Journal of Nanoparticle Research最新文献

{"title":"Paroxetine HCl-loaded hybrid nanoparticles for intranasal application to brain delivery: evaluation and cell culture studies","authors":"Elif Simsek,&nbsp;Ozge Esim,&nbsp;Canan Hascicek","doi":"10.1007/s11051-025-06411-1","DOIUrl":"10.1007/s11051-025-06411-1","url":null,"abstract":"<div><p>Depression, ranked as the fourth leading cause of disability worldwide, is typically treated with oral antidepressants. However, the inability of this treatment to achieve the intended effect prompts the search for alternative methods. The aim of this research was to develop a paroxetine HCl-loaded lipid-polymer-based nanoparticulate drug delivery system for depression treatment via intranasal administration. Lipid-polymer hybrid nanoparticles were synthesized by using a modified double-emulsion solvent evaporation method and characterized in terms of physicochemical properties. The permeability and cytotoxicity of the nanoparticles were investigated on the Caco-2 cell line. The developed lipid-polymer-based nanoparticles were functionalized with chitosan to enhance the permeability of the nanoparticles through the blood–brain barrier. The optimum nanoparticle formulation was achieved at about 300 nm and a low polydispersity index. Paroxetine HCl, a highly water-soluble drug, was encapsulated into nanoparticles with an encapsulation efficiency of 77.144%. The cationic nanoparticles exhibited mucoadhesive characteristics, which support the permeability through the Caco-2 cell monolayer. Consequently, the proposed nanoformulation exhibited significant potential for treating depression intranasally.</p></div>","PeriodicalId":653,"journal":{"name":"Journal of Nanoparticle Research","volume":"27 8","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145141860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Substrate-dependent properties of PECVD-deposited diamond-like carbon films: structural, morphological, and mechanical insights","authors":"Mohd Sarim Khan,&nbsp;Lokendra Kumar Katiyar,&nbsp;Manish Kumar,&nbsp;C. Sasikumar","doi":"10.1007/s11051-025-06409-9","DOIUrl":"10.1007/s11051-025-06409-9","url":null,"abstract":"<div><p>This study examines the influence of different substrate materials on the structural, mechanical, and hydrophobic properties of diamond-like carbon (DLC) films deposited using the PECVD technique. Substrates including stainless steel, silicon, Silica, and epoxy chip material were investigated to understand their impact on the performance of DLC coatings. Raman, FTIR spectroscopy and XPS revealed substrate-dependent variations in bonding configurations, with stainless steel exhibiting prominent sp2 clustering and graphitization, while Silica displayed a predominantly amorphous structure with enhanced sp3 content. Silicon demonstrated superior mechanical properties, attributed to its hexagonal DLC morphology and higher sp3 bonding, making it ideal for demanding applications. Epoxy chip material, characterized by a globular DLC structure and higher sp2 content, exhibited lower mechanical performance but moderate hydrophobicity. Silica was identified as the most hydrophobic substrate, followed by silicon, epoxy chip, and stainless steel. These findings underscore the importance of substrate characteristics and structural tailoring in optimizing DLC coatings for diverse industrial applications, including protective, tribological, and water-repellent surfaces.</p></div>","PeriodicalId":653,"journal":{"name":"Journal of Nanoparticle Research","volume":"27 8","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145141948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microwave-assisted synthesis of graphene-supported PtFeCu nanoparticles for enhanced methanol oxidation in direct methanol fuel cells","authors":"Kun-Yauh Shih,&nbsp;Zhu-Min Chen","doi":"10.1007/s11051-025-06401-3","DOIUrl":"10.1007/s11051-025-06401-3","url":null,"abstract":"<div><p>Direct methanol fuel cells (DMFC) are one of the most promising alternative energy sources because of their simple construction, high energy density, and high energy conversion efficiency. Platinum (Pt) stands as a quintessential catalyst in fuel cell applications, yet its widespread adoption is impeded by high costs and susceptibility to carbon monoxide (CO) poisoning. To address these challenges, we developed a PtFeCu/RGO nano-catalyst with superior activity and stability. Leveraging additional metal components and employing an efficient, environmentally benign microwave-assisted synthesis technique alongside a cost-effective approach, we synthesized PtFeCu/RGO nanoparticles. These nanoparticles exhibited a narrow size distribution (average size: 3.53 ± 0.69 nm) and uniform dispersion on reduced graphene oxide, devoid of agglomeration. Electrochemical characterization revealed that the PtFe₂Cu/RGO catalyst achieved an