Acta radiologica最新文献

{"title":"Time-dependent diffusion magnetic resonance imaging for the analysis of parotid gland tumors.","authors":"Di Geng, Liu-Ning Zhu, Jun Liu, Xian-Ce Zhao, Yi-Shi Wang, Xiao-Quan Xu, Fei-Yun Wu","doi":"10.1177/02841851241313108","DOIUrl":"https://doi.org/10.1177/02841851241313108","url":null,"abstract":"<p><strong>Background: </strong>Different parotid tumors differ in terms of treatment strategies due to their distinct biological behaviors. Time-dependent diffusion magnetic resonance imaging (t_d-dMRI) can characterize and quantify the cytological indexes, and then aid the differential diagnosis of various tumors. However, the value of t_d-dMRI in the analysis of parotid gland tumors remains unclear.</p><p><strong>Purpose: </strong>To investigate the value of quantitative parameters derived from t_d-dMRI in the analysis of parotid gland tumors.</p><p><strong>Material and methods: </strong>In total, 39 patients with parotid gland tumors were prospectively enrolled, including 24 patients with polymorphic adenomas (PAs), eight with Warthin's tumors (WTs), and seven with malignant tumors (MTs). T_d-dMRI was performed for preoperative evaluation. Intracellular volume fraction (<i>V</i>_in), mean cell size (<i>d</i>), extracellular diffusion coefficient (<i>D</i>_ex), and cellularity were obtained based on the Imaging Microstructural Parameters Using Limited Spectrally Edited Diffusion model, and compared among the three groups. One-way ANOVA, Kruskal-Wallis test, and receiver operating characteristic (ROC) curve analysis were performed for further statistical analysis as appropriate.</p><p><strong>Results: </strong>Significant differences were found in all t_d-dMRI-derived indexes among PAs, WTs, and MTs (all <i>P</i> < 0.05). <i>V</i>_in was the sole parameter with significant differences for all sub-group comparisons (PAs vs. WTs, <i>P</i> < 0.001; PAs vs. MTs, <i>P</i> = 0.031; WTs vs. MTs, <i>P</i> = 0.047). With <i>V</i>_in values of 0.267, 0.231, and 0.260 as threshold, respectively, optimal performance levels were obtained for differentiating PAs from WTs (area under the ROC curve [AUC]=0.932, sensitivity=0.917, and specificity=0.875), PAs from MTs (AUC=0.744, sensitivity=0.833, and specificity=0.714), and WTs from MTs (AUC=0.750, sensitivity=0.875, and specificity=0.714).</p><p><strong>Conclusion: </strong>Microstructural parameters derived from t_d-dMRI, especially <i>V</i>_in, might be promising imaging biomarkers for characterizing parotid gland tumors.</p>","PeriodicalId":7143,"journal":{"name":"Acta radiologica","volume":" ","pages":"2841851241313108"},"PeriodicalIF":1.1,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142998336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of neuromuscular electrical stimulation with modern rehabilitation techniques in the treatment of acute ischemic stroke patients with post-motor dysfunction.","authors":"Jie Lin, Lei Liu, Huifang Zheng, Zuojun Tian","doi":"10.1177/02841851241312227","DOIUrl":"https://doi.org/10.1177/02841851241312227","url":null,"abstract":"<p><strong>Background: </strong>Acute ischemic stroke (AIS) refers to a sudden loss of blood flow in a region of the brain, which leads to a loss of neurological function.</p><p><strong>Purpose: </strong>To unveil the efficacy of neuromuscular electrical stimulation (NMES) with modern rehabilitation techniques in AIS patients with post-motor dysfunction.</p><p><strong>Material and methods: </strong>A total of 200 AIS patients with post-motor dysfunction were divided into groups A, B, C, and D (n = 50). Patients in the four groups were routinely treated with medicine, on this basis: group B received NMES treatment; group C received modern rehabilitation technology treatment; and group D was treated with NMES and modern rehabilitation technology. Rehabilitation effect, cerebral hemodynamic indices, neurological function recovery, Fugl-Meyer Assessment (FMA) and Motor Assessment Scale (MAS) scores, self-care, and quality of life were compared.