Acta radiologica最新文献

{"title":"Assessment of intra- and inter-observer variability in T1 relaxation time measurement for rectal cancer.","authors":"Mathias Rosenfeldt Byriel, Søren Rafael Rafaelsen","doi":"10.1177/02841851261453893","DOIUrl":"10.1177/02841851261453893","url":null,"abstract":"<p><p>BackgroundIn search of more accurate methods for rectal cancer diagnostics, T1 relaxation time measurement might have potential to become highly clinically relevant. The reproducibility of the methods has only been tested in few studies.PurposeTo investigate the reproducibility of measuring T1 relaxation time in rectal cancer by assessing the intra- and inter-observer variability.Material and MethodsIn this inter- and intra-observer study, magnetic resonance imaging (MRI) T1 maps were prospectively collected and analyzed by two observers. All images were obtained on 1.5-T MRI-units. T1 relaxation time was measured by contouring around the tumor border using free hand technique on a single slice. Intra- and inter-observer agreement were evaluated by the intraclass correlation coefficient (ICC) and Bland-Altman plots.ResultsA total of 41 MRI scans were included between 1 January and 31 October 2024. The cohort comprised 26 men and 15 women, with a mean age of 70 years (range = 28-92 years). The inter-observer agreement of T1 relaxation time was excellent across two reads with an ICC of 0.93 (95% confidence interval [CI]=0.85-0.97) and 0.91 (95% CI=0.83-0.95). The intra-observer agreement was excellent for both readers with an ICC of 0.94 (95% CI=0.88-0.97) for the less experienced reader and 0.90 (95% CI=0.81-0.95) for the experienced reader.ConclusionIn conclusion, analysis of MRI T1 maps and measuring of T1 relaxation time for evaluation of rectal cancer is has a high ICC. A reliable method is essential in the evaluation of complete response after neoadjuvant treatment.</p>","PeriodicalId":7143,"journal":{"name":"Acta radiologica","volume":" ","pages":"601-606"},"PeriodicalIF":1.2,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148154827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Native <i>T</i>₁ mapping of the terminal ileum in Crohn's disease: an exploratory study.","authors":"Giovanni Grassi, Gian Luca Chabert, Antonella Balestrieri, Michele Porcu, Giovanni Maria Argiolas, Maria Valeria Cherchi, Luca Saba","doi":"10.1177/02841851261451995","DOIUrl":"10.1177/02841851261451995","url":null,"abstract":"<p><p>BackgroundNative T1 mapping can quantitatively depict small variations in tissue T1 values.PurposeTo evaluate T1 value distribution and differences within affected ileum, in active Crohn's disease (CD) patients, using native T1-maps derived from axial Modified Look-Locker inversion recovery (MOLLI) sequences.Material and MethodsMOLLI sequences were added to the magnetic resonance enterography (MRE) standard protocol. The mid-point of the ileum with the most significant wall thickening was selected. The T1 values were first measured on a single region of interest (ROI), then divided into two, and further into six equal segments (mesenteric: posterior [P], medial posterior [MP], lateral posterior [LP]; anti-mesenteric: anterior [A], medial anterior [MA], lateral anterior [LA]). The Wilcoxon signed-rank test was used to compare T1 values.ResultsIn total, 40 patients with active CD (sMARIA ≥2) were retrospectively included (22 men, 18 women; mean age = 51.1 ± 14.3 years). The cohort was stratified into two groups: mild-to-moderate (wall thickness = 4-8 mm, n = 20) and moderate-to-severe (>8 mm, n = 20). In the mild-to-moderate group, significant differences were found in anti-mesenteric side segments, between MA vs. A (z = 2.606; <i>p</i> = 0.008) and MA vs. LA (z = 2.014; <i>p</i> = 0.038); and comparing opposite segments, between P vs. A (z = 2.014; <i>p</i> = 0.038); P vs. LA (z = 2.132; <i>p</i> = 0.028) and MP vs. A segments (z = 2.014; <i>p</i> = 0.038). In the moderate-to-severe group, significant differences were found between A vs. LP (z = 2.014; <i>p</i> = 0.038) and LA vs. LP (z = 2.606; <i>p</i> = 0.008).ConclusionNative T1 maps can display heterogeneous T1 value distribution within active severe CD ileal segments, particularly in mild-to-moderate wall thickness patients. The T1 value could be a promising imaging biomarker for patient phenotyping.