黑荆芥天然汁中黄酮类化合物、芦丁和芦丁-镁复合物对组胺和血清素诱导炎症实验模型的抗炎作用。

P Borissova, S Valcheva, A Belcheva
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引用次数: 0

摘要

以芦丁为研究对象,研究了天然黑栎汁中花青素类黄酮类化合物和水溶性芦丁-镁复合物的抗炎作用。采用两种炎症实验模型。分别用0.5%组胺溶液和0.01%血清素溶液诱导大鼠后爪炎症反应。用压度计测量大鼠爪的肿胀程度。结果表明,与芦丁相比,黑檀天然汁中的花青素类黄酮在两种炎症模型中都具有更明显的作用。芦丁-镁复合物对组胺诱导的炎症没有任何抗炎活性。它对血清素引起的炎症的作用与芦丁相当。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Antiinflammatory effect of flavonoids in the natural juice from Aronia melanocarpa, rutin and rutin-magnesium complex on an experimental model of inflammation induced by histamine and serotonin.

The antiinflammatory effects of the anthocyane flavonoids in the natural juice from Aronia melanocarpa and of rutin-magnesium complex, the water-soluble derivative of rutin were studied in comparison with rutin. Two experimental models of inflammation were used. Inflammation of rat hind paw was induced either by 0.5% solution of histamine or by 0.01% solution of serotonin. The swelling of the rat paw was measured oncometrically by a pletismometer. The results showed that the anthocyane flavonoids from the natural juice of Aronia melanocarpa exerted more pronounced effects as compared to rutin in both models of inflammation. The rutin-magnesium complex did not exhibit any antiinflammatory activity against histamine-induced inflammation. Its effects against serotonin-induced inflammation were comparable to those of rutin.

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