Acta radiologicaPub Date : 2025-06-01Epub Date: 2025-03-17DOI: 10.1177/02841851251322838
Sinan Bakirci, Serkan Oner, Hazal Kiran
{"title":"Comparison of sphenoid sinus variations and morphometric values in dolichocephalic and hyperbrachycephalic individuals.","authors":"Sinan Bakirci, Serkan Oner, Hazal Kiran","doi":"10.1177/02841851251322838","DOIUrl":"10.1177/02841851251322838","url":null,"abstract":"<p><p>BackgroundThe internal carotid artery, optic, maxillary, and vidian nerves are important anatomical structures adjacent to the sphenoid sinus. In some individuals, these structures may protrude into the sinus, and this condition is important in surgical procedures.PurposeTo investigate the morphometric variations and anatomical differences in the sphenoid sinus and surrounding structures between dolichocephalic and hyperbrachycephalic skull types using computed tomography (CT).Material and MethodsCT images of dolichocephalic (n = 50), hyperbrachycephalic (n = 64), and mesocephalic (n = 52) individuals were used in the study. Sphenoid sinus position, dimensions, septum types, and protrusion and dehiscence for the carotid canal and optic canal, maxillary, and vidian nerves were evaluated. For statistical evaluation, the Mann-Whitney U-test, Kruskal-Wallis test, Pearson chi-square, Fisher's exact test, and Spearman's rho correlation were used in the study.ResultsThe difference between all skull types was found to be significant in the rates of protrusion and dehiscence in the carotid canal and the maxillary nerve and the difference between sphenoid sinus heights in two different skull types (dolichocephalic and hyperbrachycephalic) was also significant (<i>P</i> < 0.05). In septum typing, seven different septum types were detected. The most common sphenoid sinus position was postsellar in all skull types.ConclusionDifferences in the frequency of protrusion and dehiscence for the carotid canal and maxillary nerve in dolichocephalic, hyperbrachycephalic, and mesocephalic individuals reveal that the skull types of individuals are important in studies on the sphenoid sinus.</p>","PeriodicalId":7143,"journal":{"name":"Acta radiologica","volume":" ","pages":"650-659"},"PeriodicalIF":1.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143646527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Factors affecting the development of pneumothorax in transthoracic fine-needle aspiration biopsies.","authors":"Ayla Turkar, Tamer Baysal, Tunahan Refik Dumlu, Rıdvan Dizman","doi":"10.1177/02841851251322070","DOIUrl":"10.1177/02841851251322070","url":null,"abstract":"<p><p>BackgroundPneumothorax is the most common complication and reason for hospitalization in needle biopsies of lung.PurposeTo investigate the factors that determine the risk and severity of pneumothorax in needle biopsies of lung.Material and MethodsFine-needle aspiration biopsy was performed for diagnostic purposes in 505 patients under the guidance of computed tomography for lung lesions. Findings were analyzed in terms of demographic characteristics of patients' and procedure-related features.ResultsThe mean age of the patients was 65 ± 9.7 years and mean lesion size was 34.31 ± 16.99 mm. Pneumothorax developed in 176 patients. The frequency and severity of pneumothorax were higher in male patients (<i>P</i> < 0.001 and <i>P</i> = 0.003). Emphysema was a risk factor for pneumothorax (<i>P</i> = 0.002). The rate of pneumothorax was higher in lower lobe lesions. Pleural length made a significant difference, especially for the severity of pneumothorax. The severity of pneumothorax increased as dwell time increased (<i>P</i> = 0.029). The need for a chest tube was significantly higher in the group with pneumothorax thickness >1 cm (<i>P</i> < 0.001). The requirement for multiple passes increased the risk of developing pneumothorax (<i>P</i> < 0.001). Procedure-related hemorrhage reduced the risk of pneumothorax and prevented the progression of pneumothorax (<i>P</i> < 0.001 for both). The risk of developing pneumothorax was lowest in the supine position (<i>P</i> = 0.001).ConclusionPatient's sex, presence of emphysema, and lesion location are unchangeable patient-dependent factors for the development of pneumothorax. However, the aim should be to plan the process correctly and complete it with a single entry and a short dwell time.