Micro and Nano Systems Letters最新文献

{"title":"ZnO-adipic acid composites as phase change material for latent heat thermal energy storage systems","authors":"N. R. Snekha,&nbsp;V. Hari Suthan,&nbsp;K. S. Suganthi,&nbsp;S. Naren Raggavendra,&nbsp;S. Sudharsan,&nbsp;R. Aishwarya,&nbsp;K. S. Rajan","doi":"10.1186/s40486-024-00212-2","DOIUrl":"10.1186/s40486-024-00212-2","url":null,"abstract":"<div><p>This work evaluates the use of zinc oxide nanorods as intensifiers of a latent heat thermal energy storage system working with adipic acid as the phase change material (PCM). By virtue of not participating directly in the solid–liquid and liquid–solid phase transition, ZnO-adipic acid composites (ZnO-adipic acid) possessed lower specific heat and latent heat. Our results have shown that the overall heat transfer coefficient during the freezing of PCM through heat transfer to a well-mixed liquid bath is amplified by 61%, when adipic acid is replaced with 2 wt.% ZnO-adipic acid. Heterogenous nucleation due to well-dispersed, ZnO nanorods caused this enhancement. The large enhancement in discharge rate of 2 wt.% ZnO-adipic acid during freezing overweighs higher degree of latent heat loss due to its repeated thermal cycling. The enhancement in overall heat transfer coefficient reported here (61%) is the highest reported so far for any latent heat thermal energy system employing adipic acid or its composites.</p></div>","PeriodicalId":704,"journal":{"name":"Micro and Nano Systems Letters","volume":"12 1","pages":""},"PeriodicalIF":4.7,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://mnsl-journal.springeropen.com/counter/pdf/10.1186/s40486-024-00212-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142595956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating non fluorescence nanoparticle transport in Matrigel-filled microfluidic devices using synchrotron X-ray scattering","authors":"Alberto Martín-Asensio,&nbsp;Irene Pardo,&nbsp;Rocío Mesa,&nbsp;Demian Pardo,&nbsp;Juan P. Fernández-Blázquez,&nbsp;Juan Carlos Martínez-Guil,&nbsp;Milagros Castellanos,&nbsp;Jaime J. Hernández,&nbsp;Álvaro Somoza,&nbsp;Isabel Rodríguez","doi":"10.1186/s40486-024-00213-1","DOIUrl":"10.1186/s40486-024-00213-1","url":null,"abstract":"<div><p>The present study explores the application of X-ray scattering, using synchrotron radiation, to assess the diffusive transport of nanomedicines in tumor on a chip devices fabricated by 3D stereolithography using a resin with high optical and X-ray transmittance. Unlike conventional methods that require fluorescent labeling of nanoparticles, potentially altering their in vitro and in vivo behavior, this approach enables the investigation of the transport properties for unlabeled nanoparticles. In particular, the results presented confirm the influence of the porosity of the extracellular matrix-like microenvironment, specifically Matrigel, on the diffusive transport of oligonucleotide-functionalized gold nanoparticles. The analysis of the scattering patterns allows to create 2D maps showing the nanoparticle distribution with high spatial resolution. The proposed approach demonstrates the potential for studying other factors involved in nanoparticle diffusion processes. By implementing X-ray scattering to track unmodified nanomedicines within extracellular matrix-like microenvironments, increasingly accurate models for evaluating and predicting therapeutics transport behaviors can be developed.</p></div>","PeriodicalId":704,"journal":{"name":"Micro and Nano Systems Letters","volume":"12 1","pages":""},"PeriodicalIF":4.7,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://mnsl-journal.springeropen.com/counter/pdf/10.1186/s40486-024-00213-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142565808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Flexible sensing probe for the simultaneous monitoring of neurotransmitters imbalance","authors":"Hye Bin Cha,&nbsp;Yao Zhang,&nbsp;Hyun-Yong Yu,&nbsp;Yi Jae Lee","doi":"10.1186/s40486-024-00211-3","DOIUrl":"10.1186/s40486-024-00211-3","url":null,"abstract":"<div><p>Simultaneous detection of multiple neurotransmitters and their related activities is crucial for enhancing our understanding of complex neurological mechanisms and disorders. In this study, we developed a flexible, high-sensitivity multi-electrodes array probe capable of concurrent detection of four neurotransmitters: dopamine, serotonin, acetylcholine and glutamate. The probe was fabricated on a polyimide substrate with 16 circular gold-film electrodes. These electrodes were modified with PEDOT/GluOx and PEDOT/ChOx for enzymatic detection of glutamate and acetylcholine, and with rGO/PEDOT/Nafion for the detection of dopamine and serotonin. Our electrochemical sensor achieved sensitivities of 184.21 and 219.29 μA/μM cm² for glutamate and acetylcholine, respectively, with limits of detection (LOD) of 0.0242 and 0.0351 μM within a concentration range of 0.1–100 μM. For dopamine and serotonin, the sensor showed sensitivities of 195.9 and 181.2 μA/μM cm², respectively, with LOD of 0.4743 and 0.3568 μM. This research advances the field of neurochemical sensing and provides valuable insights into the balance of neurotransmitters associated with neurological disorders. These insights improve diagnostic and therapeutic strategies.