Study on the change of serum trace elements and BDNF, Hcy, Cor, neural function related factors of patients with depression before and after treatment with Olanzapine

中国临床实用医学 Pub Date : 2014-01-25 DOI:10.3760/CMA.J.ISSN.1673-8799.2014.01.012

Xue-ying Wang, Shi-chun Li

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Abstract

Objective To analyze and observe the serum trace elements and BDNF,Hcy,Cor,neural function related factors of patients with depression before and after treatment with olanzapine.Methods 64 patients with depression in our hospital from October 2011 to February 2013 were selected as research object,and they were randomly divided into control group 32 cases and observation group 32 cases,the control group were treated with only sertraline,the observation group were treated with olanzapine based on the treatment of control group,then the serum trace elements and BDNF,Hcy,Cor,neural function related factors of two groups before the treatment and at 3rd and 6th week after the treatment were compared.Results The serum Cu and Fe of observation group at 3rd and 6th week after the treatment were lower than those of control group,Zn and Mn were higher than those of control group,Hcy,Cor and neural function related factors were lower than those of control group,BDNF were higher than those of control group,all P＜0.05,there were all significant differences.Conclusion The olanzapine can effectively adjust the serum trace elements and BDNF,Hcy,Cor,neural function related factors of patients with depression,and it shows a continuous improvement state. Key words: Depression; Olanzapine; Trace elements; Brain-derived neurotrophic factor, BDNF; Homocysteine,Hcy; Cortisol,COR; Neural function related factors; Change

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抑郁症患者奥氮平治疗前后血清微量元素及BDNF、Hcy、Cor、神经功能相关因素变化的研究

目的分析观察抑郁症患者奥氮平治疗前后血清微量元素及BDNF、Hcy、Cor、神经功能相关因素。方法选取我院2011年10月至2013年2月收治的64例抑郁症患者作为研究对象，将其随机分为对照组32例和观察组32例，对照组仅给予舍曲林治疗，观察组在对照组治疗的基础上给予奥氮平治疗，分别于治疗前和治疗后第3、6周测定两组患者血清微量元素及BDNF、Hcy、Cor、神经功能相关因子比较两种治疗方法。结果观察组患者治疗后第3、6周血清Cu、Fe低于对照组，Zn、Mn高于对照组，Hcy、Cor及神经功能相关因子低于对照组，BDNF高于对照组，均P<0.05，差异均有统计学意义。结论奥氮平能有效调节抑郁症患者血清微量元素及BDNF、Hcy、Cor、神经功能相关因子，并呈持续改善状态。关键词:抑郁症;奥氮平;微量元素;脑源性神经营养因子;同型半胱氨酸(Hcy);皮质醇,心脏;神经功能相关因素;改变

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中国临床实用医学

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