International Journal of Mechanical and Materials Engineering最新文献

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Low-velocity impact response of hybrid core sandwich panels with spring and strut cores filled with resin, silicone, and foam 混合芯材夹芯板的低速冲击响应,其弹簧和支柱芯材中填充了树脂、硅酮和泡沫塑料
IF 3.4
International Journal of Mechanical and Materials Engineering Pub Date : 2024-08-22 DOI: 10.1186/s40712-024-00158-8
Assil Charkaoui, Noha M. Hassan, Zied Bahroun, Mahmoud Ibrahim
{"title":"Low-velocity impact response of hybrid core sandwich panels with spring and strut cores filled with resin, silicone, and foam","authors":"Assil Charkaoui,&nbsp;Noha M. Hassan,&nbsp;Zied Bahroun,&nbsp;Mahmoud Ibrahim","doi":"10.1186/s40712-024-00158-8","DOIUrl":"10.1186/s40712-024-00158-8","url":null,"abstract":"<div><p>Advancements in the load-bearing capacity of composite panels open doors to high-performance applications. The integration of additive manufacturing allows for the creation of intricate core designs effortlessly. Hybrid cores, combining structural elements with infill materials, play a crucial role in enhancing panel impact resistance while maintaining its low weight. This study compares sandwich panels incorporating spring and octet strut structural elements infused with different materials—silicon, foam, and epoxy resin—evaluating their energy absorption capabilities. Additive manufacturing is employed to produce these panels with structural elements then subsequently filled with infills. The drop tower test is utilized to experimentally assess panel behavior under low-velocity impact. Design of experiments and statistical analysis are used to examine the influence of core height, impact height, core geometry, and filling type on the damaged area and impactor penetration. Results showed that the strut-based structure performed better than other structures in preventing penetration, with a damaged area reduction from 501.45 to 301.58 m<sup>2</sup> compared to the spring core. The addition of foam or silicon reduced the impact damage to the front and the back sheets, with silicon infills proving to be the most effective, reducing penetration by reducing penetration by about 60%. The depth of impact was measured, with results indicating that the truss core displayed the smallest specific depth of penetration. A decision tree model predicted that a sandwich panel with a spring core would have a 100% chance of perforation while a filled core showed a significantly reduced penetration risk.</p></div>","PeriodicalId":592,"journal":{"name":"International Journal of Mechanical and Materials Engineering","volume":"19 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://jmsg.springeropen.com/counter/pdf/10.1186/s40712-024-00158-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142021727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Doped holes and/or electrons induced superconductivity domes explained with the free volume concept 用自由体积概念解释掺杂空穴和/或电子诱导的超导穹顶
IF 3.4
International Journal of Mechanical and Materials Engineering Pub Date : 2024-08-21 DOI: 10.1186/s40712-024-00159-7
Tian Hao
{"title":"Doped holes and/or electrons induced superconductivity domes explained with the free volume concept","authors":"Tian Hao","doi":"10.1186/s40712-024-00159-7","DOIUrl":"10.1186/s40712-024-00159-7","url":null,"abstract":"<div><p>The conductivity equation developed in our previous work without any restrictions to specific materials is employed to explore how superconductivity transition temperature <span>(T_{c})</span> changes with the doped hole or electron concentrations based on the free volume concept. The predicted relationship is used to fit experimental data available in the literature and a good agreement with observations is achieved. Our findings may provide an alternative explanation for doping-induced domes and/or double domes with a-dip phenomena observed among many superconductors.</p></div>","PeriodicalId":592,"journal":{"name":"International Journal of Mechanical and Materials Engineering","volume":"19 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://jmsg.springeropen.com/counter/pdf/10.1186/s40712-024-00159-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142021731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enhancing Ni–Ti shape memory alloy diffusion bonding with Ti/Ni reactive multilayer foils 利用钛/镍反应多层箔增强镍-钛形状记忆合金的扩散接合
IF 3.4
International Journal of Mechanical and Materials Engineering Pub Date : 2024-08-13 DOI: 10.1186/s40712-024-00162-y
Mohammad Mokhles, Seyed Mojtaba Zebarjad, Habib Danesh-Manesh, Tushar R. Dandekar