</p>","PeriodicalId":7143,"journal":{"name":"Acta radiologica","volume":" ","pages":"666-674"},"PeriodicalIF":1.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143655556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Acta radiologicaPub Date : 2025-06-01Epub Date: 2025-03-13DOI: 10.1177/02841851251321104
Yuan Li, Ya-Qi Song, Zhong-Ru Sun, Ning Wang, Jian-Guo Xia, Wei-Zhong Tian, Mei Lin
{"title":"A study on the changes of white matter microstructure in breast cancer patients undergoing chemotherapy based on DTI technology.","authors":"Yuan Li, Ya-Qi Song, Zhong-Ru Sun, Ning Wang, Jian-Guo Xia, Wei-Zhong Tian, Mei Lin","doi":"10.1177/02841851251321104","DOIUrl":"10.1177/02841851251321104","url":null,"abstract":"<p><p>BackgroundBreast cancer is a prevalent cancer affecting women globally, with incidence rates rising rapidly.PurposeTo examine the diffusion tensor imaging (DTI) data of patients with breast cancer before and after chemotherapy through tract-based spatial statistical analysis (TBSS).Material and MethodsCognitive and neuropsychological tests and whole-brain DTI were administered to patients with breast cancer who did not receive postoperative chemotherapy (C-) or received postoperative chemotherapy (C+) and healthy controls (HCs). Structural differences across groups were compared through fractional anisotropy (FA), mean diffusivity rate (MD), radial diffusivity tensor (RD), and axial diffusivity tensor (AD). Spearman's correlation analysis was employed to explore the association of FA, MD, RD, and AD values in different brain regions with the results of cognitive and neuropsychological tests, as well as the relationship between DTI parameters and cognitive performance as measured by the Montreal Cognitive Assessment (MoCA) scores.ResultsCompared with the C- group, the C + group exhibited significant reduced FA values and increased MD and RD values in the genu of the corpus callosum, bilateral anterior and superior corona radiata, left posterior thalamic radiation, left external capsule, and bilateral superior longitudinal fasciculus. Spearman's correlation analysis showed a notable association between reduced FA values in specific regions and decreased cognitive performance, as measured by MoCA scores.ConclusionThese findings suggest that the alterations in white matter microstructure induced by breast cancer chemotherapy may contribute to cognitive decline. Further research is warranted to strengthen evidence for this relationship.</p>","PeriodicalId":7143,"journal":{"name":"Acta radiologica","volume":" ","pages":"618-627"},"PeriodicalIF":1.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143623149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Acta radiologicaPub Date : 2025-06-01Epub Date: 2025-02-16DOI: 10.1177/02841851251319108
Jihee Kim, Jieun Koh, Jihee Park
{"title":"Utility of chest CT in the diagnosis of additional suspicious lesions on MRI in women with breast cancer.","authors":"Jihee Kim, Jieun Koh, Jihee Park","doi":"10.1177/02841851251319108","DOIUrl":"10.1177/02841851251319108","url":null,"abstract":"<p><p>BackgroundDedicated breast computed tomography (CT) is an emerging modality, but no study has compared breast lesions additionally detected on magnetic resonance imaging (MRI) with correlated CT lesions. Although there are differences between chest CT and dedicated breast CT, a preliminary evaluation would be valuable.PurposeTo evaluate the usefulness of contrast-enhanced chest CT in evaluating additional suspicious lesions preoperatively