中国临床实用医学最新文献_第7页

Study on the change of serum trace elements and BDNF, Hcy, Cor, neural function related factors of patients with depression before and after treatment with Olanzapine 抑郁症患者奥氮平治疗前后血清微量元素及BDNF、Hcy、Cor、神经功能相关因素变化的研究

中国临床实用医学 Pub Date : 2014-01-25 DOI: 10.3760/CMA.J.ISSN.1673-8799.2014.01.012

Xue-ying Wang, Shi-chun Li

{"title":"Study on the change of serum trace elements and BDNF, Hcy, Cor, neural function related factors of patients with depression before and after treatment with Olanzapine","authors":"Xue-ying Wang, Shi-chun Li","doi":"10.3760/CMA.J.ISSN.1673-8799.2014.01.012","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-8799.2014.01.012","url":null,"abstract":"Objective To analyze and observe the serum trace elements and BDNF,Hcy,Cor,neural function related factors of patients with depression before and after treatment with olanzapine.Methods 64 patients with depression in our hospital from October 2011 to February 2013 were selected as research object,and they were randomly divided into control group 32 cases and observation group 32 cases,the control group were treated with only sertraline,the observation group were treated with olanzapine based on the treatment of control group,then the serum trace elements and BDNF,Hcy,Cor,neural function related factors of two groups before the treatment and at 3rd and 6th week after the treatment were compared.Results The serum Cu and Fe of observation group at 3rd and 6th week after the treatment were lower than those of control group,Zn and Mn were higher than those of control group,Hcy,Cor and neural function related factors were lower than those of control group,BDNF were higher than those of control group,all P＜0.05,there were all significant differences.Conclusion The olanzapine can effectively adjust the serum trace elements and BDNF,Hcy,Cor,neural function related factors of patients with depression,and it shows a continuous improvement state. \u0000 \u0000Key words: \u0000Depression; Olanzapine; Trace elements; Brain-derived neurotrophic factor, BDNF; Homocysteine,Hcy; Cortisol,COR; Neural function related factors; Change","PeriodicalId":64135,"journal":{"name":"中国临床实用医学","volume":"5 1","pages":"27-29"},"PeriodicalIF":0.0,"publicationDate":"2014-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69973720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Research of the motion compensation after single segmental cervical spine fusion surgery 单节段颈椎融合术后运动补偿的研究

中国临床实用医学 Pub Date : 2014-01-25 DOI: 10.3760/CMA.J.ISSN.1673-8799.2014.01.006

Rui Zhang, B. Bai

引用次数: 0

Expression and clinical significance of PCNA and IRF2 in human pancreatic cancer PCNA和IRF2在人胰腺癌中的表达及临床意义

中国临床实用医学 Pub Date : 2014-01-25 DOI: 10.3760/CMA.J.ISSN.1673-8799.2014.01.014

Zhenwei Hu, Jiansheng Liu

{"title":"Expression and clinical significance of PCNA and IRF2 in human pancreatic cancer","authors":"Zhenwei Hu, Jiansheng Liu","doi":"10.3760/CMA.J.ISSN.1673-8799.2014.01.014","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-8799.2014.01.014","url":null,"abstract":"Objective To research the expression levels,clinical significance and the correlation of PCNA and IRF2 in human pancreatic cancer.Methods The expression levels of PCNA and IRF2 in 60 different cases of pancreatic cancer tissues and 30 different cases of para-pancreatic cancer tissues were investigated by Immunohistochemical SP staining and then analyzed through clinicopathological data.Results Immunohistochemical results:the positive expression rates of PCNA and IRF2 in pancreatic cancer tissues were 83.3％ and 78.3％ respectively,which were significantly higher than those in the adjacent pancreatic tissues,of which were 20.0％ and 23.3％ respectively.The differences were statistically significant (P＜0.001).The factors of age,gender,tumor site of patients with pancreatic carcinoma were not statistically significant with the expression of PCNA (P＞0.05),but other factors,such as the differentiation of pancreatic tissue,TNM stage and lymph node metastasis,were statistically significant (P＜O.05).The factors of age,sex,tumor location and lymph node metastasis of pancreatic carcinoma patients were not statistically significant with the expression of PCNA (P＞0.05),but the factors of differentiation of pancreatic tissue and TNM stage were statistically significant (P＜0.05).Moreover,the expression of PCNA and IRF2 was positively correlated (γ =0.416,P=0.001).Conclusion The abnormal expression of PCNA and IRF2 is correlated with occurrence of pancreatic cancer and the cancer cell proliferation activity. \u0000 \u0000Key words: \u0000Pancreatic Cancer; PCNA; IRF2; Immunohistochemistry","PeriodicalId":64135,"journal":{"name":"中国临床实用医学","volume":"5 1","pages":"33-35"},"PeriodicalIF":0.0,"publicationDate":"2014-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69973287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