electrochemically active surface area (ECSA) of 165.41 m2/g at a scan rate of 50 mV/s. It demonstrated a high mass activity for the methanol oxidation reaction (MOR), reaching 1452.71 mA/mgPt at 0.85 V vs. Ag/AgCl, and maintained a stable current density of 226.61 mA/cm2 during chronoamperometric testing. Additionally, the catalyst exhibited a low CO oxidation onset potential of 0.596 V, indicating enhanced CO tolerance. Oxygen reduction reaction (ORR) measurements using the rotating disk electrode (RDE) method confirmed the catalyst’s excellent ORR performance and durability. These results confirm the enhanced electrocatalytic properties and durability of PtFe₂Cu/rGO, attributable to the synergistic effect of alloying and the high conductivity of the rGO support. The use of a microwave-assisted green synthesis process reduces energy consumption and chemical waste, aligning with the principles of green chemistry. This work provides a cost-effective and sustainable solution for clean energy conversion and directly supports the United Nations Sustainable Development Goal 7 (Affordable and Clean Energy).</p></div>","PeriodicalId":653,"journal":{"name":"Journal of Nanoparticle Research","volume":"27 8","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145145755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fabrication of visible light-driven magnetically separable Ag3PO4/Fe3O4/g-C3N4 photo catalyst for tetracycline degradation","authors":"Akshay Verma,&nbsp;Pooja Dhiman,&nbsp;Chin Wei Lai,&nbsp;Mu. Naushad,&nbsp;Alberto García-Peñas,&nbsp;Amit Kumar,&nbsp;Gaurav Sharma","doi":"10.1007/s11051-025-06392-1","DOIUrl":"10.1007/s11051-025-06392-1","url":null,"abstract":"<div><p>The growing presence of antibiotics in wastewater is a major environmental concern, highlighting the need for effective methods to break them down. This study explores the photocatalytic performance of a Z-scheme Ag₃PO₄/Fe₃O₄/g-C₃N₄ nanocomposite for the removal of tetracycline (TC), a widely used antibiotic and emerging water pollutant. The nanocomposite was prepared using a simple physical mixing approach, ensuring uniform dispersion and strong interfacial interaction among the components. Comprehensive characterization methods including XRD, FTIR, SEM, TEM, BET, VSM, and UV–vis spectroscopy confirmed the formation of a well-structured ternary system with large surface area, efficient visible-light absorption, and superparamagnetic properties, with a saturation magnetization of 3.241 emu g⁻¹. Under optimal photocatalytic conditions (TC concentration: 10 ppm, catalyst dose: 40 mg, pH = 7), the photocatalyst achieved a high degradation efficiency of 94.32% within 90 min. The reaction followed pseudo-first-order kinetics with a calculated rate constant of 0.0307 min⁻¹. This improved efficiency is ascribed to the synergistic interaction of Fe₃O₄, Ag₃PO₄, and g-C₃N₄ constructing a Z-scheme heterojunction. This structure facilitates efficient charge carrier separation, enhances light absorption, and increases the number of active sites by expanding the surface area. Radical scavenging experiments identified superoxide (^●O₂⁻) and hydroxyl (^●OH) radicals as the key reactive species, confirming the operation of a Z-scheme charge transfer mechanism that enhances charge separation and suppresses recombination. The catalyst demonstrated excellent reusability, retaining 86.98% of its photocatalytic activity after five consecutive cycles. These results highlight the potential of Ag₃PO₄/Fe₃O₄/g-C₃N₄ as a robust, magnetically separable, and environmentally friendly photocatalyst for efficient antibiotic removal from wastewater.</p></div>","PeriodicalId":653,"journal":{"name":"Journal of Nanoparticle Research","volume":"27 8","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145145050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel double-layer MIL-88B(Fe/Co)/RGO composite as a superior microwave shielding material","authors":"Mohamed E. Elmowafy,&nbsp;Mahmoud Zorainy,&nbsp;Osama Abuzalat,&nbsp;Ahmed Baraka,&nbsp;Ramy Sadek,&nbsp;Hesham Tantawy","doi":"10.1007/s11051-025-06393-0","DOIUrl":"10.1007/s11051-025-06393-0","url":null,"abstract":"<div><p>In the quest for environmentally friendly materials with enhanced electromagnetic interference (EMI) shielding capabilities, carbon-based materials and metal–organic frameworks (MOFs) have shown significant promise. This study focuses on synthesizing a bimetallic ferromagnetic MOF [MIL-88B(Fe/Co)], in combination with graphene oxide (GO), to assess their EMI shielding performance as a composite. Controlled pyrolysis of the MOF/GO composites with varying GO content (15%, 20%, and 30%) led to partial decomposition of the MOF structure (P-Co-Fe-MOF) while preserving its crystallographic integrity and reducing GO to its reduced form (RGO). The resulting P-Co-Fe-MOF/RGO composites were evaluated at different loadings (0.5 g, 1 g, 1.5 g, and 2 g), with the P-Co-Fe-MOF/RGO30 composite exhibiting the highest EMI shielding efficiency. Based on these findings, a double-layer structure was designed, where the first layer was composed of the bimetallic MIL-88B(Fe/Co) framework. The second layer, consisting of pyrolyzed MOF combined with RGO, achieves a remarkable total shielding effectiveness (<i>SE</i>_<i>T</i>) of 33 dB within the X-band range, attenuating nearly 99% of electromagnetic waves. This innovative double-layer structure demonstrates high shielding performance, offering a promising approach for developing effective EMI shielding materials.