Acta radiologica最新文献

{"title":"Correlation between AI algorithm generated radiographic hip measurements for hip dysplasia patients and internal derangement findings on advanced MRI.","authors":"Shuda Xia, Holden Archer, Yin Xi, Joel Wells, Avneesh Chhabra","doi":"10.1177/02841851251324551","DOIUrl":"10.1177/02841851251324551","url":null,"abstract":"<p><p>BackgroundHip dysplasia (HD) involves abnormal acetabular development, resulting in reduced femoral head coverage, labral tears, and cartilage injury. Machine learning (AI) advancements have enabled reproducible radiographic measurements for HD, such as lateral center edge angle (LCEA), Tonnis, and extrusion index. Moreover, incorporating 3D magnetic resonance imaging (MRI) alongside 2D MRI enhances diagnostic capabilities.PurposeTo correlate advanced MRI-assessed labral and cartilage injuries with validated AI-generated radiographic measurements.Material and MethodsThis study enrolled 139 patients (age range = 16-68 years) with HD, comprising a total of 156 hips. All patients had 2D and 3D MRI scans, four-view X-rays, and AI-generated radiographic measurements using a commercial AI program that utilized bony landmarks to generate measurements. Labral reconstructions were obtained for each hip, and a multi-reader study was conducted. Inter-reader (ICC) analysis and Spearman correlations were calculated.ResultsThe predominant location for the largest labral tear was anterosuperior (133/156, 90%), and paralabral cysts were observed in 53/156 (34%) cases. No statistically significant correlations were found between the length of labral tears and radiographic measurements. However, statistically significant correlations were observed between paralabral cysts and femoral head coverage, extrusion index, LCEA, and Tonnis measurements.ConclusionAI-generated radiographic measurements in HD exhibited weak correlations with advanced MRI findings, likely due to the condition's complex pathophysiology.</p>","PeriodicalId":7143,"journal":{"name":"Acta radiologica","volume":" ","pages":"722-732"},"PeriodicalIF":1.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143655959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Discriminating high-grade from low-grade infratentorial tumors with non-contrast computed tomography attenuation of the solid part.","authors":"Honglu Duan, Mengya Sun, Yuan Chen, Guanglei Tang, Xuhui Zhou, Di Wei, Jian Guan","doi":"10.1177/02841851251326780","DOIUrl":"10.1177/02841851251326780","url":null,"abstract":"<p><p>BackgroundTo find a more general imaging method for preliminary grading of infratentorial brain tumors.PurposeTo investigate the value of non-contrast computed tomography (NCCT) attenuation of the solid part of a tumor (SP-T) in distinguishing high- and low-grade infratentorial tumors.Material and MethodsThis retrospective study included 196 patients with primary infratentorial tumors. A total of 56 patients also underwent magnetic resonance imaging (MRI) with diffusion-weighted imaging (DWI). CT attenuation of SP-T, caudate nucleus (normal gray matter), and centrum semiovale (normal white matter) were measured. CT attenuation ratios of SP-T to normal gray matter (R_T-G) and normal white matter (R_T-W) were calculated. Each parameter was compared, and the area under the receiver operating characteristic curve (AUC) was used to determine diagnostic efficacy. Diagnostic efficacy of apparent diffusion coefficient (ADC) value and CT-related parameters were compared in 56 patients with both NCCT and MRI with DWI.ResultsThere were significant differences (<i>P </i>< 0.001) in mean CT attenuation of SP-T (35.32 ± 8.19 HU vs. 42.91 ± 5.56 HU), R_T-G (0.95 ± 0.21 vs. 1.17 ± 0.15), and R_T-W (1.37 ± 0.33 vs. 1.74 ± 0.30) between low- and high-grade infratentorial tumors. The AUCs for differentiating low-grade from high-grade tumors are 0.783, 0.819, and 0.797 for CT attenuation of SP-T, R_T-G, and R_T-W, respectively. For 56 patients with DWI, the AUCs for CT attenuation of SP-T, R_T-G, R_T-W, and ADC value were 0.833, 0.887, 0.850, and 0.910, respectively. All three CT-related parameters were not significantly different from the ADC value.ConclusionNCCT can distinguish low- and high-grade infratentorial tumors simply and conveniently and CT-related parameters show no significant difference compared to ADC value.</p>","PeriodicalId":7143,"journal":{"name":"Acta radiologica","volume":" ","pages":"766-774"},"PeriodicalIF":1.