Chemical Society Reviews最新文献

{"title":"Cyclic natural product oligomers: diversity and (bio)synthesis of macrocycles","authors":"Songya Zhang, Shuai Fan, Haocheng He, Jing Zhu, Lauren Murray, Gong Liang, Shi Ran, Yi Zhun Zhu, Max J. Cryle, Hai-Yan He, Youming Zhang","doi":"10.1039/d2cs00909a","DOIUrl":"https://doi.org/10.1039/d2cs00909a","url":null,"abstract":"Cyclic compounds are generally preferred over linear compounds for functional studies due to their enhanced bioavailability, stability towards metabolic degradation, and selective receptor binding. This has led to a need for effective cyclization strategies for compound synthesis and hence increased interest in macrocyclization mediated by thioesterase (TE) domains, which naturally boost the chemical diversity and bioactivities of cyclic natural products. Many non-ribosomal peptide synthetase (NRPS) and polyketide synthase (PKS) derived natural products are assembled to form cyclodimeric compounds, with these molecules possessing diverse structures and biological activities. There is significant interest in identifying the biosynthetic pathways that produce such molecules given the challenge that cyclodimerization represents from a biosynthetic perspective. In the last decade, many groups have pursued the characterization of TE domains and have provided new insights into this biocatalytic machinery: however, the enzymes involved in formation of cyclodimeric compounds have proven far more elusive. In this review we focus on natural products that involve macrocyclization in their biosynthesis and chemical synthesis, with an emphasis on the function and biosynthetic investigation on the special family of TE domains responsible for forming cyclodimeric natural products. We also introduce additional macrocyclization catalysts, including butelase and the C<small>_T</small>-mediated cyclization of peptides, alongside the formation of cyclodipeptides mediated by cyclodipeptide synthases (CDPS) and single-module NRPSs. Due to the interdisciplinary nature of biosynthetic research, we anticipate that this review will prove valuable to synthetic chemists, drug discovery groups, enzymologists, and the biosynthetic community in general, and inspire further efforts to identify and exploit these biocatalysts for the formation of novel bioactive molecules.","PeriodicalId":68,"journal":{"name":"Chemical Society Reviews","volume":"232 1","pages":""},"PeriodicalIF":46.2,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142696996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Amyloid inspired single amino acid (phenylalanine)-based supramolecular functional assemblies: from disease to device applications","authors":"Subrat Vishwakarma, Om Shanker Tiwari, Ruchi Shukla, Ehud Gazit, Pandeeswar Makam","doi":"10.1039/d4cs00996g","DOIUrl":"https://doi.org/10.1039/d4cs00996g","url":null,"abstract":"In the evolving landscape of biomolecular supramolecular chemistry, recent studies on phenylalanine (Phe) have revealed important insights into the versatile nature of this essential aromatic amino acid. Phe can spontaneously self-assemble into fibrils with amyloid-like properties linked to the neurological disorder phenylketonuria (PKU). Apart from its pathological implications, Phe also displays complex phase behavior and can undergo structural changes in response to external stimuli. Its ability to co-assemble with other amino acids opens up new possibilities for studying biomolecular interactions. Furthermore, Phe's coordination with metal ions has led to the development of enzyme-mimicking catalytic systems for applications in organic chemistry, environmental monitoring, and healthcare. Research on <small>L</small> and <small>D</small> enantiomers of Phe, particularly on bio-MOFs, has highlighted their potential in advanced technologies, including bioelectronic devices. This review provides a comprehensive overview of the advancements in Phe-based supramolecular assemblies, emphasizing their interdisciplinary relevance. The Phe assemblies show great potential for future therapeutic and functional biomaterial developments, from disease treatments to innovations in bionanozymes and bioelectronics. This review presents a compelling case for the ongoing exploration of Phe's biomolecular supramolecular chemistry as a fundamental framework for developing sustainable and efficient methodologies across various scientific disciplines.","PeriodicalId":68,"journal":{"name":"Chemical Society Reviews","volume":"198 1","pages":""},"PeriodicalIF":46.2,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142696994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of the design and synthesis of metal–organic frameworks (MOFs) – from large scale attempts, functional oriented modifications, to artificial intelligence (AI) predictions","authors":"Zongsu Han, Yihao Yang, Joshua Rushlow, Jiatong