</p><p><strong>Results: </strong>After treatment, the total effective rate of group D was 96% higher than that of group A (64%), group B (82%), and group C (84%). Bilateral middle cerebral artery Vm and Vs and scores of FMA, MAS, functional independence measure, and modified Barthel index increased; RI and NHISS scores decreased; and all group D improved significantly versus groups A, B, and C, and both groups B and C improved significantly versus group A.</p><p><strong>Conclusion: </strong>NMES with modern rehabilitation technologies synergistically treat motor dysfunction after AIS with ideal rehabilitation effect, improving cerebral hemodynamics, neurological and limb motor function recovery, and self-care ability and quality of life.</p>","PeriodicalId":7143,"journal":{"name":"Acta radiologica","volume":" ","pages":"2841851241312227"},"PeriodicalIF":1.1,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142998334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Welcoming the new Editor-in-Chief of <i>Acta Radiologica</i>: Lars Lönn.","authors":"Søren Rafael Rafaelsen","doi":"10.1177/02841851251313643","DOIUrl":"https://doi.org/10.1177/02841851251313643","url":null,"abstract":"","PeriodicalId":7143,"journal":{"name":"Acta radiologica","volume":"66 1","pages":"4-5"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143078186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diffusion-weighted imaging based on intravoxel incoherent motion: correlation with molecular prognostic factors and subtypes in breast cancer.","authors":"Dan Yang, Yike Ren, Guanying Wang, Chunhong Wang","doi":"10.1177/02841851241296029","DOIUrl":"10.1177/02841851241296029","url":null,"abstract":"<p><strong>Background: </strong>Intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI), which indicates biological tissue attributes, may be applied to accurately assess breast tumors.</p><p><strong>Purpose: </strong>To analyze the IVIM parameters of different molecular prognostic factors and subtypes to find out whether there are any connections.</p><p><strong>Material and methods: </strong>A total of 181 patients enrolled in this retrospective study had preoperative magnetic resonance imaging (MRI) examinations, and pathologies were verified as breast cancers. Regions of interest were placed at all slices of the parameter maps (D, tissue diffusivity; ADC, apparent diffusion coefficient; f, perfusion fraction; and D*, pseudo-diffusivity maps) of IVIM and generated parameter values to be used for comparative analysis among molecular prognostic factors and subtypes.</p><p><strong>Results: </strong>D and ADC were greater in estrogen receptor (ER)-negative, human epidermal growth factor receptor 2 (HER2)-positive, and Ki67-low expression groups (all <i>P</i> values < 0.05). The progesterone receptor (PR)-negative group had a higher D value (<i>P</i> < 0.05). f was larger in the lymph node metastasis-negative group and the PR-positive group (<i>P</i> = 0.012 and 0.046, respectively). Among breast cancer subtypes, D and ADC were different between the HER2-overexpression and the Luminal B (HER2-negative) subtypes (<i>P</i> = 0.019 and 0.028, respectively). The difference in D between the luminal and non-luminal subtypes was statistically significant (<i>P</i> = 0.008). The triple-negative subtype significantly differs from the other subtypes in D* and f (<i>P</i> = 0.012 and 0.016, respectively).</p><p><strong>Conclusion: </strong>IVIM-related metrics exhibited relationships with breast cancer molecular prognosis factors and subtypes.</p>","PeriodicalId":7143,"journal":{"name":"Acta radiologica","volume":" ","pages":"35-41"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142680541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors related to acute kidney injury after AngioJet rheolytic thrombectomy.","authors":"Ye Eun Lee, Kun Yung Kim, Young-Min Han","doi":"10.1177/02841851241292810","DOIUrl":"10.1177/02841851241292810","url":null,"abstract":"<p><strong>Background: </strong>AngioJet rheolytic thrombectomy is associated with a higher risk of acute kidney injury due to its potential for inducing mechanical harm and intravascular hemolysis. However, previous studies have focused on a single disease entity.