Micro and Nano Systems Letters最新文献_第3页

Engineering microscopic delivery systems: a review of dissolving microneedle design, fabrication, and function 工程微型给药系统：溶解微针设计、制造和功能综述

IF 4.7

Micro and Nano Systems Letters Pub Date : 2024-08-19 DOI: 10.1186/s40486-024-00204-2

Roshan Dave, Swapnali Shinde, Nisha Kalayil, Aarati Budar

{"title":"Engineering microscopic delivery systems: a review of dissolving microneedle design, fabrication, and function","authors":"Roshan Dave, Swapnali Shinde, Nisha Kalayil, Aarati Budar","doi":"10.1186/s40486-024-00204-2","DOIUrl":"10.1186/s40486-024-00204-2","url":null,"abstract":"<div><p>Dissolving microneedles (DMNs) represent an innovative advancement in drug delivery and skincare technologies, offering significant advantages compared to traditional needles. This paper presents an overview of the historical evolution of microneedles and the rise of dissolving types, exploring their definition, concept, and diverse clinical applications such as vaccinations, drug delivery, and skincare treatments. Design and manufacturing considerations cover the materials employed, fabrication techniques, and methods for characterizing DMNs, focusing on aspects like mechanical strength, dissolution rate, and delivery efficiency. The mechanism of action section examines skin penetration mechanics, the process of microneedle dissolution, controlled release of active compounds, and considerations of biocompatibility and safety. Recent developments in DMNs encompass technological advancements, improved delivery systems, and updates on clinical trials and studies. Challenges and opportunities in scaling up production, overcoming market adoption barriers, and future research directions are discussed, aiming to address unmet medical needs and expand applications. In summary, DMNs have the potential to transform drug delivery and skincare treatments, with ongoing advancements aimed at tackling current challenges and unlocking new opportunities for enhanced healthcare outcomes.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":704,"journal":{"name":"Micro and Nano Systems Letters","volume":"12 1","pages":""},"PeriodicalIF":4.7,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://mnsl-journal.springeropen.com/counter/pdf/10.1186/s40486-024-00204-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142013470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of MRI magnetic iron oxide nanoparticles on the structural and enzymatic properties of liver-related enzymes 磁共振成像磁性氧化铁纳米粒子对肝脏相关酶的结构和酶特性的影响

IF 4.7

Micro and Nano Systems Letters Pub Date : 2024-07-31 DOI: 10.1186/s40486-024-00200-6

Fateme Mirzajani, Azam Rostamzadeh, Zepiur Tahmasian, Heydar Sudan Abbas Obaid, Seyed Mohammad Motevalli

{"title":"Effects of MRI magnetic iron oxide nanoparticles on the structural and enzymatic properties of liver-related enzymes","authors":"Fateme Mirzajani, Azam Rostamzadeh, Zepiur Tahmasian, Heydar Sudan Abbas Obaid, Seyed Mohammad Motevalli","doi":"10.1186/s40486-024-00200-6","DOIUrl":"10.1186/s40486-024-00200-6","url":null,"abstract":"<div><p>Cancer survivors undergo meticulous examinations, including regular magnetic resonance imaging (MRI) scans, to monitor the risk of disease recurrence. The use of magnetic iron nanoparticles (MNPs) enhances MRI accuracy. However, post-injection, MNPs exhibit a notable affinity for binding with proteins and biomolecules, forming a dynamic protein coating called a protein corona (CORONA). While there are reports of its elimination in the liver and kidney metabolism system, patients undergoing this method have shown symptoms of liver problems and related enzyme alterations. This study aims to discern whether the impact of MNPs on liver enzymes significantly contributes to liver damage. The investigation focuses on the effects of magnetic nanoparticles (MNPs) on selected enzymes, including alanine aminotransferase (ALT), aspartate transaminase (AST), α-amylase, and lipase. Employing 104 experiments over a central composite design (CCD), the study evaluates the effects of agents on MNP and enzyme structure, stability, and properties: enzyme assay, electron microscopy, and circular dichroism of secondary structure after interaction with MNPs. The study’s findings unveil the intricate relationship between MNPs and liver enzymes, providing valuable insights for clinical practices and refining the safety profile of MRI. This comprehensive exploration contributes to our understanding of potential implications and aids in optimizing the use of MNPs in medical imaging for cancer survivors.</p></div>","PeriodicalId":704,"journal":{"name":"Micro and Nano Systems Letters","volume":"12 1","pages":""},"PeriodicalIF":4.7,"publicationDate":"2024-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://mnsl-journal.springeropen.com/counter/pdf/10.1186/s40486-024-00200-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141866030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A study on chromium thin film with positive photoresist as a masking layer towards the wet bulk micromachining of Borofloat glass 以正光刻胶为掩蔽层的铬薄膜对 Borofloat 玻璃湿式批量微加工的研究