detected on MRI in patients with breast cancer.Material and MethodsBetween January 2020 and December 2021, 245 patients with breast cancer who underwent preoperative breast MRI and contrast-enhanced chest CT were included. Enhancing lesions detected on CT showing correlation with additional suspicious lesions detected on MRI were recorded as CT-correlated enhancements. The pathological findings were confirmed by subsequent percutaneous biopsy or lesion excision. The clinical and MRI features of additional suspicious lesions were compared according to the standard reference or the presence of CT-correlated enhancement.ResultsThere were 96 (39.2%) additional suspicious lesions detected on preoperative breast MRI and a malignancy rate of 39.6%. Of 96 lesions, chest CT revealed correlated enhancement in 64 (66.7%) lesions, including 33 malignant lesions. Among the 32 lesions that showed no correlation enhancement on chest CT, 5 (15.6%) were malignant. Malignancy, diffusion-weighted image restriction, and fast/washout kinetics were more frequently observed in lesions with CT-correlated enhancement than in those without correlated enhancement (<i>P</i> < 0.001, <i>P</i> = 0.001, and <i>P</i> = 0.020, respectively).ConclusionWhen evaluating MRI-detected additional suspicious lesions in patients with breast cancer, lesions with CT-correlated enhancement were significantly more likely to be malignant than those without CT-correlated enhancement.</p>","PeriodicalId":7143,"journal":{"name":"Acta radiologica","volume":" ","pages":"580-587"},"PeriodicalIF":1.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143432166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Acta radiologicaPub Date : 2025-06-01Epub Date: 2025-03-17DOI: 10.1177/02841851251322480
Aysun Isiklar, Nurper Denizoglu, Fatih Buyukcam, Didem Ozer Etik
{"title":"Does platelet to lymphocyte ratio predict the ultrasound stage in hepatosteatosis?","authors":"Aysun Isiklar, Nurper Denizoglu, Fatih Buyukcam, Didem Ozer Etik","doi":"10.1177/02841851251322480","DOIUrl":"10.1177/02841851251322480","url":null,"abstract":"<p><p>BackgroundThe prevalence of hepatosteatosis, or fatty liver disease, has been increasing globally in recent years largely due to increasing rates of obesity, diabetes, and metabolic syndrome.PurposeTo examine the platelet to lymphocyte ratio (PLR) reflection on the hepatosteatosis stage.Material and MethodsWe evaluated healthy individuals who applied to the check-up department in our hospital. The platelet and lymphocyte counts from blood tests, along with upper abdominal ultrasound results obtained as part of routine diagnostic check-ups, results recorded retrospectively, between November 2022 and April 2024.ResultsA total 748 participants were included in the study. All participants were divided in three groups according to hepatosteatosis stages.The PLR levels were highest in the stage 1 hepatosteatosis group. There was statistical significance in PLR levels between stage 1 and 3 hepatosteatosis (<i>P</i> = 0003). In addition, PLR levels were higher in stage 2 than in stage 3, which was also statistically significant (<i>P</i> = 0037).ConclusionThese results could help in early detection and monitoring of disease progression in patients with hepatoteatosis. Lower PLR values (<115.26) in advanced stages might prompt closer monitoring or more aggressive interventions to prevent progression to fibrosis.</p>","PeriodicalId":7143,"journal":{"name":"Acta radiologica","volume":" ","pages":"660-665"},"PeriodicalIF":1.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143646680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Acta radiologicaPub Date : 2025-06-01Epub Date: 2025-02-23DOI: 10.1177/02841851251319666
Mats Geijer, Magnus Båth, Catrin Wessman
