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Interrelation between the renal sympathetic nerve and atrial natriuretic peptide in conscious long Evans rats subjected to sodium restriction. 限钠后清醒长Evans大鼠肾交感神经与心房利钠肽的关系。
Acta physiologica et pharmacologica Bulgarica Pub Date : 1994-01-01
N Natcheff, T Avramova, L Kirkova, A Tzoncheva, O Koparanova
{"title":"Interrelation between the renal sympathetic nerve and atrial natriuretic peptide in conscious long Evans rats subjected to sodium restriction.","authors":"N Natcheff,&nbsp;T Avramova,&nbsp;L Kirkova,&nbsp;A Tzoncheva,&nbsp;O Koparanova","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The renal excretory function and plasma renin activity (PRA) were studied in conscious rats on a low sodium diet (25 mmol/kg) after atrial natriuretic peptide (ANP) infusion (100 ng/kg b.w./min) for 80 min through a catheter implanted in the right atrium. The half of the animals were with bilateral kidney denervation. The rats were housed every day from 8 a.m. to 2 p.m. in individual metabolic cages for urine collection and Na, Cl, osmolality and endogenous creatinine determination. At the last day of the experiments after the ANP infusion, blood was taken from the heart for electrolytes, endogenous creatinine and PRA. The effect of denervation was monitored by measuring of noradrenaline in kidney homogenate. The data indicated that even at low sodium diet ANP stimulates the diuresis and sodium excretion without changing the glomerular filtration rate (GFR). The kidney denervation combined with ANP infusion increased twice the diuresis and four times sodium excretion vs. the control animals. In the same time PRA was decreased by about 70%. We assume that the low sodium diet attenuates the effect of ANP in respect to the excretory function. This inhibitory effect is amplified by the renal sympathetic nerves. The decrease of PRA and possibly the increased activity of renal receptors after the denervation could explain the data obtained.</p>","PeriodicalId":7035,"journal":{"name":"Acta physiologica et pharmacologica Bulgarica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18648406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Immobilization and ultrastructure of alveolar type II cells. 肺泡II型细胞的固定化及超微结构。
Acta physiologica et pharmacologica Bulgarica Pub Date : 1994-01-01
S Kovacheva-Ivanova, J Savov
{"title":"Immobilization and ultrastructure of alveolar type II cells.","authors":"S Kovacheva-Ivanova,&nbsp;J Savov","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>We studied the ultrastructural changes in the alveolar type II cells from the lung of immobilized male Wistar rats divided into 6 groups: control; immobilized for 1, 12, 24 and 30 hours; immobilized for 30 hours and readapted for 5 hours. We used the routine methods of fixation through perfusion and electron microscopy. The results indicated progressive structural changes in the alveolar type II cells, correlating with a prolonged time of akinesia. Characteristic was the swelling affecting first the mitochondria and then all other organelles and the plasmalemma. Hypertrophy and hyperplasia of the lamellar bodies were clearly seen. The relatively quick recovery suggested the accelerated mitosis of the alveolar type II cells.</p>","PeriodicalId":7035,"journal":{"name":"Acta physiologica et pharmacologica Bulgarica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18890168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antiinflammatory effect of flavonoids in the natural juice from Aronia melanocarpa, rutin and rutin-magnesium complex on an experimental model of inflammation induced by histamine and serotonin. 黑荆芥天然汁中黄酮类化合物、芦丁和芦丁-镁复合物对组胺和血清素诱导炎症实验模型的抗炎作用。
Acta physiologica et pharmacologica Bulgarica Pub Date : 1994-01-01
P Borissova, S Valcheva, A Belcheva