IF 4.7

Micro and Nano Systems Letters Pub Date : 2024-07-08 DOI: 10.1186/s40486-024-00201-5

Vishal Sahu, Priyanka Dewangan, Robbi Vivek Vardhan, Vanlal Rinfela, P. Krishna Menon, Prem Pal

{"title":"A study on chromium thin film with positive photoresist as a masking layer towards the wet bulk micromachining of Borofloat glass","authors":"Vishal Sahu, Priyanka Dewangan, Robbi Vivek Vardhan, Vanlal Rinfela, P. Krishna Menon, Prem Pal","doi":"10.1186/s40486-024-00201-5","DOIUrl":"10.1186/s40486-024-00201-5","url":null,"abstract":"<div><p>Bulk micromachining is commonly used to fabricate microstructures such as deep cavities, through-holes, and microchannels in glass wafers, which have diverse applications in the areas of science and technology. The methods for glass bulk micromachining include mechanical, dry, and wet etching; among them, wet etching is widely used due to its multifaceted advantages. Masking layer plays an eminent role in wet etching. In the current study, Cr thin film combined with positive photoresist (AZ1512HS) is investigated as the masking layer to develop deep cavities in Borofloat glass wafers via wet etching route. Initially, DC magnetron sputtered Cr thin film is deposited at room temperature, 200 °C, and 400 °C, respectively, on three different glass wafers, followed by spin coating of photoresist on it. Photolithography process is used for patterning, and then selective etching of Cr is performed. Thereafter, wet etching of glass wafers is executed in 10% hydrofluoric acid (HF) solution. This work shows that the sustainability of the masking layer is highly dependent on the deposition temperature of Cr thin film, and the sustainability increases with the increase in the deposition temperature. The high temperature (400 °C) deposited Cr thin film along with photoresist exhibits superior sustainability as a masking layer, and it relatively provides a longer etch time of 380 min, excellent etch depth of ~ 245 µm with negligible surface defects and well-defined structures on glass wafer when etched in 10% HF solution.</p></div>","PeriodicalId":704,"journal":{"name":"Micro and Nano Systems Letters","volume":"12 1","pages":""},"PeriodicalIF":4.7,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://mnsl-journal.springeropen.com/counter/pdf/10.1186/s40486-024-00201-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141556536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Review on micro-gas chromatography system for analysis of multiple low-concentration volatile organic compounds: preconcentration, separation, detection, integration, and challenges 用于分析多种低浓度挥发性有机化合物的微型气相色谱系统综述：预浓缩、分离、检测、集成与挑战

IF 3.6

Micro and Nano Systems Letters Pub Date : 2024-06-13 DOI: 10.1186/s40486-024-00203-3

Yeongseok Lee, Hyeonwoo Son, Junwoo Lee, Si-Hyung Lim

{"title":"Review on micro-gas chromatography system for analysis of multiple low-concentration volatile organic compounds: preconcentration, separation, detection, integration, and challenges","authors":"Yeongseok Lee, Hyeonwoo Son, Junwoo Lee, Si-Hyung Lim","doi":"10.1186/s40486-024-00203-3","DOIUrl":"10.1186/s40486-024-00203-3","url":null,"abstract":"<div><p>As the dangers of volatile organic compounds (VOCs) and their potential as non-invasive diagnosis biomarkers have been reported, there has been a need for instrument capable of real-time and in-situ monitoring of multiple low-concentration VOCs in indoor air or human metabolites. A promising technology that can qualitatively and quantitatively analyze numerous VOCs as an alternative to conventional bench-top instruments is a micro-gas chromatography (µ-GC) system, which integrates three main components: a micro-gas preconcentrator, a µ-GC column, and a mini- or micro-detector fabricated using microelectromechanical system (MEMS) processes. This review covers the integration methods, features, and analysis capabilities of recently developed µ-GC systems and examines the materials, designs, and principles of the three main components. In addition, the challenging issues that must be addressed for the commercialization of this technology are discussed.</p></div>","PeriodicalId":704,"journal":{"name":"Micro and Nano Systems Letters","volume":"12 1","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://mnsl-journal.springeropen.com/counter/pdf/10.1186/s40486-024-00203-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141319731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Design of enlarged phononic bandgap 2.5D acoustic resonator via active learning and non-gradient optimization 通过主动学习和非梯度优化设计扩大声带隙的 2.5D 声共振器