Huo, Zhaoyi Liu, Yu-Chuan Hsu, Rujie Yin, Mengmeng Wang, Rongran Liang, Kun-Yu Wang, Hong-Cai Zhou","doi":"10.1039/d4cs00432a","DOIUrl":"https://doi.org/10.1039/d4cs00432a","url":null,"abstract":"Owing to the exceptional porous properties of metal–organic frameworks (MOFs), there has recently been a surge of interest, evidenced by a plethora of research into their design, synthesis, properties, and applications. This expanding research landscape has driven significant advancements in the precise regulation of MOF design and synthesis. Initially dominated by large-scale synthesis approaches, this field has evolved towards more targeted functional modifications. Recently, the integration of computational science, particularly through artificial intelligence predictions, has ushered in a new era of innovation, enabling more precise and efficient MOF design and synthesis methodologies. The objective of this review is to provide readers with an extensive overview of the development process of MOF design and synthesis, and to present visions for future developments.","PeriodicalId":68,"journal":{"name":"Chemical Society Reviews","volume":"46 1","pages":""},"PeriodicalIF":46.2,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142696997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring high-connectivity three-dimensional covalent organic frameworks: topologies, structures, and emerging applications","authors":"Fengqian Chen, Haorui Zheng, Yusran Yusran, Hui Li, Shilun Qiu, Qianrong Fang","doi":"10.1039/d4cs00703d","DOIUrl":"https://doi.org/10.1039/d4cs00703d","url":null,"abstract":"Covalent organic frameworks (COFs) represent a highly versatile class of crystalline porous materials, formed by the deliberate assembly of organic building units into ordered two-dimensional (2D) and three-dimensional (3D) structures. Their unique combination of topological precision and tunable micro- or mesoporous architectures offers unmatched flexibility in material design. By selecting specific building units, reactive sites, and functional groups, COFs can be engineered to achieve customized skeletal, porous, and interfacial properties, opening the door to materials with optimized performance for diverse applications. Among recent advances, high-connectivity 3D COFs have emerged as a particularly exciting development, with their intricate network structures enabling unprecedented levels of structural complexity, stability, and functionality. This review provides a comprehensive overview of the synthesis strategies, topological design principles, structural characterization techniques, and emerging applications of high-connectivity 3D COFs. We explore their potential across a broad range of cutting-edge applications, including gas adsorption and separation, macromolecule adsorption, dye removal, photocatalysis, electrocatalysis, lithium–sulfur batteries, and charge transport. By examining these key areas, we aim to deepen the understanding of the intricate relationship between structure and function, guiding the rational design of next-generation COF materials. The continued advancements in this field hold immense promise for revolutionizing sectors such as energy storage, catalysis, and molecular separation, making high-connectivity 3D COFs a cornerstone for future technological innovations.","PeriodicalId":68,"journal":{"name":"Chemical Society Reviews","volume":"3 1","pages":""},"PeriodicalIF":46.2,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142696993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design strategies and applications of cyanine dyes in phototherapy","authors":"Jie Yuan, Hanxue Yang, Wenhui Huang, Shilong Liu, Hua Zhang, Xiaobing Zhang, Xiaojun Peng","doi":"10.1039/d3cs00585b","DOIUrl":"https://doi.org/10.1039/d3cs00585b","url":null,"abstract":"Cyanine dyes have been widely used in phototherapy in recent years due to their excellent optical properties and diverse modifiable structures. This review provides detailed descriptions of the basic structures of various cyanines and their derivatives as well as their optical properties. It summarizes the strategies for constructing cyanine dyes for phototherapy and discusses their structure–effect relationship. Furthermore, a comprehensive classification and summary of the applications of cyanine dyes in phototherapy are presented. Importantly, this review also addresses both the advances made in this field as well as the challenges that need to be overcome. We hope that these profound insights into phototherapy using cyanine dyes will facilitate the design of future systems for clinical applications based on these compounds.","PeriodicalId":68,"journal":{"name":"Chemical Society Reviews","volume":"110 1","pages":""},"PeriodicalIF":46.2,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142685003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reactive