Frontiers of Materials Science最新文献

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Microneedles containing collagen, hyaluronic acid, and cinnamoyl-functionalized poly(hydroxyethyl acrylate-co-butyl methacrylate) with light- and temperature-dependent transdermal delivery properties 微针含有胶原蛋白、透明质酸和肉桂酰功能化聚(丙烯酸羟乙酯-甲基丙烯酸丁酯),具有光和温度依赖的透皮传递特性
IF 2.3 4区 材料科学
Frontiers of Materials Science Pub Date : 2026-02-19 DOI: 10.1007/s11706-026-0756-1
Fanyu Zhao, Yuyuan Guo, Seung-Jun Lee, Jin-Chul Kim
{"title":"Microneedles containing collagen, hyaluronic acid, and cinnamoyl-functionalized poly(hydroxyethyl acrylate-co-butyl methacrylate) with light- and temperature-dependent transdermal delivery properties","authors":"Fanyu Zhao,&nbsp;Yuyuan Guo,&nbsp;Seung-Jun Lee,&nbsp;Jin-Chul Kim","doi":"10.1007/s11706-026-0756-1","DOIUrl":"10.1007/s11706-026-0756-1","url":null,"abstract":"<div><p>This work reports a ultraviolet (UV)- and temperature-responsive dissolving microneedle matrices based on cinnamoyl-functionalized poly(hydroxyethyl acrylate-<i>co</i>-butyl methacrylate) (Cin-poly(HEA-<i>co</i>-BMA)) for controllable transdermal delivery. The lower critical solution temperature (LCST) of the copolymer decreased with increasing hydrophobic moieties, while UV irradiation increased the LCST via cinnamoyl photoreaction, enabling light-regulated thermal responsiveness. Pyramidal microneedle matrices exhibited an elastic–fracture–elastic deformation behavior under compression, with a Young’s modulus of 0.187–0.221 MPa, and UV treatment further enhanced their mechanical strength. Nearly 100% skin penetration efficiency was achieved, particularly for UV-treated needles. Dye permeation at 37 °C was significantly higher than that at 25 °C, whereas UV irradiation effectively suppressed this thermally promoted permeation by elevating the LCST. This dual-responsive microneedle matrix system provides a programmable strategy for mechanically robust and externally regulated transdermal delivery.</p></div>","PeriodicalId":572,"journal":{"name":"Frontiers of Materials Science","volume":"20 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147340338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Progress in two-dimensional nanomaterials for micro-/nano-electromechanical system sensors: fabrication and applications 微/纳米机电系统传感器用二维纳米材料的研究进展:制备与应用
IF 2.3 4区 材料科学
Frontiers of Materials Science Pub Date : 2026-02-17 DOI: 10.1007/s11706-026-0751-6
Mohammad Raza Miah, Nahida Akter, Sakil Mahmud, Ayub Nabi Khan, Md. Abdul Jalil, Ranajit Kumar Nag, Md. Mahmudul Alam Sarker, Shahjalal Khandaker, M. Mahbubul Bashar, Jin Zhu
{"title":"Progress in two-dimensional nanomaterials for micro-/nano-electromechanical system sensors: fabrication and applications","authors":"Mohammad Raza Miah,&nbsp;Nahida Akter,&nbsp;Sakil Mahmud,&nbsp;Ayub Nabi Khan,&nbsp;Md. Abdul Jalil,&nbsp;Ranajit Kumar Nag,&nbsp;Md. Mahmudul Alam Sarker,&nbsp;Shahjalal Khandaker,&nbsp;M. Mahbubul Bashar,&nbsp;Jin Zhu","doi":"10.1007/s11706-026-0751-6","DOIUrl":"10.1007/s11706-026-0751-6","url":null,"abstract":"<div><p>The performance of micro-/nano-electromechanical systems (M/NEMSs) has been significantly improved through the integration of two-dimensional (2D) nanomaterials such as graphene, transition metal chalcogenides and hexagonal boron nitride, mainly due to their excellent mechanical strength, high electrical conductivity and superior thermal and chemical stability. Moreover, the fabrication, integration and functional properties of 2D nanomaterial-based M/NEMSs have been the subject of extensive research, especially regarding device reliability, packaging and pathways to large-scale commercialization. Furthermore, in the fields of biosensing and medical diagnostics, the inherent biocompatibility, photoactivity, and mechanical flexibility of 2D nanomaterials enable rapid response and high-sensitivity detection. Finally, future industrial applications will rely on scalable and cost-effective packaging solutions. The MEMS market is expected to grow at a compound annual growth rate (CAGR) of 7.9%, from $16.5 billion in 2024 to $24.2 billion in 2029.</p></div>","PeriodicalId":572,"journal":{"name":"Frontiers of Materials Science","volume":"20 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147339547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Copper-coated yarn architectures for knitted fabrics with enhanced strain sensitivity and wrist posture recognition 用于增强应变敏感性和手腕姿势识别的针织物的铜涂层纱线结构
