Acta radiologica最新文献

{"title":"Influence of field strength on quantitative parameters and feature stability in the assessment of the ovaries using 1.5-T and 3-T MRI.","authors":"Theresa Mokry, Judith Pantke, Hans-Ulrich Kauczor, Frederik B Laun, Heinz-Peter Schlemmer, Tristan A Kuder, Sebastian Bickelhaupt","doi":"10.1177/02841851241313021","DOIUrl":"https://doi.org/10.1177/02841851241313021","url":null,"abstract":"<p><strong>Background: </strong>Little is known of the influence of scanner field strength on quantitative diffusivity variables, especially kurtosis in healthy ovaries.</p><p><strong>Purpose: </strong>To evaluate the influence of scanner field strength on quantitative diffusion variables in pelvic MRI of the ovaries.</p><p><strong>Material and methods: </strong>This prospective, single-centre study consisted of repeated 1.5-T and 3-T examinations in 30 female volunteers (mean age=27.9 years, age range=20.3-45.2 years) from July 2017 to September 2019. Multi b-value DWI 0, 50, 100, 800, 1500, 2000 s/mm² was acquired over three timepoints during the menstrual cycle. Ovaries were segmented at b = 1500 s/mm². Median apparent diffusion coefficient (ADC) and advanced kurtosis parameters D_app and K_app were calculated. Statistical analysis was performed with the variations of diffusivity variables being compared between 1.5-T and 3-T MRI using a Mann-Whitney rank-sum test.</p><p><strong>Results: </strong>Median ADC and D_app (µm²/ms) did not statistically differ. Median ADC were 1.509 (range=1.371-1.610), 1.619 (range=1.463-1.747), and 1.511 (range=1.423-1.639) at 1.5 T; 1.542 (range=1.428-1.682), 1.658 (range=1.510-1.806), and 1.572 (range=1.455-1.709) at 3 T (<i>P</i> = 0.14, 0.19, and 0.07), whereas median D_app were 2.024 (range=1.913-2.152), 2.192 (range=2.010-2.327), and 2.045 (range=1.958-2.170) at 1.5 T; 2.013 (range=1.952-2.188), 2.179 (range=2.018-2.327), and 2.082 (range=1.959-2.194) at 3 T (<i>P</i> = 0.77, 0.99, and 0.34) for timepoints 1, 2, and 3, respectively. Statistical comparison of K_app revealed significant differences for all timepoints: 0.629 (range=0.595-0.652), 0.604 (range=0.574-0.651), and 0.622 (range=0.581-0.664) at 1.5 T; 0.601 (range=0.563-0.626), 0.567 (range=0.526-0.633), and 0.599 (range=0.541-0.650) at 3 T (<i>P</i> < 0.001, 0.005, and 0.03).</p><p><strong>Conclusion: </strong>Diffusivity mapping in the ovaries provides similar absolute median diffusion values, but statistically significant differences in absolute kurtosis values between 1.5 T and 3 T.</p>","PeriodicalId":7143,"journal":{"name":"Acta radiologica","volume":" ","pages":"2841851241313021"},"PeriodicalIF":1.1,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143187952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating hyperostosis frontalis interna: a computed tomography analysis and predictive model for Hershkovitz classification.","authors":"Raza Mushtaq, Anish Bhandari, Srinivasan Vedantham, Richard Joseph Wruble, Unni Udayasankar, Samuel N Rogers","doi":"10.1177/02841851251313557","DOIUrl":"https://doi.org/10.1177/02841851251313557","url":null,"abstract":"<p><strong>Background: </strong>Axial computed tomography (CT) cross-sections offer an accessible model for assessing diverse pathologies associated with hyperostosis frontalis interna (HFI) based on the Hershkovitz classification.</p><p><strong>Purpose: </strong>To delineate the CT characteristics of HFI, emphasizing a radiological description using the Hershkovitz classification. It investigated whether the Hershkovitz classification can be predicted using density, a variable unexplored in the literature. HFI thickness and the presence of concurrent hyperostosis beyond the frontal bone (HBFB) were evaluated across varying degrees of the Hershkovitz classification.</p><p><strong>Material and methods: </strong>This retrospective study evaluated characteristics of HFI on CT. Each case was assigned a Hershkovitz classification. Density and thickness of the HFI along with the presence of concurrent HBFB were evaluated and correlated with the Hershkovitz classification.