</p>","PeriodicalId":7143,"journal":{"name":"Acta radiologica","volume":" ","pages":"568-577"},"PeriodicalIF":1.2,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147969549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasonographic assessment of chemotherapy-induced peripheral neuropathy after oxaliplatin treatment: an exploratory study.","authors":"Nina Lykkegaard Gehr, Malene Roland Vils Pedersen, Torben Frøstrup Hansen, Lars Henrik Jensen, Signe Timm, Lise Ventzel, Søren Rafael Rafaelsen","doi":"10.1177/02841851261447858","DOIUrl":"10.1177/02841851261447858","url":null,"abstract":"<p><p>BackgroundOxaliplatin is used in colorectal cancer treatment (CRC) but frequently causes chemotherapy-induced peripheral neuropathy (CIPN), a cumulative and potentially chronic adverse event. Reliable non-invasive methods for the early detection and monitoring of CIPN are lacking. Shear wave elastography (SWE) is an ultrasound-based technique that quantifies peripheral nerve stiffness and may enable CIPN assessment.PurposeTo evaluate the feasibility of SWE for detecting CIPN from oxaliplatin treatment in CRC.Material and MethodsIn this prospective, single-blinded study, patients with stage III-IV CRC receiving oxaliplatin-based (n = 18) or non-oxaliplatin chemotherapy (n = 12) were assessed at baseline, 3 months, and 6 months. Tibial nerve SWE, cross-sectional area, and diameter were measured using a standardized ultrasound protocol. CIPN symptoms were recorded through structured interviews, yielding composite scores (0-10), with possible CIPN defined as ≥2 points. Healthy controls (n = 9) underwent a single SWE evaluation. Linear mixed-effects models and non-parametric tests were used for longitudinal and group comparisons.ResultsNerve diameter increased over time in both groups (+1.50 mm, 95% confidence interval = 0.78-2.21; <i>P</i> <0.001) without between-group differences. SWE showed a trend toward higher tibial nerve stiffness at 6 months in oxaliplatin-treated patients (29.75 vs. 20.81 kPa). Possible CIPN occurred in 70% of oxaliplatin-treated patients versus none in the non-oxaliplatin (<i>P</i> <0.01). SWE correlated with CIPN scores (ρ = 0.55; <i>P</i> = 0.04).ConclusionSWE is a feasible, non-invasive method, and tibial nerve stiffness was modestly associated with CIPN symptom severity at 6 months. These findings are hypothesis-generating, and larger studies with validated neuropathy instruments are warranted to confirm clinical utility.</p>","PeriodicalId":7143,"journal":{"name":"Acta radiologica","volume":" ","pages":"613-622"},"PeriodicalIF":1.2,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148161080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dynamic breast magnetic resonance imaging features and pathological correlation of patients diagnosed with breast cancer under the age of 40.","authors":"Velican Gundogdu, Emine Meltem, Melis Baykara Ulusan, Huseyin Bozkurt, Abdullah Soydan Mahmutoglu","doi":"10.1177/02841851261457446","DOIUrl":"10.1177/02841851261457446","url":null,"abstract":"<p><p>BackgroundYoung-onset breast cancer (≤40 years) may demonstrate distinct magnetic resonance imaging (MRI) features compared with older patients, and recognition of age-related phenotypes may improve radiologic-pathologic correlation.PurposeTo evaluate dynamic breast MRI features of young-onset breast cancer, assess their correlation with histopathological characteristics, and compare these findings with those observed in an older patient population.Material and MethodsThis retrospective study included 160 women with breast cancer (80 aged ≤40 years; 80 aged ≥50 years). Breast density, background parenchymal enhancement (BPE), edema, skin thickness, lesion margins, T2 signal intensity, rim enhancement, internal enhancement pattern, kinetic curve type, ADC values were assessed according to ACR BI-RADS MRI lexicon. Histopathological features were extracted from pathology reports. Statistical analyses were performed using SPSS.ResultsYounger women more frequently demonstrated dense fibroglandular tissue, higher BPE, rim enhancement, T2 iso- to hyperintense lesions, and persistent enhancement kinetics (<i>P</i> <0.05). In contrast, older patients more commonly showed irregular morphology, diffuse edema, T2 hypointensity, and increased skin thickness (<i>P</i> <0.05). In the young-onset cohort, rim enhancement was associated with HER2-positive tumors (<i>P</i> = 0.006), and heterogeneous enhancement was associated with diffuse edema (<i>P</i> = 0.002). An ADC threshold of <830 × 10^-6 mm²/s predicted invasive carcinoma of no special type with 49.2% sensitivity and 80.0% specificity. In patients aged ≥50 years, rim enhancement was associated with triple-negative subtype (<i>P</i> = 0.006).ConclusionBreast cancer in women aged ≤40 years exhibits distinct MRI features compared with older patients. Findings such as circumscribed margins, T2 iso/hyperintensity, and persistent enhancement may still reflect aggressive tumor biology in young women.