咪达唑仑、笑气在口腔治疗清醒镇静中对血压的影响咪达唑仑、笑气在口腔治疗清醒镇静中对血压的影响

中国临床实用医学 Pub Date : 2014-01-25 DOI: 10.3760/CMA.J.ISSN.1673-8799.2014.01.027

王久国, 王霞

引用次数: 0

纳洛酮治疗老年慢性肺源性心脏病合并肺性脑病患者临床疗效和安全性观察纳洛酮治疗老年慢性肺源性心脏病合并肺性脑病患者临床疗效和安全性观察

中国临床实用医学 Pub Date : 2014-01-25 DOI: 10.3760/CMA.J.ISSN.1673-8799.2014.01.028

廖正寿, 唐云, 唐诚江, 罗小春, 张耀灵

{"title":"纳洛酮治疗老年慢性肺源性心脏病合并肺性脑病患者临床疗效和安全性观察","authors":"廖正寿, 唐云, 唐诚江, 罗小春, 张耀灵","doi":"10.3760/CMA.J.ISSN.1673-8799.2014.01.028","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-8799.2014.01.028","url":null,"abstract":"目的研究慢性肺源性心脏病合并肺性脑病的老年患者临床上应用纳洛酮进行治疗的临床效果,以及临床用药的安全性.方法选择深圳市宝安区沙井人民医院2010年11月至2012年12月收治的160例慢性肺源性心脏病合并肺性脑病的老年患者,随机均分为两组,对照组患者进行持续低流量鼻导管吸氧,氧流量为1～3 L/min,给氧浓度为25％～35％,积极对抗感染,止咳化痰,保持酸碱及电解质平衡,解痉平喘以及营养支持等.治疗组患者在上述治疗的基础上给予纳洛酮进行治疗.结果治疗组患者的总有效率为85％,对照组总有效率为60％,两组患者的临床疗效差异有统计学意义.治疗组患者的血pH值、PaO2、PaCO2指标值均优于对照组,两组差异有统计学意义(P＜0.05).结论对慢性肺源性心脏病合并肺性脑病的老年患者应用纳洛酮进行治疗,临床效果较为显著,能显著提高血PaO2、pH值,同时降低PaCO2,用药后患者未出现明显的不良反应,减少了患者恢复清醒的时间,值得在临床推广使用。","PeriodicalId":64135,"journal":{"name":"中国临床实用医学","volume":"5 1","pages":"58-59"},"PeriodicalIF":0.0,"publicationDate":"2014-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69973584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

低位直肠癌保肛手术中直肠冲洗治疗对预后的影响低位直肠癌保肛手术中直肠冲洗治疗对预后的影响

中国临床实用医学 Pub Date : 2014-01-25 DOI: 10.3760/CMA.J.ISSN.1673-8799.2014.01.036

闫保功

引用次数: 0

The relationship between children with Helicobacter pylori infection and gastroduodenal disease 儿童幽门螺杆菌感染与胃十二指肠疾病的关系