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143727074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cumulative radiation dose in children with congenital heart disease: national data 2000-2021, stratified by diagnosis, age, and imaging modality.","authors":"Susmita Afroz, Bjørn H Østerås, Utheya S Thevathas, Lise Heiberg, Trude E Robsahm, Hilde M Olerud, Gaute Dohlen","doi":"10.1177/02841851251327896","DOIUrl":"10.1177/02841851251327896","url":null,"abstract":"<p><p>BackgroundPediatric congenital heart disease (CHD) patients often undergo procedures involving ionizing radiation for diagnosis, treatment, and follow-up. Their cumulative radiation burden may increase their risk of late effects.PurposeTo assess radiation exposures from cardiac catheterization and thoracic imaging in pediatric CHD patients, stratified by diagnosis, age, and imaging modality.Material and MethodsRadiation exposure (cardiac catheterization, thoracic computed tomography [CT] and radiography) was retrospectively collected for individuals aged <18 years (born 2000-2020) with at least one catheterization for CHD. Cumulative effective dose (CED) was estimated per patient by diagnosis. Age-based variation in examination frequency and exposure was examined.ResultsA total of 1574 patients underwent 23,558 radiographic examinations. The most common diagnoses, atrial septal defect (ASD; 31% of the cohort) and patent ductus arteriosus (PDA; 30%), had a median CED of 2.3 and 2.9 mSv, respectively. The diagnoses resulting in highest CEDs were hypoplastic left heart syndrome (HLHS; 2.6%, 37.5 mSv), double inlet left ventricle (DILV; 2.4%, 48.4 mSv), and double outlet right ventricle (DORV; 2.6%, 31.3 mSv). Cardiac catheterization, thoracic CT, and radiography contributed 94%, 4%, and 2% of CED, respectively. Effective doses per patient for each diagnosis varied with age. Doses from cardiac catheterizations tended to be higher for patients exposed at ≤30 versus 31-90 months old.ConclusionMost patients with ASD and PDA had low CED and patients with HLHS, DILV, and DORV received ≥30 mSv. Patients with severe CHD often required early catheterization, which, in turn, led to higher effective doses in these patients due to larger conversion coefficients between dose area product/dose length product and effective dose in individuals aged ≤30 months.</p>","PeriodicalId":7143,"journal":{"name":"Acta radiologica","volume":" ","pages":"790-802"},"PeriodicalIF":1.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143727149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Machine learning algorithms can recognize hydronephrosis in non-contrast CT images.","authors":"Bökebatur Ahmet Raşit Mendi, Halitcan Batur","doi":"10.1177/02841851251327892","DOIUrl":"10.1177/02841851251327892","url":null,"abstract":"<p><p>BackgroundHydronephrosis, particularly attributed to the presence of renal calculi, is a clinical condition that can result in permanent renal injury, necessitating the utilization of imaging modalities for accurate diagnosis. Methodologies that can swiftly aid the radiologist by reducing workload are required for the preliminary diagnosis of hydronephrosis, which is critical in clinical practice.PurposeTo examine the efficacy of autosegmentation-assisted radiomics in predicting the presence of hydronephrosis among individuals diagnosed with renal colic.Material and MethodsThe study comprised 268 individuals who had non-contrast computed tomography (CT) scans presenting unilateral hydronephrosis. After the 3D autosegmentation of each patient's kidneys, first- and second-order radiomics parameters were acquired and Least Absolute Shrinkage and Selection Operator was employed as the dimensionality reduction tool. Machine learning (ML) procedures consisted of Support Vector Machine (SVM), Random Forest Classifier (RFC) analysis, Extreme Gradient Boosting (XGBoost), and Decision Tree Analysis.ResultsNo statistically significant difference was observed between the groups when comparing the side of hydronephrosis and the distribution of age among sexes. The repeated measurements of 3D autosegmentation exhibited a high level of intra-observer agreement. SVM, RFC, XGBoost, and Decision Tree analyses were able to predict the presence of hydronephrosis with AUC values of 0.966, 0.925, 0.994, and 0.978, respectively.ConclusionML-assisted radiomics can be considered an effective tool for accurately predicting the presence of hydronephrosis.</p>","PeriodicalId":7143,"journal":{"name":"Acta radiologica","volume":" ","pages":"782-789"},"PeriodicalIF":1.