{"title":"抑郁症患者奥氮平治疗前后血清微量元素及BDNF、Hcy、Cor、神经功能相关因素变化的研究","authors":"Xue-ying Wang, Shi-chun Li","doi":"10.3760/CMA.J.ISSN.1673-8799.2014.01.012","DOIUrl":null,"url":null,"abstract":"Objective To analyze and observe the serum trace elements and BDNF,Hcy,Cor,neural function related factors of patients with depression before and after treatment with olanzapine.Methods 64 patients with depression in our hospital from October 2011 to February 2013 were selected as research object,and they were randomly divided into control group 32 cases and observation group 32 cases,the control group were treated with only sertraline,the observation group were treated with olanzapine based on the treatment of control group,then the serum trace elements and BDNF,Hcy,Cor,neural function related factors of two groups before the treatment and at 3rd and 6th week after the treatment were compared.Results The serum Cu and Fe of observation group at 3rd and 6th week after the treatment were lower than those of control group,Zn and Mn were higher than those of control group,Hcy,Cor and neural function related factors were lower than those of control group,BDNF were higher than those of control group,all P＜0.05,there were all significant differences.Conclusion The olanzapine can effectively adjust the serum trace elements and BDNF,Hcy,Cor,neural function related factors of patients with depression,and it shows a continuous improvement state. \n \nKey words: \nDepression; Olanzapine; Trace elements; Brain-derived neurotrophic factor, BDNF; Homocysteine,Hcy; Cortisol,COR; Neural function related factors; Change","PeriodicalId":64135,"journal":{"name":"中国临床实用医学","volume":"5 1","pages":"27-29"},"PeriodicalIF":0.0000,"publicationDate":"2014-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Study on the change of serum trace elements and BDNF, Hcy, Cor, neural function related factors of patients with depression before and after treatment with Olanzapine\",\"authors\":\"Xue-ying Wang, Shi-chun Li\",\"doi\":\"10.3760/CMA.J.ISSN.1673-8799.2014.01.012\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Objective To analyze and observe the serum trace elements and BDNF,Hcy,Cor,neural function related factors of patients with depression before and after treatment with olanzapine.Methods 64 patients with depression in our hospital from October 2011 to February 2013 were selected as research object,and they were randomly divided into control group 32 cases and observation group 32 cases,the control group were treated with only sertraline,the observation group were treated with olanzapine based on the treatment of control group,then the serum trace elements and BDNF,Hcy,Cor,neural function related factors of two groups before the treatment and at 3rd and 6th week after the treatment were compared.Results The serum Cu and Fe of observation group at 3rd and 6th week after the treatment were lower than those of control group,Zn and Mn were higher than those of control group,Hcy,Cor and neural function related factors were lower than those of control group,BDNF were higher than those of control group,all P＜0.05,there were all significant differences.Conclusion The olanzapine can effectively adjust the serum trace elements and BDNF,Hcy,Cor,neural function related factors of patients with depression,and it shows a continuous improvement state. \\n \\nKey words: \\nDepression; Olanzapine; Trace elements; Brain-derived neurotrophic factor, BDNF; Homocysteine,Hcy; Cortisol,COR; Neural function related factors; Change\",\"PeriodicalId\":64135,\"journal\":{\"name\":\"中国临床实用医学\",\"volume\":\"5 1\",\"pages\":\"27-29\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2014-01-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"中国临床实用医学\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.3760/CMA.J.ISSN.1673-8799.2014.01.012\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"中国临床实用医学","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3760/CMA.J.ISSN.1673-8799.2014.01.012","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Study on the change of serum trace elements and BDNF, Hcy, Cor, neural function related factors of patients with depression before and after treatment with Olanzapine
Objective To analyze and observe the serum trace elements and BDNF,Hcy,Cor,neural function related factors of patients with depression before and after treatment with olanzapine.Methods 64 patients with depression in our hospital from October 2011 to February 2013 were selected as research object,and they were randomly divided into control group 32 cases and observation group 32 cases,the control group were treated with only sertraline,the observation group were treated with olanzapine based on the treatment of control group,then the serum trace elements and BDNF,Hcy,Cor,neural function related factors of two groups before the treatment and at 3rd and 6th week after the treatment were compared.Results The serum Cu and Fe of observation group at 3rd and 6th week after the treatment were lower than those of control group,Zn and Mn were higher than those of control group,Hcy,Cor and neural function related factors were lower than those of control group,BDNF were higher than those of control group,all P＜0.05,there were all significant differences.Conclusion The olanzapine can effectively adjust the serum trace elements and BDNF,Hcy,Cor,neural function related factors of patients with depression,and it shows a continuous improvement state.
Key words:
Depression; Olanzapine; Trace elements; Brain-derived neurotrophic factor, BDNF; Homocysteine,Hcy; Cortisol,COR; Neural function related factors; Change
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