</p></div>","PeriodicalId":704,"journal":{"name":"Micro and Nano Systems Letters","volume":"12 1","pages":""},"PeriodicalIF":4.7,"publicationDate":"2024-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://mnsl-journal.springeropen.com/counter/pdf/10.1186/s40486-024-00211-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142397582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of pure (ligand-free) nanoparticles of magnetite in sodium chloride matrix on hematological indicators, blood gases, electrolytes and serum iron","authors":"Stanislav Ye. Lytvyn,&nbsp;Elena M. Vazhnichaya,&nbsp;Daniela E. Manno,&nbsp;Yurii A. Kurapov,&nbsp;Lucio Calcagnile,&nbsp;Rosaria Rinaldi,&nbsp;Giorgio Giuseppe Carbone,&nbsp;Oleksandr V. Semaka,&nbsp;Yana V. Nedostup","doi":"10.1186/s40486-024-00209-x","DOIUrl":"10.1186/s40486-024-00209-x","url":null,"abstract":"<div><p>One of the physical methods for obtaining magnetite nanoparticles (NPs) is electron beam physical vapor deposition (EB PVD), which requires complex equipment, but allows obtaining a significant amount of pure (ligand-free) NPs. The biomedical application of such NPs is less studied than materials from other synthesis methods. The objective is to study the effect of pure magnetite NPs in the NaCl matrix obtained by EB PVD on hematological indicators, gases, electrolytes and parameters of iron metabolism in the blood of intact animals. The physical characteristics of NPs were studied using high-resolution transmission electron microscopy, scanning transmission electron microscopy, energy-dispersive X-ray spectroscopy mapping, electron energy-loss spectroscopy, selected area electron diffraction and fast Fourier transform. In vivo experiments were conducted on albino male rats, which were injected with solution of magnetite-sodium chloride NPs (1.35 mg Fe/kg). After 3 and 72 h, hematological parameters, blood gases, electrolytes, and serum iron were determined. The synthesized NPs had an average size of 11 nm. They were identified as magnetite, where polycrystals and single crystals were present. The absence of contamination in crystal boundaries, clear orientation and orderliness of atoms in crystals were established. The administration of NPs in the sodium chloride matrix to animals was characterized by a transient increase in the main indicators of red blood accompanied by an increase in the saturation of erythrocytes with hemoglobin and their mean volume after 3 h. It did not worsen blood gases and pH, but decreased blood Na⁺ content after 72 h. The investigated NPs caused changes in the parameters of serum iron characteristic to iron preparations, which after 3 h were smaller compared to the reference iron drug, and after 72 h—similar to it. More intense rapid effects on hematological parameters at lower serum iron indicate greater activity of the studied pure magnetite NPs obtained by EB PVD syntesis compared to the reference iron preparation.</p></div>","PeriodicalId":704,"journal":{"name":"Micro and Nano Systems Letters","volume":"12 1","pages":""},"PeriodicalIF":4.7,"publicationDate":"2024-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://mnsl-journal.springeropen.com/counter/pdf/10.1186/s40486-024-00209-x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142397583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel application of the micro-wire-electro-discharge-grinding (µ-WEDG) method for the generation of tantalum and brass nanoparticles","authors":"Akash Korgal,&nbsp;P. Navin Karanth,&nbsp;Arun Kumar Shettigar,&nbsp;J. Bindu Madhavi","doi":"10.1186/s40486-024-00210-4","DOIUrl":"10.1186/s40486-024-00210-4","url":null,"abstract":"<div><p>The synthesis of a co-precipitated mixture of tantalum and brass nanoparticles (Ta and Cu/Zn) using a micro-wire-electro-discharge-grinding (µ-WEDG) with a combination of multiple process parameters is explained in this article. Tantalum and brass nanoparticles are produced in a dielectric medium Diel-7500 EDM oil. µ-WEDG represents a cutting-edge mechanical micro-machining technique extensively employed for machining micro rods. This method uses a grinding process that expels debris via melting and evaporation. This process disperses a fraction of nanometre-sized debris within the dielectric medium. Traditionally, this debris consisting of nanoparticles has been classified as unwanted substances and subsequently eliminated from the system. However, it now requires a thorough reassessment for possible usage. Hence, the characterization of tantalum and brass nanoparticles is conducted through Field emission Scanning Electron Microscopy (FE-SEM), energy-dispersive spectroscopy (EDS), and X-ray diffraction (XRD) analyses. The process parameters are capacitance, voltage and spindle speed. The investigation reveals that the mean nanoparticle size of produced tantalum nanoparticles range from 25 to 200 nm, while brass nanoparticles range from 300 to 950 nm. Furthermore, a notable correlation is observed between decreasing capacitance and the corresponding reduction in the shape and size of nanoparticles.