{"title":"Enhancing Ni–Ti shape memory alloy diffusion bonding with Ti/Ni reactive multilayer foils","authors":"Mohammad Mokhles,&nbsp;Seyed Mojtaba Zebarjad,&nbsp;Habib Danesh-Manesh,&nbsp;Tushar R. Dandekar","doi":"10.1186/s40712-024-00162-y","DOIUrl":"10.1186/s40712-024-00162-y","url":null,"abstract":"<div><p>This study investigates the utilization of Ti/Ni reactive multilayer foils as an energy source for facilitating the joining of Ni–Ti shape memory alloys through diffusion bonding. Multilayered samples were prepared using a 10-cycle accumulative roll bonding (ARB) process to be used for the bonding process. Diffusion bonding employing reactive multilayers was conducted over a temperature range of 600 °C to 900 °C, at 5 MPa pressure, with a 1-h hold time. Additionally, a comparison was made with a diffusion-bonded Nitinol sample at 900 °C without a reactive multilayer. Materials characterization and testing involved scanning electron microscopy (SEM), energy-dispersive spectroscopy (EDS), shear strength testing, and differential scanning calorimetry (DSC), which were conducted on the bonded samples. The findings underscored the advantages of using reactive multilayers for diffusion bonding. These benefits included the formation of TiNi and the induction of a shape memory effect in the joint region, alongside a 1.5 times shear strength compared to identical diffusion bonding conditions without reactive multilayers. Moreover, employing reactive multilayers in the diffusion bonding of Nitinol holds promise for significantly reducing the energy needed to achieve robust and seamless bonded boundaries in the joining area.</p></div>","PeriodicalId":592,"journal":{"name":"International Journal of Mechanical and Materials Engineering","volume":"19 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://jmsg.springeropen.com/counter/pdf/10.1186/s40712-024-00162-y","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141973609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Self-assembled rectorite films with remarkable mechanical performance: preparation, structural characterization, and properties 具有卓越机械性能的自组装雷克托石薄膜:制备、结构表征和性能
IF 3.4
International Journal of Mechanical and Materials Engineering Pub Date : 2024-08-13 DOI: 10.1186/s40712-024-00161-z
Maria T. Atanasova, Walter W. Focke, Theodor Loots
{"title":"Self-assembled rectorite films with remarkable mechanical performance: preparation, structural characterization, and properties","authors":"Maria T. Atanasova,&nbsp;Walter W. Focke,&nbsp;Theodor Loots","doi":"10.1186/s40712-024-00161-z","DOIUrl":"10.1186/s40712-024-00161-z","url":null,"abstract":"<div><p>Cohesive flexible rectorite clay films with good mechanical performance were prepared by a simple casting method through the self-assembly of exfoliated natural clay from aqueous dispersions. The multi-layered microstructure of the films consisted of continuous layers of aligned clay platelets parallel to the casting surface. Layers overlap randomly in the lateral direction (plane) and join vertically in an irregular manner by edge-to-face cross-linkages (bridging) to form coherent multi-layered nanostructured films with platelet-void microstructure. The films with the highest mechanical properties had thicknesses below 30 µm. Overall films from rectorite clay with monovalent interlayer content exhibited a higher experimental tensile strength ranging up to 44 MPa and Young’s modulus up to 56 GPa. The corresponding experimental values for films with divalent interlayer cations were 23 MPa for strength and 25 GPa for modulus. The highest experimental values for strength and modulus for neat Na–Ca–rectorite films were 25 MPa and 50 GPa respectively. These two mechanical property values of the best rectorite-based clay films compare favorably with values featured by polymer films typically used for packaging applications.</p></div>","PeriodicalId":592,"journal":{"name":"International Journal of Mechanical and Materials Engineering","volume":"19 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://jmsg.springeropen.com/counter/pdf/10.1186/s40712-024-00161-z","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141973612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sustainable polymer reclamation: recycling poly(ethylene terephthalate) glycol (PETG) for 3D printing applications 可持续聚合物再生:回收聚对苯二甲酸乙二醇(PETG)用于 3D 打印应用
IF 3.4
International Journal of Mechanical and Materials Engineering Pub Date : 2024-08-12 DOI: 10.1186/s40712-024-00163-x
João Daniel Seno Flores, Thiago de Assis Augusto, Daniel Aparecido Lopes Vieira Cunha, Cesar Augusto Gonçalves Beatrice, Eduardo Henrique Backes, Lidiane Cristina Costa