{"title":"Some common statistical methods for assessing rater agreement in radiological studies.","authors":"Mats Geijer, Magnus Båth, Catrin Wessman","doi":"10.1177/02841851251319666","DOIUrl":"10.1177/02841851251319666","url":null,"abstract":"<p><p>Rater agreement is commonly assessed in radiologic studies concerning image quality. There are several methods of measuring rater agreement. To choose the appropriate method, the researcher needs to consider the scale of the outcome variable and the design of the study. This article provides a brief overview of available methods, focusing on the most practical and commonly used, including intraclass correlation, the Svensson method, variants of the kappa statistic, the agreement coefficient by Gwet (AC1/AC2), and Krippendorff's alpha. Additional methods that are not primarily intended for rater agreement analysis but are applied in some cases are also discussed.</p>","PeriodicalId":7143,"journal":{"name":"Acta radiologica","volume":" ","pages":"675-683"},"PeriodicalIF":1.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12163189/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143482018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Acta radiologicaPub Date : 2025-06-01Epub Date: 2025-02-17DOI: 10.1177/02841851251319483
Yuqi Fang, Yun He
{"title":"CT radiomics for evaluation of intervertebral disc change in the scoliosis.","authors":"Yuqi Fang, Yun He","doi":"10.1177/02841851251319483","DOIUrl":"10.1177/02841851251319483","url":null,"abstract":"<p><p>BackgroundAdvanced methods are still lacking for the computed tomography (CT) evaluation of early degenerative changes of intervertebral disc in scoliosis.PurposeTo investigate the feasibility of CT radiomics in evaluating early disc degeneration changes in scoliosis.Material and MethodsA total of 60 patients with severe scoliosis were assessed with the method of CT radiomics. CT radiomics features of the intervertebral disc were obtained by using the software of 3D Slicer and were then compared between vertex disc (VD) and normal disc (ND). The analysis of maximum correlation minimum redundancy (mRMR) and the least absolute shrinkage and selection operator (LASSO) regression method was used to establish a model. The receiver operating characteristic (ROC) curve was used to determine the performance of the model.ResultsND and VD differed in 23 radiomics features (<i>P</i> < 0.05). By using mRMR and LASSO methods, five features were finally selected to establish a model. The AUC of the model in the identification of VD were 0.93 and 0.90 for the training cohort and validation cohort, respectively. The sensitivity and specificity of the model were 90% and 85%, respectively.ConclusionCT radiomics of the intervertebral disc is feasible in identifying early degenerative changes caused by scoliosis.</p>","PeriodicalId":7143,"journal":{"name":"Acta radiologica","volume":" ","pages":"576-579"},"PeriodicalIF":1.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143439467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Acta radiologicaPub Date : 2025-05-01Epub Date: 2025-01-21DOI: 10.1177/02841851241313108
Di Geng, Liu-Ning Zhu, Jun Liu, Xian-Ce Zhao, Yi-Shi Wang, Xiao-Quan Xu, Fei-Yun Wu
{"title":"Time-dependent diffusion magnetic resonance imaging for the analysis of parotid gland tumors.","authors":"Di Geng, Liu-Ning Zhu, Jun Liu, Xian-Ce Zhao, Yi-Shi Wang, Xiao-Quan Xu, Fei-Yun Wu","doi":"10.1177/02841851241313108","DOIUrl":"10.1177/02841851241313108","url":null,"abstract":"<p><p>BackgroundDifferent parotid tumors differ in terms of treatment strategies due to their distinct biological behaviors. Time-dependent diffusion magnetic resonance imaging (t<sub>d</sub>-dMRI) can characterize and quantify the cytological indexes, and then aid the differential diagnosis of various tumors. However, the value of t<sub>d</sub>-dMRI in the analysis of parotid gland tumors remains unclear.PurposeTo investigate the value of quantitative parameters derived from t<sub>d</sub>-dMRI in the analysis of parotid gland tumors.Material and MethodsIn total, 