</p>","PeriodicalId":7143,"journal":{"name":"Acta radiologica","volume":" ","pages":"623-635"},"PeriodicalIF":1.2,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148196784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A combined model based on dual-energy CT for predicting high-risk lung adenocarcinoma in nodules with solid component.","authors":"Changjiu He, Xianyu Cao, Haomiao Qing, Peng Zhou, Yi Zhang, Xiaolei Dong, Jieke Liu","doi":"10.1177/02841851261452150","DOIUrl":"10.1177/02841851261452150","url":null,"abstract":"<p><p>BackgroundHigh-risk factors of lung adenocarcinoma (LUAD), including poorly differentiated pattern, lymphovascular invasion, visceral pleural invasion, lymph node metastasis, and spread through air spaces, are associated with poor prognosis.PurposeTo construct and validate a combined model based on dual-energy computed tomography (DECT) for predicting high-risk LUAD in nodules with solid components.Material and MethodsA total of 539 pathologically confirmed LUADs were retrospectively enrolled and were randomly divided into training (n = 377) and testing cohorts (n = 162) (ratio = 7:3). DECT quantitative parameters, conventional quantitative-semantic features, and clinical characteristics were collected. Univariable and multivariable logistic regression was used to construct the conventional CT model, DECT model, and combined model. Area under the curve (AUC) was used to evaluate diagnostic performance of models.ResultsThe combined model (features: sex, diameter, pleural indentation, electron density in venous phase [Rho_V], and NIC_A [normalized iodine concentration in arterial phase]) showed significantly higher AUC than the DECT model (features: Rho_V and NIC_A) (0.899 vs. 0.870; <i>P</i> = 0.005) and the conventional CT model (features: diameter and pleural indentation) (0.899 vs. 0.742; <i>P</i> <0.001) in the training cohort. In the testing cohort, the combined model showed significantly higher AUC than the conventional CT model (0.852 vs. 0.704; <i>P</i> <0.001), but no significant difference in AUC was found between the combined model and the DECT model (0.852 vs. 0.838; <i>P</i> = 0.354).ConclusionThe combined model based on DECT has good diagnostic performance in predicting high-risk LUAD in nodules with solid components.</p>","PeriodicalId":7143,"journal":{"name":"Acta radiologica","volume":" ","pages":"578-589"},"PeriodicalIF":1.2,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147979668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent advances in changes in the infrapatellar fat pad on MRI to predict osteoarthritis of the knee.","authors":"Yuxuan Wang, Meiqi Zheng, Jingjing Zhao, Zifan Cui, Hailong Guo, Chenxia Shi, Xiaofeng Wang","doi":"10.1177/02841851251389050","DOIUrl":"10.1177/02841851251389050","url":null,"abstract":"<p><p>Knee osteoarthritis (OA) is a very common degenerative disease occurring in middle-aged and elderly patients. Early diagnosis of knee OA is currently difficult, and it is particularly important to find new predictors of early knee OA. The infrapatellar fat pad (IPFP), as an adipose tissue, plays a role in the occurrence and development of knee OA. Currently, magnetic resonance imaging (MRI) technology can sensitively observe changes in the volume, signal intensity, and perfusion of the IPFP. Observation of IPFP changes can play a certain role in predicting the occurrence of early knee OA. In this narrative review, we take the MRI study of knee OA as the background, outline the physiological-pathological basis of IPFP, and summarize the current applications and latest progress of MRI in observing IPFP. we sorted out the role of IPFP changes in MRI images for the development of knee OA and the role of IPFP in the differential diagnosis of rheumatoid OA. It is hoped that some indicators for predicting the development of early knee OA as well as imaging methods can be found.