Tissue distribution of polybutylcyanoacrylate nanoparticles loaded with spin-labelled nitrosourea in Lewis lung carcinoma-bearing mice.

M Simeonova, T Ivanova, Z Raikov, H Konstantinov
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Abstract

The tissue distribution of polybutylcyanoacrylate nanoparticles (PBCN) with a diameter of 127 nm, loaded with 1-(2-chloroethyl)-3-(1-oxyl-2,2,6,6-tetramethylpiperidinyl)-1- nitrosourea (spin-labelled nitrosourea, SLCNU) is described. PBCN-suspensions were intraperitoneally (i.p.) injected into Lewis lung carcinoma bearing mice. The biodistribution of PBCN in the visceral organs, blood and tumor was studied by electron spin resonance (ESR) spectroscopy. A relatively low accumulation of nanoparticles in the liver and spleen was found. The accumulation was negligible in the i.m. implanted primary tumor. SLCNU-loaded nanoparticles were mainly found in the lungs, kidneys, and heart. The highest content of the particles studied was observed in the lungs of tumor bearing experimental animals damaged by metastases. These findings suggest that PBCN offer some opportunities in the targeting of SLCNU to lung metastases.

负载自旋标记亚硝基脲的聚氰丙烯酸丁酯纳米颗粒在Lewis肺癌小鼠中的组织分布。
描述了负载1-(2-氯乙基)-3-(1-氧基-2,2,6,6-四甲基哌替啶基)-1-亚硝基脲(自旋标记亚硝基脲,SLCNU)的直径为127 nm的聚氰丙烯酸丁酯纳米颗粒(PBCN)的组织分布。将pbcn -混悬液腹腔注射Lewis肺癌小鼠。采用电子自旋共振(ESR)技术研究了PBCN在内脏器官、血液和肿瘤中的生物分布。在肝脏和脾脏中发现了相对较低的纳米颗粒积聚。在移植的原发肿瘤中,这种积累可以忽略不计。负载slcnu的纳米颗粒主要存在于肺、肾和心脏。所研究的颗粒含量最高的是被转移损害的荷瘤实验动物的肺部。这些发现表明,PBCN为SLCNU靶向肺转移提供了一些机会。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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