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143690814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inter-reader reliability of MRI and CT Node Reporting and Data System 1.0 (Node-RADS) for mesorectal lymph nodes in rectal cancer.","authors":"Marco Parillo, Federica Vaccarino, Daniele Vertulli, Laura Cea, Carlo Augusto Mallio, Bruno Beomonte Zobel, Carlo Cosimo Quattrocchi","doi":"10.1177/02841851251322887","DOIUrl":"10.1177/02841851251322887","url":null,"abstract":"<p><p>BackgroundNode Reporting and Data System 1.0 (Node-RADS) classifies the risk of cancer metastases in lymph nodes at any anatomical site, using computed tomography (CT) and/or magnetic resonance imaging (MRI). This new RADS needs clinical validation through agreement studies.PurposeTo evaluate the inter-reader reliability of Node-RADS between radiologists with different levels of experience, focusing on rectal cancer CT and MRI.Material and MethodsWe designed a single-center observational retrospective study to identify staging CT or MRI of newly diagnosed individuals with rectal cancer. Four readers (two residents in radiology and two radiologists) scored each mesorectal node with Node-RADS on a per-lymph node basis. Fleiss' κ was calculated to assess the level of agreement both for the score and for each individual category of the Node-RADS. A subgroup analysis was performed on a per-patient basis to evaluate the correlation between the Node-RADS assigned by the most experienced reader and the histopathological diagnosis of node involvement.ResultsA total of 20 patients were included in the study<i>.</i> The number of Node-RADS scored per reader was 242, corresponding to 968 values to be compared for agreement assessment. Fleiss' κ for Node-RADS score among all readers was 0.65 (substantial agreement). Analysis of the individual categories of the Node-RADS demonstrated a good agreement between all readers (κ > 0.61). A moderate positive correlation was documented between the Node-RADS and the likelihood of nodes being metastatic on histology.ConclusionThe Node-RADS score exhibited good inter-reader reliability between experienced radiologists and those still in training.</p>","PeriodicalId":7143,"journal":{"name":"Acta radiologica","volume":"66 7","pages":"687-694"},"PeriodicalIF":1.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144635926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic value of color Doppler ultrasound combined with blood inflammatory markers in threatened abortion and pregnancy outcomes in early pregnancy.","authors":"Siyuan Yang, Mingyan Wang, Linxin Yang, Ning Lin","doi":"10.1177/02841851251324923","DOIUrl":"10.1177/02841851251324923","url":null,"abstract":"<p><p>BackgroundThreatened abortion is a general complication during pregnancy.PurposeTo analyze the predictive effect of color Doppler ultrasound (CDUS) combined with blood inflammatory markers in threatened abortion and pregnancy outcomes in early pregnancy.Material and MethodsUterine artery blood flow parameters, blood inflammatory marker levels, influencing factors of threatened abortion and pregnancy outcomes, and predictive value of CDUS combined with blood inflammation markers for threatened abortion and pregnancy outcomes were analyzed.ResultsThe abortion group exhibited higher resistance index (RI), pulsation index (PI), and systolic peak flow velocity/end-diastolic flow velocity (S/D), and serum IL-1β, neutrophil-to-lymphocyte ratio (NLR), and monocyte-to-lymphocyte ratio (MLR) than the continued pregnancy and control groups, and a higher proportion of subchorionic hematomas than the continued pregnancy group; IL-1β, NLR, PI, and SD were risk factors for threatened abortion. The area under the curve (AUC) of IL-1β, NLR, MLR, RI, PI, and S/D for combined prediction of threatened abortion was higher than that for individual predictors. Previous abortion history, IL-1β, NLR, PI, and S/D were risk factors for adverse pregnancy outcomes in threatened abortion. The AUC of IL-1β, NLR, RI, PI, and S/D for combined prediction of pregnancy outcomes in threatened abortion was higher than for individual predictors.ConclusionCDUS of uterine artery blood flow parameters combined with blood inflammatory markers has high predictive value for threatened abortion and pregnancy outcomes.</p>","PeriodicalId":7143,"journal":{"name":"Acta radiologica","volume":" ","pages":"733-739"},"PeriodicalIF":1.