</p><p><strong>Results: </strong>Axial CT of 77 patients with HFI was evaluated. Patient characteristics including sex were uncorrelated with CT measurements (<i>P</i> > 0.25) and Hershkovitz classification (<i>P</i> > 0.06). Increasing HFI thickness was associated with a higher Hershkovitz classification (odds ratio [OR] = 1.863, 95% confidence interval [CI] = 1.452-2.389; <i>P</i> < 0.001), and increasing density of HFI was associated with a lower Hershkovitz classification (OR = 0.995, 95% CI = 0.992-0.998; <i>P</i> = 0.002). Higher Hershkovitz classification was also found to be associated with the presence of concurrent HBFB (OR = 31.694, 95% CI = 6.483-154.938; <i>P</i> < 0.001).</p><p><strong>Conclusion: </strong>In our cohort, Hershkovitz classification on axial CT correlated with increased HFI thickness, presence of HBFB, and lower HFI density.</p>","PeriodicalId":7143,"journal":{"name":"Acta radiologica","volume":" ","pages":"2841851251313557"},"PeriodicalIF":1.1,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143121809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The magnetic resonance imaging appearance of the normal anatomy and injury pattern of capsuloligamentous complex of the first metatarsophalangeal joint.","authors":"Zhan-Hua Qian, Jin-E Wang, Rong-Jie Bai, Hui-Li Zhan, Wen-Ting Li, Nai-Li Wang, Yuming Yin","doi":"10.1177/02841851241309522","DOIUrl":"https://doi.org/10.1177/02841851241309522","url":null,"abstract":"<p><strong>Background: </strong>The capsuloligamentous complex injury of the first metatarsophalangeal joint (MTPJ) is a common cause of turf toe.</p><p><strong>Purpose: </strong>To investigate whether high<b>-</b>resolution 3 T magnetic resonance imaging (MRI) could demonstrate all the normal anatomic structures and the MR features of the capsuloligamentous complex injury of the first MTPJ, and to evaluate the diagnostic performance of MRI in the diagnosis of the capsuloligamentous complex injuries of the first MTPJ.</p><p><strong>Material and methods: </strong>A total of 115 feet were included in this study, including 48 feet from 24 healthy volunteers and 67 feet from 67 patients with the capsuloligamentous complex of the first MTPJ injuries. All feet had MRI examination. The MRI features of the capsuloligamentous complex of the first MTPJ of the volunteers and patients were analyzed. Diagnostic sensitivity, specificity, and accuracy of MRI were calculated using the surgery as the standard of reference. The inter-observer agreement was assessed using kappa analysis.</p><p><strong>Results: </strong>The central portion of the plantar plate and ligament injury manifested as discontinuity, with an indistinct appearance with hyperintense signal within the involved structures. The sensitivities, specificities, and diagnostic accuracy value of MRI for diagnosing most structures of the capsuloligamentous complex injuries of the first MTPJ were 67%-100%, 93%-100%, and 0.82-0.99, respectively, and overall good to perfect inter-observer agreements (kappa=0.63-0.95).</p><p><strong>Conclusion: </strong>High-resolution MRI allows adequate visualization of normal anatomic structures of the first MTPJ. The best visualized structure is sesamoid phalangeal ligament and the most frequent injury is complete tear of the medial sesamoid phalangeal ligament.</p>","PeriodicalId":7143,"journal":{"name":"Acta radiologica","volume":" ","pages":"2841851241309522"},"PeriodicalIF":1.1,"publicationDate":"2025-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143078148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prediction of postoperative disease-free survival in colorectal cancer patients using CT radiomics nomogram: a multicenter study.","authors":"Guodong Xu, Feng Feng, Yanfen Cui, Yigang Fu, Yong Xiao, Wang Chen, Manman Li","doi":"10.1177/02841851241302521","DOIUrl":"https://doi.org/10.1177/02841851241302521","url":null,"abstract":"<p><strong>Background: </strong>Radiomics analysis is widely used to assess tumor prognosis.