carbon capture using saline water: evaluation of prospective sources, processes, and products","authors":"Anya Dickinson-Cove, Erika La Plante, Yiming Liu, Dante Simonetti, Eric M. V. Hoek, Gaurav Sant, David Jassby","doi":"10.1039/d4cs00701h","DOIUrl":"https://doi.org/10.1039/d4cs00701h","url":null,"abstract":"Reactive carbon capture (RCC) processes involve the capture of carbon dioxide (CO<small>₂</small>) and conversion to a value-added product using a single sorbent/reaction medium. Not only can RCC processes generate valuable byproducts that can reduce the cost of carbon capture, but RCC tends to have lower energy demand than processes involving the transfer of CO<small>₂</small> between the mediums used for capture and subsequent reactions. Saline water has been proposed as a potential medium for RCC due to it's relative abundance and low cost. Additionally, the composition and chemistry of many saline water sources: (1) elevates the CO<small>₂</small> content (as compared to atmospheric concentrations), (2) provides various cations that can form valuable products with CO<small>₂</small>, and (3) enhances the kinetics of chemical reactions used to convert CO<small>₂</small> to stable byproducts. In addition to established industrial processes for converting CO<small>₂</small> into inert or valuable byproducts, we found 20 new processes and technologies that have been developed specifically to capture and convert CO<small>₂</small> using saline water. Both preexisting and emerging processes can be broadly classified as electrochemical or chemical titration processes. When assessing the potential viability of applying any of these processes for large scale carbon capture, several factors must be considered, such as the net carbon footprint of the process, the market size, location of customers and value of the end product, the energy demand and chemical costs of the process, and any other environmental impacts. The feasability of many emerging saline-based RCC processes is difficult to determine, as many technologies were tested using synthetic saline waters and/or concentrated CO<small>₂</small> sources. Notwithstanding the early stage of development of many saline-based RCC technologies, the major limitation to implementation of this approach to carbon capture is the mismatch in the scale of the markets for products of saline-based RCC and the scale of carbon capture needed to meet climate goals. However, because the products of many of the processes reviewed here are stable and non-hazardous, these technologies may also be used for carbon sequestration efforts where the products are managed as waste, in which case the carbon capture potential of these technologies can surpass the market-imposed limitations on RCC. Thus, the potential benefits of saline water-based RCC identified in this review encourage further study and development of these technologies.","PeriodicalId":68,"journal":{"name":"Chemical Society Reviews","volume":"35 1","pages":""},"PeriodicalIF":46.2,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142685008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A practical approach to quantitative analytical surface-enhanced Raman spectroscopy","authors":"Yikai Xu, Wafaa Aljuhani, Yingrui Zhang, Ziwei Ye, Chunchun Li, Steven E. J. Bell","doi":"10.1039/d4cs00861h","DOIUrl":"https://doi.org/10.1039/d4cs00861h","url":null,"abstract":"Many of the features of SERS, such as its high sensitivity, molecular specificity and speed of analysis make it attractive as an analytical technique. However, SERS currently remains a specialist technique which has not yet entered the mainstream of analytical chemistry. Therefore, this review draws out the underlying principles for analytical SERS and provides practical tips and tricks for SERS quantitation. The aim is to show the readers how to rationally design their SERS experiments to improve quantitation performance. We begin by introducing the three core components in SERS analysis: (1) the enhancing substrate material, (2) the Raman instrument and (3) the processed data that is used to establish a calibration curve. This is followed by discussion of the analytical figures of merit relevant to SERS. In the following sections each of the three essential components in SERS quantitation and how they affect the quality of the analysis are described in more detail using examples from the literature. Finally, we highlight the current challenges in applying SERS to the analysis of complex real-life samples and briefly introduce the state-of-the-art developments on multifunctional substrates, digital SERS and AI-assisted data processing, which will help SERS rise to the challenge of moving out into routine real-world analysis.","PeriodicalId":68,"journal":{"name":"Chemical Society Reviews","volume":"18 