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative evaluation of axillary lymph nodes in breast cancer on dual-phase dual-energy CT by precise match with pathology.","authors":"Tingting Qiao, Su Wang, Zhengyin Shen, Lei Zhang, Guoxuan Wang, Bin Hua, Lei Jiang","doi":"10.1177/02841851251326469","DOIUrl":"10.1177/02841851251326469","url":null,"abstract":"<p><p>BackgroundIdentification of axillary lymph node (aLN) metastasis in breast cancer (BC) is important. Dual-energy computed tomography (DECT) is a promising innovation in the field of CT. However, its role in evaluating aLNs remains unclear.PurposeTo investigate the diagnostic performance of DECT in evaluating aLN metastasis in BC patients.Material and MethodsData were prospectively collected from treatment-naïve BC patients who underwent DECT for staging, ultrasound-guided biopsy for suspicious aLNs, and placement of tissue marker in the pathology-positive aLNs. Further cross-sectional imaging was performed preoperatively to locate the marker-labeled LN and help to identify the pathologically proven LN on DECT. Maximal short diameter (MSD) and 13 DECT parameters were measured on metastatic aLNs and contralateral normal aLNs. The univariate, least absolute shrinkage and selection operator and multivariable logistic regression were performed to find independent parameters for predicting metastasis. The diagnostic performance was assessed using receiver operating characteristics (ROC) analysis.ResultsA total of 76 axillary LNs (38 metastasized, 38 normal) from 38 patients were finally included. All DECT parameters showed significant difference between metastatic and normal LNs (all <i>P</i> < 0.001). Arterial enhancement fraction (AEF) and MSD were independent predictors of metastasis (<i>P</i> = 0.010 and 0.014, respectively). The area under the ROC curve (AUC) of AEF was the highest (0.967). The combined AUC of AEF and MSD was significantly higher than that of MSD alone (0.994 vs. 0.943; <i>P</i> = 0.025).ConclusionDECT is a promising tool for preoperative evaluation of aLNs in BC patients, with MSD and AEF having the best diagnostic performance.</p>","PeriodicalId":7143,"journal":{"name":"Acta radiologica","volume":" ","pages":"757-765"},"PeriodicalIF":1.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143727119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radiological changes in anterior arm muscles after biceps long head tenotomy.","authors":"İlhan Çelik, Tacettin Ayanoğlu, Emine Dağıstan, Faruk Özdemir, Seyit Ali Kayış, Ulunay Kanatlı","doi":"10.1177/02841851251323963","DOIUrl":"10.1177/02841851251323963","url":null,"abstract":"<p><p>BackgroundAlthough a decrease in pain may be observed after tenotomy, conditions such as muscle cramp, limited elbow flexion, cosmetic deformity (Popeye sign), decreased elbow flexion-supination strength, and persistent pain are also seen, and the exact cause is not fully known.PurposeTo evaluate the changes in the short head of the biceps brachii (SHB) tendon thickness and coracobrachialis muscle after tenotomy.Material and MethodsIn this original article, magnetic resonance imaging (MRI) was performed preoperatively and 6 months postoperatively on 77 patients who underwent biceps brachii long head tenotomy during shoulder arthroscopy and who met the inclusion criteria. Changes in the thickness of the SHB and the coracobrachialis muscle were evaluated. The location where the long head of the biceps brachii (LHB) terminated after tenotomy was also investigated.ResultsIn the 6th postoperative month, we observed a significant increase in both the thickness of the SHB footprint and 2 cm distal to the tendon's origin. In addition, the LHB, which underwent tenotomy, was distracted on average 24.2 mm distally. However, no changes were observed in the thickness of the coracobrachialis muscle during the same period.ConclusionIn this study, we demonstrated prospectively increased thickness of the SHB tendon and no increase in thickness in the coracobrachialis muscle on postoperative MRI.</p>","PeriodicalId":7143,"journal":{"name":"Acta radiologica","volume":" ","pages":"695-703"},"PeriodicalIF":1.