Acta radiologica最新文献_第3页

Cone-beam CT volumetry: a new method for evaluating osteotomy healing - a clinical evaluation and MDCT comparison. 锥形束 CT 容积测量：评估截骨愈合的新方法--临床评估与 MDCT 比较。

IF 1.1 4区医学

Acta radiologica Pub Date : 2024-11-01 Epub Date: 2024-10-17 DOI: 10.1177/02841851241287903

Ivan Cetinic, Michael Ullman, Linn Hellman, Ylva Aurell

{"title":"Cone-beam CT volumetry: a new method for evaluating osteotomy healing - a clinical evaluation and MDCT comparison.","authors":"Ivan Cetinic, Michael Ullman, Linn Hellman, Ylva Aurell","doi":"10.1177/02841851241287903","DOIUrl":"10.1177/02841851241287903","url":null,"abstract":"Background: Fracture healing complications remain a major problem in trauma monitoring. An open wedge osteotomy of the distal radius provides a unique way of evaluating fracture healing. Since the introduction of cone-beam computed tomography (CBCT) at our institution, it has become the method of choice for assessing hand and wrist bones. To date, CT volumetry has been validated for multidetector CT (MDCT) but not for CBCT.Purpose: To assess osteotomy healing using CBCT volumetry and to evaluate two different segmentation techniques.Material and methods: A total of 36 patients were surgically treated for malunited distal radius fractures with open-wedge osteotomy either leaving the void empty (open wedge empty [OWE]) or filled with bone graft substitutes (BGS). They were scanned using CBCT and MDCT postoperatively and after 3, 6, and 12 months. Segmentation was performed both manually and semi-automatically for volumetric measurement. Inter- and intra-observer reliability were assessed using intraclass correlation (ICC).Results: The median osteotomy volume in the OWE group postoperatively was 0.87 cm3 (range=0.42-2.72). At 3 months, all but one of the OWE volumes had diminished to half or less of their initial volume. In the BGS group, the median postoperative volume was 1.30 cm3 (range=0.73-1.81) and at 12 months, 76% of the initial volume remained. Reliability between CBCT and MDCT volumetry expressed as ICC was ≥0.96. ICC for the two segmentation techniques was ≥0.99 and ICC for inter-observer reliability ≥0.97.Conclusion: CBCT volumetry is a reliable tool and comparable to MDCT to quantify bone healing of an osteotomy.","PeriodicalId":7143,"journal":{"name":"Acta radiologica","volume":" ","pages":"1375-1381"},"PeriodicalIF":1.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142455562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis of growth pattern of temporal bone pneumatization using 3D reconstructed computed tomography. 利用三维重建计算机断层扫描分析颞骨气化的生长模式。

IF 1.1 4区医学

Acta radiologica Pub Date : 2024-11-01 Epub Date: 2024-09-30 DOI: 10.1177/02841851241281966

Sun Wha Song, Beom Cho Jun

{"title":"Analysis of growth pattern of temporal bone pneumatization using 3D reconstructed computed tomography.","authors":"Sun Wha Song, Beom Cho Jun","doi":"10.1177/02841851241281966","DOIUrl":"10.1177/02841851241281966","url":null,"abstract":"Background: Temporal bone pneumatization (TBP) is influenced by age, sex, and race, and it seems to progress rapidly to puberty. However, the extent of TBP in childhood remains unclear.Purpose: To investigate the progression of TBP in children aged 1-18 years via three-dimensional (3D) reconstruction of high-resolution computed tomography (CT) images.Material and methods: A total of 432 temporal bones of 216 individuals aged 1-18 years with well-pneumatized mastoid antra on both sides were included in this retrospective work. We created 18 age groups, each with six boys and six girls. Surface rendering of air density was performed using -290 HU to obtain TBP. Statistical analysis employed SPSS version 24.0 software (IBM Corp., Armonk, NY, USA).Results: The linear regression equations that considered age and volume for all cases (ya), male (ym) and female (yf) were ya = 384.42x + 1790.40, R2 = 0.425; ym = 431.54x + 1440.9, R2 = 0.501; and yf = 337.26 x + 2140.5, R2 = 0.355. Both male and female individuals showed an increase in the average value of pneumatization until the age of 17, and the values of pneumatization at specific ages for boys and girls showed differences. The mean male and female TBP levels differed significantly at 3, 11, and 18 years of age (P < 0.05).Conclusion: TBP in boys was greater than that of girls at adolescence. It was possible to identify the specific periods of significant variation in the degree of pneumatization of temporal bone.","PeriodicalId":7143,"journal":{"name":"Acta radiologica","volume":" ","pages":"1341-1346"},"PeriodicalIF":1.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142339124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Machine learning models based on CT radiomics features for distinguishing benign and malignant vertebral compression fractures in patients with malignant tumors. 基于CT放射组学特征的机器学习模型，用于区分恶性肿瘤患者的良性和恶性椎体压缩骨折。