IF 2.3 4区 材料科学
Frontiers of Materials Science Pub Date : 2026-02-12 DOI: 10.1007/s11706-026-0758-z
Wei Ke, Yixin Liang, Jinchun Liu, Yan Huang, Zhao Li, Ming Yang, Sakil Mahmud
{"title":"Copper-coated yarn architectures for knitted fabrics with enhanced strain sensitivity and wrist posture recognition","authors":"Wei Ke,&nbsp;Yixin Liang,&nbsp;Jinchun Liu,&nbsp;Yan Huang,&nbsp;Zhao Li,&nbsp;Ming Yang,&nbsp;Sakil Mahmud","doi":"10.1007/s11706-026-0758-z","DOIUrl":"10.1007/s11706-026-0758-z","url":null,"abstract":"<div><p>Knitted flexible sensors, owing to their looped architecture, exhibit excellent stretchability, comfort, and responsiveness, enabling real-time monitoring of biomechanical motion. Here, we systematically investigated the electromechanical performance of conductive fabrics composed of stainless steel, silver-plated, and copper-plated yarns across rib, half-air layer, and air-layer knitting structures. Among them, copper-plated rib fabrics with (35r × 35r)/5 cm density demonstrated superior sensing performance, with stable resistance variation (∼2 to ∼1 kΩ from 0° to 90° wrist bending), high linearity (<i>R</i><sup>2</sup>= 0.959), good stability (<i>δ</i> = 0.232 after 100 cycles), and a gauge factor (GF) of ∼2.73. An equivalent resistance model was established to elucidate the impact of loop geometry on sensor performance, confirming that higher coursewise density lowers resistance and enhances sensitivity. A wearable knitted wristband sensor was fabricated that accurately distinguishes wrist postures. These findings highlight the potential of structured conductive knits as customizable, high-performance platforms for next-generation wearable health monitoring and rehabilitation systems.</p></div>","PeriodicalId":572,"journal":{"name":"Frontiers of Materials Science","volume":"20 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147339059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Secondary recrystallization behaviors and the formation mechanism of strong Goss textures of oriented electrical steels 取向电工钢的二次再结晶行为及强高斯织构的形成机制
IF 2.3 4区 材料科学
Frontiers of Materials Science Pub Date : 2026-02-12 DOI: 10.1007/s11706-026-0759-y
Weimin Mao
{"title":"Secondary recrystallization behaviors and the formation mechanism of strong Goss textures of oriented electrical steels","authors":"Weimin Mao","doi":"10.1007/s11706-026-0759-y","DOIUrl":"10.1007/s11706-026-0759-y","url":null,"abstract":"<div><p>During secondary recrystallization of oriented electrical steels, the dispersed inhibitors strongly hinder grain boundary migration. The existing secondary recrystallization theories, which mainly focus on the initial migration behavior of grain boundaries, not only fails to clarify the mechanism of secondary recrystallization, but also cannot explain the common phenomenon that smaller Goss grains can eventually engulf all other grains. This study confirms that the significant molar volume effect generated by the precipitation of inhibitors within the ferrite matrix strongly inhibits the coarsening of the central layer inhibitors in steel sheets at high temperatures, but there is still a chance for coarsening of the surface layer inhibitors. Therefore, the surface grains can grow before the growth of grains in the central layer. The highly enhanced elastic anisotropy of ferrite at high temperatures results in slow boundary migration of surface large-sized non-Goss grains towards Goss grains, while surface Goss grain boundaries can quickly migrate towards adjacent small-sized non-Goss grains, allowing Goss grains to gradually accumulate an absolute advantage in larger size, engulf all other grains, and ultimately form a strong Goss texture.</p></div>","PeriodicalId":572,"journal":{"name":"Frontiers of Materials Science","volume":"20 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147339060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hydrogel applications in myocardial infarction: classification, therapeutic mechanism and clinical translation 水凝胶在心肌梗死中的应用:分类、治疗机制及临床翻译