IF 3.6

Micro and Nano Systems Letters Pub Date : 2024-06-04 DOI: 10.1186/s40486-024-00202-4

Syed Muhammad Anas Ibrahim, Jungyul Park

引用次数: 0

Haptic interface with multimodal tactile sensing and feedback for human–robot interaction 用于人机交互的多模式触觉传感和反馈触觉界面

IF 3.6

Micro and Nano Systems Letters Pub Date : 2024-03-14 DOI: 10.1186/s40486-024-00199-w

Mingyu Kang, Cheol-Gu Gang, Sang-Kyu Ryu, Hyeon-Ju Kim, Da-Yeon Jeon, Soonjae Pyo

{"title":"Haptic interface with multimodal tactile sensing and feedback for human–robot interaction","authors":"Mingyu Kang, Cheol-Gu Gang, Sang-Kyu Ryu, Hyeon-Ju Kim, Da-Yeon Jeon, Soonjae Pyo","doi":"10.1186/s40486-024-00199-w","DOIUrl":"10.1186/s40486-024-00199-w","url":null,"abstract":"<div><p>Novel sensing and actuation technologies have notably advanced haptic interfaces, paving the way for more immersive user experiences. We introduce a haptic system that transcends traditional pressure-based interfaces by delivering more comprehensive tactile sensations. This system provides an interactive combination of a robotic hand and haptic glove to operate devices within the wireless communication range. Each component is equipped with independent sensors and actuators, enabling real-time mirroring of user’s hand movements and the effective transmission of tactile information. Remarkably, the proposed system has a multimodal feedback mechanism based on both vibration motors and Peltier elements. This mechanism ensures a varied tactile experience encompassing pressure and temperature sensations. The accuracy of tactile feedback is meticulously calibrated according to experimental data, thereby enhancing the reliability of the system and user experience. The Peltier element for temperature feedback allows users to safely experience temperatures similar to those detected by the robotic hand. Potential applications of this system are wide ranging and include operations in hazardous environments and medical interventions. By providing realistic tactile sensations, our haptic system aims to improve both the performance and safety of workers in such critical sectors, thereby highlighting the great potential of advanced haptic technologies.</p></div>","PeriodicalId":704,"journal":{"name":"Micro and Nano Systems Letters","volume":"12 1","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://mnsl-journal.springeropen.com/counter/pdf/10.1186/s40486-024-00199-w","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140135300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Possibility of large-area carbon nanotube films formation through spray coating 通过喷涂形成大面积碳纳米管薄膜的可能性

IF 3.6

Micro and Nano Systems Letters Pub Date : 2024-03-04 DOI: 10.1186/s40486-023-00193-8

Jinkyeong Kim, TaeGu Lee, Ji-Hoon Han, Joon Hyub Kim

引用次数: 0

Exploring graphene structure, material properties, and electrochemical characteristics through laser-induced temperature analysis 通过激光诱导温度分析探索石墨烯结构、材料特性和电化学特征

IF 3.6

Micro and Nano Systems Letters Pub Date : 2024-02-27 DOI: 10.1186/s40486-024-00198-x

Na-Kyoung Yang, Yoo-Kyum Shin, Saeyoung Park, Sang-Min Kim, Bon-Jae Koo, Joonsoo Jeong, Min-Ho Seo