IF 1.1 4区医学

Acta radiologica Pub Date : 2024-11-01 Epub Date: 2024-10-01 DOI: 10.1177/02841851241279896

Yuan Wan, Lei Miao, HuanHuan Zhang, YanMei Wang, Xiao Li, Meng Li, Li Zhang

{"title":"Machine learning models based on CT radiomics features for distinguishing benign and malignant vertebral compression fractures in patients with malignant tumors.","authors":"Yuan Wan, Lei Miao, HuanHuan Zhang, YanMei Wang, Xiao Li, Meng Li, Li Zhang","doi":"10.1177/02841851241279896","DOIUrl":"10.1177/02841851241279896","url":null,"abstract":"Background: Radiomics has become an important tool for distinguishing benign and malignant vertebral compression fractures (VCFs). It is more clinically significant to concentrate on patients who have malignant tumors and differentiate between benign and malignant VCFs.Purpose: To explore the value of multiple machine learning (ML) models based on CT radiomics features for differentiating benign and malignant VCFs in patients with malignant tumors.Material and methods: This study retrospectively analyzed 78 patients with malignant tumors accompanied by VCFs, 45 patients with benign VCFs, and 33 patients with malignant VCFs. A total of 140 lesions (86 benign lesions, 54 malignant lesions) were ultimately included in this study. All patients were divided into training sets (n = 98) and validation sets (n = 42) according to the 7:3 ratio. The radiomics features were screened and dimensioned, and multiple radiomics ML models were constructed. The receiver operating characteristic (ROC) curve was performed to assess the diagnostic performance.Results: Five radiomics features were included in the model. All the ML models built have good diagnostic efficiency, among which the support vector machine (SVM) model performs better. The area under the curve (AUC), sensitivity, specificity, and accuracy in the training set were 0.908, 0.816, 0.883, and 0.857, respectively, while those in the validation set were 0.911, 0.647, 0.92, and 0.81, respectively.Conclusion: A variety of ML models built based on CT radiomics features have good value for differentiating benign and malignant VCFs in malignant tumor patients, and the SVM model has a better performance.","PeriodicalId":7143,"journal":{"name":"Acta radiologica","volume":" ","pages":"1359-1367"},"PeriodicalIF":1.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142339127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A controlled study of MR DWI, FS-PDW, and CE-T1W imaging for the evaluation of the internal opening of anal fistulas. 磁共振 DWI、FS-PDW 和 CE-T1W 成像用于评估肛瘘内口的对照研究。

IF 1.1 4区医学

Acta radiologica Pub Date : 2024-11-01 Epub Date: 2024-10-15 DOI: 10.1177/02841851241284812

Jingyi Liu, Tingting Zhang, Lei Sheng

{"title":"A controlled study of MR DWI, FS-PDW, and CE-T1W imaging for the evaluation of the internal opening of anal fistulas.","authors":"Jingyi Liu, Tingting Zhang, Lei Sheng","doi":"10.1177/02841851241284812","DOIUrl":"10.1177/02841851241284812","url":null,"abstract":"Background: Anal fistula (AF) is an abnormal tunnel under the skin connecting the anal canal in the colon to the skin of buttocks. Fat-suppressed (FS) proton density-weighted (PDW) imaging is mainly used for the diagnosis of diseases involving bones and joints. Until now, its value in the diagnosis of anal fistula has been rarely reported.Purpose: To compare three magnetic resonance imaging (MRI) sequences - diffusion-weighted imaging (DWI), FS-PDW), and contrast-enhanced (CE) T1-weighted (T1W) imaging - for the diagnostic value of the internal opening of AF.Material and methods: MRI scans of 132 patients suspected of having AF between December 2021 and April 2023 were retrospectively analyzed. In total, 65 patients who underwent preoperative MRI and were treated surgically were included. The lesion conspicuity and accuracy for featuring AF were calculated by evaluating the three imaging datasets DWI, FS-PDW, and CE-T1W imaging, with surgical findings serving as the reference standard for the presence of fistulas. The statistical analysis included the application of the chi-square test and Kruskal-Wallis test.Results: In 65 patients with AF, 87 internal openings of AF were confirmed. In terms of the diagnostic accuracy of the internal openings, both FS-PDW and CE-T1W imaging sequences were significantly better than DWI sequences, and the difference was statistically significant (P < 0.05).Conclusion: The FS-PDW imaging sequence showed comparable diagnostic performance of the internal opening of AF to CE-T1W imaging, which can provide an important diagnostic basis for clinical procedures.","PeriodicalId":7143,"journal":{"name":"Acta radiologica","volume":" ","pages":"1319-1324"},"PeriodicalIF":1.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142455560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Magnetic resonance imaging characteristics of musculoskeletal hydatid disease. 肌肉骨骼包虫病的磁共振成像特征。