{"title":"Sustainable polymer reclamation: recycling poly(ethylene terephthalate) glycol (PETG) for 3D printing applications","authors":"João Daniel Seno Flores,&nbsp;Thiago de Assis Augusto,&nbsp;Daniel Aparecido Lopes Vieira Cunha,&nbsp;Cesar Augusto Gonçalves Beatrice,&nbsp;Eduardo Henrique Backes,&nbsp;Lidiane Cristina Costa","doi":"10.1186/s40712-024-00163-x","DOIUrl":"10.1186/s40712-024-00163-x","url":null,"abstract":"<div><p>Due to their versatile properties and wide-ranging applications across various industries, including manufacturing, polymers are indispensable for today’s society. However, polymer-based products significantly impact the environment since many are single-used plastics and require a long time to degrade naturally. A method to attenuate end-of-life polymers’ ill effects is recycling them to bring them again into the production cycle, from grave to cradle. This investigation involves recycling PETG sheets used in face shield production during the COVID-19 outbreak to fabricate 3D printing filaments for FFF. We assessed poly(ethylene terephthalate) glycol (PETG) processability to up to five recycling cycles and obtained filaments with properties adequate for 3D printing. Rheological, thermal, morphological, and mechanical characterization were analyzed to verify the effect of the number of processing cycles on the properties of the polymer. The recycling cycles originated a decrease in viscosity and elasticity, and the gain in molecular mobility resulted, relatively, in solids with a higher degree of crystallinity and prints with more elliptical depositions. The mechanical properties of printed parts fabricated of recycled material were comparable to those from commercial filament, especially after three extrusion cycles. Both extrusion and additive manufacturing processes successfully recycle material into filaments and printed parts, indicating that the proposed methodology is a promising alternative to bring value back to polymers from solid waste.</p></div>","PeriodicalId":592,"journal":{"name":"International Journal of Mechanical and Materials Engineering","volume":"19 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://jmsg.springeropen.com/counter/pdf/10.1186/s40712-024-00163-x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141945539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Experimental study of characterization and optimization of shape memory alloy sheet for enhanced mechanical actuation performance for microelectromechanical systems (MEMS) 表征和优化形状记忆合金薄片以提高微机电系统 (MEMS) 机械致动性能的实验研究
IF 3.4
International Journal of Mechanical and Materials Engineering Pub Date : 2024-08-11 DOI: 10.1186/s40712-024-00160-0
Suraj, Arun Kumar
{"title":"Experimental study of characterization and optimization of shape memory alloy sheet for enhanced mechanical actuation performance for microelectromechanical systems (MEMS)","authors":"Suraj,&nbsp;Arun Kumar","doi":"10.1186/s40712-024-00160-0","DOIUrl":"10.1186/s40712-024-00160-0","url":null,"abstract":"<div><p>In this paper, a shape memory alloy (SMA), NiTiNOL, zigzag sheet is used and experimental method is developed using programmable power supply, laser displacement sensor, and K-type thermocouple to investigate actuation and thermo-mechanical behavior of trained SMA zigzag sheet under three different weights, 2.5 N, 3.5 N, and 4.5 N, along with three distinct voltage levels 2.0 V, 3.0 V, and 4.0 V and hysteresis curves are comprehensively examined to get optimum value of load and voltage to achieve better life cycle and actuation as per the requirement of the design. The displacement and temperature data of the zigzag sheet is recorded for every 200 ms for the entire operating life, utilizing heating and cooling processes, of the zigzag sheet and the value of constant displacement for each cycle is optimized which can be used for the development of microelectromechanical systems (MEMS).</p></div>","PeriodicalId":592,"journal":{"name":"International Journal of Mechanical and Materials Engineering","volume":"19 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://jmsg.springeropen.com/counter/pdf/10.1186/s40712-024-00160-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141945471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advancements in bandgap engineering: bromide-doped cesium lead perovskite thin films 带隙工程的进展:溴掺杂铯铅过氧化物薄膜
IF 3.4
International Journal of Mechanical and Materials Engineering Pub Date : 2024-08-05 DOI: 10.1186/s40712-024-00156-w
Khawla Fradi, Amal Bouich, Yousaf Hameed Khattak, Faisal Baig, Bechir Slimi, Bernabé Marí Soucase, Radhouane Chtourou