39 patients with parotid gland tumors were prospectively enrolled, including 24 patients with polymorphic adenomas (PAs), eight with Warthin's tumors (WTs), and seven with malignant tumors (MTs). T<sub>d</sub>-dMRI was performed for preoperative evaluation. Intracellular volume fraction (<i>V</i><sub>in</sub>), mean cell size (<i>d</i>), extracellular diffusion coefficient (<i>D</i><sub>ex</sub>), and cellularity were obtained based on the Imaging Microstructural Parameters Using Limited Spectrally Edited Diffusion model, and compared among the three groups. One-way ANOVA, Kruskal-Wallis test, and receiver operating characteristic (ROC) curve analysis were performed for further statistical analysis as appropriate.ResultsSignificant differences were found in all t<sub>d</sub>-dMRI-derived indexes among PAs, WTs, and MTs (all <i>P</i> < 0.05). <i>V</i><sub>in</sub> was the sole parameter with significant differences for all sub-group comparisons (PAs vs. WTs, <i>P</i> < 0.001; PAs vs. MTs, <i>P</i> = 0.031; WTs vs. MTs, <i>P</i> = 0.047). With <i>V</i><sub>in</sub> values of 0.267, 0.231, and 0.260 as threshold, respectively, optimal performance levels were obtained for differentiating PAs from WTs (area under the ROC curve [AUC]=0.932, sensitivity=0.917, and specificity=0.875), PAs from MTs (AUC=0.744, sensitivity=0.833, and specificity=0.714), and WTs from MTs (AUC=0.750, sensitivity=0.875, and specificity=0.714).ConclusionMicrostructural parameters derived from t<sub>d</sub>-dMRI, especially <i>V</i><sub>in</sub>, might be promising imaging biomarkers for characterizing parotid gland tumors.</p>","PeriodicalId":7143,"journal":{"name":"Acta radiologica","volume":" ","pages":"505-511"},"PeriodicalIF":1.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142998336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Acta radiologicaPub Date : 2025-05-01Epub Date: 2025-02-18DOI: 10.1177/02841851251315717
Sabri Sirolu, Mustafa Ege Seker, Deniz Alis, Batuhan Guroz, Cavit Kerem Kayhan, Fatma Tokat, Omer Burak Argun, Ilkay Oksuz, Ercan Karaarslan
{"title":"Assessing the aggressiveness of prostate cancer using ADC and relaxation maps from synthetic MRI.","authors":"Sabri Sirolu, Mustafa Ege Seker, Deniz Alis, Batuhan Guroz, Cavit Kerem Kayhan, Fatma Tokat, Omer Burak Argun, Ilkay Oksuz, Ercan Karaarslan","doi":"10.1177/02841851251315717","DOIUrl":"10.1177/02841851251315717","url":null,"abstract":"<p><p>BackgroundEmerging evidence suggests multiparametric prostate MRI's role in evaluating prostate cancer (PCa) aggressiveness.PurposeTo evaluate the utility of quantitative sequences in prostate MRI for assessing peripheral zone PCa aggressiveness, focusing on added value of relaxation maps to ADC.Material and MethodsIn total, 64 men undergoing preoperative bi-parametric prostate MRI with synthetic sequences were retrospectively enrolled. Radiologists delineated lesions on ADC maps and synthetic MRI, matched with digitized whole-mount specimens. PCa was graded as low, intermediate, or high based on Gleason grade. Statistical analyses assessed differences in T1, T2, PD, and ADC values across grades. For significant variables, AUC curves were generated. A logistic regression model evaluated the added diagnostic value of relaxation maps to ADC.ResultsOf the 95 PCa foci, 11 were low-grade, 45 intermediate-grade, and 39 high-grade. T1 (<i>P</i> = 0.4) and PD (<i>P</i> = 0.3) showed no significant differences, while T2 and ADC differed significantly (<i>P</i> < 0.001). Median T2 values were 98 ms (low-grade), 81 ms (intermediate), and 73 ms (high-grade), and median ADC values were 1006 mm²/s, 836 mm²/s, and 721 mm²/s, respectively. ADC yielded AUCs of 0.888 (95% CI=0.794-0.963; <i>P</i> < 0.0001) for low- versus intermediate-to-high-grade PCa, and 0.825 (95% CI=0.724-0.901; <i>P</i> < 0.0001) for low-to-intermediate versus high-grade. T2 AUCs were 0.770 (95% CI=0.605-0.908; <i>P</i> = 0.021) and 0.755 (95% CI=0.648-0.864; <i>P</i> = 0.0051), respectively. A logistic regression model combining T2 and ADC showed no significant improvement over ADC alone in differentiating low- versus intermediate-to-high-grade and low-to-intermediate versus high-grade PCa (<i>P</i> > 0.05).ConclusionT1 and PD maps from synthetic MRI showed limited utility in grading PCa. Although T2 values were effective, ADC values were superior in assessing PCa aggressiveness. The addition of T2 to ADC did not significantly improve diagnostic performance.