</p><p><strong>Purpose: </strong>To identify predictors associated with acute kidney injury after AngioJet rheolytic thrombectomy across a range of disease entities.</p><p><strong>Material and methods: </strong>A total of 95 patients who underwent AngioJet rheolytic thrombectomy between October 2018 and April 2023 were retrospectively reviewed. In total, 11 patients were excluded due to the absence of a postprocedural serum creatinine test within 72 h; finally, 84 patients were included. Acute kidney injury was defined as a ≥1.5-fold increase or ≥0.3 mg/dL rise in serum creatinine within 72 h after the procedure. Univariate and multivariate analysis were performed to identify risk factors for acute kidney injury.</p><p><strong>Results: </strong>Technical and clinical success were achieved in all patients (84/84, 100%). Of the 84 patients (40 men [47.6%], 44 women [52.4%]; mean age = 67.2 ± 15.9 years), 15 (17.8%) had developed acute kidney injury. Multivariate analysis showed concurrent malignancy (odds ratio [OR] = 42.231, 95% confidence interval [CI] = 2.332-764.693; <i>P</i> = 0.011) and AngioJet rheolytic thrombectomy in arterial system (OR = 24.109, 95% CI = 1.319-440.551; <i>P</i> = 0.032) as statistically significant predictors of acute kidney injury.</p><p><strong>Conclusions: </strong>AngioJet rheolytic thrombectomy is a potential risk for acute kidney injury. Concurrent malignancy and AngioJet rheolytic thrombectomy in the arterial system are independent predictors of acute kidney injury.</p>","PeriodicalId":7143,"journal":{"name":"Acta radiologica","volume":" ","pages":"120-124"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142646778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Different iron distribution patterns in Parkinson's disease and its motor subtypes: a quantitative susceptibility mapping study.","authors":"Siting Zang, Yu Pan, Miao Chen, Gang Zhang","doi":"10.1177/02841851241297207","DOIUrl":"10.1177/02841851241297207","url":null,"abstract":"<p><strong>Background: </strong>This study utilized quantitative susceptibility mapping (QSM) to evaluate magnetic susceptibility of brain nuclei in Parkinson's disease (PD).</p><p><strong>Purpose: </strong>To explore iron deposition patterns in PD and ascertain if these patterns can distinguish between motor subtypes.</p><p><strong>Material and methods: </strong>This study enrolled 30 healthy controls and 34 patients with PD categorized mainly into postural instability and gait disorder (PIGD) (n = 12) and tremor dominance (TD) (n = 16). A total of 18 regions of interest were delineated, and a comprehensive classification of nuclei was conducted, including the differentiation of globus pallidus (GP) into its external (GPe) and internal (GPi) segments. All participants underwent brain magnetic resonance imaging.</p><p><strong>Results: </strong>Notable differences in magnetic susceptibility were identified in bilateral substantia nigra pars reticulate (SNr) and substantia nigra pars compacta (SNc) between PD and HC. Significant differences in QSM values of bilateral GPe, SNr, and SNc-R were found between TD and PIGD. The susceptibility values of bilateral putamen (PUT) were positively correlated with MDS-UPDRSIII score and Hoehn-Yahr scale in PD. QSM values of bilateral PUT and SNc-L showed associations with MDS-UPDRSIII score in TD. QSM values showed associations with MDS-UPDRSIII in bilateral PUT and Hoehn-Yahr scale in PUT-L and TH-L in PIGD.</p><p><strong>Conclusion: </strong>Pathologic iron deposition exhibits variability across nuclei of PD, with age also influencing this distribution. SN may be meaningful in identifying different subtypes of PD, such as differentiating PD from HC in the future.</p>","PeriodicalId":7143,"journal":{"name":"Acta radiologica","volume":" ","pages":"99-106"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142685755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of gadolinium-based contrast agents on ¹H-magnetic resonance spectroscopy in normal brain area: a preliminary study.","authors":"Nam Anh Ton That, Thi Tuong Van Nguyen, Thao Nguyen Thanh","doi":"10.1177/02841851241295395","DOIUrl":"10.1177/02841851241295395","url":null,"abstract":"<p><strong>Background: </strong>Giving contrast material before ¹H-magnetic resonance spectroscopy (MRS) could enhance the precision of locating the lesion of interest. However, evidence indicates that contrast material might influence the outcomes of MRS.