{"title":"Advancements in bandgap engineering: bromide-doped cesium lead perovskite thin films","authors":"Khawla Fradi,&nbsp;Amal Bouich,&nbsp;Yousaf Hameed Khattak,&nbsp;Faisal Baig,&nbsp;Bechir Slimi,&nbsp;Bernabé Marí Soucase,&nbsp;Radhouane Chtourou","doi":"10.1186/s40712-024-00156-w","DOIUrl":"10.1186/s40712-024-00156-w","url":null,"abstract":"<div><p>Perovskite materials have emerged as promising candidates for next-generation photovoltaic devices due to their unique optoelectronic properties. In this study, we investigate the incorporation of bromine into cesium lead mixed iodide and bromide perovskites (CsPbI<sub>3(1-x)</sub>Br<sub>3x</sub>) to enhance their performance. By depositing films with varying bromine concentrations (<i>x</i> = 0, 0.25, 0.5, 0.75), we employ a combination of structural and optical characterization techniques, including X-ray diffraction (XRD), scanning electron microscopy (SEM), UV–visible spectroscopy, and photoluminescence. Our analysis reveals that introducing bromine leads to structural modifications, influencing the perovskite films’ optical properties and energy gap. Specifically, we observe semiconductor behavior with a tunable energy gap controlled by the intercalation of bromine atoms into the CsPbI<sub>3</sub> lattice. Furthermore, heat treatment induces phase transitions in the perovskite films, affecting their optical responses and crystalline quality. SCAPS-1D simulations confirm the improved stability and efficiency of bromine-doped CsPbI<sub>3</sub> films compared to undoped counterparts. Our findings demonstrate that bromine incorporation facilitates the formation of highly crystalline perovskite films with reduced trap defects and enhanced carrier transport properties. These results underscore the potential of bromine-doped CsPbI<sub>3</sub> perovskites as promising materials for high-performance photovoltaic applications, paving the way for further optimization and device integration.</p></div>","PeriodicalId":592,"journal":{"name":"International Journal of Mechanical and Materials Engineering","volume":"19 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://jmsg.springeropen.com/counter/pdf/10.1186/s40712-024-00156-w","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141945541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sustainable machining of AISI4140 steel: a Taguchi-ANN perspective on eco-friendly metal cutting parameters AISI4140 钢的可持续加工:从 Taguchi-ANN 角度看生态友好型金属切削参数
IF 3.4
International Journal of Mechanical and Materials Engineering Pub Date : 2024-08-02 DOI: 10.1186/s40712-024-00154-y
Pankaj Krishnath Jadhav, R. S. N. Sahai
{"title":"Sustainable machining of AISI4140 steel: a Taguchi-ANN perspective on eco-friendly metal cutting parameters","authors":"Pankaj Krishnath Jadhav,&nbsp;R. S. N. Sahai","doi":"10.1186/s40712-024-00154-y","DOIUrl":"10.1186/s40712-024-00154-y","url":null,"abstract":"<div><p>This work explores environmentally conscious machining practices for AISI4140 steel through Taguchi analysis. The study employs a design of experiments (DOE) approach, focusing on cutting speed, depth of cut, and coolant type as parameters. Taguchi’s L9 orthogonal array facilitates systematic experimentation, and the results are analyzed using MINITAB 17 software. Signal-to-noise ratios (SNR) are utilized to establish optimum operating conditions, evaluate individual parameter influences, and create linear regression models. The experiments reveal neem oil with graphene coolant as an eco-friendly solution, addressing health and environmental concerns. Main effects plots visually represent the impact of parameters on machining quality. Additionally, regression and artificial neural network (ANN) models are compared for surface roughness prediction, with ANN showing superior performance. The findings advocate for optimized cutting conditions, emphasizing material conservation, enhanced productivity, and eco-friendly practices in AISI4140 steel machining. This research contributes valuable insights for industries seeking sustainable machining solutions.</p></div>","PeriodicalId":592,"journal":{"name":"International Journal of Mechanical and Materials Engineering","volume":"19 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://jmsg.springeropen.com/counter/pdf/10.1186/s40712-024-00154-y","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141886769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development of an opto-electrochemical sensor for the detection of malathion using manganese metal–organic framework (Mn-MOF) 利用锰金属有机框架(Mn-MOF)开发用于检测马拉硫磷的光电化学传感器
IF 3.4
International Journal of Mechanical and Materials Engineering Pub Date : 2024-07-29 DOI: 10.1186/s40712-024-00157-9