</p>","PeriodicalId":7143,"journal":{"name":"Acta radiologica","volume":" ","pages":"536-545"},"PeriodicalIF":1.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143447739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Acta radiologicaPub Date : 2025-05-01Epub Date: 2025-03-13DOI: 10.1177/02841851251316400
David Timaran-Montenegro, Luis Nunez, Antonio Dono, Octavio Arevalo, Andres Rodriguez, Kamand Khalaj, Jennifer McCarty, Jay-Jiguang Zhu, Yoshua Esquenazi, Roy Riascos
{"title":"Glioblastoma IDH-wild type: imaging independent predictors of gross total resection (GTR) using the VASARI feature set and tumoral volumetric measurements.","authors":"David Timaran-Montenegro, Luis Nunez, Antonio Dono, Octavio Arevalo, Andres Rodriguez, Kamand Khalaj, Jennifer McCarty, Jay-Jiguang Zhu, Yoshua Esquenazi, Roy Riascos","doi":"10.1177/02841851251316400","DOIUrl":"10.1177/02841851251316400","url":null,"abstract":"<p><p>BackgroundExtent of resection (EOR), including gross total resection (GTR), is one of the most important factors in predicting overall survival (OS) in IDH-wild type (IDH-WT) glioblastoma patients. Although GTR represents the complete resection of all visible contrast-enhancing parts of the tumor, imaging predictors of achieving this extent still need to be better understood.PurposeTo assess the impact of preoperative imaging phenotypes as defined by the VASARI feature set and tumoral volumetry to determine predictors of GTR in patients with IDH-WT glioblastoma.Material and MethodsThis retrospective, single-center study analyzed imaging characteristics based on the VASARI features in the preoperative scans of IDH-WT glioblastoma patients. Volumetric analysis was performed to determine associations with clinical outcomes. Univariate analysis was used to determine the association of VASARI features with GTR. A multivariate analysis model was used to determine predictors of GTR.ResultsGTR was achieved in 79/144 (54.8%) patients, near total resection in 15 (10.4%), and subtotal resection in 50 (34.7%) patients. Our results showed non-eloquent tumor regions (55% vs. 35%; <i>P </i>= 0.04) and thick margin of enhancement (56.1% vs. 43.9%; <i>P </i>= 0.04) were associated with GTR and ependymal extension (37% vs. 63%; <i>P </i>= 0.02). Deep white matter invasion (36.3% vs. 63.7%; <i>P </i>= 0.03) was significantly associated with non-gross total resection. Lower tumoral volumes were also associated with gross total resection (<i>P </i>< 0.01). After performing multivariate analysis, the thickness of the tumoral enhancing margins was correlated with GTR with an OR of 1.57 (95% CI=1.1-2.23). Furthermore, the volume of the enhancing component was significantly different according to EOR with a calculated OR of 0.95 (95% CI = 0.92-0.97; <i>P </i>< 0.01).ConclusionImaging characteristics on standard-of-care MRI can predict the rate of GTR in patients with IDH-WT glioblastomas. The thickness of enhancing margins predicts GTR after multivariate analysis. A diagnostic model that includes a combination of the discriminating depicted features on MRI and brain tumor volumetrics has an acceptable diagnostic performance with a specificity >90%.</p>","PeriodicalId":7143,"journal":{"name":"Acta radiologica","volume":" ","pages":"546-557"},"PeriodicalIF":1.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143623152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}