IF 2.3 4区 材料科学
Frontiers of Materials Science Pub Date : 2026-02-04 DOI: 10.1007/s11706-026-0755-2
Oscar Senanu James-Ocloo, Liqin Zhao, Jinqiao Jia, Akhlaq Ahmed, Naseer Ullah, Muhammad Touqeer, Aaima Siddiqui, Godfred Kuffuor Tawiah, Di Huang
{"title":"Hydrogel applications in myocardial infarction: classification, therapeutic mechanism and clinical translation","authors":"Oscar Senanu James-Ocloo,&nbsp;Liqin Zhao,&nbsp;Jinqiao Jia,&nbsp;Akhlaq Ahmed,&nbsp;Naseer Ullah,&nbsp;Muhammad Touqeer,&nbsp;Aaima Siddiqui,&nbsp;Godfred Kuffuor Tawiah,&nbsp;Di Huang","doi":"10.1007/s11706-026-0755-2","DOIUrl":"10.1007/s11706-026-0755-2","url":null,"abstract":"<div><p>Myocardial infarction (MI) remains a major cause of morbidity and mortality worldwide, stemming from the heart’s limited regenerative capacity and formation of noncontractile fibrotic tissue. Current treatments, including pharmacological and surgical interventions, manage symptoms and restore perfusion but fail to promote regeneration. Hydrogel-based therapies offer a promising approach by mimicking the cardiac extracellular matrix (ECM), delivering bioactive molecules, and providing structural support for repair. This systematic review examines recent advances in hydrogel-based cardiac repair, focusing on classification, therapeutic mechanisms, preclinical/clinical findings, and translational challenges. Hydrogels are classified as natural, synthetic, and hybrid ones, each with unique mechanical and biological properties. Key mechanisms include angiogenesis stimulation, inflammation modulation, ECM remodeling, stem cell encapsulation, and electrical conductivity enhancement. Preclinical studies demonstrate reduced infarct size, improved left ventricular function, and enhanced cardiomyocyte survival. However, clinical translation is limited, with few early-stage human trials to date.</p></div>","PeriodicalId":572,"journal":{"name":"Frontiers of Materials Science","volume":"20 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147336888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Microbeads-assisted antibacterial hydrogels for wound healing 用于伤口愈合的微珠辅助抗菌水凝胶
IF 2.3 4区 材料科学
Frontiers of Materials Science Pub Date : 2026-02-03 DOI: 10.1007/s11706-026-0753-4
Wesam Ahmed, Akhlaq Ahmed, Naseer Ullah, Jinqiao Jia, Yan Wei, Wenyu Guo, Shuo Huang, Tao Guo, Jingjing Du, Di Huang
{"title":"Microbeads-assisted antibacterial hydrogels for wound healing","authors":"Wesam Ahmed,&nbsp;Akhlaq Ahmed,&nbsp;Naseer Ullah,&nbsp;Jinqiao Jia,&nbsp;Yan Wei,&nbsp;Wenyu Guo,&nbsp;Shuo Huang,&nbsp;Tao Guo,&nbsp;Jingjing Du,&nbsp;Di Huang","doi":"10.1007/s11706-026-0753-4","DOIUrl":"10.1007/s11706-026-0753-4","url":null,"abstract":"<div><p>This review article examines the innovative incorporation of microbeads into hydrogels for wound healing applications, addressing challenges such as infection, scarring, and delayed recovery. Hydrogels are highlighted as effective wound dressings for tissue regeneration, while microbeads serve as versatile carriers for controlled drug release and targeted delivery, allowing customization for specific therapeutic needs. This article explores various preparation methods and materials for microbeads, emphasizing their role in enhancing the antibacterial properties and drug delivery functions of hydrogels. Key properties of microbeads-assisted hydrogels, including biodegradability, biocompatibility, and mechanical strength, are discussed as essential for effective wound management. The integration of microbeads improves drug delivery, antibacterial effects, and tissue regeneration capabilities, providing multifunctional solutions for wound healing. Additionally, the mechanisms of antibacterial agent release are described, focusing on controlled and sustained delivery to wound sites. Applications of microbeads-assisted hydrogels cover drug delivery, antibacterial action, tissue regeneration, and sustained release of growth factors, addressing various wound healing challenges. This article concludes by highlighting significant advancements in wound healing strategies facilitated by the integration of microbeads, promising enhanced therapeutic outcomes for patients.</p></div>","PeriodicalId":572,"journal":{"name":"Frontiers of Materials Science","volume":"20 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146099130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effective suppression of salting-out crystallization for degradation of methyl orange dye using ZnFe2O4/Ag/AgCl nanocomposites ZnFe2O4/Ag/AgCl纳米复合材料对甲基橙染料盐析结晶降解的有效抑制