</p>","PeriodicalId":7143,"journal":{"name":"Acta radiologica","volume":" ","pages":"590-600"},"PeriodicalIF":1.2,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148142266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic value of multslice spiral CT and MRI in traumatic anterior and posterior cruciate ligament injuries of the knee.","authors":"Guizhou Shen, Meilong Bai, Chengwei Xie, Sisi Zheng, Yizhong Chen, Liyong Wu, Wenxiang Yang","doi":"10.1177/02841851251393779","DOIUrl":"10.1177/02841851251393779","url":null,"abstract":"<p><p>BackgroundMultiple knee ligament injuries affecting the medial collateral ligament, anterior cruciate ligament (ACL), and posterior cruciate ligament (PCL) usually result from high-energy trauma or knee dislocations.PurposeTo explore the diagnostic value of multislice spiral computed tomography (MSCT) and magnetic resonance imaging (MRI) in detecting traumatic ACL/PCL injuries of the knee combined with clinical findings.Material and MethodsPatients with suspected ACL and PCL injuries underwent both MSCT and MRI. The length, thickness, and angle of the ACL and PCL were measured. Arthroscopy served as the gold standard to assess and compare the diagnostic performance of MSCT and MRI, including their efficacy in grading the severity of ligament injuries.ResultsMRI yielded higher values for ACL length and angle, but lower thickness than MSCT (t = 4.674, 2.340, 2.692; <i>P</i> <0.05). For the PCL, MRI revealed lower values in length, thickness, and angle than MSCT (t = 2.477, 3.359, 2.684; <i>P</i> <0.05). MSCT demonstrated higher diagnostic accuracy, while MRI provided superior positive and negative predictive values. Although MSCT had slightly lower sensitivity, specificity, and overall accuracy than MRI, the differences were not statistically significant (<i>P</i> >0.05).ConclusionBoth MSCT and MRI are valuable tools for diagnosing traumatic ACL and PCL injuries of the knee. However, MRI offers a modest diagnostic advantage over MSCT, particularly in soft tissue visualization and predictive accuracy.</p>","PeriodicalId":7143,"journal":{"name":"Acta radiologica","volume":" ","pages":"548-553"},"PeriodicalIF":1.2,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147832096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reduced beam hardening in urogenital imaging with photon-counting CT: a retrospective direct comparison with conventional CT.","authors":"Erik Gudmann Steuble Brandt, Felix Christoph Müller, Yousef Jw Nielsen, Anne Marie Ewald, Bulat Ibragimov, Henrik Thomsen, Anders Rodell, Michael Brun Andersen","doi":"10.1177/02841851261445935","DOIUrl":"10.1177/02841851261445935","url":null,"abstract":"<p><p>BackgroundBeam-hardening artefacts and image noise are very common causes of reduced image quality with computed tomography (CT) imaging of the lower pelvis and perirenal area affecting precision of diagnoses in urogenital imaging.PurposeTo investigate whether photon-counting CT (PCCT) improves image quality and/or reduces beam-hardening artefacts in the lower pelvis and in the perirenal area compared to energy-integrating CT (EIDCT).Material and MethodsWe retrospectively identified 35 patients scanned using both EIDCT and PCCT. Four radiologists read both PCCT and EIDCT images. Readers evaluated image quality both subjectively and quantitatively over the left medial perirenal fat and the urinary bladder. Continuous data were compared with a paired <i>t</i>-test and ordinal data with a Wilcoxon signed rank test.ResultsImage quality ratings were higher with PCCT compared to EIDCT. Median scores for the left medial perirenal fat were 5 (interquartile range [IQR] = 4-5) for PCCT and 3 (IQR = 3-4) for EIDCT (<i>P</i> <0.001) and for the lower pelvis 5 (IQR = 4-5) for PCCT and 3 (IQR = 2-4) for EIDCT (<i>P</i> <0.001). Image noise was significantly lower in PCCT scans compared to EIDCT scans (urinary bladder 11.9 HU vs. 17.8 HU, <i>P</i> <0.001; left medial perirenal fat 15.6 HU vs. 22.5 HU, <i>P</i> <0.001). Mean dose-length-product was significantly lower in the PCCT scans with a dose reduction of reduction 21.2% (<i>P</i> <0.001).ConclusionBeam-hardening artefacts were considerable reduced and image noise was significantly lower with PCCT compared to EIDCT at significantly reduced radiation doses. This could have potential implications in the radiological assessment of urogenital diseases.