Samvit G. Menon, K. S. Choudhari, S. A. Shivashankar, Suresh D. Kulkarni
{"title":"Ten-minute synthesis of ZnAl2O4nanoparticles by rapid annealing: dopant-inducedacceleration in the crystal growth","authors":"Samvit G. Menon, K. S. Choudhari, S. A. Shivashankar, Suresh D. Kulkarni","doi":"10.1007/s11051-025-06423-x","DOIUrl":"10.1007/s11051-025-06423-x","url":null,"abstract":"<div><p>Rapid annealing (RA) technique was used for the swift synthesis of doped and undoped ZnAl<sub>2</sub>O<sub>4</sub> nanoparticles. For a set temperature of 800 °C and heating rates of 150–200 °C/min, the corresponding hydroxide precursors transformed into crystalline and phase-pure ZnAl<sub>2</sub>O<sub>4</sub> within 10 min. The influence of Fe<sup>3+</sup>, Cr<sup>3+</sup>, and Co<sup>2+</sup> doping in ZnAl<sub>2</sub>O<sub>4</sub> was studied to determine the time taken to form phase pure materials by rapid annealing. Crystallites obtained were larger for Co<sup>2+</sup> and Cr<sup>3+</sup>-doping compared to undoped and Fe<sup>3+</sup>-doped ZnAl<sub>2</sub>O<sub>4</sub>. With higher Cr<sup>3+</sup> doping, larger crystallites were obtained, probably due to higher thermal radiation absorption by the Cr<sup>3+</sup>. Structural investigations showed a direct relationship between the dopant ion and the extent of material crystallization. Comparatively, larger crystallites for Cr<sup>3</sup>⁺- and Co<sup>2</sup>⁺-doped samples indicate that beyond conventional thermal effects, the absorption cross section of the doped samples significantly influenced the crystallization process. To test the growth dependence on these ions, Cr<sub>2</sub>O<sub>3</sub> was synthesized under similar conditions. Surprisingly, the crystal growth was ten times higher (Cr<sub>2</sub>O<sub>3</sub> —47 nm; ZnCr<sub><i>x</i></sub>Al<sub>2−<i>x</i></sub>O<sub>4</sub> — ~ 5 nm) within the same 10-min synthesis. The individual nanoparticles were single-crystalline, as seen from HRTEM proving that the nature of dopant has a crucial role in the accelerated crystal growth using RA. Compared to the usual high temperature and longer durations required for the synthesis of ceramic materials, our approach is novel being swift, energy efficient, and reliable. This opens up the possibility of implementing RA as an effective technique for synthesizing various nanoparticles in quick time.</p></div>","PeriodicalId":653,"journal":{"name":"Journal of Nanoparticle Research","volume":"27 9","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144853562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ildefonso Zamudio-Torres, José de Jesús Pérez Bueno, Adrián Sosa Domínguez, Maria Luisa Mendoza López, Hugo Martínez Gutiérrez
{"title":"Fused TiO2—Al2O3 microspheres through corona electrical arcs on TiO2 nanotubes surfaces of anodized titanium","authors":"Ildefonso Zamudio-Torres, José de Jesús Pérez Bueno, Adrián Sosa Domínguez, Maria Luisa Mendoza López, Hugo Martínez Gutiérrez","doi":"10.1007/s11051-025-06421-z","DOIUrl":"10.1007/s11051-025-06421-z","url":null,"abstract":"<div><p>Microspheres based on TiO<sup>2</sup> and TiO<sup>2</sup>–Al<sup>2</sup>O<sup>3</sup> were obtained by applying corona electrical discharges to the surfaces of anodized titanium. The high-voltage arc plasma, characterized by localized temperatures exceeding 3000 °C, melted and projected segments of the TiO<sup>2</sup> nanotube layer. During the brief flight in ambient air, the molten material underwent surface tension–driven spheroidization and rapid solidification, forming microspheres with diameters ranging from 45 to 300 nm. The nanotube layers, previously grown by anodization on sandblasted or polished industrial-grade Ti, exhibited distinct morphologies and compositions depending on the surface preparation. Sandblasting led to Al<sup>2</sup>O<sup>3</sup> contamination from the abrasive media, resulting in Al incorporation into the fused microspheres. The spherical geometry of the products supports the occurrence of complete melting followed by rapid quenching. This work demonstrates a route for transforming non-uniform nanotube films into robust microspheres suitable for photocatalytic and environmental applications. The method bridges morphological control and material reuse by exploiting localized high-temperature plasma processing.</p></div>","PeriodicalId":653,"journal":{"name":"Journal of Nanoparticle Research","volume":"27 8","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144843300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Waqas Ul Arifeen, Ali Riza, Humaira Rashid Khan, P. Rosaiah, Abdullah K. Alanazi, Iftikhar Hussain, Saood Ali, Tae Jo Ko