</p></div>","PeriodicalId":704,"journal":{"name":"Micro and Nano Systems Letters","volume":"12 1","pages":""},"PeriodicalIF":4.7,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://mnsl-journal.springeropen.com/counter/pdf/10.1186/s40486-024-00210-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142328444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A review of human augmentation and individual combat capability: focusing on MEMS-based neurotechnology","authors":"Youngsam Yoon,&nbsp;Il-Joo Cho","doi":"10.1186/s40486-024-00205-1","DOIUrl":"10.1186/s40486-024-00205-1","url":null,"abstract":"<div><p>The purpose of this paper is to identify the relationship between human augmentation and personal combat ability improvement that overcomes physical and mental limitations according to the convergence of advanced science and technology such as biotechnology, brain engineering, and mems-based technology. We will first explain the background of the emergence of human augmentation and derive the characteristics of human enhancement through conceptual analysis of the correlation of human augmentation and cognitive abilities, which hold importance for future warfare. Afterward, through the development of brain engineering, we will present areas where advanced science and technology can contribute to improving military combat capabilities, such as cognitive abilities, decision-making abilities, situation recognition abilities, and brain stimulation. Finally, we will review the MEMS-based neural interface systems for the enhancement of human augmentation and individual combat ability.</p></div>","PeriodicalId":704,"journal":{"name":"Micro and Nano Systems Letters","volume":"12 1","pages":""},"PeriodicalIF":4.7,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://mnsl-journal.springeropen.com/counter/pdf/10.1186/s40486-024-00205-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142143862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experimental study of processing of PCL (polycaprolactone)-peptides nanoparticles and its biodistribution analysis for drug delivery system","authors":"Mujibur Khan,&nbsp;Anthony Yamasta,&nbsp;Mahrima Parvin,&nbsp;Jannatul Ferdaus,&nbsp;Hossain Ahmed,&nbsp;Ali S. Arbab","doi":"10.1186/s40486-024-00208-y","DOIUrl":"10.1186/s40486-024-00208-y","url":null,"abstract":"<div><p>Two types of cells targeting Peptides, TAMS-1 (CSPGAKVRCY {Lys (Biotin)}) and MDSC-peptide (Biotin {PEG4}-MEWSLEKGYTIK), were synthesized for targeting CD206 M2 macrophage and myeloid-derived suppressor cells (MDSC), respectively. Each peptide was coaxially electro sprayed where PCL (Polycaprolactone) is the core, and the peptide is the sheath to create a PCL nanoparticle with peptides. Electro spraying parameters included applying a voltage of 44 kV, humidity between 35–44%, tip to collector distance at 160 mm, core flow rate of 0.5 ml/hr, and a sheath flow rate of 0.7 ml/hr. UV–VIS (Ultraviolet–Visible) spectrometry, SEM (Scanning Electron Microscopy) imaging, and in vivo biodistribution techniques were used to study the morphology and performance of the PCL-peptide nanoparticles. Peak absorbance values for PCL were found at around 275 nm. Peptides absorbance value was observed between 230 and 250 nm. Scanning Electron Microscope image shows nanoparticles as small as 100 nm and agglomerates as large as 1 µm. In-vivo biodistribution of PCL and CD206 M2 macrophage targeting peptide (TAMS-1) nanoparticles after intravenous injection in the tumor mice model showed uptake to the tumors. On the other hand, MDSC peptide did not show any uptake to the site of tumors. Most activity is shown in the intestine indicating excretion of the agents through the hepato-biliary system.</p></div>","PeriodicalId":704,"journal":{"name":"Micro and Nano Systems Letters","volume":"12 1","pages":""},"PeriodicalIF":4.7,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://mnsl-journal.springeropen.com/counter/pdf/10.1186/s40486-024-00208-y","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142143863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Facile extraction of scanning probe shape for improved deconvolution of tip-sample interaction artifacts","authors":"Kibum Jung,&nbsp;Jungchul Lee","doi":"10.1186/s40486-024-00207-z","DOIUrl":"10.1186/s40486-024-00207-z","url":null,"abstract":"<div><p>Atomic Force Microscopy (AFM) has intrinsic tip-sample convolution artifacts. Commercially available tip-check samples are used to obtain only the tip radius, which can be used to deconvolute surface profiles or to quantify tip wear by relying on AFM alone. When the sample height is of the order of 100 nm or more, not only the tip radius but also the overall tip shape plays a key role in imaging. Therefore, it is necessary to know the overall tip shape, which requires a structured sample that is much larger than tip-check samples. Here, we propose to use deep reactive ion-etched holes of 1 µ diameter and 5 µ height to reconstruct the overall tip shape of three different AFM probes, namely conical, pyramidal and tetrahedral. The proposed cylindrical hole structure seems promising, as simple inversion of AFM images can provide sufficient collective features to be used for deconvolution and image enhancement.