</p><p><strong>Purpose: </strong>To explore the value of computed tomography (CT) radiomics nomogram in predicting disease-free survival (DFS) of patients with colorectal cancer (CRC) after operation.</p><p><strong>Material and methods: </strong>A total of 522 CRC patients from three centers were retrospectively included. Radiomics features were extracted from CT images, and the least absolute shrinkage and selection operator Cox regression algorithm was employed to select radiomics features. Clinical risk factors associated with DFS were selected through univariate and multivariate Cox regression analysis to build the clinical model. A predictive nomogram was developed by amalgamating pertinent clinical risk factors and radiomics features. The predictive performance of the nomogram was evaluated using the C-index, calibration curve, and decision curve. DFS probabilities were estimated using the Kaplan-Meier method.</p><p><strong>Results: </strong>Integrating the retained eight radiomics features and three clinical risk factors (pathological N stage, microsatellite instability, perineural invasion), a nomogram was constructed. The C-index for the nomogram were 0.819 (95% CI=0.794-0.844), 0.782 (95% CI=0.740-0.824), 0.786 (95% CI=0.753-0.819), and 0.803 (95% CI=0.765-0.841) in the training set, internal validation set, external validation set 1, and external validation set 2, respectively. The calibration curves demonstrated a favorable congruence between the predicted and observed values as depicted by the nomogram. The decision curve analysis underscored that the nomogram yielded a heightened clinical net benefit.</p><p><strong>Conclusion: </strong>The constructed radiomics nomogram, amalgamating the radiomics features and clinical risk factors, exhibited commendable performance in the individualized prediction of postoperative DFS in CRC patients.</p>","PeriodicalId":7143,"journal":{"name":"Acta radiologica","volume":" ","pages":"2841851241302521"},"PeriodicalIF":1.1,"publicationDate":"2025-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143078147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An in vitro study of contrast agent optimization for MR hysterosalpingography.","authors":"Jin Ding, Huanzhi Ding, Ximing Wang","doi":"10.1177/02841851241298885","DOIUrl":"https://doi.org/10.1177/02841851241298885","url":null,"abstract":"<p><strong>Background: </strong>Gadolinium-iodine mixed contrast agents can significantly improve the visualization of the fallopian tubes in magnetic resonance hysterosalpingography (MR-HSG). However, the mixing ratio of gadolinium-iodine contrast agents has not yet been standardized.</p><p><strong>Purpose: </strong>To explore the optimal mixing ratio of gadolinium-iodine contrast agents suitable for MR-HSG.</p><p><strong>Material and methods: </strong>A total of 16 mixing ratios of gadolinium and saline mixtures (Gd-NS), gadolinium and iopromide mixtures (Gd-I370), and gadolinium and iodixanol mixtures (Gd-I320) were formulated for an in vitro study. These mixed contrast agents were scanned on 1.5 T and 3.0 T using T1 contrast enhancement sequences. For qualitative assessment, contrast agent imaging quality was graded on a subjective 3-point scale (good, moderate, and poor). For the quantitative evaluation, differences in the signal intensity (SI) of the three contrast agents, as well as the SI variations between 1.5 T and 3.0 T, were compared.</p><p><strong>Results: </strong>Gd-I370 and Gd-I320 exhibited the highest SI and good image at a 1:300 ratio on 1.5 T and a 1:200 ratio on 3.0 T. The difference in the SI among the three contrast agents was not statistically significant at 1.5 T (<i>P </i>> 0.05). At 3.0 T, the comparison between the SIs of Gd-I370 and Gd-I320 was not statistically significant (<i>P </i>> 0.05). The SIs of contrast agents on 3.0 T were higher than those on 1.5 T (<i>P </i>< 0.05).</p><p><strong>Conclusion: </strong>A gadolinium-iodine contrast agent with a 1:300 mixing ratio may be more suitable for 1.5 T MR-HSG, while a 1:200 mixing ratio may be more suitable for 3.0 T MR-HSG. Additionally, the contrast agent SI is higher on 3.0 T than on 1.5 T.