{"title":"Facile synthesis of vertically aligned Ni-In2O3 nanoflakes for supercapacitors","authors":"Waqas Ul Arifeen, Ali Riza, Humaira Rashid Khan, P. Rosaiah, Abdullah K. Alanazi, Iftikhar Hussain, Saood Ali, Tae Jo Ko","doi":"10.1007/s11051-025-06422-y","DOIUrl":"10.1007/s11051-025-06422-y","url":null,"abstract":"<div><p>The worldwide growing demand for energy and the depletion of conventional fossil fuel resources have intensified the search for sustainable and high-efficiency energy storage systems. Supercapacitors have gained significant attention because of their high-power density, fast charging and discharging capabilities, and long-life span. This study focuses on developing and analyzing vertically aligned Ni-In<sub>2</sub>O<sub>3</sub> nanoflakes for high-performance supercapacitors. The nanostructured electrode material was fabricated via a facile single-step hydrothermal process and systematically analyzed using various techniques. The Ni-In<sub>2</sub>O<sub>3</sub> nanoflakes electrode exhibited specific capacitance of 860 F g<sup>−1</sup> at current density of 1 A g<sup>−1</sup>, along with excellent rate performance, and low internal resistance. The Ni-In<sub>2</sub>O<sub>3</sub> electrode exhibited a cyclic stability of 71.9% and maintaining Coulombic efficiency of 99% after 3,000 charge–discharge cycles. These results suggest that Ni-In<sub>2</sub>O<sub>3</sub> nanoflakes could be highly effective electrode materials for next-generation sustainable energy storage systems.</p></div>","PeriodicalId":653,"journal":{"name":"Journal of Nanoparticle Research","volume":"27 8","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144843301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tanmay Mandal, Suranjana V. Mayani, Suhas Ballal, Abhayveer Singh, Subhashree Ray, Atreyi Pramanik, Kamal Kant Joshi
{"title":"Sustainable β-hydroxy sulfide synthesis using a recyclable magnetic copper nanocatalyst","authors":"Tanmay Mandal, Suranjana V. Mayani, Suhas Ballal, Abhayveer Singh, Subhashree Ray, Atreyi Pramanik, Kamal Kant Joshi","doi":"10.1007/s11051-025-06397-w","DOIUrl":"10.1007/s11051-025-06397-w","url":null,"abstract":"<div><p>Magnetic nanocatalysts have attracted significant attention in organic chemistry due to their high efficiency, recyclability, and eco-friendly nature. In this study, we report the synthesis and application of Fe<sub>3</sub>O<sub>4</sub>@SiO<sub>2</sub>-Gly-ImH-CuI, a novel magnetic copper catalyst, fabricated by immobilizing CuI onto Fe<sub>3</sub>O<sub>4</sub>@SiO<sub>2</sub> nanoparticles functionalized with glycyl imidazole. The catalyst was employed in a one-pot, three-component synthesis of <i>β</i>-hydroxy sulfide derivatives using aryl and heteroaryl iodides, 2-phenyloxirane derivatives, and carbon disulfide. The reaction proceeded under mild conditions using glycerol as a green solvent and potassium bicarbonate as a base, yielding high amounts of the desired products. The strong magnetic properties of Fe<sub>3</sub>O<sub>4</sub>@SiO<sub>2</sub>-Gly-ImH-CuI enabled effortless separation from the reaction mixture, and the catalyst retained its high catalytic activity over eight consecutive cycles. Comprehensive characterization techniques confirmed the catalyst’s structural integrity and stability, including FT-IR, SEM, TEM, VSM, BET, XRD, and ICP-OES. This catalyst’s remarkable efficiency, ease of recovery, and outstanding recyclability highlight its potential for sustainable green chemistry applications, offering an environmentally friendly alternative for the synthesis of valuable organic compounds.</p></div>","PeriodicalId":653,"journal":{"name":"Journal of Nanoparticle Research","volume":"27 8","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144843268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Faiz Ali, Imran Khan, Sana Begum, Zeid A. AlOthman, Won Jo Cheong