IF 1.1 4区医学

Acta radiologica Pub Date : 2024-11-01 Epub Date: 2024-09-19 DOI: 10.1177/02841851241277353

Ipek Tamsel, Hüseyin Kaya, Dündar Sabah, Remide Arkun

{"title":"Magnetic resonance imaging characteristics of musculoskeletal hydatid disease.","authors":"Ipek Tamsel, Hüseyin Kaya, Dündar Sabah, Remide Arkun","doi":"10.1177/02841851241277353","DOIUrl":"10.1177/02841851241277353","url":null,"abstract":"Background: Hydatid disease is a parasitic infection seen in endemic areas. Musculoskeletal hydatid disease is rarely reported.Purpose: To describe the magnetic resonance imaging (MRI) features of musculoskeletal hydatid disease and to highlight the specific findings in the diagnosis of hydatid cysts.Material and methods: The MRI scans of 29 cases diagnosed as musculoskeletal hydatid disease between 2000 and 2022 were retrospectively analyzed. The localization, size, appearance (unilocular or multilocular), signal characteristics, rim sign, presence of internal septa and membrane, and gadolinium enhancement pattern of hydatid cysts were evaluated.Results: A total of 29 patients diagnosed with hydatid cyst were included in the study. Of the lesions, 18 were localized in bone and 11 were in soft tissue. The bone hydatid cysts on MRI showed heterogeneous low to intermediate signal intensity on T1-weighted images and high signal intensity on T2-weighted images in the medullary bone. In 15/18 patients, there was also cortical destruction and extension into the adjacent soft tissue planes. In 8/11 cases where the cyst was located in muscle tissue, the \"cyst or cysts within a cyst\" appearance was observed on MRI. The rim sign was observed in 7/11 cases and the \"water lily\" sign was noted in 2/11 cases.Conclusion: MRI provides valuable information for the diagnosis of hydatid disease with its distinctive imaging features. Knowledge of the different patterns of hydatid cysts on MRI may be helpful in the diagnosis of this disease.","PeriodicalId":7143,"journal":{"name":"Acta radiologica","volume":" ","pages":"1368-1374"},"PeriodicalIF":1.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142278724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Placental T2-weighted MRI-based radiomics-clinical nomogram to predict postpartum hemorrhage of placenta previa. 基于胎盘 T2 加权磁共振成像的放射计量学-临床提名图，用于预测前置胎盘的产后出血。

IF 1.1 4区医学

Acta radiologica Pub Date : 2024-11-01 Epub Date: 2024-09-19 DOI: 10.1177/02841851241275034

Yanli Lu, Hongchang Yu, Hongkun Yin, Jun Yan, Jibin Zhang, Yongfei Yue

{"title":"Placental T2-weighted MRI-based radiomics-clinical nomogram to predict postpartum hemorrhage of placenta previa.","authors":"Yanli Lu, Hongchang Yu, Hongkun Yin, Jun Yan, Jibin Zhang, Yongfei Yue","doi":"10.1177/02841851241275034","DOIUrl":"10.1177/02841851241275034","url":null,"abstract":"Background: Placenta previa is an obstetric complication related to severe maternal morbidity and mortality. Magnetic resonance imaging (MRI) can be used for the preoperative evaluation of postpartum hemorrhage.Purpose: To investigate the value of MRI-based radiomics analysis in predicting postpartum hemorrhage among pregnant women with placenta previa.Material and methods: Preoperative T2-weighted MRI and related clinical data of 371 patients were retrospectively collected, and these patients were randomly allocated into two subsets: the training dataset (n = 260) and the validation dataset (n = 111). The logistic regression (LR) classifier was used for the development of the radiomics model and the calculation of the radiomics score (Radscore).Results: A total of eight radiomics features and five clinical features were selected for model development. The area under the receiver operating characteristic curve (AUC) of the radiomics model in the training and validation datasets were 0.929 (95% confidence interval [CI] = 0.891-0.957) and 0.914 (95% CI = 0.846-0.959), respectively. Combined with clinical factors, nomograms demonstrated improved diagnostic efficacy, with an AUC of 0.968 (95% CI = 0.939-0.986) in the training dataset and 0.947 (95% CI = 0.888-0.981) in the validation dataset.Conclusion: The MRI-based model has certain value in predicting postpartum hemorrhage in pregnant women with placenta previa.","PeriodicalId":7143,"journal":{"name":"Acta radiologica","volume":" ","pages":"1422-1429"},"PeriodicalIF":1.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142278726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Abnormal brain regional activity in acute thyrotoxic myopathy assessed by resting-state functional MRI. 通过静息态功能磁共振成像评估急性甲状腺毒症肌病的异常脑区活动。