</p>","PeriodicalId":7143,"journal":{"name":"Acta radiologica","volume":" ","pages":"2841851241298885"},"PeriodicalIF":1.1,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143062956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The expression of repulsive guidance molecule a in the rat brain and the diffusion tensor imaging evaluation for crossed cerebellar diaschisis.","authors":"Zhen Ma, Jingliang Cheng, Lin Lu, Meiying Cheng, Xiao Wang, Dong Wei, Xin Zhao","doi":"10.1177/02841851241299086","DOIUrl":"https://doi.org/10.1177/02841851241299086","url":null,"abstract":"<p><strong>Background: </strong>Cerebral infarction is one of the most common diseases. Diffusion tensor imaging (DTI) has been used to evaluate for crossed cerebellar diaschisis (CCD) to observe the expression of repulsive guidance molecule a (RGMa), the axonal regeneration as well as the effect on neural functional recovery in the middle cerebral artery occlusion (MCAO) rat model.</p><p><strong>Purpose: </strong>To certify the expression pattern of RGMa in cerebral infarction and the mechanism of CCD to provide a new target for clinical therapy.</p><p><strong>Material and methods: </strong>Building the MCAO rat model, every 16 rats were randomly divided into one of six groups. The brain was scanned over the time points above and the rats were sacrificed for immunohistochemistry staining and reverse transcription polymerase chain reaction (RT-PCR) to assay the RGMa expression.</p><p><strong>Results: </strong>The apparent diffusion coefficient (ADC) and fractional anisotropy (FA) value of MCAO rats declined and peaked at 12 h. The contralateral cerebellum had a lower parameter than the other side. The expression of RGMa kept climbing and achieved the maximum at 48 h (<i>P</i> < 0.05). The value of the protein in the cerebellum was higher (<i>P</i> < 0.05) compared with controls, especially the right cerebellum. The expression of RGMa was negative compared to the parameter of magnetic resonance imaging (MRI) and the axonal regeneration.</p><p><strong>Conclusion: </strong>The MRI and pathology parameters after MACO had significant differences compared to the controls, as well as the bilateral cerebellum, which provided evidence of CCD. RGMa was related to the axonal regeneration in the injured brain.</p>","PeriodicalId":7143,"journal":{"name":"Acta radiologica","volume":" ","pages":"2841851241299086"},"PeriodicalIF":1.1,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143051351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hip-spine syndrome from the perspective of radiology: correlations between hip joint disease and lumbar spine MRI findings.","authors":"Haibin Pan, MingLiang Wang, Jianyan Tang, Shiming Wu, YueHua Li, Xiaobing Li","doi":"10.1177/02841851241300329","DOIUrl":"https://doi.org/10.1177/02841851241300329","url":null,"abstract":"<p><strong>Background: </strong>Hip joint (HJ) pain, which may be caused by lumbar disease, is a common complaint.</p><p><strong>Purpose: </strong>To investigate the prevalence and specific correlations between various HJ diseases and lumbar spine magnetic resonance imaging (MRI) findings in patients with HJ pain.</p><p><strong>Material and methods: </strong>Patients with the chief complaint of HJ pain who had both HJ MRI and lumbar MRI were retrospectively included. According to the existence of HJ disease, patients were divided into the following groups: non-HJ disease; osteoarthritis (OA); femoroacetabular impingement (FAI); ischiofemoral impingement (IFI); greater trochanter pain syndrome (GTPS); and other diseases. The prevalence of major lumbar MRI findings was compared. Correlations between HJ disease and major lumbar MR findings were explored.