1","pages":""},"PeriodicalIF":46.2,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142678813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metal complex-based TADF: design, characterization, and lighting devices","authors":"Afsaneh Farokhi, Sophia Lipinski, Luca M. Cavinato, Hashem Shahroosvand, Babak Pashaei, Soheila Karimi, Sebastiano Bellani, Francesco Bonaccorso, Rubén D. Costa","doi":"10.1039/d3cs01102j","DOIUrl":"https://doi.org/10.1039/d3cs01102j","url":null,"abstract":"The development of novel, efficient and cost-effective emitters for solid-state lighting devices (SSLDs) is ubiquitous to meet the increasingly demanding needs of advanced lighting technologies. In this context, the emergence of thermally activated delayed fluorescence (TADF) materials has stunned the photonics community. In particular, inorganic TADF material-based compounds can be <em>ad hoc</em> engineered by chemical modification of the coordinated ligands and the type of metal centre, allowing control of their ultimate photo-/electroluminescence properties, while providing a viable emitter platform for enhancing the efficiency of state-of-the-art organic light-emitting diodes (OLEDs) and light-emitting electrochemical cells (LECs). By presenting an overview of the state of the art of all metal complex-based TADF compounds, this review aims to provide a comprehensive, authoritative and critical reference for their design, characterization and device application, highlighting the advantages and drawbacks for the chemical, photonic and optoelectronic communities involved in this interdisciplinary research field.","PeriodicalId":68,"journal":{"name":"Chemical Society Reviews","volume":"99 1","pages":""},"PeriodicalIF":46.2,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142673801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent advances in peptide macrocyclization strategies","authors":"Pengyuan Fang, Wing-Ka Pang, Shouhu Xuan, Wai-Lun Chan and Ken Cham-Fai Leung","doi":"10.1039/D3CS01066J","DOIUrl":"10.1039/D3CS01066J","url":null,"abstract":"<p >Recently, owing to their special spatial structures, peptide-based macrocycles have shown tremendous promise and aroused great interest in multidisciplinary research ranging from potent antibiotics against resistant strains to functional biomaterials with novel properties. Besides traditional monocyclic peptides, many fascinating polycyclic and remarkable higher-order cyclic, spherical and cylindric peptidic systems have come into the limelight owing to breakthroughs in various chemical (<em>e.g.</em>, native chemical ligation and transition metal catalysis), biological (<em>e.g.</em>, post-translational enzymatic modification and genetic code reprogramming), and supramolecular (<em>e.g.</em>, mechanically interlocked, metal-directed folding and self-assembly <em>via</em> noncovalent interactions) macrocyclization strategies developed in recent decades. In this tutorial review, diverse state-of-the-art macrocyclization methodologies and techniques for peptides and peptidomimetics are surveyed and discussed, with insights into their practical advantages and intrinsic limitations. Finally, the synthetic-technical aspects, current unresolved challenges, and outlook of this field are discussed.</p>","PeriodicalId":68,"journal":{"name":"Chemical Society Reviews","volume":" 24","pages":" 11725-11771"},"PeriodicalIF":40.4,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2024/cs/d3cs01066j?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142666649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioorthogonally activated probes for precise fluorescence imaging.","authors":"Youxin Fu, Xing Zhang, Luling Wu, Miaomiao Wu, Tony D James, Run Zhang","doi":"10.1039/d3cs00883e","DOIUrl":"10.1039/d3cs00883e","url":null,"abstract":"<p><p>Over the past two decades, bioorthogonal chemistry has undergone a remarkable development, challenging traditional assumptions in biology and medicine. Recent advancements in the design of probes tailored for bioorthogonal applications have met the increasing demand for precise imaging, facilitating the exploration of complex biological systems. These state-of-the-art probes enable highly sensitive, low background, <i>in situ</i> imaging of biological species and events within live organisms, achieving resolutions comparable to the size of the biomolecule under investigation. This review provides a comprehensive examination of various categories of bioorthogonally activated <i>in situ</i> fluorescent labels. It highlights the intricate design and benefits of bioorthogonal chemistry for precise <i>in situ</i> imaging, while also discussing future prospects in this rapidly evolving field.</p>","PeriodicalId":68,"journal":{"name":"Chemical Society Reviews","volume":" ","pages":""},"PeriodicalIF":40.4,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142646096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}