{"title":"Silica-incorporated molecularly imprinted polymers for removal of acid black ATT via solid-phase extraction","authors":"Faiz Ali, Imran Khan, Sana Begum, Zeid A. AlOthman, Won Jo Cheong","doi":"10.1007/s11051-025-06415-x","DOIUrl":"10.1007/s11051-025-06415-x","url":null,"abstract":"<div><p>Silica-incorporated molecular imprinted polymer (SiO<sub>2</sub>@MIP) was synthesized via bulk polymerization using methacrylic acid (MAA) as a functional monomer and acid black ATT as the template molecule, while the corresponding non-imprinted polymer (SiO<sub>2</sub>@NIP) was prepared in the absence of the template. The polymer was characterized via SEM, FTIR, EDX, and XRD. The effect of contact time, pH, temperature, and initial dye concentration was optimized. The adsorption mechanism followed the pseudo-second order kinetic (<i>K</i><sub>2</sub> = 0.0028 mg g<sup>−1</sup>) model. The values of (∆H˚ = −12.7486 kJ/mol), and (∆S˚ = − 12.749 J/mol) suggested that the adsorption of acid black ATT is a spontaneous exothermic process. The MIP was evaluated as the solid phase extraction media with very good results owing to its striking features such as mechanical strength, selective adsorption with very high recyclability for the acid black ATT, ease of handling, and cost effectiveness contributing to green chemistry. The silica-incorporated MIP polymer networking proved very effective in the overall adsorption characteristics of the resultant material. The resultant MIP was applied for the removal of dyes from spiked water samples (tap water, river water, and distilled water) with adsorption higher than 90%.\u0000</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":653,"journal":{"name":"Journal of Nanoparticle Research","volume":"27 8","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144832134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mahmoud A. A. Ibrahim, Manar H. A. Hamad, Mohammed N. I. Shehata, Shahzeb Khan, Stève-Jonathan Koyambo-Konzapa, Tamer Shoeib, Ahmed Rady
{"title":"DFT insights into the sensitivity of pure and TM-doped Be12O12 nanocages (TM = Cr and Fe) toward hydrides of group V elements (XH3; X = N, P, and As)","authors":"Mahmoud A. A. Ibrahim, Manar H. A. Hamad, Mohammed N. I. Shehata, Shahzeb Khan, Stève-Jonathan Koyambo-Konzapa, Tamer Shoeib, Ahmed Rady","doi":"10.1007/s11051-025-06416-w","DOIUrl":"10.1007/s11051-025-06416-w","url":null,"abstract":"<div><p>The potency of pure and transition metal (TM)–doped Be<sub>12</sub>O<sub>12</sub> nanocages (TM = Cr and Fe) toward the adsorption of XH<sub>3</sub> gases (X = N, P, and As) was minutely studied through different DFT computations. Upon the obtained energetic findings, the TM doping significantly escalated the efficacy of the investigated nanocage toward sensing XH<sub>3</sub> toxic molecules. From the energetic affirmations, the most appreciable negative adsorption and interaction energies were observed within the XH<sub>3</sub>∙∙∙CrBe<sub>11</sub>O<sub>12</sub> complexes with values up to −35.85 and −36.47 kcal/mol, respectively. The interpretations of the symmetry-adapted perturbation theory pointed out that the electrostatic force was regarded as the prevalent contribution in the adsorption process within the XH<sub>3</sub>∙∙∙Be<sub>12</sub>O<sub>12</sub> and ∙∙∙TMBe<sub>11</sub>O<sub>12</sub> complexes. An extensive investigation of the noncovalent interaction index and the quantum theory of atoms in molecules analyses pinpointed the partially covalent nature of the interactions within the XH<sub>3</sub>∙∙∙Be<sub>12</sub>O<sub>12</sub> and ∙∙∙TMBe<sub>11</sub>O<sub>12</sub> complexes. The observable alterations in the molecular orbitals distributions and global reactivity descriptors of the Be<sub>12</sub>O<sub>12</sub> and TMBe<sub>11</sub>O<sub>12</sub> nanocages after the complexation ensured the occurrence of the scouted adsorption process. In light of the calculated thermodynamic parameters, the XH<sub>3</sub>∙∙∙TMBe<sub>11</sub>O<sub>12</sub> complexes were noticed with more negative values compared to the XH<sub>3</sub>∙∙∙Be<sub>12</sub>O<sub>12</sub> ones, affirming the effect of doping in enhancing the sensitivity of the nanocage. The outcomes of this study will provide a durable ground for the experimentalists to gain a comprehensive grasp of the efficacy of the Be<sub>12</sub>O<sub>12</sub> and TMBe<sub>11</sub>O<sub>12</sub> nanocages in sensing toxic molecules, particularly XH<sub>3</sub> toxic molecules.</p></div>","PeriodicalId":653,"journal":{"name":"Journal of Nanoparticle Research","volume":"27 8","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144832297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Niklas Kost, Oleg Prymak, Kateryna Loza, Marc Heggen, Cristiano L. P. Oliveira, Christine Beuck, Peter Bayer, Matthias Epple