IF 1.1 4区医学

Acta radiologica Pub Date : 2024-11-01 Epub Date: 2024-09-24 DOI: 10.1177/02841851241280115

Yaqi Kuang, Xinghuan Liang, Wei Ye, Shien Fu, Yingfen Qin, Yan Ma, Zuojie Luo

{"title":"Abnormal brain regional activity in acute thyrotoxic myopathy assessed by resting-state functional MRI.","authors":"Yaqi Kuang, Xinghuan Liang, Wei Ye, Shien Fu, Yingfen Qin, Yan Ma, Zuojie Luo","doi":"10.1177/02841851241280115","DOIUrl":"10.1177/02841851241280115","url":null,"abstract":"Background: The neurophysiological mechanisms underlying manifestations of bulbar paralysis in acute thyrotoxic myopathy (ATM) and the afflicted brain areas are unclear.Purpose: We used resting-state functional magnetic resonance imaging (rs-fMRI) to evaluate the regional brain activities in patients with ATM.Material and methods: In total, 16 patients with ATM, 16 patients with hyperthyroidism without ATM, and 16 healthy controls underwent functional MRI scans. By calculating the fractional amplitude of low-frequency fluctuation (fALFF), regional homogeneity (ReHo), and functional connectivity (FC), we assessed variations in resting-state cerebral activity. The correlation between the resting-state functional indexes and clinical assessments was also explored.Results: Compared to the hyperthyroid patients, patients with ATM had stronger ReHo in the left precentral gyrus, reduced ReHo in the left orbitofrontal gyrus (OFG), and decreased FC in the left precentral gyri, left superior frontal gyrus (SFG), and left middle frontal gyrus (MFG). Patients with ATM showed reduced fALFF and ReHo in the right SFG and decreased ReHo in the bilateral supplementary motor area (SMA). A significantly decreased FC in the left SFG and left MFG, right precentral gyrus, and the orbital part of the right interior frontal gyrus was observed in patients with ATM compared to healthy controls. Additionally, fALFF and ReHo values were positively correlated with serum thyroid-related hormones and antibodies.Conclusion: The findings of rs-fMRI demonstrate that particular brain regions' functional activity was aberrant in individuals with ATM, especially in SFG area. This finding may help with better understanding of underlying pathophysiology of patients with ATM.","PeriodicalId":7143,"journal":{"name":"Acta radiologica","volume":" ","pages":"1347-1358"},"PeriodicalIF":1.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142306934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Siglec-15 expression in diffuse gliomas and its correlation with MRI morphologic features and apparent diffusion coefficient. 弥漫性胶质瘤中 Siglec-15 的表达及其与磁共振成像形态特征和表观弥散系数的相关性。

IF 1.1 4区医学

Acta radiologica Pub Date : 2024-11-01 Epub Date: 2024-10-21 DOI: 10.1177/02841851241286109

Quan Chen, Chunhua Wang, Yingqian Geng, Wanyi Zheng, Zhen Chen, Rifeng Jiang, Xiaomei Hu