</p></div>","PeriodicalId":704,"journal":{"name":"Micro and Nano Systems Letters","volume":"12 1","pages":""},"PeriodicalIF":4.7,"publicationDate":"2024-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://mnsl-journal.springeropen.com/counter/pdf/10.1186/s40486-024-00207-z","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142050495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contrasting responses of motile and non-motile Escherichia coli strains in resuscitation against stable ultrafine gold nanosystems","authors":"Anindita Thakur,&nbsp;Pranay Amruth Maroju,&nbsp;Ramakrishnan Ganesan,&nbsp;Jayati Ray Dutta","doi":"10.1186/s40486-024-00206-0","DOIUrl":"10.1186/s40486-024-00206-0","url":null,"abstract":"<div><p>Global public health confronts a pressing challenge in antimicrobial resistance (AMR), necessitating urgent intervention strategies due to the low success rate of new antibiotic development. Bacterial motility, beyond conventional antibiotic usage, significantly influences resistance evolution and ecological dynamics. Our recent study marks a breakthrough, revealing the unexplored ability of ultrafine gold nanosystems (UGNs) to inhibit bacterial resuscitation using a motile <i>Escherichia coli</i> (<i>E.coli</i>) K12 strain. We aim to deepen our comparative understanding of UGNs’ efficacy and resuscitation propensity against a non-motile <i>E. coli</i> K12 strain to assess the role of motility. Through UGN application, we identified heritable resistance in both strains, with motile strains exhibiting notably higher mutation rates. Resuscitation experiments unveiled faster recovery in motile strains, attributable to virulence factors, compared to non-motile strains. Additionally, our investigation into aggregation dynamics highlighted the role of protein-mediated aggregation in resistance development to nano-antimicrobials. Overall, the study reveals that the non-motile strains are more susceptible against UGNs, which shows promise in combating AMR.</p></div>","PeriodicalId":704,"journal":{"name":"Micro and Nano Systems Letters","volume":"12 1","pages":""},"PeriodicalIF":4.7,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://mnsl-journal.springeropen.com/counter/pdf/10.1186/s40486-024-00206-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142041503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Engineering microscopic delivery systems: a review of dissolving microneedle design, fabrication, and function","authors":"Roshan Dave,&nbsp;Swapnali Shinde,&nbsp;Nisha Kalayil,&nbsp;Aarati Budar","doi":"10.1186/s40486-024-00204-2","DOIUrl":"10.1186/s40486-024-00204-2","url":null,"abstract":"<div><p>Dissolving microneedles (DMNs) represent an innovative advancement in drug delivery and skincare technologies, offering significant advantages compared to traditional needles. This paper presents an overview of the historical evolution of microneedles and the rise of dissolving types, exploring their definition, concept, and diverse clinical applications such as vaccinations, drug delivery, and skincare treatments. Design and manufacturing considerations cover the materials employed, fabrication techniques, and methods for characterizing DMNs, focusing on aspects like mechanical strength, dissolution rate, and delivery efficiency. The mechanism of action section examines skin penetration mechanics, the process of microneedle dissolution, controlled release of active compounds, and considerations of biocompatibility and safety. Recent developments in DMNs encompass technological advancements, improved delivery systems, and updates on clinical trials and studies. Challenges and opportunities in scaling up production, overcoming market adoption barriers, and future research directions are discussed, aiming to address unmet medical needs and expand applications. In summary, DMNs have the potential to transform drug delivery and skincare treatments, with ongoing advancements aimed at tackling current challenges and unlocking new opportunities for enhanced healthcare outcomes.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":704,"journal":{"name":"Micro and Nano Systems Letters","volume":"12 1","pages":""},"PeriodicalIF":4.7,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://mnsl-journal.springeropen.com/counter/pdf/10.1186/s40486-024-00204-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142013470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}