Gaayatri Silvaraju, Nur Airin Syahira Johari, Azren Aida Asmawi, Rosniza Razali, Fatmawati Adam, Yan Loo Shan, Nurul Akmarina Mohd Abdul Kamal
{"title":"透明质酸功能化沸石咪唑酸框架-8纳米颗粒：一锅合成方法用于乳腺癌治疗","authors":"Gaayatri Silvaraju, Nur Airin Syahira Johari, Azren Aida Asmawi, Rosniza Razali, Fatmawati Adam, Yan Loo Shan, Nurul Akmarina Mohd Abdul Kamal","doi":"10.1007/s11051-025-06412-0","DOIUrl":null,"url":null,"abstract":"<div><p>Effective breast cancer chemotherapy is hindered by dose-limiting systemic toxicity and off-target effects of conventional chemotherapeutics. Here we report a one-pot, surfactant-free solvothermal synthesis of hyaluronic acid-functionalized Zeolitic Imidazolate Framework-8 nanoparticles (HA@nZIF-8). The physicochemical properties of both functionalized and non-functionalized nanoparticles were characterized using characterization techniques, including powder X-ray diffraction (PXRD), Fourier transform infrared (FTIR) spectroscopy, high-resolution transmission electron microscopy (HR-TEM), scanning electron microscopy (SEM), nitrogen adsorption–desorption isotherms, and thermogravimetric analysis (TGA). SEM measured well-dispersed nanoparticles (93.5 ± 14.4 nm), whereas HR-TEM gave an average size of 127.3 ± 18.9 nm. Brunauer–Emmett–Teller (BET) surface area was reduced by 30%, corresponding to a successful surface functionalization. The HA@nZIF-8 demonstrates inhibitory effects within human breast cancer cells, MCF-7 (IC<sub>50</sub> = 21.5 ± 3.8 µg mL<sup>−1</sup>), and is selectively toxic towards cancer cells with a selectivity index (SI) of 3.8. This work indicates that surface functionalization of ZIF-8 using hyaluronic acid (HA) promotes promising in vitro cytotoxic effects with selective activity toward MCF-7 cells.</p></div>","PeriodicalId":653,"journal":{"name":"Journal of Nanoparticle Research","volume":"27 8","pages":""},"PeriodicalIF":2.6000,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s11051-025-06412-0.pdf","citationCount":"0","resultStr":"{\"title\":\"Hyaluronic acid-functionalized zeolitic imidazolate framework-8 nanoparticles: a one-pot synthesis approach for breast cancer therapy\",\"authors\":\"Gaayatri Silvaraju, Nur Airin Syahira Johari, Azren Aida Asmawi, Rosniza Razali, Fatmawati Adam, Yan Loo Shan, Nurul Akmarina Mohd Abdul Kamal\",\"doi\":\"10.1007/s11051-025-06412-0\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Effective breast cancer chemotherapy is hindered by dose-limiting systemic toxicity and off-target effects of conventional chemotherapeutics. Here we report a one-pot, surfactant-free solvothermal synthesis of hyaluronic acid-functionalized Zeolitic Imidazolate Framework-8 nanoparticles (HA@nZIF-8). The physicochemical properties of both functionalized and non-functionalized nanoparticles were characterized using characterization techniques, including powder X-ray diffraction (PXRD), Fourier transform infrared (FTIR) spectroscopy, high-resolution transmission electron microscopy (HR-TEM), scanning electron microscopy (SEM), nitrogen adsorption–desorption isotherms, and thermogravimetric analysis (TGA). SEM measured well-dispersed nanoparticles (93.5 ± 14.4 nm), whereas HR-TEM gave an average size of 127.3 ± 18.9 nm. Brunauer–Emmett–Teller (BET) surface area was reduced by 30%, corresponding to a successful surface functionalization. The HA@nZIF-8 demonstrates inhibitory effects within human breast cancer cells, MCF-7 (IC<sub>50</sub> = 21.5 ± 3.8 µg mL<sup>−1</sup>), and is selectively toxic towards cancer cells with a selectivity index (SI) of 3.8. 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Hyaluronic acid-functionalized zeolitic imidazolate framework-8 nanoparticles: a one-pot synthesis approach for breast cancer therapy
Effective breast cancer chemotherapy is hindered by dose-limiting systemic toxicity and off-target effects of conventional chemotherapeutics. Here we report a one-pot, surfactant-free solvothermal synthesis of hyaluronic acid-functionalized Zeolitic Imidazolate Framework-8 nanoparticles (HA@nZIF-8). The physicochemical properties of both functionalized and non-functionalized nanoparticles were characterized using characterization techniques, including powder X-ray diffraction (PXRD), Fourier transform infrared (FTIR) spectroscopy, high-resolution transmission electron microscopy (HR-TEM), scanning electron microscopy (SEM), nitrogen adsorption–desorption isotherms, and thermogravimetric analysis (TGA). SEM measured well-dispersed nanoparticles (93.5 ± 14.4 nm), whereas HR-TEM gave an average size of 127.3 ± 18.9 nm. Brunauer–Emmett–Teller (BET) surface area was reduced by 30%, corresponding to a successful surface functionalization. The HA@nZIF-8 demonstrates inhibitory effects within human breast cancer cells, MCF-7 (IC50 = 21.5 ± 3.8 µg mL−1), and is selectively toxic towards cancer cells with a selectivity index (SI) of 3.8. This work indicates that surface functionalization of ZIF-8 using hyaluronic acid (HA) promotes promising in vitro cytotoxic effects with selective activity toward MCF-7 cells.
期刊介绍：
The objective of the Journal of Nanoparticle Research is to disseminate knowledge of the physical, chemical and biological phenomena and processes in structures that have at least one lengthscale ranging from molecular to approximately 100 nm (or submicron in some situations), and exhibit improved and novel properties that are a direct result of their small size.
Nanoparticle research is a key component of nanoscience, nanoengineering and nanotechnology.
The focus of the Journal is on the specific concepts, properties, phenomena, and processes related to particles, tubes, layers, macromolecules, clusters and other finite structures of the nanoscale size range. Synthesis, assembly, transport, reactivity, and stability of such structures are considered. Development of in-situ and ex-situ instrumentation for characterization of nanoparticles and their interfaces should be based on new principles for probing properties and phenomena not well understood at the nanometer scale. Modeling and simulation may include atom-based quantum mechanics; molecular dynamics; single-particle, multi-body and continuum based models; fractals; other methods suitable for modeling particle synthesis, assembling and interaction processes. Realization and application of systems, structures and devices with novel functions obtained via precursor nanoparticles is emphasized. Approaches may include gas-, liquid-, solid-, and vacuum-based processes, size reduction, chemical- and bio-self assembly. Contributions include utilization of nanoparticle systems for enhancing a phenomenon or process and particle assembling into hierarchical structures, as well as formulation and the administration of drugs. Synergistic approaches originating from different disciplines and technologies, and interaction between the research providers and users in this field, are encouraged.
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