中国临床实用医学 Pub Date : 2014-01-25 DOI: 10.3760/CMA.J.ISSN.1673-8799.2014.01.007

Zeng-bin Xu, Xianglian Li, Shenghua Wan

{"title":"The relationship between children with Helicobacter pylori infection and gastroduodenal disease","authors":"Zeng-bin Xu, Xianglian Li, Shenghua Wan","doi":"10.3760/CMA.J.ISSN.1673-8799.2014.01.007","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-8799.2014.01.007","url":null,"abstract":"Objective To explore the relationship among different types of Helicobacter pylori (HP),the gastroduodenal disease type and the severity of gastric mucosal inflammation in childhood.Methods By western blot method to detect serum antibodies of CagA and VacA obtained from 112 patients infected by HP-related Chronic Gastritis (CG) and Peptic ulcer (PU).and observe the pathologic changes of gastric mucosa.Results In 112 cases,the CagA,VacA antibody detection rate was 82.14％ and 82.14％,no significant difference (P＞0.05).The detection rate of CagA,VacA antibodies in patients with chronic gastritis (CG) was 79.10％ and 83.58％,and in patients with Peptic ulcer (PU) was 86.67％ and 91.11％,The detection rate of CagA,VacA antibody in PU,CG had no obvious difference (P＞0.05).Of 112 cases of children with Hp infection,I type HP accounted for 80.36％,Ⅱ type HP accounted for 11.61％ and intermediate type accounted for 8.03％,No significant differences existed in the detection rate of these three types of HP in CG or PU (P＞0.05); Among the 90 patients with Ⅰ type HP,92.22％ of them caused severe gastric mucosal inflammation,7.78％ of them got mild inflammation.23.08％of 13 patients with Ⅱ type HP and 55.56％ of 9 patients with intermediate type HP got severe gastric mucosal inflammation,which showed that the differences are significant (P＜0.01).Conclusion CagA and VaCA are closely related to the onset of CG and PU,but can not be used as the basis for judging the onset of CG and PU,when children infected with Ⅰ type HP,their gastric mucosa suffers the greatest damage,they should be treated actively. \u0000 \u0000Key words: \u0000Helicobacter pylori,children; Cytotoxin associated protein; Vacuolating toxin protein; Antibody; Chronic Gastritis; Ulcer","PeriodicalId":64135,"journal":{"name":"中国临床实用医学","volume":"5 1","pages":"15-17"},"PeriodicalIF":0.0,"publicationDate":"2014-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69973667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

The repairing of the soft tissue defect in the eyebrow area with hatchet skin flap 短柄皮瓣修复眉区软组织缺损

中国临床实用医学 Pub Date : 2014-01-25 DOI: 10.3760/CMA.J.ISSN.1673-8799.2014.01.017

Wei Feng, N. Luo, Tairan Li, Yiping Xiu, Xu Zhang, Qingyan Meng

{"title":"The repairing of the soft tissue defect in the eyebrow area with hatchet skin flap","authors":"Wei Feng, N. Luo, Tairan Li, Yiping Xiu, Xu Zhang, Qingyan Meng","doi":"10.3760/CMA.J.ISSN.1673-8799.2014.01.017","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-8799.2014.01.017","url":null,"abstract":"Objective To found out a suitable method for the repairing of the eyebrow area soft tissue defect based on research and the clinical application of the ‘Hatchet Skin Flap’.Methods All 23 patients with eyebrow area soft tissue defect was included.The skin flap was designed along the longitudinal axle of the defect and with the curve of the ‘Hatchet Skin Flap’ parallel to the curve of the eyebrow.The scale of the width to the length of the flap should not less than 1:3.The flap was dissected and transferred to the defected area.The unnecessary skin in the tip area of the flap was dissected.The skin flap was sutured in different layer and without any tension in the sutured area.Results All 23 skin flaps was survived well and without any necrosis and blood supply disorder.The eyebrow was tot be influnced.After 6 months to 3 years follow up all of the skin flap with a satisfactory appearance.Conclusion Having the advantages as easy to design,no influence to the eyebrow,well-distributed tension and without obvious scar,the ‘Hatched Skin Flap’is suitable for the repairing of the soft tissue defect in the eyebrow area. \u0000 \u0000Key words: \u0000Hatched skin flap; Eyebrow area; Soft tissue defect; Repairing","PeriodicalId":64135,"journal":{"name":"中国临床实用医学","volume":"5 1","pages":"40-42"},"PeriodicalIF":0.0,"publicationDate":"2014-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69973301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

脑钠肽灰色区域与急性呼吸困难的诊断进展脑钠肽灰色区域与急性呼吸困难的诊断进展

中国临床实用医学 Pub Date : 2014-01-25 DOI: 10.3760/CMA.J.ISSN.1673-8799.2014.01.041

姜凯莲, 别自东

引用次数: 0

2013冠心病抗栓治疗进展 2013冠心病抗栓治疗进展

中国临床实用医学 Pub Date : 2014-01-25 DOI: 10.3760/CMA.J.ISSN.1673-8799.2014.01.002

韩雅玲

引用次数: 0