胆囊收缩素与学习和记忆过程有关。

Christina Hadjiivanova, Stiliana Belcheva, Iren Belcheva
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引用次数: 0

摘要

胆囊收缩素(Cholecystokinin, CCK)是一种经典的脑肠肽,在胃肠道和中枢神经系统中发挥多种生理作用。CCK以不同氨基酸长度的几种分子形式存在,硫化八肽(CCK-8)是大脑中的主要形式。CCK通过与特定受体的相互作用介导其作用,这些受体被细分为两种亚型——CCK- a(存在于外周和少数选定的脑核中)和CCK- b(大脑中主要的受体亚型)。CCK涉及多种行为功能,如饱腹感、焦虑、探索和运动活动以及学习和记忆。本文简要介绍了CCK在大脑中的分布、分子形态、释放、失活等方面的研究进展,并对CCK在学习记忆中的作用进行了综述。CCK的记忆增强作用已在各种类型的记忆中得到证实。CCK-A受体介导记忆效应,CCK-B受体介导遗忘效应。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Cholecystokinin and learning and memory processes.

Cholecystokinin (CCK) is a classical brain-gut peptide that exerts a variety of physiological actions in the gastrointestinal tract and central nervous system. CCK occurs in several molecular forms of varying aminoacid length, the sulphated octapeptide (CCK-8) being the predominant form in the brain. CCK mediates its effects through interaction with specific receptors subdivided in two subtypes--CCK-A (present in the periphery and in few selected brain nuclei) and CCK-B (the predominant receptor subtype in the brain). CCK is implicated in variety of behavioral functions as satiety, anxiety, exploratory and locomotor activity and learning and memory. After a brief description of the distribution, molecular forms, release, inactivation, etc. of CCK in the brain, the present review summarizes the recent data on the role of CCK in learning and memory. The memory-enhancing effects of CCK have been demonstrated in various types of memory. Data showing that CCK-A receptors mediate mnemonic while CCK-B receptors mediate amnestic effects are also presented.

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