{"title":"Synthesis and characterization of ultrasmall rhenium nanoparticles (1.5 nm)","authors":"Niklas Kost, Oleg Prymak, Kateryna Loza, Marc Heggen, Cristiano L. P. Oliveira, Christine Beuck, Peter Bayer, Matthias Epple","doi":"10.1007/s11051-025-06420-0","DOIUrl":"10.1007/s11051-025-06420-0","url":null,"abstract":"<div><p>Ultrasmall rhenium nanoparticles were prepared by a reduction of rhenium trichloride with sodium borohydride in water capped with the tripeptide glutathione. The particles were approximately spherical with an average diameter of 1.5 nm and had a high degree of internal crystallinity as shown by transmission electron microscopy and X-ray powder diffraction. They were well dispersible in water as differential centrifugal sedimentation (DCS), <sup>1</sup>H-NMR DOSY spectroscopy (nuclear magnetic resonance–diffusion-enhanced spectroscopy), and small-angle X-ray scattering (SAXS) showed. <sup>1</sup>H-NMR spectroscopy and <sup>13</sup>C-NMR spectroscopy confirmed that glutathione was attached to the nanoparticle via the terminal thiol group of cysteine. Upon heating in oxygen, the nanoparticles were converted into dirhenium heptoxide which evaporated above 360 °C.\u0000</p></div>","PeriodicalId":653,"journal":{"name":"Journal of Nanoparticle Research","volume":"27 8","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s11051-025-06420-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144832298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Wei Yee Low, Fuei Pien Chee, Norini Tahir, Nur Amira Solehah Pungut, Mohd Hafiz Abd Majid, Rachel Fran Mansa, Siow Hwa Teo, Pak Yan Moh
{"title":"MIL-125-NH2/MIL-88-NH2 composite as a dual-function adsorbent with enhanced photocatalytic and photo-Fenton-like behavior for the removal of organic pollutant in water","authors":"Wei Yee Low, Fuei Pien Chee, Norini Tahir, Nur Amira Solehah Pungut, Mohd Hafiz Abd Majid, Rachel Fran Mansa, Siow Hwa Teo, Pak Yan Moh","doi":"10.1007/s11051-025-06408-w","DOIUrl":"10.1007/s11051-025-06408-w","url":null,"abstract":"<div><p>Metal–organic frameworks are nanoporous materials extensively studied for post-synthesis modification due to their exceptional adsorption and photocatalytic properties. However, their practical application is often limited by rapid electron–hole recombination, suboptimal band gap energies, and poor chemical and physical stability, limiting their reusability as adsorbents or photocatalysts. In this study, a novel <i>Z</i>-scheme MIL-125-NH<sub>2</sub>/MIL-88-NH<sub>2</sub> composite was synthesized via reflux heating method. The composite demonstrated improved thermal stability compared to MIL-125-NH<sub>2</sub> and a higher surface area than MIL-88-NH<sub>2</sub>, improving the physical and chemical properties. It selectively adsorbed cationic pollutants, following Langmuir isotherm with monolayer adsorption and physisorption mechanisms achieving a maximum adsorption capacity of 249 mg/g towards methylene blue (MB). Photocatalytic degradation of MB under visible and UV-A light irradiation reached 61% (<i>k</i><sub>1</sub> = 0.0067 min<sup>−1</sup>) and 69% (<i>k</i><sub>1</sub> = 0.0087 min<sup>−1</sup>), respectively. The addition of 1 mM hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>), tripling MB removal to 89% removal (<i>k</i><sub>1</sub> = 0.0155 min<sup>−1</sup>) under visible light and 94% removal (<i>k</i><sub>1</sub> = 0.0217 min<sup>−1</sup>) under UV-A light. The synergistic effect of MIL-125-NH<sub>2</sub>/MIL-88-NH<sub>2</sub> composite surpassed MIL-125-NH<sub>2</sub>/H<sub>2</sub>O<sub>2</sub>/UV-A (<i>k</i><sub>1</sub> = 0.0024 min<sup>−1</sup>) and MIL-88-NH<sub>2</sub>/H<sub>2</sub>O<sub>2</sub>/UV-A (<i>k</i><sub>1</sub> = 0.0150 min<sup>−1</sup>). Scavenger experiments identified hole (<i>h</i><sup>+</sup>) and electron (<i>e</i><sup>−</sup>) were the primary active species while hydroxyl radical (·OH) and superoxide (·O<sub>2</sub><sup>−</sup>) also played key roles, with their generation further amplified by H<sub>2</sub>O<sub>2</sub>. These findings demonstrate the enhanced photocatalytic performance of the MIL-125-NH<sub>2</sub>/MIL-88-NH<sub>2</sub> composite, attributed to its Z-scheme heterojunction structure and photo-Fenton-like behavior. The composite exhibits a promising stability and capability in advanced water treatment applications.