</p><p><strong>Purpose: </strong>To verify the effect of gadolinium-based contrast agent (GBCA) on MRS in normal white matter.</p><p><strong>Material and methods: </strong>A total of 34 patients were referred for brain magnetic resonance imaging (MRI) with GBCAs, and they underwent single-volume MRS before and after administering contrast material. Those patients had the MRS voxel placed at the right frontal normal white matter, which remained consistent across all examinations. Measurements were taken for the integral concerning N-acetyl aspartate (NAA), choline (Cho), creatine (Cr and Cr2), and myo-inositol (Ins) in all examinations.</p><p><strong>Results: </strong>NAA (<i>P</i> = 0.0313) and Cho (<i>P</i> = 0.0094) had a significant decrease in their integral after intravenous GBCA administration. No significant differences were found between the pre- and post-contrast MRS studies for Cr, Cr2, and Ins.</p><p><strong>Conclusion: </strong>Intravenous GBCA can alter NAA and Cho integrals in normal white matter. Therefore, brain ¹H-MRS should precede intravenous GBCA administration to avoid the potential impact of contrast material on peak integrals.</p>","PeriodicalId":7143,"journal":{"name":"Acta radiologica","volume":" ","pages":"82-87"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142646786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The use of dual and triple rule-out computerized tomography angiography by using diagnostic low-dose contrast material and radiation in acute chest pain.","authors":"Ahmet Kerem Imrek, Mustafa Hızal, Yunus Yılmazsoy, Zeliha Coşgun","doi":"10.1177/02841851241298900","DOIUrl":"10.1177/02841851241298900","url":null,"abstract":"<p><strong>Background: </strong>Triple rule-out computed tomography angiography (CTA) provides imaging of the coronary arteries, pulmonary arteries, and thoracic aorta filled with contrast material (CM) to exclude or diagnose the pathologies of these three systems. Although dual rule-out adapted to exclude aortic and pulmonary pathologies. Iodinated CM may result in contrast-induced nephropathy, which lengthens hospital stay.</p><p><strong>Purpose: </strong>To compare image quality of dual/triple rule-out CTA by reducing the radiation dose by using relatively high mAs with less contrast material and low kilovoltage without affecting the diagnostic value.</p><p><strong>Methods: </strong>We acquired standard dual/triple rule-out CTA 120 kilovoltage peak (kVp) with 95 mL contrast material. The low-dose group acquired 80 Kvp with total 60 contrast material. There were 91 patients in the standard-dose group and 88 patients in the low-dose group.</p><p><strong>Results: </strong>Signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) were calculated separately. There was no significant difference in CNR values between the two groups in the aorta and pulmonary and coronary arteries; however, a significant difference was found in SNR values. In subjective image quality evaluation, no significant difference was found between the standard- and low-dose patients. The radiation dose was reduced by 63.80% and the contrast material by 31.5% in the low-dose group in comparison to the standard dose.</p><p><strong>Conclusion: </strong>Our study showed that dual/triple rule-out CTA can be performed with low-dose radiation and low-volume contrast material. Low-dose CTA may be preferred in emergencies situations that patients with borderline renal function tests or the risk group.</p>","PeriodicalId":7143,"journal":{"name":"Acta radiologica","volume":" ","pages":"125-133"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142891279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A combined model integrating radiomics and deep learning based on multiparametric magnetic resonance imaging for classification of brain metastases.","authors":"Bo Zhang, Jinling Zhu, Ruizhe Xu, Li Zou, Yixin Lian, Xin Xie, Ye Tian","doi":"10.1177/02841851241292528","DOIUrl":"10.1177/02841851241292528","url":null,"abstract":"<p><strong>Background: </strong>Radiomics and deep learning (DL) can individually and efficiently identify the pathological type of brain metastases (BMs).