{"title":"Antiinflammatory effect of flavonoids in the natural juice from Aronia melanocarpa, rutin and rutin-magnesium complex on an experimental model of inflammation induced by histamine and serotonin.","authors":"P Borissova,&nbsp;S Valcheva,&nbsp;A Belcheva","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The antiinflammatory effects of the anthocyane flavonoids in the natural juice from Aronia melanocarpa and of rutin-magnesium complex, the water-soluble derivative of rutin were studied in comparison with rutin. Two experimental models of inflammation were used. Inflammation of rat hind paw was induced either by 0.5% solution of histamine or by 0.01% solution of serotonin. The swelling of the rat paw was measured oncometrically by a pletismometer. The results showed that the anthocyane flavonoids from the natural juice of Aronia melanocarpa exerted more pronounced effects as compared to rutin in both models of inflammation. The rutin-magnesium complex did not exhibit any antiinflammatory activity against histamine-induced inflammation. Its effects against serotonin-induced inflammation were comparable to those of rutin.</p>","PeriodicalId":7035,"journal":{"name":"Acta physiologica et pharmacologica Bulgarica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18890170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of agonists and antagonists of some serotonin-receptor subtypes on memory and their modulation by the 5-HT-uptake inhibitor fluoxetine. 某些5-羟色胺受体亚型激动剂和拮抗剂对记忆的影响及其被5-羟色胺摄取抑制剂氟西汀调节。
Acta physiologica et pharmacologica Bulgarica Pub Date : 1994-01-01
V D Petkov, R Kehayov
{"title":"Effects of agonists and antagonists of some serotonin-receptor subtypes on memory and their modulation by the 5-HT-uptake inhibitor fluoxetine.","authors":"V D Petkov,&nbsp;R Kehayov","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The memory effects of agonists and antagonists of some serotonin (5-HT)-receptor subtypes were studied in experiments on rats using the method for passive avoidance with punishment reinforcement (step-down). The 5-HT1A-receptor agonist buspirone (1 mg/kg i.p.) elicited behavioural responses which suggested the lack of pronounced effect on learning and retention; the 5-HT1A-receptor antagonists NAN-190 (1 mg/kg i.p.) and pindolol (6 mg/kg i.p.) impaired retention tested 24 hours and 7 days after training as compared to controls. The 5-HT2-receptor antagonist ritanserin (1 mg/kg i.p.) impaired retention tested 24 hours and 7 days after training as compared to controls, while the 5-HT3-receptor antagonist ondansetron (0.1 mg/kg i.p.) improved it. The 5-HT1/5-HT2-receptor antagonist dotarizine (50 mg/kg orally), characterized by a calcium-antagonistic action, too, exerted some facilitating effect on learning. Most of the effects of the 5-HT-receptor agonists and antagonists were changed when the 5-HT concentration in the synaptic region was increased by the 5-HT-uptake inhibitor fluoxetine (20 mg/kg orally). The results suggest different participation of 5-HT1A-, 5-HT2- and 5-HT3-receptors in the mechanisms of memory process and its modulation by the serotonin level in the cerebral serotonergic synapses.</p>","PeriodicalId":7035,"journal":{"name":"Acta physiologica et pharmacologica Bulgarica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18648408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In vitro study of cytotoxic activity of vinblastine in a free form and associated with nanoparticles. 游离形态长春花碱与纳米颗粒相关细胞毒活性的体外研究。
Acta physiologica et pharmacologica Bulgarica Pub Date : 1994-01-01
M Simeonova, M Antcheva
{"title":"In vitro study of cytotoxic activity of vinblastine in a free form and associated with nanoparticles.","authors":"M Simeonova,&nbsp;M Antcheva","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The cytotoxic activities of unloaded polybutylcyanoacrylate nanoparticles (PBCN), free vinblastine, vinblastine-loaded nanoparticles (by incorporation and adsorption processes) and a mixture of vinblastine-free and unloaded PBCN were compared in vitro on human erythroleukemic K-562 cells. Enhanced cytotoxicity was observed when vinblastine was either adsorbed on PBCN or mixed with them rather than free. When vinblastine was incorporated into polymer matrix of nanoparticles, a lag period and postponed cytotoxic effect on K-562 cells were observed.</p>","PeriodicalId":7035,"journal":{"name":"Acta physiologica et pharmacologica Bulgarica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18726594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Disorders of ventricular contractility and electrogenesis in the early stage of endotoxin shocked rabbits. 内毒素休克兔早期心室收缩性和电生成障碍。