</p></div>","PeriodicalId":653,"journal":{"name":"Journal of Nanoparticle Research","volume":"27 8","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s11051-025-06393-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145145047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Construction of pH-mutation responsive NIR-II fluorophore for imaging of tumor cells","authors":"Xinxin Wu,&nbsp;Yang Wang,&nbsp;Yuyou Huang,&nbsp;Jiayun Xu,&nbsp;Quan Cheng","doi":"10.1007/s11051-025-06406-y","DOIUrl":"10.1007/s11051-025-06406-y","url":null,"abstract":"<div><p>The pH-responsive second near infrared window (NIR-II) probes, used at the subcellular range, are unfrequent. Here, we designed and synthesized the NIR-II fluorescence probes ETN and mPE-NPS with significant pH response property and unique fluorescence mutation range (pH 4.5–5.0). It was worth noting that the mPE-NPS probe exhibited favorable biocompatibility and excellent NIR-II tumor cellular imaging capability, which is expected to be used for specific NIR-II fluorescence imaging of subcellular structures.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":653,"journal":{"name":"Journal of Nanoparticle Research","volume":"27 8","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145144861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potentiality of gold-doped small tin clusters as lung cancer detectors: a DFT investigation","authors":"Md. Ahsan Habib,&nbsp;Mst. Tania Khatun,&nbsp;Eshrat Ashraf Ema,&nbsp;Mimi Saha Katha,&nbsp;Noor Ahammad,&nbsp;Aoly Ur Rahman,&nbsp;Md. Kabir Uddin Sikder","doi":"10.1007/s11051-025-06403-1","DOIUrl":"10.1007/s11051-025-06403-1","url":null,"abstract":"<div><p>Lung cancer (LC) is the foremost global cause of mortality, and its growing threat continues owing to the inability to diagnose it. In recent years, the research on lower-dimensional nanomaterial-based sensors has garnered extensive attention as a non-invasive as well as inexpensive LC detector by sensing specific volatile organic compounds (VOCs) associated with the exhaled breath of patients. In this study, we employed the density functional theory (DFT) approach implying B3LYP hybrid functional along with LanL2DZ basis set in the Gaussian 09 software package to comprehend the potentiality of tin clusters (Sn₈) doped with transition metal gold (Au) in two distinct positions as LC detector material by adsorbing two VOCs, Isoprene (C₅H₈) and Benzene (C₆H₆). The analysis of the adsorption mechanism reveals that Au-doped Sn clusters have greater sensitivity towards both the targeted VOCs compared to the pristine cluster. Among all the nanoclusters, the Sn₆-Au_{_S}-Au__M exhibited a 46.88% increase in C₅H₈ adsorption and a 54.80% increase in C₆H₆ adsorption compared to the pristine Sn₈ nanocluster, suggesting its potentiality as a valuable sensor material for detecting lung cancer by identifying VOCs. Further, to comprehend the sensing behavior, an extensive analysis of crucial parameters, including minimum adsorbing distance, charge analysis, molecular orbital analysis, and density of states (DOS) spectrum have been investigated along with thermodynamic behavior for the VOCs adsorbed systems which has revealed the feasibility of Sn₆-Au_{_S}-Au_{_M} nanocluster as a sensor material for lung cancer detector.</p></div>","PeriodicalId":653,"journal":{"name":"Journal of Nanoparticle Research","volume":"27 8","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145144713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Melting entropy and enthalpy of metallic nanoparticles: size and shape effects","authors":"Nguyen Van Phuoc,&nbsp;Nguyen Trong Tam,&nbsp;Ho Khac Hieu","doi":"10.1007/s11051-025-06402-2","DOIUrl":"10.1007/s11051-025-06402-2","url":null,"abstract":"<div><p>This work provides a comprehensive theoretical study on the size and shape dependence of melting entropy and enthalpy for metallic nanoparticles by utilizing the bond energy framework. Numerical computations have been carried out for silver (Ag), copper (Cu), indium (In), and tin (Sn) nanoparticles up to 50 nm with various shapes. Our theoretical predictions are validated by comparing with reported experimental data, molecular simulations, and previous theoretical calculations. Our findings reveal that both melting entropy and enthalpy rise sharply with size when the nanoparticle diameter is smaller than 10 nm. Beyond this range, melting entropy and enthalpy tend to converge toward those of bulk material, highlighting the significant role of surface effects in the thermodynamic properties of metallic nanoparticles. The size presents a stronger influence than shape on nanoparticle melting enthalpy and entropy.