Acta physiologica et pharmacologica Bulgarica最新文献

The effect of swimming exercise on lipid peroxidation in the rat brain, liver and heart. 游泳运动对大鼠脑、肝、心脂质过氧化的影响。

Acta physiologica et pharmacologica Bulgarica Pub Date : 2003-01-01

Günfer Turgut, Süleyman Demir, Osman Genç, Ismail Karabulut, Nalan Akalin

{"title":"The effect of swimming exercise on lipid peroxidation in the rat brain, liver and heart.","authors":"Günfer Turgut, Süleyman Demir, Osman Genç, Ismail Karabulut, Nalan Akalin","doi":"","DOIUrl":"","url":null,"abstract":"We intended to study the effect of swimming exercise on the brain, liver and heart malondialdehyde (MDA) levels which are the last product of oxidation, and to compare them with the brain, liver and heart MDA levels of controls. The experiments were carried out on 20 Wistar rats which were fed with a standard laboratory chow diet ad libitum. Rats were distributed in two groups, control group (n = 10) and exercise group (n = 10). The exercise group rats were exposed to swimming exercise for 30 minutes. After this animals in each group were sacrificed by decapitation, their brain, liver and heart tissues were quickly removed. MDA levels of the brain, liver and heart were determined according to the method in which MDA reacts with thiobarbituric acid. Results were evaluated by the Mann-Whitney U test. The liver and heart MDA levels in the exercise group were (29.59+/-6.73 and 10.49+/-1.90 nmol/g tissue, respectively) significantly higher than in the control group (21.78+/-3.46 and 8.86+/-1.25 nmol/g tissue, p<0.01 and p<0.05, respectively). However, the brain MDA levels were similar in both groups (exercise group 19.37+/-5.50 nmol/g tissue and control group 16.58+/-2.44 nmol/g tissue; p=0.325). It is concluded that swimming exercise might cause oxidative stress.","PeriodicalId":7035,"journal":{"name":"Acta physiologica et pharmacologica Bulgarica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2003-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24037405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exercise performance and oxygen uptake efficiency slope in obese children performing standardized exercise. 肥胖儿童标准化运动的运动表现与摄氧效率斜率。

Acta physiologica et pharmacologica Bulgarica Pub Date : 2003-01-01

B Marinov, S Kostianev

{"title":"Exercise performance and oxygen uptake efficiency slope in obese children performing standardized exercise.","authors":"B Marinov, S Kostianev","doi":"","DOIUrl":"","url":null,"abstract":"Oxygen uptake efficiency slope (OUES) is an index meant to provide an objective measure of cardiopulmonary function at submaximal exercise. The aim was to study the exercise performance and OUES in obese children performing standardized exercise. Sixty children aged 6-17 years performed incremental treadmill exercise test. They were divided into two groups matched by age, sex and height: thirty obese subjects (15 girls/15 boys; BMI = 27.4+/-1.7 m x kg(-2)) and 30 controls (BMI = 18.8+/-1.0 m x kg(-2)). Perceived exertion was assessed by means of CR-10 Borg scale. The duration of the exercise for the obese children was significantly shorter than for controls (p = 0.010) but obese children had greater absolute values for oxygen uptake (VO2 peak mL x min(-1) = 1907+/-249 vs. 1495+/-208; p = 0.013) which, adjusted for body mass, decreased significantly (VO2/kg mL x min(-1) x kg(-1) = 29.2+/-1.4 vs. 33.6+/-1.3; p < 0.001). OUES correlated strongly with VO2 peak (r = 0.91) and oxygen pulse (r = 0.80), as well as with anthropometric variables height (r = 0.88) and age (r = 0.83). Extremely high correlation was found between OUES calculated for 100% of exercise duration and OUES at the anaerobic threshold (r = 0.979; p < 0.001). No significant differences were found between the studied groups concerning the absolute values of OUES. Obese children rated perceived exertion significantly higher than controls (Borg score 6.2+/-0.4 vs. 5.2+/-0.4; p = 0.001). In conclusion, the absolute metabolic cost of exercise and perceived exertion were higher in the obesity group. OUES is an objective measure of cardiopulmonary reserve that doesn't require a maximal effort but it is considerably dependent on anthropometric variables which impedes its interpretation as exercise index in childhood.","PeriodicalId":7035,"journal":{"name":"Acta physiologica et pharmacologica Bulgarica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2003-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24037408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adolescent erythrocytes: influence of high density lipoproteins-cholesterol (HDL-c) plasmatic levels on Na+/Li+ exchange kinetics. 青少年红细胞:高密度脂蛋白-胆固醇(HDL-c)血浆水平对Na+/Li+交换动力学的影响

