Expression and clinical significance of PCNA and IRF2 in human pancreatic cancer

中国临床实用医学 Pub Date : 2014-01-25 DOI:10.3760/CMA.J.ISSN.1673-8799.2014.01.014

Zhenwei Hu, Jiansheng Liu

{"title":"Expression and clinical significance of PCNA and IRF2 in human pancreatic cancer","authors":"Zhenwei Hu, Jiansheng Liu","doi":"10.3760/CMA.J.ISSN.1673-8799.2014.01.014","DOIUrl":null,"url":null,"abstract":"Objective To research the expression levels,clinical significance and the correlation of PCNA and IRF2 in human pancreatic cancer.Methods The expression levels of PCNA and IRF2 in 60 different cases of pancreatic cancer tissues and 30 different cases of para-pancreatic cancer tissues were investigated by Immunohistochemical SP staining and then analyzed through clinicopathological data.Results Immunohistochemical results:the positive expression rates of PCNA and IRF2 in pancreatic cancer tissues were 83.3％ and 78.3％ respectively,which were significantly higher than those in the adjacent pancreatic tissues,of which were 20.0％ and 23.3％ respectively.The differences were statistically significant (P＜0.001).The factors of age,gender,tumor site of patients with pancreatic carcinoma were not statistically significant with the expression of PCNA (P＞0.05),but other factors,such as the differentiation of pancreatic tissue,TNM stage and lymph node metastasis,were statistically significant (P＜O.05).The factors of age,sex,tumor location and lymph node metastasis of pancreatic carcinoma patients were not statistically significant with the expression of PCNA (P＞0.05),but the factors of differentiation of pancreatic tissue and TNM stage were statistically significant (P＜0.05).Moreover,the expression of PCNA and IRF2 was positively correlated (γ =0.416,P=0.001).Conclusion The abnormal expression of PCNA and IRF2 is correlated with occurrence of pancreatic cancer and the cancer cell proliferation activity. \n \nKey words: \nPancreatic Cancer; PCNA; IRF2; Immunohistochemistry","PeriodicalId":64135,"journal":{"name":"中国临床实用医学","volume":"5 1","pages":"33-35"},"PeriodicalIF":0.0000,"publicationDate":"2014-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"中国临床实用医学","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3760/CMA.J.ISSN.1673-8799.2014.01.014","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 1

Abstract

Objective To research the expression levels,clinical significance and the correlation of PCNA and IRF2 in human pancreatic cancer.Methods The expression levels of PCNA and IRF2 in 60 different cases of pancreatic cancer tissues and 30 different cases of para-pancreatic cancer tissues were investigated by Immunohistochemical SP staining and then analyzed through clinicopathological data.Results Immunohistochemical results:the positive expression rates of PCNA and IRF2 in pancreatic cancer tissues were 83.3％ and 78.3％ respectively,which were significantly higher than those in the adjacent pancreatic tissues,of which were 20.0％ and 23.3％ respectively.The differences were statistically significant (P＜0.001).The factors of age,gender,tumor site of patients with pancreatic carcinoma were not statistically significant with the expression of PCNA (P＞0.05),but other factors,such as the differentiation of pancreatic tissue,TNM stage and lymph node metastasis,were statistically significant (P＜O.05).The factors of age,sex,tumor location and lymph node metastasis of pancreatic carcinoma patients were not statistically significant with the expression of PCNA (P＞0.05),but the factors of differentiation of pancreatic tissue and TNM stage were statistically significant (P＜0.05).Moreover,the expression of PCNA and IRF2 was positively correlated (γ =0.416,P=0.001).Conclusion The abnormal expression of PCNA and IRF2 is correlated with occurrence of pancreatic cancer and the cancer cell proliferation activity. Key words: Pancreatic Cancer; PCNA; IRF2; Immunohistochemistry

查看原文本刊更多论文

PCNA和IRF2在人胰腺癌中的表达及临床意义

目的探讨PCNA与IRF2在人胰腺癌组织中的表达水平、临床意义及相关性。方法采用免疫组化SP染色法检测60例不同类型胰腺癌组织和30例不同类型胰腺旁癌组织中PCNA和IRF2的表达水平，并结合临床病理资料进行分析。结果免疫组化结果:PCNA和IRF2在胰腺癌组织中的阳性表达率分别为83.3%和78.3%，显著高于癌旁胰腺组织的20.0%和23.3%。差异有统计学意义(P<0.001)。胰腺癌患者年龄、性别、肿瘤部位等因素对PCNA表达的影响无统计学意义(P< 0.05)，而胰腺组织分化程度、TNM分期、淋巴结转移等因素对PCNA表达的影响有统计学意义(P< 0.05)。胰腺癌患者年龄、性别、肿瘤部位、淋巴结转移等因素与PCNA表达差异无统计学意义(P<0.05)，而胰腺组织分化、TNM分期等因素与PCNA表达差异有统计学意义(P<0.05)。PCNA与IRF2表达呈正相关(γ =0.416,P=0.001)。结论PCNA和IRF2的异常表达与胰腺癌的发生及癌细胞的增殖活性有关。关键词:胰腺癌;PCNA;IRF2;免疫组织化学

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

中国临床实用医学

自引率

0.00%

发文量

6167