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation of radiological volume parameters using magnetic resonance imaging with surgical intervention, postoperative outcome, and renal function in adult patients of pelvic ureteric junction obstruction.","authors":"Trijoy Saha, Sameer Trivedi, Amit Nandan Dwivedi","doi":"10.1177/02841851251351096","DOIUrl":"https://doi.org/10.1177/02841851251351096","url":null,"abstract":"<p><p>BackgroundThis study examines the correlation between magnetic resonance imaging (MRI)-derived volume parameters, surgical outcomes, and renal function in adults undergoing ureteropelvic junction (UPJ) obstruction surgery. Understanding these relationships can improve surgical planning, patient selection, and postoperative prognosis.PurposeTo assess the correlation between anatomical parameters and surgical outcomes in adult patients with UPJ obstruction.Material and MethodsA prospective cross-sectional study was conducted on 60 patients with UPJ obstruction, selected via simple random sampling. The hydronephrosis volume (HV) to renal volume (RV) ratio was calculated using MR urography (MRU). Preoperative diethylene triamine pentaacetic acid (DTPA) differential renal function (DRF) and creatinine levels were also recorded. Patients requiring surgery were followed up after 6 months, measuring pelvis/RV ratio, creatinine, and DTPA DRF. Statistical analyses were performed to find correlations.ResultsOperated patients had a higher preoperative HV/RV ratio (AUC=0.914, 95% confidence interval [CI]=0.829-1.000; <i>P</i> <0.001) and higher DTPA DRF values (AUC=0.936, 95% CI=0.860-1.000; <i>P</i> <0.001). Patients with greater preoperative HV/RV ratios were less likely to achieve anatomical normalization. Significant correlations were found between HV/RV ratios with DTPA DRF and creatinine (<i>P</i> <0.05). DeLong's test showed no significant differences between HV/RV ratios and DTPA DRF in predicting surgical need.ConclusionQuantitative volumetric analysis using MRU can effectively predict the need for surgery and renal function deterioration in patients with UPJ obstruction. The HV/RV ratio plays a crucial role in guiding surgical decisions and predicting outcomes. This study emphasizes and tests the hypothesis that higher degree of hydronephrosis correlates with higher degree of deterioration of renal function and need for surgical intervention.</p>","PeriodicalId":7143,"journal":{"name":"Acta radiologica","volume":" ","pages":"2841851251351096"},"PeriodicalIF":1.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144537684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiparametric gadoxetic acid-enhanced MR versus dual-layer spectral detector CT for differentiating hepatocellular carcinoma from hypervascular pseudolesions.","authors":"Akahiko Sato, Masahiro Okada, Kenichiro Tago, Yujiro Nakazawa, Mariko Mizuno, Takahiro Miyauchi, Yuko Kobashi","doi":"10.1177/02841851251323965","DOIUrl":"10.1177/02841851251323965","url":null,"abstract":"<p><p>BackgroundIt can be difficult to differentiate hypervascular hepatocellular carcinoma (HCC) from hypervascular pseudolesion (HPL) such as arteriovenous shunts.PurposeTo determine retrospectively whether double-layer detector computed tomography (DLCT) can differentiate HCC from HPL compared to gadoxetate-enhanced magnetic resonance imaging (EOB-MRI).Material and MethodsWe retrospectively analyzed 46 patients who underwent EOB-MRI and DLCT for suspected HCCs. Arterial/portal phase and hepatobiliary phase (HBP) on EOB-MRI, T2-weighted (T2W) imaging, diffusion-weighted imaging (DWI), apparent diffusion coefficient (ADC), CT value, iodine-density (ID), atomic-number (Zeff), and electron-density (ED) of the lesion and liver were evaluated. The reduction rates of ID (R-ID) between each phase of the arterial/portal phase on EOB-MRI were calculated. ROC analysis was performed to determine the accuracy for differentiating HCC from HPL.ResultsThere were 55 HCCs and 14 HPLs. On DWI, 42, 11, and two HCCs showed high, slightly high, and iso intensity, respectively. However, all 14 HPLs showed iso intensity on DWI. Area under ROC curve (AUC) of DWI (0.982, 95% confidence interval [CI]=0.957-1) was significantly higher than that of HBP (AUC=0.714; 95% CI=0.580-0.849; <i>P</i> < 0.001), R-ID (AUC=0.742, 95% CI=0.580-0.903; <i>P</i> = 0.004), and ED of portal phase (AUC=0.786, 95% CI=0.640-0.891; <i>P</i> = 0.001) in differentiating HCC and HPL. ADC (<0.001), T2W imaging (<0.001), HBP (<0.001), ED-arterial-phase (<0.001), ED-portal-phase (=0.003), ED-equilibrium-phase (=0.001), R-ID-between-arterial/equilibrium-phase (=0.032), and R-ID-between-portal/equilibrium-phase (=0.042) showed significant differences between HPL and HCC.ConclusionDWI is most useful for differentiating HCC from HPL, although ADC, T2W, HBP, R-ID, and ED may also be relatively useful to differentiate between HPLs and HCCs.</p>","PeriodicalId":7143,"journal":{"name":"Acta radiologica","volume":" ","pages":"712-721"},"PeriodicalIF":1.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143655626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}