IF 2.3 4区 材料科学
Frontiers of Materials Science Pub Date : 2025-12-18 DOI: 10.1007/s11706-025-0742-z
Minu Pius, Santhi Ani Joseph
{"title":"Effective suppression of salting-out crystallization for degradation of methyl orange dye using ZnFe2O4/Ag/AgCl nanocomposites","authors":"Minu Pius,&nbsp;Santhi Ani Joseph","doi":"10.1007/s11706-025-0742-z","DOIUrl":"10.1007/s11706-025-0742-z","url":null,"abstract":"<div><p>Herein, we report how the effective suppression of salting-out crystallization leads to the photocatalytic degradation of methyl orange as a bare dye and binary mixed form with methylene blue using the zinc ferrite/silver/silver chloride (ZF/Ag/AgCl) nanocomposite. The work presents the first-time report of photocatalytic degradation of the mixed dye, comprising both anionic and cationic species, as a model industrial discharge using the ZF/Ag/AgCl nanocomposite. High-resolution transmission electron microscopy and Brunauer–Emmett–Teller surface area analysis are performed to validate the characteristics and suitability of samples. This study revealed the photocatalytic degradation of binary mixed dyes exposed under solar irradiation for 3.5 h with degradation efficiencies of 97.5% and 96% against anionic and cationic dyes, respectively, without the addition of any oxidizing agents, as well as efficient magnetic retrievability, recyclability, and stability of the sample, comparable with that against single and binary mixed dyes. The evaluation of the total organic carbon was also conducted to monitor the effective mineralization of the dye. Thus, the suitability of the sample as a magnetically retrievable and visible light-active photocatalyst for the degradation of toxic mixed dyes is explored.</p></div>","PeriodicalId":572,"journal":{"name":"Frontiers of Materials Science","volume":"19 4","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145778586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Magnesium-containing materials for brain and neural repair: advances and perspectives 脑和神经修复用含镁材料:进展与展望
IF 2.3 4区 材料科学
Frontiers of Materials Science Pub Date : 2025-12-16 DOI: 10.1007/s11706-025-0745-9
Xiaoxiao Zhao, Wenjing Yu, Jiawei Wang, Yue Zhang, Li’ang Zhao, Huazhe Yang, Na Zhang
{"title":"Magnesium-containing materials for brain and neural repair: advances and perspectives","authors":"Xiaoxiao Zhao,&nbsp;Wenjing Yu,&nbsp;Jiawei Wang,&nbsp;Yue Zhang,&nbsp;Li’ang Zhao,&nbsp;Huazhe Yang,&nbsp;Na Zhang","doi":"10.1007/s11706-025-0745-9","DOIUrl":"10.1007/s11706-025-0745-9","url":null,"abstract":"<div><p>Nerve damage, including conditions such as traumatic brain injury, cerebral palsy, and other neurological disorders, constitutes a major clinical challenge affecting millions of people globally. Recently, magnesium-containing materials have attracted growing interest in brain research due to their notable biocompatibility, favorable degradation profile, and neuroprotective capabilities. This article provides a comprehensive overview of developments in magnesium-based materials, with a specific focus on their application in brain and neural repair. Leveraging bibliometric analysis and a comprehensive literature review, the therapeutic potential of magnesium-based compounds in neurological disorders is evaluated. These neurological conditions encompass epilepsy, Alzheimer’s disease, and depression. Notably, magnesium-based materials show distinct advantages in enhancing cognitive function and promoting neural regeneration, indicating their strong therapeutic potential. Furthermore, this review also examines key research areas and contemporary trends in brain and neural repair, assesses the current landscape, highlights persistent challenges, and identifies emerging research directions. This synthesis provides a foundation for understanding how magnesium-based materials can inform the development of novel therapeutic strategies.</p></div>","PeriodicalId":572,"journal":{"name":"Frontiers of Materials Science","volume":"19 4","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145778561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Blazing fast MOF magic: carbon nanotubes derived from MOFs for catalysis 燃烧快速MOF魔法:从MOF衍生的碳纳米管用于催化