</p><h3>Graphical Abstract</h3><p>Schematic illustration of the photocatalytic mechanism of MIL-125-NH<sub>2</sub>/MIL-88-NH<sub>2</sub> composite under visible and UV-A light with H<sub>2</sub>O<sub>2</sub> activation.</p>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":653,"journal":{"name":"Journal of Nanoparticle Research","volume":"27 8","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s11051-025-06408-w.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145142871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Enhancing thermoelectric properties in zigzag bismuth nanoribbons via introduction of random impurities","authors":"Hossein Karbaschi","doi":"10.1007/s11051-025-06382-3","DOIUrl":"10.1007/s11051-025-06382-3","url":null,"abstract":"<div><p>In this study, we explore the effects of introducing random impurities into zigzag bismuth nanoribbons on their edge states and thermoelectric properties. Bismuth nanoribbons with zigzag edges are known for their unique electronic properties, particularly the presence of robust edge states that significantly influence their thermoelectric performance. By strategically incorporating random impurities into the nanoribbons, we aim to manipulate and separate these edge states, thereby enhancing the overall thermoelectric efficiency. Our results demonstrate that the introduction of impurities effectively decouples the edge states from the bulk states, leading to a clear enhancement in thermoelectric properties. This indicates the potential of this method for developing advanced thermoelectric materials. This approach opens new avenues for the design of high-performance thermoelectric devices through impurity engineering in low-dimensional materials.</p></div>","PeriodicalId":653,"journal":{"name":"Journal of Nanoparticle Research","volume":"27 8","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145142798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gaayatri Silvaraju, Nur Airin Syahira Johari, Azren Aida Asmawi, Rosniza Razali, Fatmawati Adam, Yan Loo Shan, Nurul Akmarina Mohd Abdul Kamal
{"title":"Hyaluronic acid-functionalized zeolitic imidazolate framework-8 nanoparticles: a one-pot synthesis approach for breast cancer therapy","authors":"Gaayatri Silvaraju, Nur Airin Syahira Johari, Azren Aida Asmawi, Rosniza Razali, Fatmawati Adam, Yan Loo Shan, Nurul Akmarina Mohd Abdul Kamal","doi":"10.1007/s11051-025-06412-0","DOIUrl":"10.1007/s11051-025-06412-0","url":null,"abstract":"<div><p>Effective breast cancer chemotherapy is hindered by dose-limiting systemic toxicity and off-target effects of conventional chemotherapeutics. Here we report a one-pot, surfactant-free solvothermal synthesis of hyaluronic acid-functionalized Zeolitic Imidazolate Framework-8 nanoparticles (HA@nZIF-8). The physicochemical properties of both functionalized and non-functionalized nanoparticles were characterized using characterization techniques, including powder X-ray diffraction (PXRD), Fourier transform infrared (FTIR) spectroscopy, high-resolution transmission electron microscopy (HR-TEM), scanning electron microscopy (SEM), nitrogen adsorption–desorption isotherms, and thermogravimetric analysis (TGA). SEM measured well-dispersed nanoparticles (93.5 ± 14.4 nm), whereas HR-TEM gave an average size of 127.3 ± 18.9 nm. Brunauer–Emmett–Teller (BET) surface area was reduced by 30%, corresponding to a successful surface functionalization. The HA@nZIF-8 demonstrates inhibitory effects within human breast cancer cells, MCF-7 (IC<sub>50</sub> = 21.5 ± 3.8 µg mL<sup>−1</sup>), and is selectively toxic towards cancer cells with a selectivity index (SI) of 3.8. This work indicates that surface functionalization of ZIF-8 using hyaluronic acid (HA) promotes promising in vitro cytotoxic effects with selective activity toward MCF-7 cells.</p></div>","PeriodicalId":653,"journal":{"name":"Journal of Nanoparticle Research","volume":"27 8","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s11051-025-06412-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145142676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}