Acta physiologica et pharmacologica Bulgarica Pub Date : 2003-01-01

Raquel Serrani, Diego Taborda, Ines DeMaria, Juan Corchs

引用次数: 0

Corrections of prooxidant-antioxidant homeostasis of organism under hypoxia of different genesis by yackton, a new pharmacological preparation. 一种新的药物制剂——亚克顿对不同原因缺氧条件下机体促氧化-抗氧化平衡的纠正作用。

Acta physiologica et pharmacologica Bulgarica Pub Date : 2003-01-01

O Gonchar, E Klyuchko, M Seredenko, S Oliynik

{"title":"Corrections of prooxidant-antioxidant homeostasis of organism under hypoxia of different genesis by yackton, a new pharmacological preparation.","authors":"O Gonchar, E Klyuchko, M Seredenko, S Oliynik","doi":"","DOIUrl":"","url":null,"abstract":"The aim of the present work was to study the antioxidant activity of the new derivative of succinic acid-succinate mono[(2-dimethyl-amino) ethyl ether] of succinic acid (yackton) under conditions of hypoxic and hemic hypoxia as well as to examine in vitro the antiradical activity of this preparation. Hypoxia in the rats was modelled by: (i) allowing the rats to breath a gas mixture with 7% O2 and 93% N2 for 30 minutes (hypoxic hypoxia), and (ii) injecting the rats sodium nitrite subcutaneously in a dose of 60 mg/kg body weight (hemic hypoxia). Yackton was injected intraperitoneally to both groups 30 minutes before the extreme influence in a dose of 140 mg/kg body weight. Then in homogenates and in post-mitochondrial fractions of liver, heart, lungs, brain we studied the content of secondary products of lipid peroxidation (LPO), activity of antioxidant enzymes superoxide dismutase (SOD) and catalase, and the activity of enzymes responsible for the maintenance of reduced glutathione (GSH) glutathione reductase (GR-ase) and glutathione peroxidase (GP-ase). In vitro studies were made on the antiradical activity of yackton in reaction with the stable radical diphenylpicrylhydrazine (DPPH) as well as on the reaction velocity of the preparation with DPPH, and its period of semi-transformation in a non-radical form. It was shown that yackton treatment before hypoxic and hemic hypoxia decreased lipid peroxidation (LPO) level and increased SOD activity. After the yackton injection the state of glutathione system was normalized in comparison with its state at hypoxic and hemic hypoxia. Yackton had no antiradical properties in vitro. We concluded that yackton promotes optimization of prooxidant-antioxidant homeostasis of the organism under the hemic and hypoxic hypoxia acting as antioxidant of a non-direct action.","PeriodicalId":7035,"journal":{"name":"Acta physiologica et pharmacologica Bulgarica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2003-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24037407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sulfated polysaccharides of brown seaweed Cystoseira canariensis bind to serum myostatin protein. 棕色海藻中的硫酸化多糖与血清肌生成蛋白结合