</p><p><strong>Results: </strong>A total of 585 patients were included, of which 566 (96.8%) had major findings on lumbar MRI. The HJ disease group was more likely to be female and had more spondylolisthesis, while the non-HJ disease group had more low back or leg pain. The OA group was older and correlated with lumbar spinal stenosis (contingency coefficient = 0.164) and spondylolisthesis (contingency coefficient = 0.095). The FAI group was younger, had more male patients, and correlated with lumbosacral transitional vertebrae (contingency coefficient = 0.122). The IFI group was older, had more female patients, and correlated with facet joint osteoarthritis (contingency coefficient = 0.168). The GTPS group was older, had more female patients, and correlated with spondylolisthesis (contingency coefficient = 0.097).</p><p><strong>Conclusion: </strong>Major lumbar MRI findings were frequently observed in patients with hip pain, even in patients without HJ disease. Specific lumbar MRI finding correlated with different HJ disease.</p>","PeriodicalId":7143,"journal":{"name":"Acta radiologica","volume":" ","pages":"2841851241300329"},"PeriodicalIF":1.1,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143051350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiple microcysts and clivus invasion diagnose T-box pituitary transcription factor 19 lineage adenomas in non-functioning pituitary adenomas.","authors":"Xuening Zhao, Xiaochen Wang, Sihui Wang, Lingxu Chen, Mengyuan Yuan, Shengjun Sun","doi":"10.1177/02841851251313555","DOIUrl":"https://doi.org/10.1177/02841851251313555","url":null,"abstract":"<p><strong>Background: </strong>Preoperative identification of T-box pituitary transcription factor 19 (TPIT) lineage silent adenomas in non-functioning pituitary adenomas (NFPAs) is important.</p><p><strong>Purpose: </strong>To compare the clinical, laboratory, and radiological features of the three cell lineages of adenomas in NFPAs and evaluate the diagnostic efficacy of multiple microcysts and clivus invasion on magnetic resonance imaging (MRI) for TPIT lineage adenomas in NFPAs.</p><p><strong>Material and methods: </strong>A total of 405 patients with NFPA were retrospectively enrolled, including steroidogenic factor 1 (SF-1) lineage adenomas (n = 204), TPIT lineage adenomas (n = 111), and pituitary transcription factor 1 (PIT-1) lineage adenomas (n = 90). The clinical, laboratory, and radiological features of the three lineages adenomas were compared. The sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy of multiple microcysts, clivus invasion, and their combination were calculated to diagnose TPIT lineage adenomas in NFPAs.</p><p><strong>Results: </strong>Among the three lineages of NFPAs, patients with SF-1 lineage were older than those with TPIT and PIT-1 lineages (<i>P</i> < 0.001). TPIT lineage adenomas were most common in women (<i>P</i> < 0.001) and had the highest tumor volume (<i>P</i> < 0.001), and incidence of clivus invasion (<i>P</i> < 0.001). The multiple microcysts and clivus invasion in the diagnosis of TPIT lineage adenomas in NFPAs had high specificity (88.44% vs. 98.64%) and accuracy (77.28%).</p><p><strong>Conclusion: </strong>The MRI findings of multiple microcysts and clivus invasion can help diagnose TPIT lineage adenomas in NFPAs with high specificity.</p>","PeriodicalId":7143,"journal":{"name":"Acta radiologica","volume":" ","pages":"2841851251313555"},"PeriodicalIF":1.1,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143045429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of four-dimensional flow MRI as an adjunct to endoscopy for predicting variceal bleeding in patients with cirrhosis.","authors":"Chung Man Moon, Yun Young Lee, Sung Ho Park, Hyungkyu Huh, Seul Kee Kim, Suk Hee Heo, Sang Soo Shin","doi":"10.1177/02841851241313023","DOIUrl":"https://doi.org/10.1177/02841851241313023","url":null,"abstract":"<p><strong>Background: </strong>Non-invasive approach other than conventional endoscopy could be effectively used for screening and monitoring esophageal variceal bleeding (EVB).</p><p><strong>Purpose: </strong>To retrospectively investigate the role of four-dimensional (4D) flow magnetic resonance imaging (MRI) as an add-on tool to endoscopy for predicting EVB in cirrhotic patients with esophageal varices (EVs).