Lakshya Sankhla, Himmat Singh Kushwaha
{"title":"Development of an opto-electrochemical sensor for the detection of malathion using manganese metal–organic framework (Mn-MOF)","authors":"Lakshya Sankhla,&nbsp;Himmat Singh Kushwaha","doi":"10.1186/s40712-024-00157-9","DOIUrl":"10.1186/s40712-024-00157-9","url":null,"abstract":"<div><p>This paper presents a new method for detecting malathion pesticides using a modified screen-printed electrode (SPE) with a fluorescence quenching technique. The manganese-based MOF was synthesized using the solvothermal method. The synthesized MOFs were characterized by transmission electron microscopy (TEM), x-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), and Raman spectroscopy. The material’s electrocatalytic properties were assessed via electrochemical impedance spectroscopy (EIS) and cyclic voltammetry (CV). Within the concentration range of 0.89 µM to 5.95 µM, the material’s response to malathion was analyzed with square wave voltammetry (SWV), giving rise to a detection limit of 39.097 nM. Fluorescence quenching studies have been carried out between 0.039 and 0.56 µM, with a lower detection limit of 62.03 nM. A sensor with good anti-interference properties was tested for selectivity and practicability in detecting malathion in real samples, proving its potential use in this area.</p></div>","PeriodicalId":592,"journal":{"name":"International Journal of Mechanical and Materials Engineering","volume":"19 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://jmsg.springeropen.com/counter/pdf/10.1186/s40712-024-00157-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141867569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Concentration modulated microstructure and rheological properties of nanofibrous hydrogels derived from decellularized human amniotic membrane for 3D cell culture 用于三维细胞培养的脱细胞人羊膜纳米纤维水凝胶的浓度调节微结构和流变特性
IF 3.4
International Journal of Mechanical and Materials Engineering Pub Date : 2024-07-29 DOI: 10.1186/s40712-024-00153-z
Golara Kafili, Elnaz Tamjid, Hassan Niknejad, Abdolreza Simchi
{"title":"Concentration modulated microstructure and rheological properties of nanofibrous hydrogels derived from decellularized human amniotic membrane for 3D cell culture","authors":"Golara Kafili,&nbsp;Elnaz Tamjid,&nbsp;Hassan Niknejad,&nbsp;Abdolreza Simchi","doi":"10.1186/s40712-024-00153-z","DOIUrl":"10.1186/s40712-024-00153-z","url":null,"abstract":"<div><p>Decellularized amnion (dAM)-derived hydrogels have been extensively exploited for versatile medical and therapeutical applications, particularly for soft tissue engineering of skin, vascular graft, and endometrium. In contrast to polyacrylamide-based hydrogels, which have been extensively employed as a 3D cell culture platform, the cell response of dAM hydrogel is yet to be understood. In this study, we have prepared hydrogels containing different concentrations of dAM and systematically investigated their microstructural features, gelation kinetics, and rheological properties. The results show that dAM hydrogels possess a network of fibers with an average diameter of 56 ± 5 nm at 1% dAM, which increases to 110 ± 14 nm at 3% dAM. The enhanced intermolecular crosslinking between the microfibrillar units increases the gelation rate in the growth phase of the self-assembly process. Moreover, increasing the concentration of dAM in the hydrogel formulation (from 1 to 3%w/v) enhances the dynamic mechanical moduli of the derived hydrogels by about two orders of magnitude (from 41.8 ± 2.5 to 896.2 ± 72.3 Pa). It is shown that the variation in the hydrogel stiffness significantly affects the morphology of dermal fibroblast cells cultured in the hydrogels. It is shown that the hydrogels containing up to 2%w/v dAM provide a suitable microenvironment for embedded fibroblast cells with spindle-like morphology. Nevertheless, at the higher concentration, an adverse effect on the proliferation and morphology of fibroblast cells is noticed due to stiffness-induced phenotype transformation of cells. Concentration-modulated properties of dAM hydrogels offer an in vitro platform to study cell-related responses, disease modeling, and drug studies.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":592,"journal":{"name":"International Journal of Mechanical and Materials Engineering","volume":"19 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://jmsg.springeropen.com/counter/pdf/10.1186/s40712-024-00153-z","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141867568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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