Acta physiologica et pharmacologica Bulgarica Pub Date : 2003-01-01

Zakir Ramazanov, Miguel Jimenez del Rio, Tim Ziegenfuss

引用次数: 0

About the biological effects of high and extremely high frequency electromagnetic fields. 关于高频和极高频电磁场的生物效应。

Acta physiologica et pharmacologica Bulgarica Pub Date : 2003-01-01

K Mileva, B Georgieva, N Radicheva

引用次数: 0

The effects of peptide and nonpeptide antagonists of angiotensin II receptors on the noradrenaline uptake of different brain structures in rats with angiotensin II-induced increase of water intake. 血管紧张素II受体多肽和非肽拮抗剂对血管紧张素II诱导的饮水增加大鼠不同脑结构去甲肾上腺素摄取的影响。

Acta physiologica et pharmacologica Bulgarica Pub Date : 2003-01-01

S Stancheva, L Alova, M Velkova, V Georgiev

引用次数: 0

Hematological alterations in the Otsuka Long-Evans Tokushima fatty (OLETF) rats--a model of type 2 diabetes mellitus. 大冢Long-Evans德岛脂肪(OLETF)大鼠- 2型糖尿病模型的血液学改变

Acta physiologica et pharmacologica Bulgarica Pub Date : 2003-01-01

Z Kamenov, H Higashino, M Todorova, N Aoki, M Imamura, M Orita, H Yamanishi, A Suzuki, Y Yamanishi, V Christov

{"title":"Hematological alterations in the Otsuka Long-Evans Tokushima fatty (OLETF) rats--a model of type 2 diabetes mellitus.","authors":"Z Kamenov, H Higashino, M Todorova, N Aoki, M Imamura, M Orita, H Yamanishi, A Suzuki, Y Yamanishi, V Christov","doi":"","DOIUrl":"","url":null,"abstract":"The OLETF rat develops microangiopathic complications similar to human diabetes and is considered a useful model of Type 2 DM. Erythrocyte, platelet and leucocyte abnormalities described in diabetic patients are thought to play a role in the development of diabetic microangiopathy. This study was designed to investigate whether OLETF rats show hematological alterations and the effect of sucrose treatment on metabolic and blood parameters. Hematological parameters, body weight, food and water intake, fasting and non-fasting blood glucose (BG) and HbA1c were measured in OLETF rats treated for two months with 30% sucrose added to drinking water. Non-treated OLETF rats and non-diabetic Long-Evans Tokushima Otsuka (LETO) rats were used as controls. In the control OLETF rats the number of platelets (Plt) and red blood cells (RBC) was higher, while the mean cell volume (MCV) and the mean cell hemoglobin content (MCH) were lower compared with LETO. Mean cell hemoglobin concentration (MCHC) was significantly higher in the diabetic rats. Sucrose administration decreased food intake and body weight and increased fasting blood glucose and HbA1c. It resulted in a decrease of RBC, Hb, Hct, MCV and MCH compared with control OLETF, while Plt count increased significantly. Our results point to significant alterations in erythrocyte count and morphology and Plt count in diabetic OLETF rats compared with non-diabetic LETO. Sucrose administration accelerated the development of diabetes, affected blood cells inducing the suppression of RBC and an increase in Plt count and some of its effects persisted after sucrose withdrawal.","PeriodicalId":7035,"journal":{"name":"Acta physiologica et pharmacologica Bulgarica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2003-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24037410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Abstracts of the VIIIth Congress of the Bulgarian Society of Physiological Sciences. June 20-21, 2003. 保加利亚生理科学学会第八届大会摘要。2003年6月20日至21日。

Acta physiologica et pharmacologica Bulgarica Pub Date : 2003-01-01

引用次数: 0

Cholecystokinin and learning and memory processes. 胆囊收缩素与学习和记忆过程有关。

Acta physiologica et pharmacologica Bulgarica Pub Date : 2003-01-01

Christina Hadjiivanova, Stiliana Belcheva, Iren Belcheva

引用次数: 0