</p><p><strong>Material and methods: </strong>A cohort of 109 cirrhotic patients with EVs was divided into four groups: A = negative red color [RC] sign, no EVB, n = 60; B = negative RC sign, EVB, n = 13; C = positive RC sign, no EVB, n = 10; and D = positive RC sign, EVB, n = 26. All patients underwent laboratory assessments and 4D flow MRI using a 3-T scanner to analyze hemodynamic parameters within the main portal vein (PV), splenic vein, and superior mesenteric vein. Comparative analysis of 4D flow parameters among the groups was performed using the Mann-Whitney U-test, and diagnostic accuracy was assessed through the area under the receiver operator characteristic curve (AUC).</p><p><strong>Results: </strong>In the main PV, all 4D flow parameters were significantly lower in patients with a positive RC sign compared to those with a negative RC sign (<i>P</i> < 0.05). Patients with EVB had lower parameters than those without EVB (<i>P</i> < 0.05). The AUC values predicting actual variceal bleeding was 0.762 for endoscopy alone and 0.770-0.787 for 4D flow MRI. Integrating the endoscopic classification with the 4D flow MRI significantly improved the AUC value to 0.871 (<i>P</i> < 0.05).</p><p><strong>Conclusion: </strong>Four-dimensional flow MRI may be useful as an add-on tool to endoscopy for predicting actual bleeding in cirrhotic patients with EVs.</p>","PeriodicalId":7143,"journal":{"name":"Acta radiologica","volume":" ","pages":"2841851241313023"},"PeriodicalIF":1.1,"publicationDate":"2025-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143045431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative diagnostic performance of ⁶⁸Ga-PSMA-11 PET/CT and ⁶⁸Ga-PSMA-11 PET/MRI in detecting biochemical recurrent bone metastasis in prostate cancer: a systematic review and meta-analysis.","authors":"Xin Wen, Cheng-Yi Jiang, Xu Jiang, Yan Chen, Meng Li","doi":"10.1177/02841851241307336","DOIUrl":"https://doi.org/10.1177/02841851241307336","url":null,"abstract":"<p><strong>Background: </strong>The comparative diagnostic performance of ⁶⁸Gallium (Ga)-PSMA-11 PET/CT and ⁶⁸Ga-PSMA-11 PET/MRI in detecting bone metastases in prostate cancer (PCa) remains unclear.</p><p><strong>Purpose: </strong>To systematically evaluate the early detection rate of biochemical recurrent (BCR) bone metastasis in PCa utilizing ⁶⁸Ga-PSMA-11 PET/CT and ⁶⁸Ga-PSMA-11 PET/MRI.</p><p><strong>Material and methods: </strong>We searched PubMed, Embase, and Web of Science for relevant articles up to April 2023 and extracted studies that examined the positivity rate of both ⁶⁸Ga-PSMA-11 PET/CT and ⁶⁸Ga-PSMA-11 PET/MRI in the context of the BCR bone metastasis of PCa patients. Random-effects model was used to compare positivity rates for two imaging modalities. Heterogeneity among studies was assessed using the <i>I</i>² statistic. To evaluate the methodological quality of studies, we employed Quality Assessment of Diagnostic Performance Studies method. The study protocol was registered in PROSPERO (CRD42023454118).</p><p><strong>Results: </strong>A total of 1670 publications were originally identified; 58 studies, encompassing a cohort of 8037 patients, met the inclusion criteria. Regarding the evaluation of BCR bone metastasis, results suggest no statistically significant difference in the utilization of ⁶⁸Ga-PSMA-11 PET/CT versus ⁶⁸Ga-PSMA-11 PET/MRI in 58 non-head-to-head studies (0.21, 95% CI=0.19-0.24 and 0.17, 95% CI=0.11-0.23; <i>P </i>= 0.19) and four head-to-head studies (0.16, 95% CI=0.08-0.27 and 0.16, 95% CI=0.08-0.27; <i>P </i>= 1.00). Meta-regression showed the study design of influenced the heterogeneity in the PET/MRI group (<i>P</i> < 0.01); but analysis of PET/CT did not identify the potential reason for heterogeneity.</p><p><strong>Conclusion: </strong>There was no statistically significant difference in identifying BCR bone metastasis in PCa patients between ⁶⁸Ga-PSMA-11 PET/CT and ⁶⁸Ga-PSMA-11 PET/MRI.</p>","PeriodicalId":7143,"journal":{"name":"Acta radiologica","volume":" ","pages":"2841851241307336"},"PeriodicalIF":1.1,"publicationDate":"2025-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143045408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}