</p>","PeriodicalId":7143,"journal":{"name":"Acta radiologica","volume":" ","pages":"540-547"},"PeriodicalIF":1.2,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147832141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thin-slice 3D MR arthrographic analysis of capsular folds and fold-like structures in the superior shoulder joint.","authors":"Rodi Ertogrul, Hayri Ogul, Yusuf Yahsi, Zakir Sakci, Mustafa Ozdemir, Mecit Kantarci, Akin Levent","doi":"10.1177/02841851261438758","DOIUrl":"10.1177/02841851261438758","url":null,"abstract":"<p><p>BackgroundSuperior capsular folds and fold-like structures in the glenohumeral joint are potential sources of superior shoulder POS=12ptpain.PurposeTo obtain detailed information about the arthrographic anatomy and morphology of superior capsular folds and fold-like structures.Material and MethodsThis study followed a retrospective design and involved 300 consecutive shoulder magnetic resonance (MR) images and MR arthrograms in two centers. The origins and insertions of the superior capsular folds and fold-like structures in the glenohumeral joints were carefully examined and documented. Four subtypes of extensions in the sagittal-oblique plane of the posterior synovial fold were identified from the MR arthrograms, according to their associations with the biceps tendon long head, superior glenoid notch, and supraspinatus tendon. Further, two morphological subtypes of superior synovial folds were identified: cord-shaped and fan-shaped.ResultsSuperior capsular folds and fold-like structures in the shoulder joint were identified in 11 (4%) patients. Of these 11 superior capsular folds, 6 (54.5%) were then confirmed upon arthroscopy. The cord-shaped type was the most common MR arthrographic superior synovial fold and was detected in 8/11 (72.7%) patients. Type B was the most common form according to the course and insertion of the superior capsular fold (4/11 [37%] patients).ConclusionSuperior capsular folds, probably normal capsular anatomical variants, tend to be present in the posterior portions of the superior shoulder joint capsule and are rarely seen in MR arthrograms. These anatomical variations tend to be symptomatic, especially in young individuals.</p>","PeriodicalId":7143,"journal":{"name":"Acta radiologica","volume":" ","pages":"487-493"},"PeriodicalIF":1.2,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147621503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Short-term repeatability of monoexponential apparent diffusion coefficient in prostate cancer: dependence on b-value, tumor grade, lesion size, and lesion location.","authors":"Ivan Jambor, Harri Merisaari","doi":"10.1177/02841851261441869","DOIUrl":"10.1177/02841851261441869","url":null,"abstract":"<p><p>BackgroundDiffusion-weighted magnetic resonance imaging (DWI) of prostate cancer (PCa) is commonly quantified using monoexponential apparent diffusion coefficient (ADCm) values. However, repeatability of ADCm as qualitative biomarker for PCa is not well established.PurposeTo evaluate repeatability of prostate ADCm.Material and MethodsA total of 112 patients with PCa who underwent two repeated prostate DWI scans (12 b-values, 0-2000 s/mm²) on the same day before prostatectomy. ADCm values were analyzed across different b-value combinations and PCa lesion sizes. Bland-Altman plots, Spearman rank correlation, within-subject standard deviation (wSD), and coefficient of variation (wCV) were calculated.ResultsBland-Altman plots demonstrated no observable trend differences across ADCm intensity ranges. The results indicate correlation of ADCm repeatability with PCa aggressiveness, expressed as Gleason Grade Group (GGG). Specifically, wCV decreased towards higher GGG compared with GGG=1, wCV was <0.07 with b-value pairs from 0, 700 to 0, 1300 s/mm². Majority of evaluated lesions that had high wSD up to 0.2 × 10^-3 mm²/s were found in lower GGGs. Different b-value combinations demonstrated varying effects on ADCm performance. The lowest repeatability was observed with the lesion size <5 mL while for the lesion size ≥5 mL wSD was <0.1 × 10^-3 mm²/s.ConclusionOur study demonstrated repeatability of ADCm mean values as quantitative imaging biomarkers for PCa detection and characterization.</p>","PeriodicalId":7143,"journal":{"name":"Acta radiologica","volume":" ","pages":"502-507"},"PeriodicalIF":1.2,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147721457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}