{"title":"Siglec-15 expression in diffuse gliomas and its correlation with MRI morphologic features and apparent diffusion coefficient.","authors":"Quan Chen, Chunhua Wang, Yingqian Geng, Wanyi Zheng, Zhen Chen, Rifeng Jiang, Xiaomei Hu","doi":"10.1177/02841851241286109","DOIUrl":"10.1177/02841851241286109","url":null,"abstract":"Background: Sialic acid-binding immunoglobulin-like lectin 15 (Siglec-15) enhances tumor immune escape and leads to tumor growth.Purpose: To investigate the expression of Siglec-15 in diffuse gliomas and its correlation with tumor magnetic resonance imaging (MRI) features.Material and methods: This study included 57 patients with gliomas. Morphological MRI features, including the largest tumor diameter, enhancement category, location, calcification, cysts, and hemorrhage, were visually rated. Apparent diffusion coefficient (ADC) values were calculated in tumor region. MRI morphologic features and ADC were compared between patients with positive and negative Siglec-15 expression. Receiver operating characteristic (ROC) curves were further constructed to assess the diagnostic performance.Results: Siglec-15 was expressed in immunocytes, such as macrophages in the peritumoral area. Siglec-15 expression was positive in 20/57 (35.09%) patients, with higher expression in patients with IDH-mutant gliomas and lower grade gliomas. The tumor diameter was significantly smaller in patients with positive Siglec-15 expression than in those with negative expression for all patients (P = 0.017) and for patients with IDH-mutant gliomas (P = 0.020). Moreover, ADC values of the tumor were significantly higher in patients with positive Siglec-15 expression than in those with negative expression for all patients (P = 0.027). The areas under the ROC curve (AUCs) of the diameter and ADC were 0.702 and 0.686, respectively. A combination of these two parameters generated an improved AUC of 0.762.Conclusion: Siglec-15 was expressed in immunocytes such as macrophages in the peritumoral area, with a positive rate of 35.09%. Positive Siglec-15 expression in diffuse gliomas was correlated with smaller tumor size and higher ADC values.","PeriodicalId":7143,"journal":{"name":"Acta radiologica","volume":" ","pages":"1401-1410"},"PeriodicalIF":1.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142455569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Implementation of template-based reporting for rectal cancer. 对直肠癌实施基于模板的报告。

IF 1.1 4区医学

Acta radiologica Pub Date : 2024-11-01 Epub Date: 2024-09-23 DOI: 10.1177/02841851241285545

Søren Rafael Rafaelsen

引用次数: 0

Nomograms combining clinical factors and apparent diffusion coefficient to predict downstaging and progression-free survival after concurrent chemoradiotherapy in patients with cervical cancer. 结合临床因素和表观扩散系数预测宫颈癌患者同期化放疗后的降期和无进展生存期的提名图。

IF 1.1 4区医学

Acta radiologica Pub Date : 2024-11-01 DOI: 10.1177/02841851241283042

Jiawei Fan, Wenfei Li, Mengyu Cheng, Zhehan Wang, Zhanqiu Wang, Tao Chen, Tao Gu

{"title":"Nomograms combining clinical factors and apparent diffusion coefficient to predict downstaging and progression-free survival after concurrent chemoradiotherapy in patients with cervical cancer.","authors":"Jiawei Fan, Wenfei Li, Mengyu Cheng, Zhehan Wang, Zhanqiu Wang, Tao Chen, Tao Gu","doi":"10.1177/02841851241283042","DOIUrl":"https://doi.org/10.1177/02841851241283042","url":null,"abstract":"Background: Concurrent chemoradiotherapy (CCRT) is used as the primary treatment modality for currently limited cervical cancer and lacks non-invasive quantitative parameters to assess clinical outcomes of treatment for cervical cancer treatment.Purpose: To develop nomograms based on clinical prognostic factors and apparent diffusion coefficient (ADC) in predicting downstaging and progression-free survival (PFS) after CCRT for cervical cancer.Material and methods: X-tile was used to calculate the optimal threshold for ΔADCmean(%) for prognostic stratification. Kaplan-Meier curves were used to calculate the difference in PFS between high- and low-risk groups. Univariate and multivariate Cox proportional risk regression models were used to identify clinical and radiological risk factors for prognosis and construct a prognostic nomogram model.Results: ΔADCmean(%) was significantly correlated with tumor downstaging; the area under the receiver operating characteristic curve (AUC) was 0.868. X-tile showed that the optimal threshold for ΔADCmean(%) to diagnose prognosis was 40.8. Kaplan-Meier curves showed that the low-risk population in the training group had significantly longer PFS within 3 years (P < 0.001). Multivariate Cox regression showed that ΔADC (%) is independent risk factor for PFS. The C-index of ΔADC(%) predicting 3-year PFS in the training set is 0.761 and the C-index of the nomogram model is 0.862.Conclusion: ΔADCmean(%) is a non-invasive biomarker for predicting tumor downstaging in cervical cancer after CCRT. The nomograms based on ΔADCmean(%) predict PFS of patients with cervical cancer with moderate accuracy.","PeriodicalId":7143,"journal":{"name":"Acta radiologica","volume":"65 11","pages":"1430-1439"},"PeriodicalIF":1.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142611775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0