</p></div>","PeriodicalId":653,"journal":{"name":"Journal of Nanoparticle Research","volume":"27 8","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145144523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Environmental (aquatic) exposure reduction of product released engineered nanomaterials: safer-by-design approach","authors":"Mbuyiselwa Shadrack Moloi,&nbsp;Raisibe Florence Lehutso,&nbsp;Lehlohonolo Trinity Thato Motaung,&nbsp;Mariana Erasmus,&nbsp;Paul J. Oberholster,&nbsp;Melusi Thwala","doi":"10.1007/s11051-025-06395-y","DOIUrl":"10.1007/s11051-025-06395-y","url":null,"abstract":"<div><p>Environmental exposure and impact of engineered nanomaterials (ENMs) have the potential to induce various undesirable effects. To mitigate these effects, the safer-by-design (SbD) approach for ENMs synthesis and formulation of nano-enabled products (NEPs) has been proposed. The current study investigated the application of SbD (to reduce the ENMs’ release from the product matrix) in the formulation of skin moisturisers, focusing on reducing ENMs concentrations in the NEPs. Specifically, industrial cosmetic titania (nT-Avo) was incorporated into skin moisturisers at different concentrations [1.5, 5, and 10% (w/v)] to assess the effects of T-Avo reduction on the potential for ENMs environmental exposure. The incorporated needle-like (31.45 × 9.499 nm) nT-Avo particles coated with a silicon (Si) layer were negatively charged and in the rutile phase. The incorporation into skin moisturisers did not affect their physicochemical properties; nT-Avo maintained their morphology (needle-like shape, 28.68–32.53 × 10.50–11.24 nm), negative zeta potential (− 44.04 to − 76.67 mV) and Si coating. The reduction of T-Avo from 10 to 5% reduced nT-Avo release by 30%, indicating the effectiveness of reducing ENMs in the NEPs to reduce their environmental exposure. ENMs concentration reduction from 10 to 5% did not affect the functional efficiency; the moisturiser met the required UV protection standards (SPF = 21). However, reduction from 5 to 1.5% indicated the loss of functional efficiency (SPF 21.01 vs 2.72). The current findings illustrate that it is possible for manufacturers to minimise nanopollution at the product formulation stage whilst retaining envisaged nanofunctionality. The study demonstrated SbD application for commercial products. For products that exhibit a high likelihood to emit ENMs, manufacturers are encouraged to investigate the optimisation of environmental safety-informed design of their products.</p></div>","PeriodicalId":653,"journal":{"name":"Journal of Nanoparticle Research","volume":"27 8","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s11051-025-06395-y.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145144522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative analysis of Co–Pt clusters using Gupta potential with two parameter sets","authors":"Xia Wu,&nbsp;Yue Zhang","doi":"10.1007/s11051-025-06399-8","DOIUrl":"10.1007/s11051-025-06399-8","url":null,"abstract":"<div><p>The configurations of Co–Pt clusters exhibit significant dependence on the parameterization of the potential function. A comparative analysis of Co–Pt bimetallic clusters using the Gupta potential with two parameter sets (P_I and P_II) is performed. Parameter set P_I was derived by fitting bulk properties, while P_II combined homo- and heteronuclear interactions from binary clusters. Structural optimizations for 38-, 98-, and partial 147-atom Co–Pt clusters were carried out using adaptive immune optimization algorithms (AIOA) and its variants. The results reveal significant parameter-dependent structural differences: in 98-atom Co–Pt clusters, P_I favors truncated octahedral (TO) and Leary tetrahedral (LT) motifs, whereas P_II stabilizes LT and icosahedral (Ih) configurations. Atomic pressure analysis highlights stronger compressive/tensile stresses in P_I-derived clusters, attributed to variations in Co–Co and Co–Pt bond strengths. Excess energy calculations identify Co₅₆Pt₄₂ as the most stable composition for P_II. These findings emphasize the critical role of parameterization in predicting cluster geometries and atomic distributions, with implications for catalytic and magnetic applications.</p></div>","PeriodicalId":653,"journal":{"name":"Journal of Nanoparticle Research","volume":"27 8","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145144088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}