Effect of dopamine receptor blockade on the renal excretory response to acute volume expansion (AVE) in conscious Brattleboro rats.

Acta physiologica et pharmacologica Bulgarica Pub Date : 1994-01-01

N Tzaneva, N Belova, L Kirkova, B Piryova

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Abstract

Unlabelled: All the studies were performed on chronically cannulated, conscious Brattleboro rats, housed in metabolic cages under standard conditions. The renal excretory indices: diuresis (V), sodium (UNa.V), potassium (UK.V), chloride (UCl.V) and osmotic (Uosm.V) excretion were measured under the following experimental protocol: (1) controls, (2) 2% volume expansion (AVE)-0.9% NaCl i.v. for 2 min, (3) Dopamine (DA) receptor antagonist Flupentixol (FLU) 0.5 mg.kg-1 i.v., and (4) AVE 10 min after i.v. application of FLU. All the indices studied, given as cumulative curves, showed a firm linearity with time during the whole experimental period (5 h) in groups 1 and 2 (p < 0.05), while such a relationship was not found significantly in groups 3 and 4. AVE quickly, strongly and significantly (p < 0.01) increased V and especially UNa.V, UCl.V and Uosm.V. Pretreatment with FLU potently suppressed the effect of AVE on the renal excretion. FLU alone decreased almost equally V and saliuresis.

In conclusion: the DA antagonist FLU blocks the diuretic and saliuretic response to AVE probably by affecting tubular processes.

本刊更多论文

多巴胺受体阻断对有意识大鼠急性容量扩张(AVE)时肾脏排泄反应的影响。

未标记:所有的研究都是在标准条件下的代谢笼子里进行的，长期插管，有意识的伯氏波罗大鼠。在以下实验方案下测定肾脏排泄指标:利尿(V)、钠(UNa.V)、钾(UK.V)、氯(UCl.V)和渗透(uusm .V)排泄:(1)对照组，(2)2%体积膨胀(AVE)-0.9% NaCl静脉注射2min，(3)多巴胺(DA)受体拮抗剂氟哌噻醇(FLU) 0.5 mg。kg-1静脉滴注，(4)静脉滴注FLU后10分钟的AVE。各指标均以累积曲线表示，在整个实验期间(5 h)， 1组和2组与时间呈较强的线性关系(p < 0.05)，而3组和4组与时间的线性关系不显著。AVE快速、强烈、显著(p < 0.01)提高了V，尤其是UNa。V,伦敦大学学院。V和乌斯姆。流感预处理能有效抑制AVE对肾脏排泄的影响。流感本身几乎同样减少V和流涎。结论:DA拮抗剂流感阻断对AVE的利尿和唾液反应可能是通过影响肾小管突。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Acta physiologica et pharmacologica Bulgarica

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