</p><p><strong>Purpose: </strong>To investigate the feasibility of utilizing multi-parametric MRI-based deep transfer learning radiomics (DTLR) for the classification of lung adenocarcinoma (LUAD) and non-LUAD BMs.</p><p><strong>Material and methods: </strong>A retrospective analysis was performed on 342 patients with 1389 BMs. These instances were randomly assigned to a training set of 273 (1179 BMs) and a testing set of 69 (210 BMs) in an 8:2 ratio. Eight machine learning algorithms were employed to construct the radiomics models. A DL model was developed using four pre-trained convolutional neural networks (CNNs). The DTLR model was formulated by integrating the optimal performing radiomics model and the DL model using a classification probability averaging approach. The area under the curve (AUC), calibration curve, and decision curve analysis (DCA) were utilized to assess the performance and clinical utility of the models.</p><p><strong>Results: </strong>The AUC for the optimal radiomics and DL model in the testing set were 0.824 (95% confidence interval [CI]= 0.726-0.923) and 0.775 (95% CI=0.666-0.884), respectively. The DTLR model demonstrated superior discriminatory power, achieving an AUC of 0.880 (95% CI=0.803-0.957). In addition, the DTLR model exhibited good consistency between actual and predicted probabilities based on the calibration curve and DCA analysis, indicating its significant clinical value.</p><p><strong>Conclusion: </strong>Our study's DTLR model demonstrated high diagnostic accuracy in distinguishing LUAD from non-LUAD BMs. This method shows potential for the non-invasive identification of the histological subtype of BMs.</p>","PeriodicalId":7143,"journal":{"name":"Acta radiologica","volume":" ","pages":"24-34"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142646771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can smartphone cameras help with diagnostic adequacy in renal biopsy?","authors":"Mehmet Karagulle, Sıbel Hamarat Gulcicek, Emin Taha Keskin","doi":"10.1177/02841851241295393","DOIUrl":"10.1177/02841851241295393","url":null,"abstract":"<p><strong>Background: </strong>In this prospective study, we evaluated whether a sufficient number of glomeruli were achieved using the 8× magnification of smartphone cameras.</p><p><strong>Purpose: </strong>To increase the percutaneous ultrasound-guided renal biopsy (PURB) diagnostic value with a method that has not been tried before and reduce the need for repetition of the procedure.</p><p><strong>Material and methods: </strong>A total of 39 adult patients who underwent PURB were included in our study. After the PURB was applied to the patients, the biopsy specimen was placed on the previously prepared sterile gauze. At this stage, 8× magnification photos were taken of the biopsy samples using the smartphone camera. The glomeruli in the photograph were counted and recorded and compared with the number of glomeruli seen at the end of the histopathological examination.</p><p><strong>Results: </strong>The mean number of glomeruli in the evaluated samples was counted as 6 ± 2.2 (range = 1-10) in the 8× magnification photograph. The mean number of glomeruli detected in the histopathological examination of these samples was 11 ± 5.7 (range = 2-30). A pathological glomeruli count of 10 was associated with more than five brown spots in the 8× magnification photograph (area under the curve = 0.977, <i>P</i>=0.0001).</p><p><strong>Conclusion: </strong>To obtain more than 10 glomeruli in a PURB specimen, five or more brownish-red dots should be counted on the 8x magnification photograph. Using smartphones as an alternative tool for evaluating renal biopsy tissue adequacy can be practical and advantageous in terms of time and labor.</p>","PeriodicalId":7143,"journal":{"name":"Acta radiologica","volume":" ","pages":"115-119"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142646776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}