Acta physiologica et pharmacologica Bulgarica Pub Date : 1994-01-01
R Lolov, Z Velkov
{"title":"Disorders of ventricular contractility and electrogenesis in the early stage of endotoxin shocked rabbits.","authors":"R Lolov,&nbsp;Z Velkov","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This is a report on ventricular contractility and electrogenesis disorders in rabbits, following intravenous injection of E. coli endotoxin at a dose of 2 mg.kg-1. At the 30th min, the right ventricular contractility indices (dP/dtmax)/P and [(dP/dt)/P]max had lower values, whereas end diastolic pressure (EDP), right ventricular systolic pressure (RVSP) and P(dP/dtmax) showed higher values compared to the initial ones. Most of the left ventricular contractility indices tested showed significantly lower values at the 30th and 60th min of the registration. In the scalar orthogonal ECG leads, at the 5th min an increased Qz amplitude, and at the 60th min an increased Rz amplitude, a decreased Ry amplitude, and QRS complex widening and bradicardia, were registered. In the spatial magnitude curve an increased amplitude of the main vectors of ventricular depolarization was documented. The changes in electrogenesis are interpreted first and foremost by the presence of hemodynamic disorders. The inference is reached that both left and right ventricular dysfunction have been already formed during the initial stage of endotoxin shock.</p>","PeriodicalId":7035,"journal":{"name":"Acta physiologica et pharmacologica Bulgarica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18648410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tissue distribution of polybutylcyanoacrylate nanoparticles loaded with spin-labelled nitrosourea in Lewis lung carcinoma-bearing mice. 负载自旋标记亚硝基脲的聚氰丙烯酸丁酯纳米颗粒在Lewis肺癌小鼠中的组织分布。
Acta physiologica et pharmacologica Bulgarica Pub Date : 1994-01-01
M Simeonova, T Ivanova, Z Raikov, H Konstantinov
{"title":"Tissue distribution of polybutylcyanoacrylate nanoparticles loaded with spin-labelled nitrosourea in Lewis lung carcinoma-bearing mice.","authors":"M Simeonova,&nbsp;T Ivanova,&nbsp;Z Raikov,&nbsp;H Konstantinov","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The tissue distribution of polybutylcyanoacrylate nanoparticles (PBCN) with a diameter of 127 nm, loaded with 1-(2-chloroethyl)-3-(1-oxyl-2,2,6,6-tetramethylpiperidinyl)-1- nitrosourea (spin-labelled nitrosourea, SLCNU) is described. PBCN-suspensions were intraperitoneally (i.p.) injected into Lewis lung carcinoma bearing mice. The biodistribution of PBCN in the visceral organs, blood and tumor was studied by electron spin resonance (ESR) spectroscopy. A relatively low accumulation of nanoparticles in the liver and spleen was found. The accumulation was negligible in the i.m. implanted primary tumor. SLCNU-loaded nanoparticles were mainly found in the lungs, kidneys, and heart. The highest content of the particles studied was observed in the lungs of tumor bearing experimental animals damaged by metastases. These findings suggest that PBCN offer some opportunities in the targeting of SLCNU to lung metastases.</p>","PeriodicalId":7035,"journal":{"name":"Acta physiologica et pharmacologica Bulgarica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18648407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Location of the electrical center of ventricular depolarization in rabbits. 家兔心室去极化电中心的定位。
Acta physiologica et pharmacologica Bulgarica Pub Date : 1994-01-01
R Lolov
{"title":"Location of the electrical center of ventricular depolarization in rabbits.","authors":"R Lolov","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This is a study on the location of the ventricular depolarization center, carried out on fifteen healthy rabbits according to the method of Ritsema van Eck. It is established that the level of equivalent heart dipole coincides with the fourth or fifth intercostal space, but in some laboratory animals this level displays a lower positioning. The inference is reached that to secure correct application of Frank's lead system it is necessary to use a prompt and precision method for determination of the level in question in each individual case. Such a method has not been developed as yet. For the time being, the optimal solution of the problem could be accomplished through a lead system that is less sensitive to electrode positioning errors.</p>","PeriodicalId":7035,"journal":{"name":"Acta physiologica et pharmacologica Bulgarica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18648409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Behavioral effects of the Ca2+/5-HT antagonist dotarizine. 钙离子/5-羟色胺拮抗剂多巴胺的行为效应。
