain (55 women; mean age = 64.5 years; age range = 41-81 years) using the DKW technique in semiflexion, followed by SKW. Medial and lateral mJSW, coronal translation, and tibial plateau alignment (intermargin distance) were measured manually. Intra- and inter-rater agreement was assessed using 100 knee radiographs. In addition, mJSW was measured using a fully automated computerized technique. Manual measurements were adjusted for magnification, while computerized measurements were not.ResultsInter- and intra-rater reliability of manual measurements was excellent. Both manual and computerized mJSW measurements showed a non-significant trend toward larger medial mJSW with DKW compared to SKW. Coronal translation did not differ between SKW and DKW. The intermargin distances were small, with no significant differences between SKW and DKW, indicating reproducible knee positioning. Computerized measurements consistently showed larger mJSW than manual measurements.ConclusionMedial and lateral mJSW did not differ significantly between SKW and DKW techniques using either manual or computerized measurements. However, a systematic difference was observed between manual and computerized mJSW measurements. The SKW technique did not offer any advantages over the DKW technique for assessing knee osteoarthritis.</p>","PeriodicalId":7143,"journal":{"name":"Acta radiologica","volume":" ","pages":"142-150"},"PeriodicalIF":1.1,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145601662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Acta radiologicaPub Date : 2026-02-01Epub Date: 2025-11-18DOI: 10.1177/02841851251393507
Jinhua Wang, Liang Wang, Zhongxian Yang, Qian Zou, Yubao Liu
{"title":"The role of interdisciplinary collaboration and artificial intelligence in radiology residency education.","authors":"Jinhua Wang, Liang Wang, Zhongxian Yang, Qian Zou, Yubao Liu","doi":"10.1177/02841851251393507","DOIUrl":"10.1177/02841851251393507","url":null,"abstract":"<p><p>BackgroundModern medical education demands refined methods, especially in radiology, where accuracy, speed, and clinical decision-making are critical.PurposeTo evaluate the impact of artificial intelligence (AI)-assisted and interdisciplinary educational interventions on residents' theoretical knowledge, confidence in professional skills, and practical clinical abilities. Assessments were conducted at Kirkpatrick Level 2 (Learning) for knowledge. Level 3 (Behavior) and Level 4 (Results) were not assessed in this study due to logistical constraints.Material and MethodsThe study was conducted between January and June 2024 at three medical centers in Shenzhen, China. A total of 240 residents were randomly assigned to three groups of 80 each: group 1 received standard training; group 2 participated in interdisciplinary seminars; and group 3 engaged in AI-assisted learning activities. The study included three stages: baseline assessment, core educational intervention, and final evaluation. Statistical analyses included Shapiro-Wilk and Kolmogorov-Smirnov tests for normality, followed by ANOVA and Tukey's post hoc tests for group comparisons.ResultsResidents in groups 2 and 3 demonstrated significant improvements across all measured domains. Group 3 (AI-assisted training) showed the greatest gains, with theoretical knowledge increasing by 21.5%, confidence in professional skills by 39.4%, and clinical skill performance by 27.1%. All between-group differences were statistically significant (<i>P</i> <0.01).ConclusionThe findings underscore the benefit of combining technology-driven exercises with collaborative, multispecialty learning to strengthen clinical competence. Future research should examine how such AI-based interventions influence long-term performance and how they can be adapted to different training environments.</p>","PeriodicalId":7143,"journal":{"name":"Acta radiologica","volume":" ","pages":"115-123"},"PeriodicalIF":1.1,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145547645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"MRI quantitative parameters combined with pathological microvascular characteristics predict lymph node metastasis of cervical squamous cell carcinoma.","authors":"Yiyi Luan, Yanmei Zhu, Lili Sun, Fengying Qin, Huiting Pang, Yong Zhang, Yue Dong","doi":"10.1177/02841851251397595","DOIUrl":"10.1177/02841851251397595","url":null,"abstract":"<p><p>BackgroundLymph node metastasis (LNM) greatly affects the prognosis and treatment of cervical squamous cell carcinoma (CSCC). Non-invasive imaging biomarkers that reflect tumor angiogenesis and vascular maturity may help predict LNM.PurposeTo determine whether the magnetic resonance imaging (MRI) quantitative parameters combined with microvascular characteristics predict the potential of LNM by reflecting angiogenesis or vascular maturation in CSCC.Material and MethodsThe clinicopathological characteristics, microvascular characteristics and MRI quantitative parameters of the LNM group (43 cases) and the non-LNM group (42 cases) were analyzed. The correlation between microvascular and MRI quantitative parameters and the ability of combined diagnosis of LNM were analyzed.ResultsThere were significant differences in the FIGO stage and the short diameter of the largest lymph node between patients with or without LNM. There was no significant difference in the apparent diffusion coefficient (ADC) value of the primary tumor between the LNM group and the non-LNM group (<i>P</i> >0.05). Spearman's correlation analysis showed that there was no correlation between ADC and MVD or microvessel pericyte coverage index (MPI) (all <i>P</i> >0.05). K<sup>trans</sup> and K<sub>ep</sub> were significantly higher, and MPI was significantly lower in patients with LNM. There were negative correlations between K<sup>trans</sup> and MPI, and K<sub>ep</sub> and MPI. Binary logistic regression analysis showed that a combined prediction model constructed by K<sup>trans</sup>, K<sub>ep</sub>, and MPI had the highest diagnostic efficacy.ConclusionK<sup>trans</sup> and K<sub>ep</sub> of CSCC can predict LNM by non-invasively reflecting the maturity of tumor vessels, and the combined K<sup>trans</sup>, K<sub>ep</sub>, and MPI have promising diagnostic efficiency for LNM.</p>","PeriodicalId":7143,"journal":{"name":"Acta radiologica","volume":" ","pages":"188-198"},"PeriodicalIF":1.1,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145706963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}