{"title":"Exploring graphene structure, material properties, and electrochemical characteristics through laser-induced temperature analysis","authors":"Na-Kyoung Yang, Yoo-Kyum Shin, Saeyoung Park, Sang-Min Kim, Bon-Jae Koo, Joonsoo Jeong, Min-Ho Seo","doi":"10.1186/s40486-024-00198-x","DOIUrl":"10.1186/s40486-024-00198-x","url":null,"abstract":"<div><p>Laser-induced graphene (LIG) is a three-dimensional graphene structure fabricated through the irradiation of a polymer substrate with laser energy (or fluence, equivalently). This methodology offers a cost-effective and facile means of producing 3D nanostructures, yielding graphene materials characterized by extremely high surface area and superior electrical properties, rendering them advantageous for various electrochemical applications. Nonetheless, it is imperative to acknowledge that the structures and material properties of LIG are subject to substantial variations contingent upon processing parameters, thereby underscoring the necessity for systematic inquiry and systematic comprehension of processing conditions, such as fluence and multi-passing, and resultant outcomes. Herein, we explored the impact of different laser fluence levels on the structural and material properties of LIG. We, especially, focused on how laser fluence affected substrate temperature and found that it caused polyimide (PI) substrate pyrolysis, resulting in changes in 3D structures and material density to LIG properties. We also investigated the effects of a multi-passing process on 3D LIG structures and material qualities, varying fluences, and temperature fluctuations. Lastly, we assessed electrochemical properties using LIGs produced under different conditions as working electrodes, leading to distinct impedance profiles and cyclic voltammetry (CV) curves. These variations were linked to the unique structural and material characteristics of the LIG samples.</p></div>","PeriodicalId":704,"journal":{"name":"Micro and Nano Systems Letters","volume":"12 1","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://mnsl-journal.springeropen.com/counter/pdf/10.1186/s40486-024-00198-x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139976342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quasi-statically actuated MEMS scanner with concentric vertical comb electrodes 带同心垂直梳状电极的准静致动 MEMS 扫描仪

IF 3.6

Micro and Nano Systems Letters Pub Date : 2024-01-31 DOI: 10.1186/s40486-023-00188-5

Daehwan Chae, Do-hyeon Jeong, Seong-jong Yun, Kyoung-woo Jo, Jong-Hyun Lee

引用次数: 0

Comprehensive study and scientific process to increase the accuracy in estimating the thermal conductivity of nanofluids containing SWCNTs and CuO nanoparticles using an artificial neural network 利用人工神经网络提高含 SWCNT 和 CuO 纳米颗粒的纳米流体导热系数估算精度的综合研究和科学过程

IF 3.6

Micro and Nano Systems Letters Pub Date : 2024-01-10 DOI: 10.1186/s40486-023-00195-6

Mohammad Hemmat Esfe, Fatemeh Amoozad, Hossein Hatami, Davood Toghraie

{"title":"Comprehensive study and scientific process to increase the accuracy in estimating the thermal conductivity of nanofluids containing SWCNTs and CuO nanoparticles using an artificial neural network","authors":"Mohammad Hemmat Esfe, Fatemeh Amoozad, Hossein Hatami, Davood Toghraie","doi":"10.1186/s40486-023-00195-6","DOIUrl":"10.1186/s40486-023-00195-6","url":null,"abstract":"<div><p>This investigation aimed to evaluate the thermal conductivity ratio (TCR) of SWCNT-CuO/Water nanofluid (NF) using experimental data in the T range of 28–50 ℃ and solid volume fraction range of SVF = 0.03 to 1.15% by an artificial neural network (ANN). MLP network with Lundberg-Marquardt algorithm (LMA) was utilized to predict data (TCR) by ANN. In the best case, from the set of various structures of ANN for this nanofluid, the optimal structure was chosen, which consists of 2 hidden layers, the first layer with the optimal structure consisting of 5 neurons and the second layer containing 7 neurons. Eventually, for the optimal structure, the R<sup>2</sup> coefficient and MSE are 0.9999029 and 6.33377E-06, respectively. Based on all ANN information, MOD is in a limited area of − 3% < MOD < + 3%. Comparison of test, correlation yield, and ANN yield display that ANN evaluates laboratory information more exactly.</p></div>","PeriodicalId":704,"journal":{"name":"Micro and Nano Systems Letters","volume":"12 1","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://mnsl-journal.springeropen.com/counter/pdf/10.1186/s40486-023-00195-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139419563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0