Acta physiologica et pharmacologica Bulgarica Pub Date : 1994-01-01
V D Petkov, S Belcheva, E Konstantinova, J Vaglenova, V V Petkov
{"title":"Behavioral effects of the Ca2+/5-HT antagonist dotarizine.","authors":"V D Petkov,&nbsp;S Belcheva,&nbsp;E Konstantinova,&nbsp;J Vaglenova,&nbsp;V V Petkov","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The diphenyl-methyl-piperazine derivatives with Ca(2+)-antagonistic effect dotarizine (DOT), Fl-6020 and flunarizine were investigated in experiments on rats. The substances tested were administered repeatedly at an oral dose of 50 mg/kg. Behavioral methods were used to study the exploratory activity when the animals were placed in an environment that was unfamiliar to them (the chamber of the Opto Varimex apparatus), the elevated plus-maze method for examining the effect on anxiety, and the method of recording changes in motor activity (using the Automex II apparatus). DOT was found to increase motor activity and to have an anxiolytic effect. Combination of DOT--a compound with Ca(2+)--and 5-HT2-receptor antagonistic action--and the 5-HT-receptor agonists and antagonists used (buspirone, NAN190, pindolol, ritanserin and ondansetron) resulted in such changes in the development of habituation and in anxiety, which suggest that the modulating effects of DOT depend but partly on its typical interaction with the 5-HT2 receptor. Apparently, the Ca(2+)-antagonistic action of DOT plays a definite role, changing its biological activity depending on the 5-HT receptor subtype at the level of which the interaction is taking place.</p>","PeriodicalId":7035,"journal":{"name":"Acta physiologica et pharmacologica Bulgarica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18890171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of dopamine receptor blockade on the renal excretory response to acute volume expansion (AVE) in conscious Brattleboro rats. 多巴胺受体阻断对有意识大鼠急性容量扩张(AVE)时肾脏排泄反应的影响。
Acta physiologica et pharmacologica Bulgarica Pub Date : 1994-01-01
N Tzaneva, N Belova, L Kirkova, B Piryova
{"title":"Effect of dopamine receptor blockade on the renal excretory response to acute volume expansion (AVE) in conscious Brattleboro rats.","authors":"N Tzaneva,&nbsp;N Belova,&nbsp;L Kirkova,&nbsp;B Piryova","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Unlabelled: </strong>All the studies were performed on chronically cannulated, conscious Brattleboro rats, housed in metabolic cages under standard conditions. The renal excretory indices: diuresis (V), sodium (UNa.V), potassium (UK.V), chloride (UCl.V) and osmotic (Uosm.V) excretion were measured under the following experimental protocol: (1) controls, (2) 2% volume expansion (AVE)-0.9% NaCl i.v. for 2 min, (3) Dopamine (DA) receptor antagonist Flupentixol (FLU) 0.5 mg.kg-1 i.v., and (4) AVE 10 min after i.v. application of FLU. All the indices studied, given as cumulative curves, showed a firm linearity with time during the whole experimental period (5 h) in groups 1 and 2 (p < 0.05), while such a relationship was not found significantly in groups 3 and 4. AVE quickly, strongly and significantly (p < 0.01) increased V and especially UNa.V, UCl.V and Uosm.V. Pretreatment with FLU potently suppressed the effect of AVE on the renal excretion. FLU alone decreased almost equally V and saliuresis.</p><p><strong>In conclusion: </strong>the DA antagonist FLU blocks the diuretic and saliuretic response to AVE probably by affecting tubular processes.</p>","PeriodicalId":7035,"journal":{"name":"Acta physiologica et pharmacologica Bulgarica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18648405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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