IF 2.3 4区 材料科学
Frontiers of Materials Science Pub Date : 2025-12-16 DOI: 10.1007/s11706-025-0750-z
Chuan Xu, Junge Zhang, Jiaxin Liu, Weiqiang Zhou, Xianghai Song, Xin Liu, Yangyang Yang, Qian Yang, Yi Guo, Yuqiao Zhang, Jisheng Zhang, Pengwei Huo, Long Zhang
{"title":"Blazing fast MOF magic: carbon nanotubes derived from MOFs for catalysis","authors":"Chuan Xu,&nbsp;Junge Zhang,&nbsp;Jiaxin Liu,&nbsp;Weiqiang Zhou,&nbsp;Xianghai Song,&nbsp;Xin Liu,&nbsp;Yangyang Yang,&nbsp;Qian Yang,&nbsp;Yi Guo,&nbsp;Yuqiao Zhang,&nbsp;Jisheng Zhang,&nbsp;Pengwei Huo,&nbsp;Long Zhang","doi":"10.1007/s11706-025-0750-z","DOIUrl":"10.1007/s11706-025-0750-z","url":null,"abstract":"<div><p>We developed metal–organic framework (MOF) derivatives via rapid thermal processing (RTP) of ZIF-67, achieving synthesis in ∼30 min far faster than conventional pyrolysis. These derivatives retain the morphology of ZIF-67, integrating carbon nanotubes and nickel–cobalt nanoparticles within a porous carbon matrix. With surface areas of ∼ 208–225 m<sup>2</sup>·g<sup>−1</sup>, they excel in styrene epoxidation, yielding 80% conversion and 50%–60% selectivity. This efficient RTP method enhances stability and activity, offering a scalable approach to advance MOF-based catalysis.</p></div>","PeriodicalId":572,"journal":{"name":"Frontiers of Materials Science","volume":"19 4","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145778656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of tandem-type stabilization of Nb2CTx MXene on their colloidal and cytotoxic properties Nb2CTx - MXene串联稳定对其胶体和细胞毒性的影响
IF 2.3 4区 材料科学
Frontiers of Materials Science Pub Date : 2025-12-16 DOI: 10.1007/s11706-025-0749-5
M. Jakubczak, A. Wojciechowska, J. Mitrzak, A. Szuplewska, M. Chudy, A. Wójcik, D. Moszczyńska, K. Prenger, M. Naguib, A. M. Jastrzębska
{"title":"Effect of tandem-type stabilization of Nb2CTx MXene on their colloidal and cytotoxic properties","authors":"M. Jakubczak,&nbsp;A. Wojciechowska,&nbsp;J. Mitrzak,&nbsp;A. Szuplewska,&nbsp;M. Chudy,&nbsp;A. Wójcik,&nbsp;D. Moszczyńska,&nbsp;K. Prenger,&nbsp;M. Naguib,&nbsp;A. M. Jastrzębska","doi":"10.1007/s11706-025-0749-5","DOIUrl":"10.1007/s11706-025-0749-5","url":null,"abstract":"<div><p>Two-dimensional (2D) Nb<sub>2</sub>CT<sub><i>x</i></sub> MXene hold great promise for biomedical applications due to their tunable surface chemistry and biocompatibility. However, their practical use requires long-term colloidal and oxidative stability. Here, we propose a tandem-type stabilization strategy combining antioxidant protection and macromolecular surface functionalization. Nb<sub>2</sub>CT<sub><i>x</i></sub> was first treated with L-ascorbic acid (LA) to suppress oxidation by binding to reactive edges, followed by modification with polyethylene glycol (PEG), poly-L-lysine (PLL), or polydopamine (PDA). This dual approach enhanced stability in biological media — phosphate-buffered saline (PBS) and Dulbecco’s Modified Eagle’s Medium (DMEM) — while preserving non-cytotoxicity toward A375 and HaCaT skin cell lines across 0–100 mg·L<sup>−1</sup>. Among the tested systems, LA/PEG and LA/PDA-modified MXenes maintained stable zeta potentials (−15 to −12 mV) and particle sizes for 72 h, whereas LA/PLL samples showed aggregation and charge loss. This tandem stabilization effectively prevents oxidation and aggregation without compromising biocompatibility, offering a versatile route for developing oxidation-resistant MXenes for biomedical and nanomedicine applications.</p></div>","PeriodicalId":572,"journal":{"name":"Frontiers of Materials Science","volume":"19 4","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s11706-025-0749-5.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145778562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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